| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 6,651,429 | 6,651,429 | 0 | 2.82 | 2.72 | -0.10 | hold |
| Avoro Capital Advisors LLC | 6,555,555 | 6,350,000 | -205,555 | 5.01 | 4.65 | -0.36 | sell |
| FMR LLC | 5,431,994 | 5,879,611 | +447,617 | 0.01 | 0.02 | +0.00 | buy |
| BVF INC/IL | 5,502,710 | 5,502,710 | 0 | 8.58 | 12.63 | +4.05 | hold |
| VANGUARD GROUP INC | 5,619,848 | 5,421,722 | -198,126 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,372,061 | 5,195,691 | -176,370 | 0.04 | 0.05 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,859,202 | 5,097,378 | -1,761,824 | 0.03 | 0.03 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 4,896,462 | 4,896,462 | 0 | 32.26 | 36.82 | +4.56 | hold |
| BlackRock, Inc. | 4,148,260 | 4,365,448 | +217,188 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 3,428,150 | 3,428,150 | 0 | 7.74 | 7.59 | -0.15 | hold |
| STATE STREET CORP | 1,554,431 | 2,019,454 | +465,023 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,193,112 | 1,276,766 | +83,654 | 0.00 | 0.00 | +0.00 | buy |
| Capital Research Global Investors | 1,262,182 | 1,262,182 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JENNISON ASSOCIATES LLC | 825,025 | 1,027,739 | +202,714 | 0.02 | 0.03 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 933,890 | 939,094 | +5,204 | 0.33 | 0.38 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 818,927 | 863,762 | +44,835 | 0.01 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 840,333 | +840,333 | 0.00 | 0.11 | +0.11 | buy |
| Merck & Co., Inc. | 772,165 | 772,165 | 0 | 15.63 | 19.17 | +3.54 | hold |
| Commodore Capital LP | 750,000 | 750,000 | 0 | 2.31 | 2.07 | -0.24 | hold |
| DIMENSIONAL FUND ADVISORS LP | 563,365 | 731,420 | +168,055 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 278,736 | 711,444 | +432,708 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 557,734 | 648,718 | +90,984 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 562,990 | 644,590 | +81,600 | 0.43 | 0.60 | +0.17 | buy |
| Alyeska Investment Group, L.P. | 50,000 | 615,091 | +565,091 | 0.01 | 0.11 | +0.10 | buy |
| T. Rowe Price Investment Management, Inc. | 90,628 | 611,221 | +520,593 | 0.00 | 0.02 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 653,000 | 572,258 | -80,742 | 0.52 | 0.50 | -0.02 | sell |
| FEDERATED HERMES, INC. | 0 | 558,700 | +558,700 | 0.00 | 0.06 | +0.06 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 491,810 | 518,057 | +26,247 | 0.20 | 0.26 | +0.06 | buy |
| AJU IB Investment Co., Ltd. | 457,059 | 457,059 | 0 | 21.71 | 22.47 | +0.76 | hold |
| Rock Springs Capital Management LP | 450,374 | 450,374 | 0 | 1.22 | 1.49 | +0.27 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 429,304 | 439,825 | +10,521 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 409,353 | 437,120 | +27,767 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 487,961 | 435,014 | -52,947 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 159,163 | 429,975 | +270,812 | 0.01 | 0.04 | +0.02 | buy |
| Polar Capital Holdings Plc | 250,000 | 397,041 | +147,041 | 0.06 | 0.11 | +0.05 | buy |
| MORGAN STANLEY | 237,605 | 377,799 | +140,194 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 224,300 | 372,400 | +148,100 | 0.02 | 0.04 | +0.02 | buy |
| Octagon Capital Advisors LP | 266,000 | 360,000 | +94,000 | 2.55 | 3.18 | +0.63 | buy |
| MARSHALL WACE, LLP | 269,284 | 359,076 | +89,792 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 33,324 | 351,246 | +317,922 | 0.00 | 0.04 | +0.04 | buy |
| Pictet Asset Management Holding SA | 5,558 | 346,817 | +341,259 | 0.00 | 0.02 | +0.02 | buy |
| Nextech Invest, Ltd. | 340,909 | 340,909 | 0 | 2.82 | 2.94 | +0.12 | hold |
| Deer Management Co. LLC | 325,895 | 325,895 | 0 | 1.13 | 1.65 | +0.52 | hold |
| Boxer Capital Management, LLC | 432,010 | 319,100 | -112,910 | 9.49 | 5.76 | -3.73 | sell |
| First Turn Management, LLC | 0 | 277,726 | +277,726 | 0.00 | 2.36 | +2.36 | buy |
| BRAIDWELL LP | 0 | 276,692 | +276,692 | 0.00 | 0.46 | +0.46 | buy |
| Logos Global Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.40 | +1.40 | buy |
| Woodline Partners LP | 498,111 | 248,000 | -250,111 | 0.11 | 0.07 | -0.05 | sell |
| GILDER GAGNON HOWE & CO LLC | 329,020 | 246,704 | -82,316 | 0.15 | 0.14 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 304,200 | 238,000 | -66,200 | 0.02 | 0.02 | -0.00 | sell |
| ROYAL BANK OF CANADA | 156,253 | 236,974 | +80,721 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 234,970 | 209,248 | -25,722 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 207,722 | 192,699 | -15,023 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 154,103 | 191,639 | +37,536 | 0.04 | 0.06 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 134,939 | 186,254 | +51,315 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 184,478 | 173,900 | -10,578 | 0.02 | 0.02 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 210,106 | 169,796 | -40,310 | 0.34 | 0.28 | -0.07 | sell |
| BARCLAYS PLC | 143,181 | 155,144 | +11,963 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 130,714 | 152,452 | +21,738 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 146,332 | 146,332 | 0 | 3.59 | 3.20 | -0.39 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 152,165 | 126,490 | -25,675 | 0.01 | 0.01 | -0.00 | sell |
| Yiheng Capital Management, L.P. | 122,605 | 122,605 | 0 | 1.94 | 2.30 | +0.36 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 107,438 | 107,703 | +265 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 100,447 | 106,705 | +6,258 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 56,536 | 94,961 | +38,425 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 140,000 | 92,592 | -47,408 | 2.20 | 1.40 | -0.80 | sell |
| Ensign Peak Advisors, Inc | 91,897 | 91,897 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Swiss National Bank | 74,400 | 81,600 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 146,600 | 81,300 | -65,300 | 0.67 | 0.39 | -0.28 | sell |
| Invesco Ltd. | 47,884 | 79,807 | +31,923 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.24 | 0.24 | -0.00 | hold |
| FIRST TRUST ADVISORS LP | 0 | 74,852 | +74,852 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 71,058 | 74,173 | +3,115 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 50,663 | 72,924 | +22,261 | 0.02 | 0.04 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 50,915 | 72,737 | +21,822 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 40,138 | 68,295 | +28,157 | 0.01 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 106,991 | 61,750 | -45,241 | 2.18 | 1.17 | -1.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 110,213 | 61,640 | -48,573 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 38,705 | 58,480 | +19,775 | 0.03 | 0.04 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 57,585 | +57,585 | 0.00 | 0.37 | +0.37 | buy |
| Cubist Systematic Strategies, LLC | 118,752 | 52,754 | -65,998 | 0.06 | 0.04 | -0.01 | sell |
| Nicholas Investment Partners, LP | 0 | 52,625 | +52,625 | 0.00 | 0.23 | +0.23 | buy |
| COMERICA BANK | 49,113 | 51,423 | +2,310 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 47,040 | 48,769 | +1,729 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 41,523 | 43,497 | +1,974 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 518,887 | 41,823 | -477,064 | 0.02 | 0.00 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,318 | 40,699 | +4,381 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 58,924 | 39,746 | -19,178 | 0.02 | 0.02 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 29,786 | 36,455 | +6,669 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,571 | 32,061 | +6,490 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 33,649 | 31,662 | -1,987 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 8,484 | 31,471 | +22,987 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 29,633 | 31,289 | +1,656 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 25,950 | 31,052 | +5,102 | 0.05 | 0.05 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 30,875 | 30,875 | 0 | 2.12 | 2.93 | +0.81 | hold |
| HARBOR CAPITAL ADVISORS, INC. | 33,472 | 29,928 | -3,544 | 0.06 | 0.13 | +0.07 | sell |
| MetLife Investment Management, LLC | 27,787 | 29,499 | +1,712 | 0.01 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 34,797 | 28,910 | -5,887 | 0.29 | 0.31 | +0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,772 | 27,772 | -5,000 | 0.00 | 0.00 | +0.00 | sell |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.02 | +0.01 | hold |