| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,375,340 | 4,750,400 | +375,060 | 0.58 | 0.38 | -0.20 | buy |
| Aquilo Capital Management, LLC | 651,325 | 782,219 | +130,894 | 9.83 | 9.85 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 376,948 | 463,533 | +86,585 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 99,915 | 184,082 | +84,167 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 55,730 | 128,532 | +72,802 | 0.06 | 0.08 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,007,148 | 5,057,425 | +50,277 | 0.02 | 0.01 | -0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 21,184 | 51,088 | +29,904 | 0.05 | 0.07 | 0.00 | buy |
| Simplify Asset Management Inc. | 10,532 | 30,515 | +19,983 | 0.04 | 0.07 | +0.03 | buy |
| Rock Springs Capital Management LP | 1,487,551 | 1,504,351 | +16,800 | 0.81 | 0.56 | -0.25 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 31,377 | 35,211 | +3,834 | 0.14 | 0.10 | -0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 224,831 | 227,580 | +2,749 | 0.01 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 725 | 1,421 | +696 | 0.01 | 0.01 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 45,125 | 45,186 | +61 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,215 | 3,837 | -378 | 0.06 | 0.03 | -0.03 | sell |
| Woodline Partners LP | 108,781 | 103,189 | -5,592 | 0.03 | 0.02 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 88,732 | 81,865 | -6,867 | 0.03 | 0.02 | -0.01 | sell |
| Dynamic Technology Lab Private Ltd | 21,070 | 11,359 | -9,711 | 0.06 | 0.02 | -0.05 | sell |
| PROFUND ADVISORS LLC | 38,829 | 25,454 | -13,375 | 0.05 | 0.02 | -0.03 | sell |
| Rafferty Asset Management, LLC | 214,490 | 150,099 | -64,391 | 0.03 | 0.01 | -0.02 | sell |
| WASATCH ADVISORS LP | 1,199,350 | 572,907 | -626,443 | 0.17 | 0.05 | -0.12 | sell |