| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,750,400 | 5,995,928 | +1,245,528 | 0.38 | 1.74 | +1.36 | buy |
| Artal Group S.A. | 1,805,346 | 2,530,735 | +725,389 | 1.08 | 2.14 | +1.07 | buy |
| BVF INC/IL | 4,739,004 | 5,161,801 | +422,797 | 1.78 | 3.29 | +1.51 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,057,425 | 5,335,712 | +278,287 | 0.01 | 0.02 | +0.01 | buy |
| Aquilo Capital Management, LLC | 782,219 | 881,337 | +99,118 | 9.85 | 15.74 | +5.88 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 227,580 | 185,299 | +42,281 | 0.00 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 128,532 | 99,372 | +29,160 | 0.08 | 0.10 | 0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 51,088 | 22,576 | +28,512 | 0.07 | 0.05 | 0.00 | sell |
| Rock Springs Capital Management LP | 1,504,351 | 1,522,238 | +17,887 | 0.56 | 0.95 | +0.39 | buy |
| PROFUND ADVISORS LLC | 25,454 | 19,887 | +5,567 | 0.02 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,421 | 6,423 | +5,002 | 0.01 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 184,082 | 186,482 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 4,180 | 3,971 | +209 | 0.00 | 0.00 | 0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 45,186 | 45,303 | +117 | 0.01 | 0.01 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 10,753 | 10,806 | +53 | 0.03 | 0.05 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 3,837 | 3,638 | -199 | 0.03 | 0.06 | +0.03 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 35,211 | 34,641 | -570 | 0.10 | 0.17 | +0.06 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 463,533 | 462,675 | -858 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 103,189 | 100,751 | -2,438 | 0.02 | 0.03 | +0.01 | sell |
| Rafferty Asset Management, LLC | 150,099 | 120,189 | -29,910 | 0.01 | 0.01 | +0.00 | sell |
| Redmile Group, LLC | 1,868,507 | 1,823,956 | -44,551 | 1.24 | 1.66 | +0.43 | sell |
| Avoro Capital Advisors LLC | 3,855,000 | 3,775,000 | -80,000 | 0.84 | 1.33 | +0.49 | sell |
| Candriam S.C.A. | 488,306 | 343,302 | -145,004 | 0.05 | 0.06 | +0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 1,610,496 | 1,295,943 | -314,553 | 0.02 | 0.02 | +0.01 | sell |