| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,750,400 | 5,995,928 | +1,245,528 | 0.38 | 1.74 | +1.36 | buy |
| Artal Group S.A. | 1,805,346 | 2,530,735 | +725,389 | 1.09 | 2.20 | +1.10 | buy |
| GOLDMAN SACHS GROUP INC | 204,708 | 674,655 | +469,947 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 437,633 | +437,633 | 0.00 | 0.09 | +0.09 | buy |
| BVF INC/IL | 4,739,004 | 5,161,801 | +422,797 | 1.78 | 3.29 | +1.51 | buy |
| NORGES BANK | 117,883 | 504,083 | +386,200 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,057,425 | 5,335,712 | +278,287 | 0.01 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 0 | 203,564 | +203,564 | 0.00 | 0.12 | +0.12 | buy |
| CITADEL ADVISORS LLC | 218,983 | 371,443 | +152,460 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 162,759 | 300,463 | +137,704 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 121,079 | +121,079 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 126,815 | 241,798 | +114,983 | 0.01 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 107,307 | +107,307 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 339,328 | 441,278 | +101,950 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 782,219 | 881,337 | +99,118 | 9.85 | 15.74 | +5.88 | buy |
| JANE STREET GROUP, LLC | 99,052 | 195,967 | +96,915 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 95,580 | +95,580 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 3,925,213 | 3,997,564 | +72,351 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 834,227 | 880,515 | +46,288 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 31,097 | +31,097 | 0.00 | 0.07 | +0.07 | buy |
| Engineers Gate Manager LP | 0 | 25,123 | +25,123 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Middle East FZE | 0 | 24,629 | +24,629 | 0.00 | 0.04 | +0.04 | buy |
| Capital Impact Advisors, LLC | 0 | 23,889 | +23,889 | 0.00 | 0.80 | +0.80 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 76,980 | 100,073 | +23,093 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 22,677 | +22,677 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 18,563 | +18,563 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 31,112 | 49,111 | +17,999 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,504,351 | 1,522,238 | +17,887 | 0.56 | 0.96 | +0.40 | buy |
| ROYCE & ASSOCIATES LP | 0 | 16,004 | +16,004 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 14,208 | +14,208 | 0.00 | 0.04 | +0.04 | buy |
| Graham Capital Management, L.P. | 0 | 13,794 | +13,794 | 0.00 | 0.01 | +0.01 | buy |
| Corton Capital Inc. | 0 | 12,511 | +12,511 | 0.00 | 0.10 | +0.10 | buy |
| ROYAL BANK OF CANADA | 0 | 11,854 | +11,854 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 0 | 9,834 | +9,834 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 9,648 | +9,648 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 9,162 | +9,162 | 0.00 | 0.04 | +0.04 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 9,014 | +9,014 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 8,135 | +8,135 | 0.00 | 0.05 | +0.05 | buy |
| Legal & General Group Plc | 31,008 | 38,390 | +7,382 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 126,264 | 133,591 | +7,327 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,421 | 6,423 | +5,002 | 0.01 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 301,741 | 306,692 | +4,951 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 0 | 4,767 | +4,767 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 3,910 | +3,910 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 295 | 2,993 | +2,698 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 184,082 | 186,482 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 1,644 | 3,931 | +2,287 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 5,493 | 7,359 | +1,866 | 0.00 | 0.01 | +0.00 | buy |
| COMERICA BANK | 1,509 | 2,924 | +1,415 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 22,416 | 22,940 | +524 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 38,000 | 38,400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,884 | 20,068 | +184 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 45,186 | 45,303 | +117 | 0.01 | 0.01 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 59 | +59 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 10,753 | 10,806 | +53 | 0.03 | 0.05 | +0.02 | buy |
| Allworth Financial LP | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,775 | 3,775 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,040 | 6,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 40,207 | 40,207 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 22,000 | 22,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 221 | 221 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deer Management Co. LLC | 615,895 | 615,895 | 0 | 1.04 | 2.03 | +0.99 | hold |
| MetLife Investment Management, LLC | 19,965 | 19,965 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 163 | 163 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avalon Trust Co | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Simplify Asset Management Inc. | 30,515 | 30,515 | 0 | 0.07 | 0.12 | +0.05 | hold |
| Atlas Venture Life Science Advisors, LLC | 5,858,262 | 5,858,262 | 0 | 12.61 | 17.76 | +5.15 | hold |
| Erste Asset Management GmbH | 27,000 | 27,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 26,109 | 26,109 | 0 | 0.00 | 0.01 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,925 | 10,925 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 5 | 4 | -1 | 0.00 | 0.00 | 0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 72,995 | 72,974 | -21 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 11,583 | 11,551 | -32 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 19,091 | 19,056 | -35 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 18,962 | 18,886 | -76 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 53,627 | 53,503 | -124 | 0.00 | 0.00 | +0.00 | sell |
| Advisors Asset Management, Inc. | 7,048 | 6,893 | -155 | 0.00 | 0.00 | +0.00 | sell |
| Arizona State Retirement System | 10,236 | 10,069 | -167 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,837 | 3,638 | -199 | 0.03 | 0.06 | +0.03 | sell |
| NATIXIS | 4,180 | 3,971 | -209 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,904 | 16,620 | -284 | 0.00 | 0.00 | +0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,486 | 2,198 | -288 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 5,818 | 5,424 | -394 | 0.00 | 0.00 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 35,211 | 34,641 | -570 | 0.10 | 0.17 | +0.06 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 463,533 | 462,675 | -858 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 24,940 | 24,000 | -940 | 0.01 | 0.01 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,705 | 390 | -1,315 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 1,642 | 0 | -1,642 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,154 | 38,321 | -1,833 | 0.00 | 0.00 | +0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,201 | 8,316 | -1,885 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 30,388 | 28,198 | -2,190 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 103,189 | 100,751 | -2,438 | 0.02 | 0.03 | +0.01 | sell |
| HSBC HOLDINGS PLC | 13,244 | 10,185 | -3,059 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,652 | 2,753 | -3,899 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 5,183 | 0 | -5,183 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 25,454 | 19,887 | -5,567 | 0.02 | 0.02 | +0.00 | sell |
| NORTHERN TRUST CORP | 366,255 | 358,579 | -7,676 | 0.00 | 0.00 | +0.00 | sell |