| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 223,413 | 1,328,703 | +1,105,290 | 0.06 | 0.54 | +0.48 | buy |
| Avoro Capital Advisors LLC | 3,888,888 | 4,500,000 | +611,112 | 1.55 | 3.11 | +1.56 | buy |
| JENNISON ASSOCIATES LLC | 429,287 | 797,681 | +368,394 | 0.01 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,390,658 | 6,645,474 | +254,816 | 0.02 | 0.04 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 130,729 | 291,340 | +160,611 | 0.05 | 0.16 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 348,918 | 270,035 | +78,883 | 0.03 | 0.03 | 0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 405,870 | 453,377 | +47,507 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 462,099 | 507,902 | +45,803 | 0.24 | 0.41 | +0.18 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 162,201 | 143,692 | +18,509 | 0.01 | 0.01 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 31,011 | 40,303 | +9,292 | 0.07 | 0.08 | 0.00 | buy |
| Woodline Partners LP | 517,797 | 525,094 | +7,297 | 0.15 | 0.21 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 27,533 | 21,482 | +6,051 | 0.06 | 0.09 | 0.00 | sell |
| E Fund Management Co., Ltd. | 48,946 | 54,292 | +5,346 | 0.08 | 0.13 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 7,208 | 12,422 | +5,214 | 0.03 | 0.06 | +0.03 | buy |
| Atika Capital Management LLC | 92,000 | 97,000 | +5,000 | 0.27 | 0.47 | +0.20 | buy |
| PROFUND ADVISORS LLC | 17,011 | 13,311 | +3,700 | 0.02 | 0.02 | 0.00 | sell |
| ALGERT GLOBAL LLC | 32,706 | 30,256 | +2,450 | 0.03 | 0.04 | 0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 4,330 | 4,096 | +234 | 0.01 | 0.01 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,596 | 2,640 | +44 | 0.04 | 0.06 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,929 | +1 | 2.29 | 2.94 | +0.65 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 7,784 | 5,794 | -1,990 | 0.05 | 0.05 | +0.01 | sell |
| Keudell/Morrison Wealth Management | 7,105 | 4,830 | -2,275 | 0.06 | 0.06 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 218,804 | 206,894 | -11,910 | 0.01 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 90,820 | 65,451 | -25,369 | 0.01 | 0.01 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 50,626 | 11,856 | -38,770 | 0.30 | 0.09 | -0.21 | sell |
| Rock Springs Capital Management LP | 1,163,973 | 1,049,386 | -114,587 | 1.05 | 1.62 | +0.57 | sell |
| Aquilo Capital Management, LLC | 328,743 | 208,743 | -120,000 | 9.46 | 11.12 | +1.66 | sell |
| Candriam S.C.A. | 238,165 | 95,821 | -142,344 | 0.04 | 0.03 | -0.02 | sell |
| Redmile Group, LLC | 1,579,275 | 1,393,256 | -186,019 | 2.85 | 3.88 | +1.03 | sell |
| Atlas Venture Life Science Advisors, LLC | 5,350,422 | 4,896,462 | -453,960 | 16.82 | 21.48 | +4.67 | sell |
| Deep Track Capital, LP | 1,500,000 | 600,326 | -899,674 | 1.34 | 0.91 | -0.43 | sell |