| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,702,450 | 6,859,202 | +156,752 | 0.02 | 0.03 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,995,929 | 6,651,429 | +655,500 | 1.82 | 2.82 | +1.00 | buy |
| Avoro Capital Advisors LLC | 6,460,000 | 6,555,555 | +95,555 | 2.76 | 5.01 | +2.25 | buy |
| VANGUARD GROUP INC | 5,231,392 | 5,619,848 | +388,456 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 5,161,801 | 5,502,710 | +340,909 | 5.76 | 8.58 | +2.82 | buy |
| FMR LLC | 4,409,234 | 5,431,994 | +1,022,760 | 0.01 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,996,873 | 5,372,061 | -624,812 | 0.03 | 0.04 | +0.01 | sell |
| Atlas Venture Life Science Advisors, LLC | 4,896,462 | 4,896,462 | 0 | 25.69 | 32.26 | +6.58 | hold |
| BlackRock, Inc. | 4,282,903 | 4,148,260 | -134,643 | 0.00 | 0.00 | +0.00 | sell |
| Siren, L.L.C. | 3,240,313 | 3,428,150 | +187,837 | 5.00 | 7.74 | +2.74 | buy |
| STATE STREET CORP | 1,760,707 | 1,554,431 | -206,276 | 0.00 | 0.00 | +0.00 | sell |
| Capital Research Global Investors | 365,190 | 1,262,182 | +896,992 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,133,765 | 1,193,112 | +59,347 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,168,791 | 933,890 | -234,901 | 0.31 | 0.33 | +0.02 | sell |
| JENNISON ASSOCIATES LLC | 552,286 | 825,025 | +272,739 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 896,404 | 818,927 | -77,477 | 0.01 | 0.01 | +0.00 | sell |
| Redmile Group, LLC | 983,413 | 803,289 | -180,124 | 2.54 | 3.73 | +1.19 | sell |
| Merck & Co., Inc. | 772,165 | 772,165 | 0 | 12.86 | 15.63 | +2.77 | hold |
| Commodore Capital LP | 0 | 750,000 | +750,000 | 0.00 | 2.31 | +2.31 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 593,000 | 653,000 | +60,000 | 0.32 | 0.52 | +0.20 | buy |
| DIMENSIONAL FUND ADVISORS LP | 395,468 | 563,365 | +167,897 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 525,138 | 562,990 | +37,852 | 0.29 | 0.43 | +0.14 | buy |
| UBS Group AG | 593,606 | 557,734 | -35,872 | 0.00 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 518,887 | +518,887 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 525,245 | 498,111 | -27,134 | 0.09 | 0.11 | +0.02 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 131,963 | 491,810 | +359,847 | 0.04 | 0.20 | +0.16 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 420,045 | 487,961 | +67,916 | 0.00 | 0.01 | +0.00 | buy |
| AJU IB Investment Co., Ltd. | 457,059 | 457,059 | 0 | 14.88 | 21.71 | +6.82 | hold |
| Rock Springs Capital Management LP | 794,437 | 450,374 | -344,063 | 1.24 | 1.22 | -0.02 | sell |
| Boxer Capital Management, LLC | 325,000 | 432,010 | +107,010 | 2.68 | 9.49 | +6.81 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,708 | 429,304 | +47,596 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 421,660 | 409,353 | -12,307 | 0.00 | 0.00 | +0.00 | sell |
| Nextech Invest, Ltd. | 0 | 340,909 | +340,909 | 0.00 | 2.82 | +2.82 | buy |
| GILDER GAGNON HOWE & CO LLC | 318,381 | 329,020 | +10,639 | 0.11 | 0.15 | +0.04 | buy |
| Deer Management Co. LLC | 415,895 | 325,895 | -90,000 | 1.05 | 1.13 | +0.08 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 304,200 | +304,200 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 344,237 | 278,736 | -65,501 | 0.00 | 0.00 | +0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 275,000 | +275,000 | 0.00 | 0.45 | +0.45 | buy |
| MARSHALL WACE, LLP | 201,900 | 269,284 | +67,384 | 0.01 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 0 | 266,000 | +266,000 | 0.00 | 2.55 | +2.55 | buy |
| Polar Capital Holdings Plc | 0 | 250,000 | +250,000 | 0.00 | 0.06 | +0.06 | buy |
| MORGAN STANLEY | 172,082 | 237,605 | +65,523 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 202,092 | 234,970 | +32,878 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 183,300 | 224,300 | +41,000 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 210,106 | +210,106 | 0.00 | 0.34 | +0.34 | buy |
| JPMORGAN CHASE & CO | 46,874 | 207,722 | +160,848 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 184,478 | +184,478 | 0.00 | 0.02 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 144,224 | 162,315 | +18,091 | 0.01 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 147,620 | 159,163 | +11,543 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 156,253 | +156,253 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 154,103 | +154,103 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 142,587 | 152,165 | +9,578 | 0.00 | 0.01 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 146,600 | +146,600 | 0.00 | 0.67 | +0.67 | buy |
| Foresite Capital Management VI LLC | 146,332 | 146,332 | 0 | 2.19 | 3.59 | +1.40 | hold |
| BARCLAYS PLC | 85,212 | 143,181 | +57,969 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 142,201 | 140,000 | -2,201 | 1.61 | 2.20 | +0.59 | sell |
| BANK OF AMERICA CORP /DE/ | 96,805 | 134,939 | +38,134 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 126,877 | 130,714 | +3,837 | 0.00 | 0.00 | +0.00 | buy |
| Yiheng Capital Management, L.P. | 122,605 | 122,605 | 0 | 1.18 | 1.94 | +0.76 | hold |
| Cubist Systematic Strategies, LLC | 0 | 118,752 | +118,752 | 0.00 | 0.06 | +0.06 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 158,338 | 110,213 | -48,125 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 85,046 | 107,438 | +22,392 | 0.00 | 0.01 | +0.00 | buy |
| Checkpoint Capital L.P. | 136,605 | 106,991 | -29,614 | 2.05 | 2.18 | +0.12 | sell |
| ExodusPoint Capital Management, LP | 29,501 | 100,997 | +71,496 | 0.01 | 0.05 | +0.04 | buy |
| Nuveen, LLC | 143,238 | 100,447 | -42,791 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 0 | 91,897 | +91,897 | 0.00 | 0.01 | +0.01 | buy |
| AXA S.A. | 108,994 | 90,971 | -18,023 | 0.01 | 0.01 | +0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 90,628 | +90,628 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 85,000 | +85,000 | 0.00 | 1.96 | +1.96 | buy |
| Burkehill Global Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.24 | +0.24 | buy |
| Swiss National Bank | 75,300 | 74,400 | -900 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 69,928 | 71,058 | +1,130 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 95,430 | 64,170 | -31,260 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 48,160 | 58,924 | +10,764 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,768 | 57,456 | -6,312 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 510,480 | 56,536 | -453,944 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 54,007 | 50,915 | -3,092 | 0.00 | 0.00 | +0.00 | sell |
| Weiss Asset Management LP | 0 | 50,787 | +50,787 | 0.00 | 0.04 | +0.04 | buy |
| Trexquant Investment LP | 0 | 50,663 | +50,663 | 0.00 | 0.02 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.57 | +0.57 | buy |
| COMERICA BANK | 21,374 | 49,113 | +27,739 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 42,075 | 47,884 | +5,809 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 44,990 | 47,040 | +2,050 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 40,037 | 41,523 | +1,486 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 49,697 | 41,370 | -8,327 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 58,982 | 40,138 | -18,844 | 0.01 | 0.01 | -0.00 | sell |
| Jain Global LLC | 0 | 38,705 | +38,705 | 0.00 | 0.03 | +0.03 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 38,141 | 38,141 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,839 | 36,318 | -521 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 0 | 34,797 | +34,797 | 0.00 | 0.29 | +0.29 | buy |
| ROYCE & ASSOCIATES LP | 0 | 33,797 | +33,797 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 32,827 | 33,649 | +822 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,878 | 33,472 | +2,594 | 0.04 | 0.06 | +0.02 | buy |
| Squarepoint Ops LLC | 49,189 | 33,324 | -15,865 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,220 | 32,772 | -24,448 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 30,875 | 30,875 | 0 | 0.69 | 2.12 | +1.44 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 38,624 | 29,786 | -8,838 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 13,040 | 29,633 | +16,593 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 28,906 | +28,906 | 0.00 | 0.01 | +0.01 | buy |