| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,480,230 | 11,232,834 | +2,752,604 | 0.00 | 0.01 | +0.01 | buy |
| Avoro Capital Advisors LLC | 5,000,000 | 7,188,888 | +2,188,888 | 0.93 | 3.04 | +2.11 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,911,889 | 6,845,276 | +933,387 | 0.82 | 1.87 | +1.04 | buy |
| Capital World Investors | 0 | 5,367,723 | +5,367,723 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 1,809,610 | 4,752,921 | +2,943,311 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,001 | 4,652,032 | +4,582,031 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,495,399 | 3,644,813 | +1,149,414 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,471,873 | 3,065,390 | +593,517 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Investors | 0 | 2,963,410 | +2,963,410 | 0.00 | 0.03 | +0.03 | buy |
| Octagon Capital Advisors LP | 2,440,000 | 2,950,000 | +510,000 | 5.10 | 12.74 | +7.63 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,304,749 | 2,949,734 | +1,644,985 | 0.00 | 0.02 | +0.02 | buy |
| Deep Track Capital, LP | 3,000,000 | 2,750,000 | -250,000 | 1.17 | 1.91 | +0.74 | sell |
| Commodore Capital LP | 2,000,000 | 2,000,000 | 0 | 2.19 | 5.60 | +3.42 | hold |
| ALLIANCEBERNSTEIN L.P. | 91,703 | 1,803,287 | +1,711,584 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,675,411 | 1,800,852 | +125,441 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,333,442 | 1,688,587 | +355,145 | 0.02 | 0.05 | +0.03 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.61 | +0.61 | buy |
| Siren, L.L.C. | 919,493 | 1,419,493 | +500,000 | 0.48 | 1.36 | +0.87 | buy |
| MARSHALL WACE, LLP | 1,200,825 | 1,298,946 | +98,121 | 0.02 | 0.05 | +0.03 | buy |
| NORTHERN TRUST CORP | 798,987 | 1,169,238 | +370,251 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 966,608 | 1,148,363 | +181,755 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 698,130 | 1,105,314 | +407,184 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,083,576 | +1,083,576 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 808,715 | 1,083,576 | +274,861 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 752,792 | 1,003,641 | +250,849 | 0.05 | 0.15 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,150,000 | 1,000,000 | -150,000 | 0.03 | 0.07 | +0.03 | sell |
| Boxer Capital Management, LLC | 598,500 | 998,500 | +400,000 | 1.49 | 3.54 | +2.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,201,610 | 921,818 | -279,792 | 0.02 | 0.03 | +0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,274,221 | 897,658 | -376,563 | 0.05 | 0.08 | +0.03 | sell |
| Holocene Advisors, LP | 1,091,967 | 796,574 | -295,393 | 0.05 | 0.09 | +0.04 | sell |
| AWM Investment Company, Inc. | 1,076,893 | 784,800 | -292,093 | 2.25 | 3.20 | +0.95 | sell |
| Bank of New York Mellon Corp | 752,922 | 777,271 | +24,349 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 777,253 | +777,253 | 0.00 | 0.10 | +0.10 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 686,162 | 710,000 | +23,838 | 0.21 | 0.45 | +0.23 | buy |
| Neuberger Berman Group LLC | 133,369 | 687,539 | +554,170 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 426,055 | 682,901 | +256,846 | 0.01 | 0.04 | +0.02 | buy |
| Candriam S.C.A. | 1,293,629 | 614,425 | -679,204 | 0.13 | 0.13 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 1,594,717 | 564,069 | -1,030,648 | 0.80 | 1.10 | +0.30 | sell |
| Catalio Capital Management, LP | 1,037,984 | 562,672 | -475,312 | 4.10 | 4.97 | +0.88 | sell |
| Blackstone Inc. | 508,668 | 561,612 | +52,944 | 0.04 | 0.09 | +0.05 | buy |
| Integral Health Asset Management, LLC | 400,000 | 550,000 | +150,000 | 0.40 | 1.06 | +0.66 | buy |
| BAMCO INC /NY/ | 0 | 520,108 | +520,108 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 493,977 | 499,467 | +5,490 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 486,219 | +486,219 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 175,490 | 483,980 | +308,490 | 0.01 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 546,783 | 466,106 | -80,677 | 0.02 | 0.04 | +0.02 | sell |
| MORGAN STANLEY | 438,573 | 454,912 | +16,339 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 425,000 | +425,000 | 0.00 | 4.71 | +4.71 | buy |
| RTW INVESTMENTS, LP | 300,000 | 400,000 | +100,000 | 0.06 | 0.16 | +0.10 | buy |
| Cormorant Asset Management, LP | 0 | 400,000 | +400,000 | 0.00 | 0.96 | +0.96 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 400,000 | +400,000 | 0.00 | 2.09 | +2.09 | buy |
| ASSETMARK, INC | 0 | 396,542 | +396,542 | 0.00 | 0.03 | +0.03 | buy |
| ORBIMED ADVISORS LLC | 804,000 | 365,400 | -438,600 | 0.33 | 0.33 | -0.01 | sell |
| Duquesne Family Office LLC | 0 | 356,600 | +356,600 | 0.00 | 0.39 | +0.39 | buy |
| D. E. Shaw & Co., Inc. | 271,717 | 315,410 | +43,693 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 199,994 | 286,990 | +86,996 | 0.74 | 2.20 | +1.45 | buy |
| MILLENNIUM MANAGEMENT LLC | 846,896 | 266,076 | -580,820 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 264,545 | 265,955 | +1,410 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 344,166 | 255,903 | -88,263 | 0.33 | 0.64 | +0.32 | sell |
| PFM Health Sciences, LP | 205,317 | 249,020 | +43,703 | 0.41 | 1.02 | +0.61 | buy |
| HighVista Strategies LLC | 185,856 | 242,884 | +57,028 | 0.97 | 2.60 | +1.64 | buy |
| Trexquant Investment LP | 0 | 233,199 | +233,199 | 0.00 | 0.07 | +0.07 | buy |
| SEVEN GRAND MANAGERS, LLC | 225,000 | 225,000 | 0 | 0.28 | 0.43 | +0.14 | hold |
| Swiss National Bank | 158,400 | 221,200 | +62,800 | 0.00 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 160,723 | 217,185 | +56,462 | 0.20 | 0.56 | +0.36 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,413 | 211,183 | +208,770 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 209,460 | +209,460 | 0.00 | 0.01 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 234,051 | 208,551 | -25,500 | 0.04 | 0.08 | +0.04 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 351,461 | 188,282 | -163,179 | 4.75 | 5.59 | +0.85 | sell |
| EMERALD ADVISERS, LLC | 0 | 178,751 | +178,751 | 0.00 | 0.20 | +0.20 | buy |
| Aberdeen Group plc | 0 | 175,000 | +175,000 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 158,345 | 164,575 | +6,230 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 369,588 | 162,996 | -206,592 | 0.98 | 0.94 | -0.04 | sell |
| RHUMBLINE ADVISERS | 119,972 | 158,096 | +38,124 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 211,488 | 156,812 | -54,676 | 0.04 | 0.10 | +0.06 | sell |
| LMR Partners LLP | 0 | 150,200 | +150,200 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,404 | 146,368 | +119,964 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 143,187 | +143,187 | 0.00 | 0.33 | +0.33 | buy |
| DEUTSCHE BANK AG\ | 411,834 | 142,947 | -268,887 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 142,489 | +142,489 | 0.00 | 0.18 | +0.18 | buy |
| Russell Investments Group, Ltd. | 119,464 | 140,177 | +20,713 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 325,483 | 137,124 | -188,359 | 1.18 | 1.12 | -0.07 | sell |
| AQR CAPITAL MANAGEMENT LLC | 57,094 | 134,152 | +77,058 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 128,346 | +128,346 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 277,511 | 128,131 | -149,380 | 0.29 | 0.21 | -0.09 | sell |
| FRED ALGER MANAGEMENT, LLC | 92,165 | 125,256 | +33,091 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 39,973 | 122,033 | +82,060 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 122,000 | +122,000 | 0.00 | 0.57 | +0.57 | buy |
| AdvisorShares Investments LLC | 91,301 | 121,381 | +30,080 | 0.31 | 0.69 | +0.37 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 121,249 | +121,249 | 0.00 | 0.20 | +0.20 | buy |
| Informed Momentum Co LLC | 0 | 120,928 | +120,928 | 0.00 | 0.51 | +0.51 | buy |
| Schonfeld Strategic Advisors LLC | 10,412 | 119,610 | +109,198 | 0.00 | 0.03 | +0.03 | buy |
| HSBC HOLDINGS PLC | 0 | 117,482 | +117,482 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 110,388 | +110,388 | 0.00 | 0.02 | +0.02 | buy |
| Data Collective IV GP, LLC | 100,350 | 100,350 | 0 | 3.39 | 6.01 | +2.62 | hold |
| ROYAL BANK OF CANADA | 97,192 | 100,063 | +2,871 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.09 | 0.17 | +0.08 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 23,356 | 96,510 | +73,154 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,384 | 95,166 | +78,782 | 0.00 | 0.00 | +0.00 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 95,100 | +95,100 | 0.00 | 0.24 | +0.24 | buy |