| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,699,950 | 12,349,256 | +649,306 | 0.05 | 0.06 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 8,657,242 | 8,657,242 | 0 | 4.14 | 4.97 | +0.83 | hold |
| Avoro Capital Advisors LLC | 7,474,747 | 7,474,747 | 0 | 6.13 | 7.70 | +1.56 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,060,847 | 7,112,980 | +1,052,133 | 0.06 | 0.08 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 5,464,997 | 6,257,261 | +792,264 | 0.31 | 0.47 | +0.16 | buy |
| BlackRock, Inc. | 5,060,876 | 5,538,210 | +477,334 | 0.01 | 0.01 | +0.00 | buy |
| BVF INC/IL | 5,502,710 | 3,872,052 | -1,630,658 | 14.60 | 11.35 | -3.25 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,889,687 | 3,675,028 | -214,659 | 0.06 | 0.07 | +0.01 | sell |
| Siren, L.L.C. | 3,186,830 | 2,935,830 | -251,000 | 7.36 | 6.83 | -0.52 | sell |
| Atlas Venture Life Science Advisors, LLC | 4,578,008 | 2,847,541 | -1,730,467 | 48.26 | 37.05 | -11.21 | sell |
| STATE STREET CORP | 2,389,767 | 2,737,226 | +347,459 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,645,350 | 1,816,331 | +170,981 | 0.01 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 1,673,275 | 1,388,881 | -284,394 | 0.02 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 888,409 | 1,187,333 | +298,924 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 1,023,852 | 1,007,777 | -16,075 | 0.02 | 0.02 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 888,035 | 981,521 | +93,486 | 0.02 | 0.03 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,043,583 | 919,233 | -124,350 | 0.64 | 0.61 | -0.03 | sell |
| Merck & Co., Inc. | 772,165 | 772,165 | 0 | 18.40 | 16.82 | -1.58 | hold |
| NORGES BANK | 0 | 757,246 | +757,246 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 536,680 | 749,398 | +212,718 | 0.07 | 0.12 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 592,879 | 745,152 | +152,273 | 0.01 | 0.02 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 759,848 | 740,866 | -18,982 | 0.65 | 0.79 | +0.14 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 875,872 | 736,866 | -139,006 | 0.02 | 0.02 | +0.00 | sell |
| Holocene Advisors, LP | 836,759 | 636,579 | -200,180 | 0.17 | 0.17 | -0.00 | sell |
| NORTHERN TRUST CORP | 494,439 | 581,907 | +87,468 | 0.01 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 529,729 | +529,729 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 495,262 | 529,729 | +34,467 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 361,772 | 515,050 | +153,278 | 0.01 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 626,925 | 504,210 | -122,715 | 0.86 | 0.77 | -0.09 | sell |
| JENNISON ASSOCIATES LLC | 508,999 | 502,978 | -6,021 | 0.03 | 0.03 | +0.01 | sell |
| Woodline Partners LP | 203,585 | 500,868 | +297,283 | 0.06 | 0.18 | +0.11 | buy |
| Rock Springs Capital Management LP | 496,871 | 453,156 | -43,715 | 2.44 | 2.54 | +0.10 | sell |
| Boxer Capital Management, LLC | 329,100 | 429,100 | +100,000 | 3.60 | 3.71 | +0.11 | buy |
| Pictet Asset Management Holding SA | 468,728 | 395,540 | -73,188 | 0.04 | 0.04 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 289,416 | 378,286 | +88,870 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 337,559 | 378,163 | +40,604 | 0.94 | 1.60 | +0.67 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 285,871 | 375,868 | +89,997 | 0.02 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 256,501 | 371,374 | +114,873 | 0.02 | 0.03 | +0.01 | buy |
| Clearbridge Investments, LLC | 0 | 347,221 | +347,221 | 0.00 | 0.03 | +0.03 | buy |
| Octagon Capital Advisors LP | 425,000 | 310,000 | -115,000 | 3.92 | 3.26 | -0.65 | sell |
| Nextech Invest, Ltd. | 278,896 | 278,896 | 0 | 1.63 | 1.52 | -0.12 | hold |
| Alyeska Investment Group, L.P. | 342,698 | 276,455 | -66,243 | 0.08 | 0.08 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 287,100 | 272,900 | -14,200 | 0.02 | 0.03 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 198,808 | 269,914 | +71,106 | 0.02 | 0.03 | +0.01 | buy |
| Commodore Capital LP | 750,000 | 250,000 | -500,000 | 3.61 | 1.71 | -1.91 | sell |
| RTW INVESTMENTS, LP | 240,000 | 240,000 | 0 | 0.20 | 0.23 | +0.04 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 209,005 | 233,713 | +24,708 | 0.01 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 235,433 | 229,053 | -6,380 | 0.24 | 0.27 | +0.04 | sell |
| Bank of New York Mellon Corp | 193,200 | 215,588 | +22,388 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 215,200 | 203,747 | -11,453 | 0.08 | 0.07 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 335,000 | 200,000 | -135,000 | 0.04 | 0.03 | -0.01 | sell |
| MORGAN STANLEY | 212,702 | 194,843 | -17,859 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 201,672 | 192,880 | -8,792 | 0.09 | 0.10 | +0.01 | sell |
| MARSHALL WACE, LLP | 0 | 167,517 | +167,517 | 0.00 | 0.02 | +0.02 | buy |
| Eagle Health Investments LP | 145,816 | 166,148 | +20,332 | 2.55 | 3.16 | +0.61 | buy |
| TimesSquare Capital Management, LLC | 168,846 | 157,327 | -11,519 | 0.24 | 0.27 | +0.03 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 152,381 | 151,810 | -571 | 0.03 | 0.03 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 104,279 | 149,908 | +45,629 | 0.02 | 0.03 | +0.01 | buy |
| Foresite Capital Management VI LLC | 146,332 | 146,332 | 0 | 2.65 | 2.61 | -0.04 | hold |
| Nuveen, LLC | 128,091 | 138,478 | +10,387 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 135,584 | +135,584 | 0.00 | 0.00 | +0.00 | buy |
| Deer Management Co. LLC | 125,895 | 125,895 | 0 | 1.69 | 1.78 | +0.09 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 120,151 | 119,503 | -648 | 0.01 | 0.01 | +0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 113,173 | +113,173 | 0.00 | 3.04 | +3.04 | buy |
| JPMORGAN CHASE & CO | 125,419 | 113,062 | -12,357 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 118,597 | 111,555 | -7,042 | 0.01 | 0.01 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 83,876 | 106,272 | +22,396 | 0.23 | 0.34 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 91,882 | 106,049 | +14,167 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 104,000 | +104,000 | 0.00 | 1.18 | +1.18 | buy |
| First Turn Management, LLC | 254,672 | 102,533 | -152,139 | 2.37 | 1.26 | -1.11 | sell |
| Ensign Peak Advisors, Inc | 113,842 | 97,660 | -16,182 | 0.02 | 0.02 | +0.00 | sell |
| Squarepoint Ops LLC | 12,839 | 97,189 | +84,350 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 94,500 | 90,100 | -4,400 | 0.00 | 0.01 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 103,200 | 89,494 | -13,706 | 0.01 | 0.02 | +0.00 | sell |
| RHUMBLINE ADVISERS | 71,678 | 80,684 | +9,006 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 12,264 | 77,784 | +65,520 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.31 | 0.31 | +0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 67,995 | 74,340 | +6,345 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,767 | 72,160 | +45,393 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 51,238 | 65,659 | +14,421 | 0.01 | 0.01 | +0.00 | buy |
| Yiheng Capital Management, L.P. | 73,440 | 63,440 | -10,000 | 2.65 | 3.10 | +0.45 | sell |
| BNP Paribas Asset Management Holding S.A. | 64,467 | 61,657 | -2,810 | 0.01 | 0.01 | +0.00 | sell |
| Russell Investments Group, Ltd. | 48,812 | 61,645 | +12,833 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 61,501 | +61,501 | 0.00 | 0.09 | +0.09 | buy |
| FIRST TRUST ADVISORS LP | 93,617 | 61,368 | -32,249 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 110,415 | 60,813 | -49,602 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 27,347 | 54,569 | +27,222 | 0.16 | 0.35 | +0.19 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,282 | 54,429 | -1,853 | 0.00 | 0.01 | +0.00 | sell |
| Patient Square Capital LP | 100,000 | 47,500 | -52,500 | 1.48 | 0.84 | -0.63 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 45,671 | +45,671 | 0.00 | 0.17 | +0.17 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,299 | 41,126 | +2,827 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,185 | 36,833 | -352 | 0.01 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 31,507 | 36,494 | +4,987 | 0.01 | 0.02 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 33,948 | 36,368 | +2,420 | 0.23 | 0.28 | +0.06 | buy |
| Legal & General Group Plc | 36,734 | 36,237 | -497 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 55,331 | 35,287 | -20,044 | 0.02 | 0.01 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 32,061 | 33,591 | +1,530 | 0.01 | 0.01 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 32,367 | 31,367 | -1,000 | 0.00 | 0.01 | +0.00 | sell |
| Nan Fung Group Holdings Ltd | 30,875 | 30,875 | 0 | 2.12 | 2.69 | +0.57 | hold |
| MOODY ALDRICH PARTNERS LLC | 38,195 | 30,006 | -8,189 | 0.57 | 0.62 | +0.04 | sell |