| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,390,658 | 6,645,474 | +254,816 | 0.02 | 0.04 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,929 | +1 | 2.29 | 2.94 | +0.65 | buy |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 4.32 | 7.15 | +2.83 | hold |
| FMR LLC | 4,826,840 | 5,109,141 | +282,301 | 0.01 | 0.01 | +0.01 | buy |
| Atlas Venture Life Science Advisors, LLC | 5,350,422 | 4,896,462 | -453,960 | 16.82 | 21.48 | +4.67 | sell |
| VANGUARD GROUP INC | 4,822,416 | 4,753,766 | -68,650 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,309,405 | 4,618,359 | +308,954 | 0.02 | 0.04 | +0.02 | buy |
| Avoro Capital Advisors LLC | 3,888,888 | 4,500,000 | +611,112 | 1.55 | 3.11 | +1.56 | buy |
| STATE STREET CORP | 1,910,691 | 1,728,144 | -182,547 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 1,579,275 | 1,393,256 | -186,019 | 2.85 | 3.88 | +1.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 223,413 | 1,328,703 | +1,105,290 | 0.06 | 0.54 | +0.48 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,054,220 | 1,053,224 | -996 | 0.00 | 0.00 | +0.00 | sell |
| Rock Springs Capital Management LP | 1,163,973 | 1,049,386 | -114,587 | 1.05 | 1.62 | +0.57 | sell |
| JENNISON ASSOCIATES LLC | 429,287 | 797,681 | +368,394 | 0.01 | 0.02 | +0.02 | buy |
| Deep Track Capital, LP | 1,500,000 | 600,326 | -899,674 | 1.34 | 0.91 | -0.43 | sell |
| Woodline Partners LP | 517,797 | 525,094 | +7,297 | 0.15 | 0.21 | +0.06 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 462,099 | 507,902 | +45,803 | 0.24 | 0.41 | +0.18 | buy |
| Avidity Partners Management LP | 0 | 500,000 | +500,000 | 0.00 | 1.21 | +1.21 | buy |
| MORGAN STANLEY | 631,738 | 488,077 | -143,661 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 402,385 | 472,626 | +70,241 | 0.00 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 405,870 | 453,377 | +47,507 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 433,573 | 428,529 | -5,044 | 0.00 | 0.01 | +0.00 | sell |
| Deer Management Co. LLC | 415,895 | 415,895 | 0 | 2.55 | 3.12 | +0.57 | hold |
| First Light Asset Management, LLC | 0 | 406,348 | +406,348 | 0.00 | 1.60 | +1.60 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 392,263 | +392,263 | 0.00 | 0.17 | +0.17 | buy |
| NORTHERN TRUST CORP | 368,141 | 384,175 | +16,034 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 375,101 | 366,841 | -8,260 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 367,000 | 336,300 | -30,700 | 0.02 | 0.04 | +0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 130,729 | 291,340 | +160,611 | 0.05 | 0.16 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 348,918 | 270,035 | -78,883 | 0.02 | 0.03 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 273,519 | 234,771 | -38,748 | 0.03 | 0.04 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 462,309 | 224,831 | -237,478 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 210,301 | 217,619 | +7,318 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 328,743 | 208,743 | -120,000 | 9.46 | 11.12 | +1.66 | sell |
| TD ASSET MANAGEMENT INC | 218,804 | 206,894 | -11,910 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 295,572 | 188,197 | -107,375 | 0.01 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 289,463 | 179,186 | -110,277 | 0.07 | 0.07 | +0.00 | sell |
| Invesco Ltd. | 29,834 | 163,919 | +134,085 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 162,201 | 143,692 | -18,509 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 44,944 | 140,491 | +95,547 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 130,077 | 128,267 | -1,810 | 0.00 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 93,668 | 124,614 | +30,946 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 138,636 | 123,045 | -15,591 | 0.00 | 0.01 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 49,720 | 122,090 | +72,370 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 156,211 | 121,645 | -34,566 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 376,562 | 117,681 | -258,881 | 0.02 | 0.01 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 151,191 | 111,032 | -40,159 | 0.00 | 0.00 | +0.00 | sell |
| AXA S.A. | 109,279 | 109,312 | +33 | 0.01 | 0.02 | +0.01 | buy |
| Atika Capital Management LLC | 92,000 | 97,000 | +5,000 | 0.32 | 0.49 | +0.17 | buy |
| Candriam S.C.A. | 238,165 | 95,821 | -142,344 | 0.04 | 0.03 | -0.02 | sell |
| BARCLAYS PLC | 49,093 | 91,755 | +42,662 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 117,883 | 91,231 | -26,652 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 90,128 | 88,474 | -1,654 | 0.00 | 0.01 | +0.00 | sell |
| Neuberger Berman Group LLC | 119,192 | 78,236 | -40,956 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 108,563 | 73,525 | -35,038 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 90,100 | 65,900 | -24,200 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 90,820 | 65,451 | -25,369 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 64,535 | 62,296 | -2,239 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 66,706 | 62,177 | -4,529 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 153,657 | 61,332 | -92,325 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 53,433 | 59,783 | +6,350 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 9,386 | 59,709 | +50,323 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 56,801 | +56,801 | 0.00 | 0.15 | +0.15 | buy |
| Propel Bio Management, LLC | 56,359 | 56,359 | 0 | 1.09 | 1.55 | +0.46 | hold |
| E Fund Management Co., Ltd. | 48,946 | 54,292 | +5,346 | 0.08 | 0.13 | +0.05 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 46,213 | +46,213 | 0.00 | 0.05 | +0.05 | buy |
| HRT FINANCIAL LP | 0 | 45,652 | +45,652 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 36,233 | 43,716 | +7,483 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 66,437 | 40,730 | -25,707 | 0.01 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 31,011 | 40,303 | +9,292 | 0.07 | 0.08 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 38,141 | 38,141 | 0 | 0.01 | 0.01 | +0.00 | hold |
| COMERICA BANK | 2,940 | 38,073 | +35,133 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 18,286 | 38,006 | +19,720 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 44,488 | 37,229 | -7,259 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 19,586 | 34,564 | +14,978 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,696 | 32,708 | -11,988 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 32,162 | +32,162 | 0.00 | 0.02 | +0.02 | buy |
| Simplify Asset Management Inc. | 30,515 | 30,515 | 0 | 0.08 | 0.10 | +0.02 | hold |
| ALGERT GLOBAL LLC | 32,706 | 30,256 | -2,450 | 0.03 | 0.04 | +0.01 | sell |
| Campbell & CO Investment Adviser LLC | 30,975 | 30,208 | -767 | 0.08 | 0.11 | +0.03 | sell |
| FRANKLIN RESOURCES INC | 21,793 | 29,440 | +7,647 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,570 | 26,949 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,888 | 25,888 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BAMCO INC /NY/ | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 23,931 | 23,785 | -146 | 0.00 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,792 | 23,714 | +5,922 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 23,562 | 23,562 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 27,533 | 21,482 | -6,051 | 0.06 | 0.08 | +0.02 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,917 | 21,305 | -4,612 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 18,141 | +18,141 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 15,400 | 17,300 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,849 | 15,649 | -5,200 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 18,808 | 15,108 | -3,700 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 10,887 | 14,719 | +3,832 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,379 | 14,452 | +73 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 0 | 14,378 | +14,378 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,727 | +13,727 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 17,011 | 13,311 | -3,700 | 0.02 | 0.02 | +0.01 | sell |
| HSBC HOLDINGS PLC | 18,182 | 13,058 | -5,124 | 0.00 | 0.00 | +0.00 | sell |