| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Propel Bio Management, LLC | 0 | 896,701 | +896,701 | 0.00 | 2.41 | +2.41 | buy |
| MILLENNIUM MANAGEMENT LLC | 243,473 | 702,543 | +459,070 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 219,387 | +219,387 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 79,185 | +79,185 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 70,600 | +45,600 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 36,769 | +36,769 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 27,644 | +27,644 | 0.00 | 0.02 | +0.02 | buy |
| Cannon Global Investment Management, LLC | 0 | 22,607 | +22,607 | 0.00 | 0.23 | +0.23 | buy |
| Hudson Bay Capital Management LP | 49,425 | 71,134 | +21,709 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 134,073 | 155,242 | +21,169 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 19,001 | +19,001 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 18,919 | +18,919 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 0 | 18,076 | +18,076 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 171,681 | 188,484 | +16,803 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 14,656 | +14,656 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 12,389 | +12,389 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 86,698 | 98,887 | +12,189 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 473,363 | 485,492 | +12,129 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 10,953 | +10,953 | 0.00 | 0.00 | +0.00 | buy |
| Garden State Investment Advisory Services LLC | 0 | 10,562 | +10,562 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 159,033 | 169,410 | +10,377 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 110,899 | 118,274 | +7,375 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,458 | 25,529 | +6,071 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 630,901 | 635,714 | +4,813 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 7,100 | 11,300 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 250,000 | 253,651 | +3,651 | 0.48 | 0.64 | +0.16 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,381 | +2,381 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 106,742 | 108,953 | +2,211 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 263,788 | 265,499 | +1,711 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorNet Financial, Inc | 0 | 1,696 | +1,696 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,201 | 10,020 | +819 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 388 | +388 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,744 | 2,945 | +201 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,109 | 1,260 | +151 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 126,841 | 126,841 | 0 | 0.12 | 0.12 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 1,000,000 | 1,000,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| HighTower Advisors, LLC | 18,275 | 18,275 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 8,306,063 | 8,306,063 | 0 | 0.35 | 0.35 | +0.01 | hold |
| NewEdge Advisors, LLC | 44,083 | 44,083 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ABLE Financial Group, LLC | 13,402 | 13,402 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Holos Integrated Wealth LLC | 51,595 | 51,595 | 0 | 0.12 | 0.11 | -0.01 | hold |
| Tower Research Capital LLC (TRC) | 646 | 547 | -99 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 312 | 0 | -312 | 0.00 | 0.00 | -0.00 | sell |
| HARBOUR INVESTMENTS, INC. | 1,988 | 0 | -1,988 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 10,773 | 0 | -10,773 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 13,623 | 0 | -13,623 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 17,007 | 1,456 | -15,551 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 16,290 | 0 | -16,290 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 16,290 | 0 | -16,290 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 18,268 | 0 | -18,268 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 204,076 | 185,000 | -19,076 | 0.07 | 0.07 | +0.00 | sell |
| Cresset Asset Management, LLC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 24,900 | 0 | -24,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 86,552 | 60,107 | -26,445 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 27,100 | 0 | -27,100 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,518 | 0 | -32,518 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 94,517 | 59,342 | -35,175 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 44,343 | 0 | -44,343 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 45,692 | 0 | -45,692 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 50,358 | 0 | -50,358 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 67,100 | 16,200 | -50,900 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 155,130 | 97,521 | -57,609 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 161,946 | 87,888 | -74,058 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 151,300 | 70,900 | -80,400 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 5,127,256 | 5,037,906 | -89,350 | 0.39 | 0.42 | +0.03 | sell |
| ExodusPoint Capital Management, LP | 95,635 | 0 | -95,635 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 572,804 | 402,550 | -170,254 | 0.17 | 0.10 | -0.07 | sell |
| JANE STREET GROUP, LLC | 173,765 | 0 | -173,765 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 364,645 | 0 | -364,645 | 0.00 | 0.00 | -0.00 | sell |