| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 4,618,359 | 5,307,326 | +688,967 | 0.04 | 0.04 | +0.00 | buy |
| Avoro Capital Advisors LLC | 4,500,000 | 5,150,000 | +650,000 | 3.11 | 2.93 | -0.18 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 593,000 | +593,000 | 0.00 | 0.45 | +0.45 | buy |
| JANUS HENDERSON GROUP PLC | 15,108 | 377,384 | +362,276 | 0.00 | 0.01 | +0.01 | buy |
| EcoR1 Capital, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.56 | +0.56 | buy |
| UBS Group AG | 217,619 | 469,842 | +252,223 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,645,474 | 6,870,333 | +224,859 | 0.04 | 0.03 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 224,831 | 433,944 | +209,113 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,211,649 | 4,356,303 | +144,654 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,753,766 | 4,887,312 | +133,546 | 0.00 | 0.00 | -0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 120,373 | +120,373 | 0.00 | 0.08 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 38,006 | 115,918 | +77,912 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 77,535 | +77,535 | 0.00 | 1.59 | +1.59 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,328,703 | 1,390,372 | +61,669 | 0.54 | 0.46 | -0.08 | buy |
| NORTHERN TRUST CORP | 384,175 | 437,833 | +53,658 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 123,045 | 176,220 | +53,175 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,053,224 | 1,105,487 | +52,263 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.25 | +0.25 | buy |
| Atika Capital Management LLC | 97,000 | 136,500 | +39,500 | 0.49 | 0.71 | +0.22 | buy |
| Schonfeld Strategic Advisors LLC | 179,186 | 215,480 | +36,294 | 0.07 | 0.05 | -0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 291,340 | 326,349 | +35,009 | 0.16 | 0.14 | -0.02 | buy |
| CITIGROUP INC | 34,564 | 64,416 | +29,852 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 43,716 | 72,442 | +28,726 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 206,894 | 228,560 | +21,666 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 366,841 | 387,187 | +20,346 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 143,692 | 163,896 | +20,204 | 0.01 | 0.01 | -0.00 | buy |
| Nan Fung Group Holdings Ltd | 10,875 | 30,875 | +20,000 | 0.44 | 1.06 | +0.62 | buy |
| Aquatic Capital Management LLC | 0 | 19,431 | +19,431 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,267 | 147,296 | +19,029 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,126 | +14,126 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 54,292 | 67,068 | +12,776 | 0.13 | 0.14 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 7,256 | 19,899 | +12,643 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 525,094 | 537,428 | +12,334 | 0.21 | 0.15 | -0.06 | buy |
| Swiss National Bank | 65,900 | 76,200 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 9,838 | +9,838 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 91,755 | 101,005 | +9,250 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 29,440 | 38,367 | +8,927 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 8,544 | +8,544 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 21,482 | 29,540 | +8,058 | 0.08 | 0.09 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,727 | 21,772 | +8,045 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,452 | 21,939 | +7,487 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,714 | 30,410 | +6,696 | 0.00 | 0.00 | -0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 6,234 | +6,234 | 0.00 | 0.00 | +0.00 | buy |
| Vident Advisory, LLC | 0 | 5,863 | +5,863 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 4,410 | 10,249 | +5,839 | 0.03 | 0.06 | +0.03 | buy |
| Bank of New York Mellon Corp | 121,645 | 127,093 | +5,448 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,730 | 45,588 | +4,858 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 13,058 | 17,483 | +4,425 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,708 | 36,839 | +4,131 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 12,222 | 16,293 | +4,071 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8,464 | 11,490 | +3,026 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 37,229 | 40,047 | +2,818 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 0 | 2,729 | +2,729 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,462 | 4,812 | +2,350 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,888 | 28,211 | +2,323 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,949 | 28,960 | +2,011 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 62,296 | 64,157 | +1,861 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 9,718 | 11,221 | +1,503 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,422 | 13,733 | +1,311 | 0.06 | 0.05 | -0.01 | buy |
| State of Wyoming | 0 | 1,120 | +1,120 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 8,600 | 9,600 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 1,399 | 2,151 | +752 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,303 | 40,987 | +684 | 0.08 | 0.07 | -0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,289 | 11,954 | +665 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 487 | +487 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,506 | 4,912 | +406 | 0.01 | 0.01 | -0.00 | buy |
| Verition Fund Management LLC | 5,135 | 5,347 | +212 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 143 | +143 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 14 | 84 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 297 | 351 | +54 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 534 | 585 | +51 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 20 | +20 | 0.00 | 0.00 | 0.00 | buy |
| Amundi | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 12 | 26 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 46 | 49 | +3 | 0.00 | 0.00 | -0.00 | buy |
| Hexagon Capital Partners LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 10,491 | 10,491 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BESSEMER GROUP INC | 65 | 65 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,161,801 | 5,161,801 | 0 | 7.15 | 7.04 | -0.11 | hold |
| SHELL ASSET MANAGEMENT CO | 4,096 | 4,096 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 5,995,929 | 5,995,929 | 0 | 2.94 | 2.58 | -0.36 | hold |
| NORGES BANK | 91,231 | 91,231 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 9,014 | 9,014 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 59 | 59 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 23,562 | 23,562 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 3,454 | 3,454 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 245 | 245 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deer Management Co. LLC | 415,895 | 415,895 | 0 | 3.12 | 1.31 | -1.82 | hold |
| Clear Harbor Asset Management, LLC | 10,000 | 10,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 38,141 | 38,141 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Allworth Financial LP | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avidity Partners Management LP | 500,000 | 500,000 | 0 | 1.21 | 2.01 | +0.80 | hold |
| Simplify Asset Management Inc. | 30,515 | 30,515 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Covestor Ltd | 3 | 3 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 4,896,462 | 4,896,462 | 0 | 21.48 | 24.03 | +2.55 | hold |