| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 223,413 | 1,328,703 | +1,105,290 | 0.06 | 0.54 | +0.48 | buy |
| Avoro Capital Advisors LLC | 3,888,888 | 4,500,000 | +611,112 | 1.55 | 3.11 | +1.56 | buy |
| Avidity Partners Management LP | 0 | 500,000 | +500,000 | 0.00 | 1.21 | +1.21 | buy |
| First Light Asset Management, LLC | 0 | 406,348 | +406,348 | 0.00 | 1.60 | +1.60 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 392,263 | +392,263 | 0.00 | 0.17 | +0.17 | buy |
| JENNISON ASSOCIATES LLC | 429,287 | 797,681 | +368,394 | 0.01 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,309,405 | 4,618,359 | +308,954 | 0.02 | 0.04 | +0.02 | buy |
| FMR LLC | 4,826,840 | 5,109,141 | +282,301 | 0.01 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,390,658 | 6,645,474 | +254,816 | 0.02 | 0.04 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 130,729 | 291,340 | +160,611 | 0.05 | 0.16 | +0.12 | buy |
| Invesco Ltd. | 29,834 | 163,919 | +134,085 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 44,944 | 140,491 | +95,547 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 49,720 | 122,090 | +72,370 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 402,385 | 472,626 | +70,241 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 56,801 | +56,801 | 0.00 | 0.15 | +0.15 | buy |
| Qube Research & Technologies Ltd | 9,386 | 59,709 | +50,323 | 0.00 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 405,870 | 453,377 | +47,507 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 46,213 | +46,213 | 0.00 | 0.05 | +0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 462,099 | 507,902 | +45,803 | 0.24 | 0.41 | +0.18 | buy |
| HRT FINANCIAL LP | 0 | 45,652 | +45,652 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 49,093 | 91,755 | +42,662 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 2,940 | 38,073 | +35,133 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 32,162 | +32,162 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 93,668 | 124,614 | +30,946 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 18,286 | 38,006 | +19,720 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 18,141 | +18,141 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 368,141 | 384,175 | +16,034 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,586 | 34,564 | +14,978 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 0 | 14,378 | +14,378 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,727 | +13,727 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 12,743 | +12,743 | 0.00 | 0.21 | +0.21 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 12,260 | +12,260 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 12,154 | +12,154 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 10,449 | +10,449 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 9,976 | +9,976 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 9,400 | +9,400 | 0.00 | 0.05 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 31,011 | 40,303 | +9,292 | 0.07 | 0.08 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 8,600 | +8,600 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 21,793 | 29,440 | +7,647 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 36,233 | 43,716 | +7,483 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 210,301 | 217,619 | +7,318 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 517,797 | 525,094 | +7,297 | 0.15 | 0.21 | +0.06 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 6,617 | +6,617 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 53,433 | 59,783 | +6,350 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Advisors Network LLC | 0 | 6,218 | +6,218 | 0.00 | 0.01 | +0.01 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 5,992 | +5,992 | 0.00 | 0.56 | +0.56 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,792 | 23,714 | +5,922 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 48,946 | 54,292 | +5,346 | 0.08 | 0.13 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 7,208 | 12,422 | +5,214 | 0.03 | 0.06 | +0.03 | buy |
| Atika Capital Management LLC | 92,000 | 97,000 | +5,000 | 0.32 | 0.49 | +0.17 | buy |
| Pictet Asset Management Holding SA | 0 | 4,685 | +4,685 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 4,410 | +4,410 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 10,887 | 14,719 | +3,832 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 9,250 | 12,222 | +2,972 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,570 | 26,949 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,328 | +2,328 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,000 | +2,000 | 0.00 | 0.03 | +0.03 | buy |
| Handelsbanken Fonder AB | 15,400 | 17,300 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,184 | 5,775 | +1,591 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 1,296 | +1,296 | 0.00 | 0.03 | +0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,374 | 11,289 | +915 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 800 | +800 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,832 | 2,336 | +504 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,070 | 4,506 | +436 | 0.00 | 0.01 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 297 | +297 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 7,051 | 7,256 | +205 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 278 | 361 | +83 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,379 | 14,452 | +73 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 122 | 182 | +60 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 474 | 534 | +60 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,596 | 2,640 | +44 | 0.04 | 0.06 | +0.02 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 55 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 210 | 245 | +35 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 109,279 | 109,312 | +33 | 0.01 | 0.02 | +0.01 | buy |
| CWM, LLC | 3 | 30 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 8 | 21 | +13 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| CVA Family Office, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 6,727 | 6,734 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 8 | 14 | +6 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,929 | +1 | 2.29 | 2.94 | +0.65 | buy |
| CANADA LIFE ASSURANCE Co | 10,491 | 10,491 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 4.32 | 7.15 | +2.83 | hold |
| KBC Group NV | 1,399 | 1,399 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 59 | 59 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 23,562 | 23,562 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deer Management Co. LLC | 415,895 | 415,895 | 0 | 2.55 | 3.12 | +0.57 | hold |
| Clear Harbor Asset Management, LLC | 10,000 | 10,000 | 0 | 0.03 | 0.04 | +0.01 | hold |
| MetLife Investment Management, LLC | 25,888 | 25,888 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 38,141 | 38,141 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Allworth Financial LP | 29 | 29 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NVWM, LLC | 7,254 | 7,254 | 0 | 0.06 | 0.09 | +0.03 | hold |
| Nan Fung Group Holdings Ltd | 10,875 | 10,875 | 0 | 0.35 | 0.44 | +0.10 | hold |
| Simplify Asset Management Inc. | 30,515 | 30,515 | 0 | 0.08 | 0.10 | +0.02 | hold |
| Propel Bio Management, LLC | 56,359 | 56,359 | 0 | 1.09 | 1.55 | +0.46 | hold |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.02 | +0.00 | hold |