| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,879,825 | 4,375,340 | +1,495,515 | 0.46 | 0.58 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,666,681 | 5,007,148 | +340,467 | 0.02 | 0.02 | -0.00 | buy |
| Rock Springs Capital Management LP | 1,228,379 | 1,487,551 | +259,172 | 0.87 | 0.81 | -0.06 | buy |
| WASATCH ADVISORS LP | 1,037,414 | 1,199,350 | +161,936 | 0.19 | 0.17 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 242,512 | 187,304 | +55,208 | 0.02 | 0.01 | 0.00 | sell |
| Aquilo Capital Management, LLC | 601,325 | 651,325 | +50,000 | 10.44 | 9.83 | -0.61 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 11,318 | 31,377 | +20,059 | 0.10 | 0.14 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 94,015 | 99,915 | +5,900 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 38,738 | 38,829 | +91 | 0.07 | 0.05 | 0.00 | buy |
| Redmile Group, LLC | 2,410,769 | 1,868,507 | -542,262 | 3.10 | 1.65 | -1.45 | sell |