| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,150,000 | 6,460,000 | +1,310,000 | 2.93 | 2.76 | -0.17 | buy |
| JANUS HENDERSON GROUP PLC | 377,384 | 770,582 | +393,198 | 0.01 | 0.01 | 0.00 | buy |
| Siren, L.L.C. | 2,969,733 | 3,240,313 | +270,580 | 5.28 | 5.00 | -0.28 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 455,728 | 525,138 | +69,410 | 0.33 | 0.29 | -0.05 | buy |
| Affinity Asset Advisors, LLC | 40,000 | 100,000 | +60,000 | 0.25 | 0.43 | +0.18 | buy |
| Checkpoint Capital L.P. | 77,535 | 136,605 | +59,070 | 1.59 | 2.05 | +0.46 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,987 | 30,878 | +10,109 | 0.07 | 0.04 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 163,896 | 158,338 | +5,558 | 0.01 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 67,068 | 71,863 | +4,795 | 0.14 | 0.09 | -0.04 | buy |
| Rafferty Asset Management, LLC | 56,878 | 58,982 | +2,104 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 29,540 | 31,537 | +1,997 | 0.10 | 0.09 | 0.00 | buy |
| PROFUND ADVISORS LLC | 11,497 | 12,549 | +1,052 | 0.02 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 419,490 | 420,045 | +555 | 0.01 | 0.00 | -0.00 | buy |
| Clear Harbor Asset Management, LLC | 10,000 | 10,356 | +356 | 0.03 | 0.02 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,360 | 1,658 | +298 | 0.00 | 0.00 | -0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 4,096 | 3,926 | +170 | 0.01 | 0.01 | 0.00 | sell |
| Truvestments Capital LLC | 351 | 318 | +33 | 0.00 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,733 | 13,027 | -706 | 0.05 | 0.03 | -0.02 | sell |
| GILDER GAGNON HOWE & CO LLC | 326,349 | 318,381 | -7,968 | 0.14 | 0.11 | -0.03 | sell |
| Woodline Partners LP | 537,428 | 525,245 | -12,183 | 0.15 | 0.09 | -0.05 | sell |
| Cinctive Capital Management LP | 36,035 | 23,492 | -12,543 | 0.08 | 0.05 | -0.03 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 150,172 | 131,963 | -18,209 | 0.06 | 0.04 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 228,560 | 202,092 | -26,468 | 0.01 | 0.01 | -0.00 | sell |
| Aquilo Capital Management, LLC | 183,521 | 138,521 | -45,000 | 12.64 | 10.22 | -2.42 | sell |
| Boxer Capital Management, LLC | 425,000 | 325,000 | -100,000 | 1.46 | 2.68 | +1.22 | sell |
| Redmile Group, LLC | 1,100,432 | 983,413 | -117,019 | 3.09 | 2.54 | -0.54 | sell |
| JENNISON ASSOCIATES LLC | 716,933 | 552,286 | -164,647 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,870,333 | 6,702,450 | -167,883 | 0.03 | 0.02 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,390,372 | 1,168,791 | -221,581 | 0.46 | 0.31 | -0.15 | sell |
| Rock Springs Capital Management LP | 1,034,137 | 794,437 | -239,700 | 1.58 | 1.24 | -0.34 | sell |