| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,928,574 | 11,699,950 | +2,771,376 | 0.04 | 0.05 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 8,657,242 | 8,657,242 | 0 | 3.94 | 4.14 | +0.20 | hold |
| Avoro Capital Advisors LLC | 7,474,747 | 7,474,747 | 0 | 5.72 | 6.13 | +0.42 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,159,335 | 6,060,847 | -98,488 | 0.05 | 0.06 | +0.01 | sell |
| BVF INC/IL | 5,502,710 | 5,502,710 | 0 | 14.41 | 14.60 | +0.19 | hold |
| T. Rowe Price Investment Management, Inc. | 629,745 | 5,464,997 | +4,835,252 | 0.03 | 0.31 | +0.28 | buy |
| BlackRock, Inc. | 5,004,095 | 5,060,876 | +56,781 | 0.01 | 0.01 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 4,659,874 | 4,578,008 | -81,866 | 41.91 | 48.26 | +6.35 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,412,933 | 3,889,687 | -523,246 | 0.06 | 0.06 | +0.00 | sell |
| Siren, L.L.C. | 3,286,830 | 3,186,830 | -100,000 | 7.63 | 7.36 | -0.27 | sell |
| STATE STREET CORP | 2,209,837 | 2,389,767 | +179,930 | 0.01 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 1,560,791 | 1,673,275 | +112,484 | 0.02 | 0.02 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,417,389 | 1,645,350 | +227,961 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,069,238 | 1,043,583 | -25,655 | 0.57 | 0.64 | +0.07 | sell |
| UBS Group AG | 737,032 | 1,023,852 | +286,820 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 740,306 | 888,409 | +148,103 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 952,065 | 888,035 | -64,030 | 0.02 | 0.02 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 912,498 | 875,872 | -36,626 | 0.02 | 0.02 | +0.00 | sell |
| Holocene Advisors, LP | 761,209 | 836,759 | +75,550 | 0.12 | 0.17 | +0.04 | buy |
| Merck & Co., Inc. | 772,165 | 772,165 | 0 | 21.75 | 18.40 | -3.34 | hold |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 635,957 | 759,848 | +123,891 | 0.53 | 0.65 | +0.13 | buy |
| Commodore Capital LP | 750,000 | 750,000 | 0 | 3.88 | 3.61 | -0.27 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 626,430 | 626,925 | +495 | 0.76 | 0.86 | +0.10 | buy |
| DIMENSIONAL FUND ADVISORS LP | 624,027 | 592,879 | -31,148 | 0.01 | 0.01 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 561,170 | 561,170 | 0 | 0.56 | 0.55 | -0.01 | hold |
| FEDERATED HERMES, INC. | 763,920 | 536,680 | -227,240 | 0.10 | 0.07 | -0.03 | sell |
| JENNISON ASSOCIATES LLC | 496,665 | 508,999 | +12,334 | 0.02 | 0.03 | +0.01 | buy |
| Rock Springs Capital Management LP | 496,871 | 496,871 | 0 | 1.98 | 2.44 | +0.46 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 497,026 | 495,262 | -1,764 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 467,022 | 494,439 | +27,417 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 483,199 | 468,728 | -14,471 | 0.04 | 0.04 | +0.00 | sell |
| Octagon Capital Advisors LP | 535,000 | 425,000 | -110,000 | 5.21 | 3.92 | -1.29 | sell |
| FRANKLIN RESOURCES INC | 354,575 | 361,772 | +7,197 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 371,889 | 342,698 | -29,191 | 0.08 | 0.08 | -0.00 | sell |
| BRAIDWELL LP | 454,259 | 337,559 | -116,700 | 1.13 | 0.94 | -0.19 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 430,000 | 335,000 | -95,000 | 0.05 | 0.04 | -0.01 | sell |
| Boxer Capital Management, LLC | 329,100 | 329,100 | 0 | 5.60 | 3.60 | -2.01 | hold |
| BANK OF AMERICA CORP /DE/ | 338,999 | 289,416 | -49,583 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 221,178 | 287,100 | +65,922 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,798 | 285,871 | +277,073 | 0.00 | 0.02 | +0.02 | buy |
| Nextech Invest, Ltd. | 278,896 | 278,896 | 0 | 2.10 | 1.63 | -0.46 | hold |
| TWO SIGMA INVESTMENTS, LP | 265,532 | 256,501 | -9,031 | 0.03 | 0.02 | -0.01 | sell |
| First Turn Management, LLC | 206,445 | 254,672 | +48,227 | 1.84 | 2.37 | +0.53 | buy |
| RTW INVESTMENTS, LP | 240,000 | 240,000 | 0 | 0.19 | 0.20 | +0.01 | hold |
| GILDER GAGNON HOWE & CO LLC | 239,916 | 235,433 | -4,483 | 0.20 | 0.24 | +0.04 | sell |
| Polar Capital Holdings Plc | 200,946 | 215,200 | +14,254 | 0.07 | 0.08 | +0.01 | buy |
| MORGAN STANLEY | 274,018 | 212,702 | -61,316 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 289,404 | 209,005 | -80,399 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 203,585 | 203,585 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Candriam S.C.A. | 201,672 | 201,672 | 0 | 0.08 | 0.09 | +0.01 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 28,940 | 198,808 | +169,868 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 192,748 | 193,200 | +452 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 189,900 | 168,846 | -21,054 | 0.22 | 0.24 | +0.02 | sell |
| Freestone Grove Partners LP | 0 | 156,763 | +156,763 | 0.00 | 0.09 | +0.09 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 105,194 | 152,381 | +47,187 | 0.02 | 0.03 | +0.01 | buy |
| Foresite Capital Management VI LLC | 146,332 | 146,332 | 0 | 3.44 | 2.65 | -0.79 | hold |
| Eagle Health Investments LP | 136,300 | 145,816 | +9,516 | 2.33 | 2.55 | +0.22 | buy |
| Nuveen, LLC | 125,050 | 128,091 | +3,041 | 0.00 | 0.00 | +0.00 | buy |
| Deer Management Co. LLC | 230,811 | 125,895 | -104,916 | 1.75 | 1.69 | -0.06 | sell |
| JPMORGAN CHASE & CO | 131,353 | 125,419 | -5,934 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 135,894 | 120,151 | -15,743 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 159,865 | 118,597 | -41,268 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 95,047 | 113,842 | +18,795 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 116,747 | 110,415 | -6,332 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 104,279 | +104,279 | 0.00 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 105,554 | 103,200 | -2,354 | 0.01 | 0.01 | +0.00 | sell |
| Patient Square Capital LP | 139,000 | 100,000 | -39,000 | 2.32 | 1.48 | -0.84 | sell |
| Swiss National Bank | 94,200 | 94,500 | +300 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 58,862 | 93,617 | +34,755 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 79,843 | 91,882 | +12,039 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 81,165 | 83,876 | +2,711 | 0.15 | 0.23 | +0.08 | buy |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.38 | 0.31 | -0.07 | hold |
| Yiheng Capital Management, L.P. | 73,440 | 73,440 | 0 | 2.49 | 2.65 | +0.16 | hold |
| RHUMBLINE ADVISERS | 72,304 | 71,678 | -626 | 0.00 | 0.01 | +0.00 | sell |
| Neuberger Berman Group LLC | 58,482 | 71,116 | +12,634 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 67,086 | 67,995 | +909 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 64,723 | 66,457 | +1,734 | 0.03 | 0.03 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 64,775 | 64,467 | -308 | 0.01 | 0.01 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,742 | 56,282 | +10,540 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 58,653 | 55,331 | -3,322 | 0.02 | 0.02 | +0.00 | sell |
| FIFTH THIRD BANCORP | 0 | 51,238 | +51,238 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 45,977 | 48,812 | +2,835 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52,671 | 43,243 | -9,428 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 56,455 | 42,341 | -14,114 | 0.49 | 0.41 | -0.08 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,777 | 38,299 | -2,478 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 38,535 | 38,195 | -340 | 0.56 | 0.57 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,513 | 37,185 | +10,672 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 43,428 | 36,734 | -6,694 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 100,000 | 35,100 | -64,900 | 4.38 | 1.59 | -2.79 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 30,573 | 33,948 | +3,375 | 0.18 | 0.23 | +0.04 | buy |
| Rockefeller Capital Management L.P. | 25,533 | 32,367 | +6,834 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 32,235 | 32,235 | 0 | 0.42 | 0.39 | -0.03 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,631 | 32,061 | +16,430 | 0.00 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 31,394 | 31,507 | +113 | 0.01 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 30,875 | 30,875 | 0 | 2.15 | 2.12 | -0.03 | hold |
| SEVEN GRAND MANAGERS, LLC | 30,000 | 30,000 | 0 | 0.18 | 0.17 | -0.01 | hold |
| ExodusPoint Capital Management, LP | 0 | 28,318 | +28,318 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 13,769 | 28,246 | +14,477 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 55,788 | 27,347 | -28,441 | 0.32 | 0.16 | -0.15 | sell |
| Neo Ivy Capital Management | 0 | 27,033 | +27,033 | 0.00 | 0.59 | +0.59 | buy |