| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,409,234 | 5,431,994 | +1,022,760 | 0.01 | 0.01 | +0.01 | buy |
| Capital Research Global Investors | 365,190 | 1,262,182 | +896,992 | 0.00 | 0.01 | +0.01 | buy |
| Commodore Capital LP | 0 | 750,000 | +750,000 | 0.00 | 2.31 | +2.31 | buy |
| BAKER BROS. ADVISORS LP | 5,995,929 | 6,651,429 | +655,500 | 1.82 | 2.82 | +1.00 | buy |
| CITADEL ADVISORS LLC | 0 | 518,887 | +518,887 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 5,231,392 | 5,619,848 | +388,456 | 0.00 | 0.00 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 131,963 | 491,810 | +359,847 | 0.04 | 0.20 | +0.16 | buy |
| BVF INC/IL | 5,161,801 | 5,502,710 | +340,909 | 5.76 | 8.58 | +2.82 | buy |
| Nextech Invest, Ltd. | 0 | 340,909 | +340,909 | 0.00 | 2.82 | +2.82 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 304,200 | +304,200 | 0.00 | 0.02 | +0.02 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 275,000 | +275,000 | 0.00 | 0.45 | +0.45 | buy |
| JENNISON ASSOCIATES LLC | 552,286 | 825,025 | +272,739 | 0.01 | 0.02 | +0.01 | buy |
| Octagon Capital Advisors LP | 0 | 266,000 | +266,000 | 0.00 | 2.55 | +2.55 | buy |
| Polar Capital Holdings Plc | 0 | 250,000 | +250,000 | 0.00 | 0.06 | +0.06 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 210,106 | +210,106 | 0.00 | 0.34 | +0.34 | buy |
| Siren, L.L.C. | 3,240,313 | 3,428,150 | +187,837 | 5.00 | 7.74 | +2.74 | buy |
| Point72 Asset Management, L.P. | 0 | 184,478 | +184,478 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 395,468 | 563,365 | +167,897 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 46,874 | 207,722 | +160,848 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,702,450 | 6,859,202 | +156,752 | 0.02 | 0.03 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 156,253 | +156,253 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 154,103 | +154,103 | 0.00 | 0.04 | +0.04 | buy |
| Atika Capital Management LLC | 0 | 146,600 | +146,600 | 0.00 | 0.67 | +0.67 | buy |
| Cubist Systematic Strategies, LLC | 0 | 118,752 | +118,752 | 0.00 | 0.06 | +0.06 | buy |
| Boxer Capital Management, LLC | 325,000 | 432,010 | +107,010 | 2.68 | 9.49 | +6.81 | buy |
| Avoro Capital Advisors LLC | 6,460,000 | 6,555,555 | +95,555 | 2.76 | 5.01 | +2.25 | buy |
| Ensign Peak Advisors, Inc | 0 | 91,897 | +91,897 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 90,628 | +90,628 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 85,000 | +85,000 | 0.00 | 1.96 | +1.96 | buy |
| Burkehill Global Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.24 | +0.24 | buy |
| ExodusPoint Capital Management, LP | 29,501 | 100,997 | +71,496 | 0.01 | 0.05 | +0.04 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 420,045 | 487,961 | +67,916 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 201,900 | 269,284 | +67,384 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 172,082 | 237,605 | +65,523 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 593,000 | 653,000 | +60,000 | 0.32 | 0.52 | +0.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,133,765 | 1,193,112 | +59,347 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 85,212 | 143,181 | +57,969 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 50,787 | +50,787 | 0.00 | 0.04 | +0.04 | buy |
| Trexquant Investment LP | 0 | 50,663 | +50,663 | 0.00 | 0.02 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.57 | +0.57 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,708 | 429,304 | +47,596 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 183,300 | 224,300 | +41,000 | 0.01 | 0.02 | +0.01 | buy |
| Jain Global LLC | 0 | 38,705 | +38,705 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 96,805 | 134,939 | +38,134 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 525,138 | 562,990 | +37,852 | 0.29 | 0.43 | +0.14 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 34,797 | +34,797 | 0.00 | 0.29 | +0.29 | buy |
| ROYCE & ASSOCIATES LP | 0 | 33,797 | +33,797 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 202,092 | 234,970 | +32,878 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 28,906 | +28,906 | 0.00 | 0.01 | +0.01 | buy |
| COMERICA BANK | 21,374 | 49,113 | +27,739 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 85,046 | 107,438 | +22,392 | 0.00 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 22,065 | +22,065 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 21,600 | +21,600 | 0.00 | 0.09 | +0.09 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 144,224 | 162,315 | +18,091 | 0.01 | 0.03 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 17,011 | +17,011 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 13,040 | 29,633 | +16,593 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 11,546 | +11,546 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 147,620 | 159,163 | +11,543 | 0.01 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 11,107 | +11,107 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 10,850 | +10,850 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 48,160 | 58,924 | +10,764 | 0.01 | 0.02 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 318,381 | 329,020 | +10,639 | 0.11 | 0.15 | +0.04 | buy |
| Virtu Financial LLC | 0 | 10,362 | +10,362 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 13,027 | 23,079 | +10,052 | 0.03 | 0.09 | +0.06 | buy |
| Ghisallo Capital Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 142,587 | 152,165 | +9,578 | 0.00 | 0.01 | +0.00 | buy |
| Vident Advisory, LLC | 0 | 8,606 | +8,606 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 8,083 | +8,083 | 0.00 | 0.00 | +0.00 | buy |
| Keudell/Morrison Wealth Management | 0 | 7,660 | +7,660 | 0.00 | 0.07 | +0.07 | buy |
| Mach-1 Financial Group, LLC | 0 | 7,594 | +7,594 | 0.00 | 0.10 | +0.10 | buy |
| Proficio Capital Partners LLC | 0 | 7,000 | +7,000 | 0.00 | 0.02 | +0.02 | buy |
| Diametric Capital, LP | 0 | 6,600 | +6,600 | 0.00 | 0.15 | +0.15 | buy |
| INCEPTIONR LLC | 0 | 6,468 | +6,468 | 0.00 | 0.07 | +0.07 | buy |
| Neo Ivy Capital Management | 14,420 | 20,499 | +6,079 | 0.13 | 0.29 | +0.16 | buy |
| SEI INVESTMENTS CO | 0 | 6,075 | +6,075 | 0.00 | 0.00 | +0.00 | buy |
| Fieldview Capital Management, LLC | 0 | 5,929 | +5,929 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 5,882 | +5,882 | 0.00 | 0.05 | +0.05 | buy |
| Invesco Ltd. | 42,075 | 47,884 | +5,809 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 5,644 | +5,644 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 5,558 | +5,558 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 5,289 | +5,289 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 5,090 | +5,090 | 0.00 | 0.02 | +0.02 | buy |
| Hudson Bay Capital Management LP | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 4,836 | +4,836 | 0.00 | 0.01 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 4,598 | +4,598 | 0.00 | 0.07 | +0.07 | buy |
| Brooklyn Investment Group | 6 | 4,344 | +4,338 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 15,374 | 19,533 | +4,159 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 1,716 | 5,661 | +3,945 | 0.01 | 0.06 | +0.05 | buy |
| Bank of New York Mellon Corp | 126,877 | 130,714 | +3,837 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 13,366 | +3,366 | 0.05 | 0.09 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 22,433 | 25,571 | +3,138 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,567 | 5,425 | +2,858 | 0.00 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 2,664 | +2,664 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,878 | 33,472 | +2,594 | 0.04 | 0.06 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 44,990 | 47,040 | +2,050 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,348 | 13,259 | +1,911 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 1,664 | +1,664 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,417 | 4,982 | +1,565 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 40,037 | 41,523 | +1,486 | 0.00 | 0.00 | +0.00 | buy |