| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,335,712 | 6,332,012 | +996,300 | 0.02 | 0.03 | +0.01 | buy |
| Artal Group S.A. | 2,530,735 | 3,027,135 | +496,400 | 2.14 | 3.10 | +0.96 | buy |
| Woodline Partners LP | 100,751 | 500,930 | +400,179 | 0.03 | 0.19 | +0.16 | buy |
| Avoro Capital Advisors LLC | 3,775,000 | 3,888,888 | +113,888 | 1.33 | 1.82 | +0.50 | buy |
| Rafferty Asset Management, LLC | 120,189 | 210,861 | +90,672 | 0.01 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 99,372 | 28,084 | +71,288 | 0.10 | 0.04 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 185,299 | 120,847 | +64,452 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 186,482 | 218,804 | +32,322 | 0.00 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 3,910 | 18,043 | +14,133 | 0.01 | 0.05 | +0.04 | buy |
| PROFUND ADVISORS LLC | 19,887 | 32,825 | +12,938 | 0.02 | 0.05 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 22,576 | 11,645 | +10,931 | 0.05 | 0.04 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 34,641 | 41,332 | +6,691 | 0.17 | 0.22 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 6,423 | 11,753 | +5,330 | 0.03 | 0.06 | +0.03 | buy |
| CONGRESS ASSET MANAGEMENT CO | 45,303 | 45,836 | +533 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,638 | 3,407 | -231 | 0.06 | 0.07 | +0.01 | sell |
| NATIXIS | 3,971 | 1,979 | -1,992 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 12,511 | 9,951 | -2,560 | 0.10 | 0.15 | +0.05 | sell |
| ROYCE & ASSOCIATES LP | 16,004 | 7,076 | -8,928 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 343,302 | 328,302 | -15,000 | 0.06 | 0.08 | +0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 462,675 | 395,139 | -67,536 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 1,823,956 | 1,734,089 | -89,867 | 1.66 | 2.56 | +0.90 | sell |
| Deer Management Co. LLC | 615,895 | 415,895 | -200,000 | 2.03 | 3.03 | +1.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 5,858,262 | 5,377,362 | -480,900 | 17.76 | 19.95 | +2.19 | sell |
| Aquilo Capital Management, LLC | 881,337 | 388,743 | -492,594 | 15.74 | 11.71 | -4.02 | sell |