| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,000,000 | 7,188,888 | +2,188,888 | 0.93 | 3.04 | +2.11 | buy |
| RTW INVESTMENTS, LP | 300,000 | 400,000 | +100,000 | 0.06 | 0.16 | +0.10 | buy |
| TFG Asset Management GP Ltd | 199,994 | 286,990 | +86,996 | 0.73 | 2.13 | +1.39 | buy |
| HighVista Strategies LLC | 185,856 | 242,884 | +57,028 | 0.97 | 2.60 | +1.64 | buy |
| Eversept Partners, LP | 160,723 | 217,185 | +56,462 | 0.16 | 0.53 | +0.37 | buy |
| PFM Health Sciences, LP | 205,317 | 249,020 | +43,703 | 0.35 | 1.01 | +0.65 | buy |
| AdvisorShares Investments LLC | 91,301 | 121,381 | +30,080 | 0.31 | 0.69 | +0.37 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 686,162 | 710,000 | +23,838 | 0.21 | 0.45 | +0.23 | buy |
| Bay Rivers Group | 26,346 | 31,208 | +4,862 | 0.21 | 0.50 | +0.29 | buy |
| China Universal Asset Management Co., Ltd. | 20,192 | 21,358 | +1,166 | 0.03 | 0.06 | +0.03 | buy |
| High Note Wealth, LLC | 1,500 | 1,600 | +100 | 0.01 | 0.01 | +0.01 | buy |
| Heritage Wealth Management, Inc. /CA/ | 14,375 | 12,000 | -2,375 | 0.15 | 0.28 | +0.13 | sell |
| SCOTIA CAPITAL INC. | 40,548 | 34,722 | -5,826 | 0.00 | 0.01 | +0.00 | sell |
| Rathbones Group PLC | 30,200 | 22,800 | -7,400 | 0.00 | 0.00 | +0.00 | sell |
| Sofinnova Investments, Inc. | 344,166 | 255,903 | -88,263 | 0.25 | 0.62 | +0.38 | sell |
| BIT Capital GmbH | 277,511 | 128,131 | -149,380 | 0.25 | 0.18 | -0.07 | sell |
| AWM Investment Company, Inc. | 1,076,893 | 784,800 | -292,093 | 2.25 | 3.20 | +0.95 | sell |
| Holocene Advisors, LP | 1,091,967 | 796,574 | -295,393 | 0.05 | 0.08 | +0.03 | sell |
| Candriam S.C.A. | 1,293,629 | 614,425 | -679,204 | 0.13 | 0.13 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 1,594,717 | 564,069 | -1,030,648 | 0.80 | 1.10 | +0.30 | sell |