| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,150,000 | 6,460,000 | +1,310,000 | 2.93 | 2.76 | -0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,307,326 | 5,996,873 | +689,547 | 0.04 | 0.03 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 404,667 | 896,404 | +491,737 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 115,918 | 510,480 | +394,562 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 377,384 | 770,582 | +393,198 | 0.01 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 0 | 365,190 | +365,190 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,887,312 | 5,231,392 | +344,080 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 2,969,733 | 3,240,313 | +270,580 | 5.28 | 5.00 | -0.28 | buy |
| MARSHALL WACE, LLP | 6,835 | 201,900 | +195,065 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 0 | 142,201 | +142,201 | 0.00 | 1.61 | +1.61 | buy |
| UBS Group AG | 469,842 | 593,606 | +123,764 | 0.00 | 0.00 | -0.00 | buy |
| Yiheng Capital Management, L.P. | 0 | 122,605 | +122,605 | 0.00 | 1.18 | +1.18 | buy |
| STATE STREET CORP | 1,688,789 | 1,760,707 | +71,918 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 455,728 | 525,138 | +69,410 | 0.33 | 0.29 | -0.05 | buy |
| Affinity Asset Advisors, LLC | 40,000 | 100,000 | +60,000 | 0.25 | 0.43 | +0.18 | buy |
| Checkpoint Capital L.P. | 77,535 | 136,605 | +59,070 | 1.59 | 2.05 | +0.46 | buy |
| JANE STREET GROUP, LLC | 16,764 | 65,399 | +48,635 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 10,249 | 54,154 | +43,905 | 0.06 | 0.07 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 62,260 | 96,805 | +34,545 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,410 | 63,768 | +33,358 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,105,487 | 1,133,765 | +28,278 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 5,347 | 29,890 | +24,543 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 58,923 | 82,507 | +23,584 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 64,416 | 81,072 | +16,656 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 14,126 | 29,501 | +15,375 | 0.01 | 0.01 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 14,420 | +14,420 | 0.00 | 0.13 | +0.13 | buy |
| NATIXIS | 0 | 12,674 | +12,674 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,588 | 57,220 | +11,632 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 30,732 | 42,075 | +11,343 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 21,772 | 32,792 | +11,020 | 0.01 | 0.01 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 10,418 | +10,418 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 10,059 | +10,059 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 37,065 | 46,874 | +9,809 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 8,544 | 15,374 | +6,830 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 64,157 | 69,928 | +5,771 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 67,068 | 71,863 | +4,795 | 0.14 | 0.09 | -0.04 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,891 | +3,891 | 0.00 | 0.03 | +0.03 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2,467 | +2,467 | 0.00 | 0.05 | +0.05 | buy |
| Advisors Asset Management, Inc. | 2,729 | 4,959 | +2,230 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 56,878 | 58,982 | +2,104 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 29,540 | 31,537 | +1,997 | 0.09 | 0.08 | -0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,960 | 30,793 | +1,833 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 87 | 1,716 | +1,629 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 17,483 | 18,547 | +1,064 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 11,497 | 12,549 | +1,052 | 0.02 | 0.01 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,524 | 10,409 | +885 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 48,374 | 49,189 | +815 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 20,631 | 21,374 | +743 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 419,490 | 420,045 | +555 | 0.01 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 21,939 | 22,433 | +494 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 26 | 428 | +402 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 10,000 | 10,356 | +356 | 0.03 | 0.02 | -0.01 | buy |
| KBC Group NV | 2,151 | 2,479 | +328 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,360 | 1,658 | +298 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 14,072 | 14,334 | +262 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 3,454 | 3,693 | +239 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,393 | 1,626 | +233 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 169 | 244 | +75 | 0.00 | 0.00 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 131 | 171 | +40 | 0.00 | 0.00 | -0.00 | buy |
| Kestra Investment Management, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 33 | +30 | 0.00 | 0.00 | +0.00 | buy |
| SIERRA OCEAN, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 29 | 52 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 19 | 40 | +21 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 59 | 75 | +16 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,158 | 2,173 | +15 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 13 | 28 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 16 | 28 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Hexagon Capital Partners LLC | 3 | 13 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 45 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Hemington Wealth Management | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| SBI Securities Co., Ltd. | 284 | 285 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Global Financial Private Client, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 593,000 | 593,000 | 0 | 0.45 | 0.32 | -0.13 | hold |
| MAI Capital Management | 1,400 | 1,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 10,491 | 10,491 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,912 | 4,912 | 0 | 0.01 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 7.04 | 5.76 | -1.28 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,839 | 36,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 5,995,929 | 5,995,929 | 0 | 2.58 | 1.82 | -0.76 | hold |
| Sterling Capital Management LLC | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 8,733 | 8,733 | 0 | 0.13 | 0.09 | -0.04 | hold |
| Handelsbanken Fonder AB | 16,500 | 16,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 9,014 | 9,014 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 23,562 | 23,562 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 245 | 245 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deer Management Co. LLC | 415,895 | 415,895 | 0 | 1.31 | 1.05 | -0.25 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 38,141 | 38,141 | 0 | 0.01 | 0.01 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AJU IB Investment Co., Ltd. | 457,059 | 457,059 | 0 | 17.89 | 14.88 | -3.01 | hold |