| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,364,410 | 4,826,840 | +462,430 | 0.01 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 19,774 | 462,099 | +442,325 | 0.01 | 0.24 | +0.22 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 179,938 | 433,573 | +253,635 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 1,262,246 | 1,500,000 | +237,754 | 1.46 | 1.34 | -0.12 | buy |
| D. E. Shaw & Co., Inc. | 67,762 | 295,572 | +227,810 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 223,413 | +223,413 | 0.00 | 0.06 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 127,746 | 348,918 | +221,172 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 209,100 | 367,000 | +157,900 | 0.02 | 0.02 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 143,093 | +143,093 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 965,700 | 1,054,220 | +88,520 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 547,140 | 631,738 | +84,598 | 0.00 | 0.00 | -0.00 | buy |
| Checkpoint Capital L.P. | 0 | 82,000 | +82,000 | 0.00 | 1.48 | +1.48 | buy |
| FIRST TRUST ADVISORS LP | 67,742 | 138,636 | +70,894 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 64,000 | +64,000 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,332,012 | 6,390,658 | +58,646 | 0.03 | 0.02 | -0.01 | buy |
| VANGUARD GROUP INC | 4,767,050 | 4,822,416 | +55,366 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 349,209 | 402,385 | +53,176 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 41,009 | 90,128 | +49,119 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 120,847 | 162,201 | +41,354 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 9,965 | 48,946 | +38,981 | 0.02 | 0.08 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 16,000 | 50,626 | +34,626 | 0.18 | 0.30 | +0.13 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 29,952 | +29,952 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,847 | 66,437 | +28,590 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 130,894 | 156,211 | +25,317 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 23,517 | +23,517 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 85,251 | 108,563 | +23,312 | 0.01 | 0.01 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 21,793 | +21,793 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 354,106 | 375,101 | +20,995 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 500,930 | 517,797 | +16,867 | 0.19 | 0.15 | -0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 11,645 | 27,533 | +15,888 | 0.04 | 0.06 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,293,697 | 4,309,405 | +15,708 | 0.03 | 0.02 | -0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 15,471 | +15,471 | 0.00 | 0.05 | +0.05 | buy |
| Handelsbanken Fonder AB | 0 | 15,400 | +15,400 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 114,757 | 130,077 | +15,320 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 704 | 13,125 | +12,421 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 450,518 | 462,309 | +11,791 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,120 | +11,120 | 0.00 | 0.06 | +0.06 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 395,139 | 405,870 | +10,731 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 10,665 | +10,665 | 0.00 | 0.06 | +0.06 | buy |
| Swiss National Bank | 79,700 | 90,100 | +10,400 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 0 | 9,600 | +9,600 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 9,386 | +9,386 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 10,043 | 18,182 | +8,139 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 7,956 | +7,956 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 7,784 | +7,784 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 57,392 | 64,535 | +7,143 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 3,953 | 10,887 | +6,934 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 6,748 | +6,748 | 0.00 | 0.02 | +0.02 | buy |
| CANADA LIFE ASSURANCE Co | 3,931 | 10,491 | +6,560 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 267,514 | 273,519 | +6,005 | 0.04 | 0.03 | -0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 71,493 | 76,818 | +5,325 | 0.13 | 0.05 | -0.08 | buy |
| MetLife Investment Management, LLC | 20,754 | 25,888 | +5,134 | 0.01 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 4,933 | +4,933 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 347 | 5,212 | +4,865 | 0.00 | 0.02 | +0.02 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 4,672 | +4,672 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 28,084 | 32,706 | +4,622 | 0.04 | 0.03 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,423 | 44,696 | +4,273 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 4,184 | +4,184 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,677 | 20,849 | +4,172 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 425,920 | 429,287 | +3,367 | 0.01 | 0.01 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 2,856 | +2,856 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 11,800 | 13,900 | +2,100 | 0.02 | 0.02 | -0.00 | buy |
| Legal & General Group Plc | 42,485 | 44,488 | +2,003 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 11,100 | 12,830 | +1,730 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 51,757 | 53,433 | +1,676 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,058 | 14,379 | +1,321 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8,990 | 10,066 | +1,076 | 0.00 | 0.00 | -0.00 | buy |
| Keudell/Morrison Wealth Management | 6,625 | 7,105 | +480 | 0.08 | 0.06 | -0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 49,395 | 49,720 | +325 | 0.00 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 278 | +278 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 23 | 204 | +181 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,325 | 1,393 | +68 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 109,217 | 109,279 | +62 | 0.01 | 0.01 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 78 | 122 | +44 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 451 | 474 | +23 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 15 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,070 | 4,070 | 0 | 0.01 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 218,804 | 218,804 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 5.70 | 4.32 | -1.39 | hold |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,928 | 0 | 3.02 | 2.29 | -0.74 | hold |
| NORGES BANK | 117,883 | 117,883 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KBC Group NV | 1,399 | 1,399 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 10,014 | 10,014 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 59 | 59 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 23,562 | 23,562 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 210 | 210 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deer Management Co. LLC | 415,895 | 415,895 | 0 | 3.03 | 2.55 | -0.48 | hold |
| Clear Harbor Asset Management, LLC | 10,000 | 10,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 38,141 | 38,141 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CWM, LLC | 3 | 3 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Allworth Financial LP | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avoro Capital Advisors LLC | 3,888,888 | 3,888,888 | 0 | 1.82 | 1.55 | -0.28 | hold |
| Parallel Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 10,875 | 10,875 | 0 | 0.41 | 0.35 | -0.06 | hold |
| Simplify Asset Management Inc. | 30,515 | 30,515 | 0 | 0.12 | 0.08 | -0.04 | hold |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Propel Bio Management, LLC | 56,359 | 56,359 | 0 | 1.32 | 1.09 | -0.23 | hold |
| Farther Finance Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.01 | -0.00 | hold |