| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 19,774 | 462,099 | +442,325 | 0.01 | 0.24 | +0.22 | buy |
| Deep Track Capital, LP | 1,262,246 | 1,500,000 | +237,754 | 1.46 | 1.34 | -0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 127,746 | 348,918 | +221,172 | 0.01 | 0.03 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,332,012 | 6,390,658 | +58,646 | 0.03 | 0.02 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 120,847 | 162,201 | +41,354 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 9,965 | 48,946 | +38,981 | 0.02 | 0.08 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 16,000 | 50,626 | +34,626 | 0.18 | 0.30 | +0.13 | buy |
| Woodline Partners LP | 500,930 | 517,797 | +16,867 | 0.19 | 0.15 | -0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 11,645 | 27,533 | +15,888 | 0.04 | 0.06 | 0.00 | buy |
| PROFUND ADVISORS LLC | 32,825 | 17,011 | +15,814 | 0.05 | 0.02 | 0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 395,139 | 405,870 | +10,731 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 71,493 | 76,818 | +5,325 | 0.13 | 0.05 | -0.08 | buy |
| ALGERT GLOBAL LLC | 28,084 | 32,706 | +4,622 | 0.04 | 0.03 | 0.00 | buy |
| JENNISON ASSOCIATES LLC | 425,920 | 429,287 | +3,367 | 0.01 | 0.01 | -0.00 | buy |
| Keudell/Morrison Wealth Management | 6,625 | 7,105 | +480 | 0.08 | 0.06 | -0.02 | buy |
| NVWM, LLC | 7,304 | 7,254 | -50 | 0.08 | 0.06 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 3,407 | 2,596 | -811 | 0.07 | 0.04 | -0.03 | sell |
| GILDER GAGNON HOWE & CO LLC | 132,989 | 130,729 | -2,260 | 0.07 | 0.05 | -0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 18,176 | 14,476 | -3,700 | 0.02 | 0.02 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,753 | 7,208 | -4,545 | 0.06 | 0.03 | -0.03 | sell |
| Atika Capital Management LLC | 102,000 | 92,000 | -10,000 | 0.40 | 0.27 | -0.13 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 41,332 | 31,011 | -10,321 | 0.22 | 0.07 | -0.15 | sell |
| Artal Group S.A. | 3,027,135 | 3,005,610 | -21,525 | 3.10 | 2.29 | -0.81 | sell |
| Atlas Venture Life Science Advisors, LLC | 5,377,362 | 5,350,422 | -26,940 | 19.95 | 16.82 | -3.13 | sell |
| Aquilo Capital Management, LLC | 388,743 | 328,743 | -60,000 | 11.71 | 9.46 | -2.25 | sell |
| Candriam S.C.A. | 328,302 | 238,165 | -90,137 | 0.08 | 0.04 | -0.04 | sell |
| Rafferty Asset Management, LLC | 210,861 | 90,820 | -120,041 | 0.03 | 0.01 | -0.02 | sell |
| Redmile Group, LLC | 1,734,089 | 1,579,275 | -154,814 | 2.56 | 2.85 | +0.29 | sell |
| Rock Springs Capital Management LP | 1,522,238 | 1,163,973 | -358,265 | 1.55 | 1.05 | -0.51 | sell |