| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 4,500,000 | 5,150,000 | +650,000 | 3.11 | 2.93 | -0.18 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,645,474 | 6,870,333 | +224,859 | 0.04 | 0.03 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 270,035 | 173,753 | +96,282 | 0.03 | 0.02 | 0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,328,703 | 1,390,372 | +61,669 | 0.54 | 0.46 | -0.08 | buy |
| Atika Capital Management LLC | 97,000 | 136,500 | +39,500 | 0.47 | 0.58 | +0.11 | buy |
| GILDER GAGNON HOWE & CO LLC | 291,340 | 326,349 | +35,009 | 0.16 | 0.14 | -0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 122,090 | 96,817 | +25,273 | 0.01 | 0.01 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 206,894 | 228,560 | +21,666 | 0.01 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 143,692 | 163,896 | +20,204 | 0.01 | 0.01 | -0.00 | buy |
| Nan Fung Group Holdings Ltd | 10,875 | 30,875 | +20,000 | 0.44 | 1.06 | +0.62 | buy |
| E Fund Management Co., Ltd. | 54,292 | 67,068 | +12,776 | 0.13 | 0.14 | +0.00 | buy |
| Woodline Partners LP | 525,094 | 537,428 | +12,334 | 0.21 | 0.15 | -0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 21,482 | 29,540 | +8,058 | 0.09 | 0.10 | 0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 4,410 | 10,249 | +5,839 | 0.03 | 0.06 | +0.03 | buy |
| PROFUND ADVISORS LLC | 13,311 | 11,497 | +1,814 | 0.02 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,422 | 13,733 | +1,311 | 0.06 | 0.05 | -0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,303 | 40,987 | +684 | 0.08 | 0.07 | 0.00 | buy |
| Truvestments Capital LLC | 297 | 351 | +54 | 0.00 | 0.00 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,995,928 | 5,995,929 | +1 | 2.29 | 2.58 | 0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 5,992 | 5,991 | -1 | 0.55 | 0.55 | -0.01 | sell |
| NVWM, LLC | 7,254 | 7,191 | -63 | 0.09 | 0.07 | -0.01 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 5,794 | 5,069 | -725 | 0.05 | 0.04 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 2,640 | 1,686 | -954 | 0.06 | 0.03 | -0.03 | sell |
| ADAR1 Capital Management, LLC | 11,856 | 10,000 | -1,856 | 0.09 | 0.08 | -0.01 | sell |
| HighVista Strategies LLC | 12,743 | 8,733 | -4,010 | 0.21 | 0.13 | -0.08 | sell |
| Rafferty Asset Management, LLC | 65,451 | 56,878 | -8,573 | 0.01 | 0.01 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,049,386 | 1,034,137 | -15,249 | 1.62 | 1.58 | -0.03 | sell |
| Cinctive Capital Management LP | 56,801 | 36,035 | -20,766 | 0.15 | 0.07 | -0.07 | sell |
| First Light Asset Management, LLC | 406,348 | 383,310 | -23,038 | 1.60 | 1.48 | -0.12 | sell |
| Aquilo Capital Management, LLC | 208,743 | 183,521 | -25,222 | 11.12 | 12.64 | +1.52 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 453,377 | 419,490 | -33,887 | 0.01 | 0.01 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 507,902 | 455,728 | -52,174 | 0.41 | 0.33 | -0.08 | sell |
| JENNISON ASSOCIATES LLC | 797,681 | 716,933 | -80,748 | 0.02 | 0.02 | -0.01 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 392,263 | 150,172 | -242,091 | 0.17 | 0.06 | -0.12 | sell |
| Redmile Group, LLC | 1,393,256 | 1,100,432 | -292,824 | 3.88 | 3.09 | -0.80 | sell |