| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 365,190 | 1,262,182 | +896,992 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,995,929 | 6,651,429 | +655,500 | 1.82 | 2.82 | +1.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 131,963 | 491,810 | +359,847 | 0.04 | 0.20 | +0.16 | buy |
| BVF INC/IL | 5,161,801 | 5,502,710 | +340,909 | 5.76 | 8.58 | +2.82 | buy |
| JENNISON ASSOCIATES LLC | 552,286 | 825,025 | +272,739 | 0.01 | 0.02 | +0.01 | buy |
| Siren, L.L.C. | 3,240,313 | 3,428,150 | +187,837 | 5.00 | 7.74 | +2.74 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,702,450 | 6,859,202 | +156,752 | 0.02 | 0.03 | +0.01 | buy |
| Boxer Capital Management, LLC | 325,000 | 432,010 | +107,010 | 2.68 | 9.49 | +6.81 | buy |
| Avoro Capital Advisors LLC | 6,460,000 | 6,555,555 | +95,555 | 2.76 | 5.01 | +2.25 | buy |
| ExodusPoint Capital Management, LP | 29,501 | 100,997 | +71,496 | 0.01 | 0.05 | 0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 420,045 | 487,961 | +67,916 | 0.00 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 593,000 | 653,000 | +60,000 | 0.32 | 0.52 | +0.20 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 158,338 | 110,213 | +48,125 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 525,138 | 562,990 | +37,852 | 0.29 | 0.43 | +0.14 | buy |
| TD ASSET MANAGEMENT INC | 202,092 | 234,970 | +32,878 | 0.01 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 318,381 | 329,020 | +10,639 | 0.11 | 0.15 | +0.04 | buy |
| NATIXIS | 12,674 | 2,595 | +10,079 | 0.00 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,027 | 23,079 | +10,052 | 0.03 | 0.09 | +0.06 | buy |
| Neo Ivy Capital Management | 14,420 | 20,499 | +6,079 | 0.13 | 0.29 | +0.16 | buy |
| Aster Capital Management (DIFC) Ltd | 1,716 | 5,661 | +3,945 | 0.01 | 0.06 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 13,366 | +3,366 | 0.05 | 0.09 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,878 | 33,472 | +2,594 | 0.04 | 0.06 | 0.00 | buy |
| Clear Harbor Asset Management, LLC | 10,356 | 11,194 | +838 | 0.02 | 0.04 | +0.01 | buy |
| Kestra Investment Management, LLC | 35 | 164 | +129 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 3,926 | 3,817 | +109 | 0.01 | 0.01 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 3,891 | 1,988 | -1,903 | 0.03 | 0.03 | +0.00 | sell |
| Patient Square Capital LP | 142,201 | 140,000 | -2,201 | 1.61 | 2.20 | +0.59 | sell |
| PROFUND ADVISORS LLC | 12,549 | 8,831 | -3,718 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 58,982 | 40,138 | -18,844 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 525,245 | 498,111 | -27,134 | 0.09 | 0.11 | +0.02 | sell |
| Checkpoint Capital L.P. | 136,605 | 106,991 | -29,614 | 2.05 | 2.18 | +0.12 | sell |
| Deer Management Co. LLC | 415,895 | 325,895 | -90,000 | 1.05 | 1.13 | +0.08 | sell |
| Redmile Group, LLC | 983,413 | 803,289 | -180,124 | 2.54 | 3.73 | +1.19 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,168,791 | 933,890 | -234,901 | 0.31 | 0.33 | +0.02 | sell |
| Rock Springs Capital Management LP | 794,437 | 450,374 | -344,063 | 1.24 | 1.22 | -0.02 | sell |