| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 534,600 | 4,364,410 | +3,829,810 | 0.00 | 0.01 | +0.01 | buy |
| Deep Track Capital, LP | 0 | 1,262,246 | +1,262,246 | 0.00 | 1.46 | +1.46 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,335,712 | 6,332,012 | +996,300 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 1,894,279 | 2,672,518 | +778,239 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,997,564 | 4,767,050 | +769,486 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 572,926 | +572,926 | 0.00 | 0.04 | +0.04 | buy |
| Artal Group S.A. | 2,530,735 | 3,027,135 | +496,400 | 2.20 | 3.14 | +0.94 | buy |
| JENNISON ASSOCIATES LLC | 0 | 425,920 | +425,920 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 100,751 | 500,930 | +400,179 | 0.03 | 0.19 | +0.16 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 156,377 | +156,377 | 0.00 | 0.05 | +0.05 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 132,989 | +132,989 | 0.00 | 0.07 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 29,998 | 162,291 | +132,293 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 88,929 | 220,911 | +131,982 | 0.00 | 0.01 | +0.01 | buy |
| Avoro Capital Advisors LLC | 3,775,000 | 3,888,888 | +113,888 | 1.33 | 1.82 | +0.50 | buy |
| AXA S.A. | 0 | 109,217 | +109,217 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 441,278 | 547,140 | +105,862 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 102,000 | +102,000 | 0.00 | 0.46 | +0.46 | buy |
| Rafferty Asset Management, LLC | 120,189 | 210,861 | +90,672 | 0.01 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 28,089 | 113,367 | +85,278 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 880,515 | 965,700 | +85,185 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 71,493 | +71,493 | 0.00 | 0.13 | +0.13 | buy |
| D. E. Shaw & Co., Inc. | 0 | 67,762 | +67,762 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 67,742 | +67,742 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 38,400 | 102,103 | +63,703 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 28,198 | 85,251 | +57,053 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 49,395 | +49,395 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 306,692 | 354,106 | +47,414 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 46,373 | +46,373 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 170,900 | 209,100 | +38,200 | 0.01 | 0.02 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 38,141 | +38,141 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 186,482 | 218,804 | +32,322 | 0.00 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 241,798 | 267,514 | +25,716 | 0.02 | 0.04 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 22,774 | 47,667 | +24,893 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,068 | 41,876 | +21,808 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 20,343 | +20,343 | 0.00 | 0.07 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 19,774 | +19,774 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 16,364 | +16,364 | 0.00 | 0.05 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 0 | 16,000 | +16,000 | 0.00 | 0.18 | +0.18 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,073 | 114,757 | +14,684 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 358,579 | 372,786 | +14,207 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 14,150 | +14,150 | 0.00 | 0.05 | +0.05 | buy |
| BIT Capital GmbH | 3,910 | 18,043 | +14,133 | 0.01 | 0.06 | +0.05 | buy |
| PROFUND ADVISORS LLC | 19,887 | 32,825 | +12,938 | 0.02 | 0.05 | +0.03 | buy |
| Aquatic Capital Management LLC | 0 | 11,800 | +11,800 | 0.00 | 0.02 | +0.02 | buy |
| Scientech Research LLC | 0 | 11,572 | +11,572 | 0.00 | 0.25 | +0.25 | buy |
| Nebula Research & Development LLC | 0 | 10,933 | +10,933 | 0.00 | 0.09 | +0.09 | buy |
| Nan Fung Group Holdings Ltd | 0 | 10,875 | +10,875 | 0.00 | 0.41 | +0.41 | buy |
| E Fund Management Co., Ltd. | 0 | 9,965 | +9,965 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 71,000 | 79,700 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,599 | 37,847 | +8,248 | 0.00 | 0.00 | +0.00 | buy |
| NVWM, LLC | 0 | 7,304 | +7,304 | 0.00 | 0.08 | +0.08 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 7,075 | +7,075 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 6,930 | +6,930 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 6,766 | +6,766 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 34,641 | 41,332 | +6,691 | 0.17 | 0.22 | +0.05 | buy |
| Keudell/Morrison Wealth Management | 0 | 6,625 | +6,625 | 0.00 | 0.08 | +0.08 | buy |
| Integrated Advisors Network LLC | 0 | 6,218 | +6,218 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 0 | 5,546 | +5,546 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 6,423 | 11,753 | +5,330 | 0.03 | 0.06 | +0.03 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 5,183 | +5,183 | 0.00 | 0.13 | +0.13 | buy |
| Virtu Financial LLC | 0 | 5,147 | +5,147 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,040 | 10,375 | +4,335 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 121,079 | 125,179 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 38,390 | 42,485 | +4,095 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 53,503 | 57,392 | +3,889 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 31,097 | 34,695 | +3,598 | 0.07 | 0.12 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 176,500 | 179,938 | +3,438 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 49,111 | 51,757 | +2,646 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,790 | 13,058 | +2,268 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,321 | 40,423 | +2,102 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 9,834 | 11,609 | +1,775 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,925 | 12,645 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 22,000 | 23,562 | +1,562 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 22,940 | 24,471 | +1,531 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,399 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 18,886 | 20,095 | +1,209 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,069 | 11,100 | +1,031 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 9,014 | 10,014 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 981 | +981 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,965 | 20,754 | +789 | 0.00 | 0.01 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8,316 | 8,990 | +674 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,551 | 12,098 | +547 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 45,303 | 45,836 | +533 | 0.01 | 0.01 | +0.00 | buy |
| COMERICA BANK | 2,924 | 3,324 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,775 | 4,070 | +295 | 0.00 | 0.01 | +0.00 | buy |
| US BANCORP \DE\ | 2,993 | 3,065 | +72 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 11 | 78 | +67 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 390 | 451 | +61 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,620 | 16,677 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 19,056 | 19,075 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| CANADA LIFE ASSURANCE Co | 3,931 | 3,931 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 3.29 | 5.70 | +2.42 | hold |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,928 | 0 | 1.74 | 3.02 | +1.29 | hold |
| SIGNATUREFD, LLC | 59 | 59 | 0 | 0.00 | 0.00 | +0.00 | hold |