| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,335,712 | 6,332,012 | +996,300 | 0.02 | 0.03 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,928 | 0 | 1.74 | 3.02 | +1.29 | hold |
| Atlas Venture Life Science Advisors, LLC | 5,858,262 | 5,377,362 | -480,900 | 17.76 | 19.95 | +2.19 | sell |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 3.29 | 5.70 | +2.42 | hold |
| VANGUARD GROUP INC | 3,997,564 | 4,767,050 | +769,486 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 534,600 | 4,364,410 | +3,829,810 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,815,558 | 4,293,697 | -521,861 | 0.02 | 0.03 | +0.01 | sell |
| Avoro Capital Advisors LLC | 3,775,000 | 3,888,888 | +113,888 | 1.33 | 1.82 | +0.50 | buy |
| Artal Group S.A. | 2,530,735 | 3,027,135 | +496,400 | 2.20 | 3.14 | +0.94 | buy |
| STATE STREET CORP | 1,894,279 | 2,672,518 | +778,239 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 1,823,956 | 1,734,089 | -89,867 | 1.66 | 2.56 | +0.90 | sell |
| Rock Springs Capital Management LP | 1,522,238 | 1,522,238 | 0 | 0.96 | 1.56 | +0.60 | hold |
| Deep Track Capital, LP | 0 | 1,262,246 | +1,262,246 | 0.00 | 1.46 | +1.46 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 880,515 | 965,700 | +85,185 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 572,926 | +572,926 | 0.00 | 0.04 | +0.04 | buy |
| MORGAN STANLEY | 441,278 | 547,140 | +105,862 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 100,751 | 500,930 | +400,179 | 0.03 | 0.19 | +0.16 | buy |
| JPMORGAN CHASE & CO | 512,246 | 455,936 | -56,310 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 674,655 | 450,518 | -224,137 | 0.00 | 0.00 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 425,920 | +425,920 | 0.00 | 0.01 | +0.01 | buy |
| Deer Management Co. LLC | 615,895 | 415,895 | -200,000 | 2.03 | 3.03 | +1.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 462,675 | 395,139 | -67,536 | 0.00 | 0.00 | +0.00 | sell |
| Aquilo Capital Management, LLC | 881,337 | 388,743 | -492,594 | 15.74 | 11.71 | -4.02 | sell |
| Schonfeld Strategic Advisors LLC | 437,633 | 380,442 | -57,191 | 0.09 | 0.12 | +0.03 | sell |
| NORTHERN TRUST CORP | 358,579 | 372,786 | +14,207 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 306,692 | 354,106 | +47,414 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 533,723 | 349,209 | -184,514 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 343,302 | 328,302 | -15,000 | 0.06 | 0.08 | +0.02 | sell |
| BARCLAYS PLC | 381,781 | 319,901 | -61,880 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 300,463 | 296,680 | -3,783 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 241,798 | 267,514 | +25,716 | 0.02 | 0.04 | +0.02 | buy |
| CITADEL ADVISORS LLC | 371,443 | 261,381 | -110,062 | 0.01 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 88,929 | 220,911 | +131,982 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 186,482 | 218,804 | +32,322 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 120,189 | 210,861 | +90,672 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 170,900 | 209,100 | +38,200 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 176,500 | 179,938 | +3,438 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 29,998 | 162,291 | +132,293 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 203,564 | 162,115 | -41,449 | 0.12 | 0.13 | +0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 0 | 156,377 | +156,377 | 0.00 | 0.05 | +0.05 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 132,989 | +132,989 | 0.00 | 0.07 | +0.07 | buy |
| Bank of New York Mellon Corp | 133,591 | 130,894 | -2,697 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 132,564 | 127,746 | -4,818 | 0.01 | 0.01 | +0.00 | sell |
| Neuberger Berman Group LLC | 121,079 | 125,179 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 185,299 | 120,847 | -64,452 | 0.01 | 0.01 | -0.00 | sell |
| NORGES BANK | 504,083 | 117,883 | -386,200 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,073 | 114,757 | +14,684 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,089 | 113,367 | +85,278 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 0 | 109,217 | +109,217 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 38,400 | 102,103 | +63,703 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 102,000 | +102,000 | 0.00 | 0.46 | +0.46 | buy |
| Squarepoint Ops LLC | 28,198 | 85,251 | +57,053 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 71,000 | 79,700 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 71,493 | +71,493 | 0.00 | 0.13 | +0.13 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 72,974 | 70,440 | -2,534 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 67,762 | +67,762 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 67,742 | +67,742 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 53,503 | 57,392 | +3,889 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 56,359 | 56,359 | 0 | 1.19 | 1.32 | +0.13 | hold |
| MILLENNIUM MANAGEMENT LLC | 98,296 | 53,052 | -45,244 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 49,111 | 51,757 | +2,646 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 49,395 | +49,395 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 22,774 | 47,667 | +24,893 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 46,373 | +46,373 | 0.00 | 0.02 | +0.02 | buy |
| CONGRESS ASSET MANAGEMENT CO | 45,303 | 45,836 | +533 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 38,390 | 42,485 | +4,095 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,068 | 41,876 | +21,808 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 34,641 | 41,332 | +6,691 | 0.17 | 0.22 | +0.05 | buy |
| JANE STREET GROUP, LLC | 195,967 | 41,009 | -154,958 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,321 | 40,423 | +2,102 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 38,141 | +38,141 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,599 | 37,847 | +8,248 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 31,097 | 34,695 | +3,598 | 0.07 | 0.12 | +0.05 | buy |
| PROFUND ADVISORS LLC | 19,887 | 32,825 | +12,938 | 0.02 | 0.05 | +0.03 | buy |
| Simplify Asset Management Inc. | 30,515 | 30,515 | 0 | 0.12 | 0.12 | -0.00 | hold |
| ALGERT GLOBAL LLC | 99,372 | 28,084 | -71,288 | 0.10 | 0.04 | -0.06 | sell |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 26,109 | 25,917 | -192 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,277 | 25,631 | -4,646 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 22,940 | 24,471 | +1,531 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 24,000 | 24,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Capital Impact Advisors, LLC | 23,889 | 23,889 | 0 | 0.80 | 1.25 | +0.45 | hold |
| DekaBank Deutsche Girozentrale | 22,000 | 23,562 | +1,562 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 25,123 | 20,994 | -4,129 | 0.02 | 0.02 | +0.00 | sell |
| MetLife Investment Management, LLC | 19,965 | 20,754 | +789 | 0.00 | 0.01 | +0.00 | buy |
| FORA Capital, LLC | 0 | 20,343 | +20,343 | 0.00 | 0.07 | +0.07 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 18,886 | 20,095 | +1,209 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 19,774 | +19,774 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 19,056 | 19,075 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 18,176 | 18,176 | 0 | 0.01 | 0.02 | +0.01 | hold |
| BIT Capital GmbH | 3,910 | 18,043 | +14,133 | 0.01 | 0.06 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,620 | 16,677 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 16,364 | +16,364 | 0.00 | 0.05 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 0 | 16,000 | +16,000 | 0.00 | 0.18 | +0.18 | buy |
| Bayesian Capital Management, LP | 0 | 14,150 | +14,150 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 10,790 | 13,058 | +2,268 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,925 | 12,645 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,551 | 12,098 | +547 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 11,800 | +11,800 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 6,423 | 11,753 | +5,330 | 0.03 | 0.06 | +0.03 | buy |