| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 0 | 5,367,723 | +5,367,723 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,001 | 4,652,032 | +4,582,031 | 0.00 | 0.02 | +0.02 | buy |
| Capital International Investors | 0 | 2,963,410 | +2,963,410 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 1,809,610 | 4,752,921 | +2,943,311 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 8,480,230 | 11,232,834 | +2,752,604 | 0.00 | 0.01 | +0.01 | buy |
| Avoro Capital Advisors LLC | 5,000,000 | 7,188,888 | +2,188,888 | 0.93 | 3.04 | +2.11 | buy |
| ALLIANCEBERNSTEIN L.P. | 91,703 | 1,803,287 | +1,711,584 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,304,749 | 2,949,734 | +1,644,985 | 0.00 | 0.02 | +0.02 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.61 | +0.61 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,495,399 | 3,644,813 | +1,149,414 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,083,576 | +1,083,576 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,911,889 | 6,845,276 | +933,387 | 0.82 | 1.87 | +1.04 | buy |
| Polar Capital Holdings Plc | 0 | 777,253 | +777,253 | 0.00 | 0.10 | +0.10 | buy |
| STATE STREET CORP | 2,471,873 | 3,065,390 | +593,517 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 133,369 | 687,539 | +554,170 | 0.00 | 0.02 | +0.02 | buy |
| BAMCO INC /NY/ | 0 | 520,108 | +520,108 | 0.00 | 0.04 | +0.04 | buy |
| Octagon Capital Advisors LP | 2,440,000 | 2,950,000 | +510,000 | 5.10 | 12.74 | +7.63 | buy |
| Siren, L.L.C. | 919,493 | 1,419,493 | +500,000 | 0.48 | 1.36 | +0.87 | buy |
| FRANKLIN RESOURCES INC | 0 | 486,219 | +486,219 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 425,000 | +425,000 | 0.00 | 4.71 | +4.71 | buy |
| Nuveen, LLC | 698,130 | 1,105,314 | +407,184 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 0 | 400,000 | +400,000 | 0.00 | 0.96 | +0.96 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 400,000 | +400,000 | 0.00 | 2.09 | +2.09 | buy |
| Boxer Capital Management, LLC | 598,500 | 998,500 | +400,000 | 1.49 | 3.54 | +2.05 | buy |
| ASSETMARK, INC | 0 | 396,542 | +396,542 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 798,987 | 1,169,238 | +370,251 | 0.00 | 0.01 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 356,600 | +356,600 | 0.00 | 0.39 | +0.39 | buy |
| CITADEL ADVISORS LLC | 1,333,442 | 1,688,587 | +355,145 | 0.02 | 0.05 | +0.03 | buy |
| Point72 Asset Management, L.P. | 175,490 | 483,980 | +308,490 | 0.01 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 808,715 | 1,083,576 | +274,861 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 426,055 | 682,901 | +256,846 | 0.01 | 0.04 | +0.02 | buy |
| Woodline Partners LP | 752,792 | 1,003,641 | +250,849 | 0.05 | 0.15 | +0.09 | buy |
| Trexquant Investment LP | 0 | 233,199 | +233,199 | 0.00 | 0.07 | +0.07 | buy |
| TD ASSET MANAGEMENT INC | 0 | 209,460 | +209,460 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,413 | 211,183 | +208,770 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 966,608 | 1,148,363 | +181,755 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 0 | 178,751 | +178,751 | 0.00 | 0.20 | +0.20 | buy |
| Aberdeen Group plc | 0 | 175,000 | +175,000 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 150,200 | +150,200 | 0.00 | 0.05 | +0.05 | buy |
| Integral Health Asset Management, LLC | 400,000 | 550,000 | +150,000 | 0.40 | 1.06 | +0.66 | buy |
| Rock Springs Capital Management LP | 0 | 143,187 | +143,187 | 0.00 | 0.33 | +0.33 | buy |
| SummitTX Capital, L.P. | 0 | 142,489 | +142,489 | 0.00 | 0.18 | +0.18 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 128,346 | +128,346 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,675,411 | 1,800,852 | +125,441 | 0.00 | 0.01 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 122,000 | +122,000 | 0.00 | 0.57 | +0.57 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 121,249 | +121,249 | 0.00 | 0.20 | +0.20 | buy |
| Informed Momentum Co LLC | 0 | 120,928 | +120,928 | 0.00 | 0.51 | +0.51 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,404 | 146,368 | +119,964 | 0.00 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 117,482 | +117,482 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 110,388 | +110,388 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 10,412 | 119,610 | +109,198 | 0.00 | 0.03 | +0.03 | buy |
| RTW INVESTMENTS, LP | 300,000 | 400,000 | +100,000 | 0.06 | 0.16 | +0.10 | buy |
| MARSHALL WACE, LLP | 1,200,825 | 1,298,946 | +98,121 | 0.02 | 0.05 | +0.03 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 95,100 | +95,100 | 0.00 | 0.24 | +0.24 | buy |
| Pier Capital, LLC | 0 | 88,598 | +88,598 | 0.00 | 0.55 | +0.55 | buy |
| TFG Asset Management GP Ltd | 199,994 | 286,990 | +86,996 | 0.74 | 2.20 | +1.45 | buy |
| XTX Topco Ltd | 0 | 84,393 | +84,393 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 39,973 | 122,033 | +82,060 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 80,000 | +80,000 | 0.00 | 0.42 | +0.42 | buy |
| Logos Global Management LP | 0 | 80,000 | +80,000 | 0.00 | 0.16 | +0.16 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,384 | 95,166 | +78,782 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 78,310 | +78,310 | 0.00 | 2.57 | +2.57 | buy |
| AQR CAPITAL MANAGEMENT LLC | 57,094 | 134,152 | +77,058 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 23,356 | 96,510 | +73,154 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 63,700 | +63,700 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 158,400 | 221,200 | +62,800 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 185,856 | 242,884 | +57,028 | 0.97 | 2.60 | +1.64 | buy |
| PEAK FINANCIAL ADVISORS LLC | 0 | 56,915 | +56,915 | 0.00 | 1.11 | +1.11 | buy |
| Eversept Partners, LP | 160,723 | 217,185 | +56,462 | 0.20 | 0.56 | +0.36 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 54,466 | +54,466 | 0.00 | 0.05 | +0.05 | buy |
| Cerity Partners LLC | 0 | 53,883 | +53,883 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 26,486 | 79,547 | +53,061 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 508,668 | 561,612 | +52,944 | 0.04 | 0.09 | +0.05 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 51,025 | +51,025 | 0.00 | 0.43 | +0.43 | buy |
| Atom Investors LP | 0 | 49,436 | +49,436 | 0.00 | 0.21 | +0.21 | buy |
| Polymer Capital Management (HK) LTD | 0 | 44,100 | +44,100 | 0.00 | 0.21 | +0.21 | buy |
| PFM Health Sciences, LP | 205,317 | 249,020 | +43,703 | 0.41 | 1.02 | +0.61 | buy |
| D. E. Shaw & Co., Inc. | 271,717 | 315,410 | +43,693 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 43,124 | +43,124 | 0.00 | 0.07 | +0.07 | buy |
| Ghisallo Capital Management LLC | 0 | 41,500 | +41,500 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 119,972 | 158,096 | +38,124 | 0.00 | 0.01 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 1,802 | 36,694 | +34,892 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 92,165 | 125,256 | +33,091 | 0.01 | 0.02 | +0.01 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 30,729 | +30,729 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 39,958 | 70,682 | +30,724 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 91,301 | 121,381 | +30,080 | 0.31 | 0.69 | +0.37 | buy |
| STABLEFORD CAPITAL II LLC | 0 | 27,141 | +27,141 | 0.00 | 0.44 | +0.44 | buy |
| Janney Montgomery Scott LLC | 0 | 26,664 | +26,664 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 24,500 | +24,500 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 0 | 24,391 | +24,391 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 752,922 | 777,271 | +24,349 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 686,162 | 710,000 | +23,838 | 0.21 | 0.45 | +0.23 | buy |
| IFG Advisory, LLC | 0 | 22,043 | +22,043 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 54,261 | 75,859 | +21,598 | 0.01 | 0.02 | +0.01 | buy |
| TFB Advisors LLC | 0 | 21,523 | +21,523 | 0.00 | 0.45 | +0.45 | buy |
| Russell Investments Group, Ltd. | 119,464 | 140,177 | +20,713 | 0.00 | 0.01 | +0.00 | buy |
| Birchview Capital, LP | 0 | 20,000 | +20,000 | 0.00 | 0.44 | +0.44 | buy |
| Fore Capital, LLC | 0 | 20,000 | +20,000 | 0.00 | 1.25 | +1.25 | buy |
| SG Americas Securities, LLC | 10,493 | 28,262 | +17,769 | 0.00 | 0.00 | +0.00 | buy |