| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,879,611 | 8,928,574 | +3,048,963 | 0.02 | 0.04 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 6,651,429 | 8,657,242 | +2,005,813 | 2.72 | 3.94 | +1.22 | buy |
| Avoro Capital Advisors LLC | 6,350,000 | 7,474,747 | +1,124,747 | 4.65 | 5.72 | +1.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,097,378 | 6,159,335 | +1,061,957 | 0.03 | 0.05 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 48,769 | 952,065 | +903,296 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 5,421,722 | 6,267,644 | +845,922 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,365,448 | 5,004,095 | +638,647 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 31,662 | 354,575 | +322,913 | 0.00 | 0.01 | +0.01 | buy |
| Capital Research Global Investors | 1,262,182 | 1,560,791 | +298,609 | 0.01 | 0.02 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 240,000 | +240,000 | 0.00 | 0.19 | +0.19 | buy |
| FEDERATED HERMES, INC. | 558,700 | 763,920 | +205,220 | 0.06 | 0.10 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 238,000 | 430,000 | +192,000 | 0.02 | 0.05 | +0.03 | buy |
| STATE STREET CORP | 2,019,454 | 2,209,837 | +190,383 | 0.00 | 0.01 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 0 | 189,900 | +189,900 | 0.00 | 0.22 | +0.22 | buy |
| BRAIDWELL LP | 276,692 | 454,259 | +177,567 | 0.46 | 1.13 | +0.67 | buy |
| Octagon Capital Advisors LP | 360,000 | 535,000 | +175,000 | 3.18 | 5.21 | +2.03 | buy |
| BANK OF AMERICA CORP /DE/ | 186,254 | 338,999 | +152,745 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,276,766 | 1,417,389 | +140,623 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 346,817 | 483,199 | +136,382 | 0.02 | 0.04 | +0.02 | buy |
| Eagle Health Investments LP | 0 | 136,300 | +136,300 | 0.00 | 2.33 | +2.33 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 939,094 | 1,069,238 | +130,144 | 0.38 | 0.57 | +0.18 | buy |
| CITADEL ADVISORS LLC | 41,823 | 159,865 | +118,042 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 518,057 | 635,957 | +117,900 | 0.26 | 0.53 | +0.26 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 105,194 | +105,194 | 0.00 | 0.02 | +0.02 | buy |
| Monashee Investment Management LLC | 0 | 100,000 | +100,000 | 0.00 | 4.38 | +4.38 | buy |
| UBS Group AG | 648,718 | 737,032 | +88,314 | 0.01 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 81,165 | +81,165 | 0.00 | 0.15 | +0.15 | buy |
| ALPS ADVISORS INC | 0 | 64,723 | +64,723 | 0.00 | 0.03 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 412 | 64,775 | +64,363 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 0 | 58,482 | +58,482 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 439,825 | 497,026 | +57,201 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 863,762 | 912,498 | +48,736 | 0.01 | 0.02 | +0.00 | buy |
| Rock Springs Capital Management LP | 450,374 | 496,871 | +46,497 | 1.49 | 1.98 | +0.49 | buy |
| Patient Square Capital LP | 92,592 | 139,000 | +46,408 | 1.40 | 2.32 | +0.91 | buy |
| Bank of New York Mellon Corp | 152,452 | 192,748 | +40,296 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 79,807 | 116,747 | +36,940 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 36,429 | +36,429 | 0.00 | 0.06 | +0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 31,289 | 67,086 | +35,797 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 34,589 | +34,589 | 0.00 | 0.39 | +0.39 | buy |
| WELLS FARGO & COMPANY/MN | 32,061 | 66,489 | +34,428 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 33,538 | +33,538 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 32,235 | +32,235 | 0.00 | 0.42 | +0.42 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.18 | +0.18 | buy |
| NORTHERN TRUST CORP | 437,120 | 467,022 | +29,902 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 711,444 | 740,306 | +28,862 | 0.01 | 0.01 | +0.00 | buy |
| Virtu Financial LLC | 0 | 27,283 | +27,283 | 0.00 | 0.08 | +0.08 | buy |
| Russell Investments Group, Ltd. | 18,991 | 45,977 | +26,986 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 118 | 25,533 | +25,415 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 24,143 | +24,143 | 0.00 | 0.05 | +0.05 | buy |
| Verition Fund Management LLC | 31,471 | 54,319 | +22,848 | 0.01 | 0.02 | +0.01 | buy |
| Man Group plc | 0 | 20,026 | +20,026 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 19,181 | +19,181 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 18,639 | +18,639 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 611,221 | 629,745 | +18,524 | 0.02 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 106,705 | 125,050 | +18,345 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,173 | +18,173 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 16,543 | +16,543 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 15,607 | +15,607 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 15,000 | +15,000 | 0.00 | 0.15 | +0.15 | buy |
| SG Americas Securities, LLC | 8,432 | 22,693 | +14,261 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,918 | 40,777 | +13,859 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 7,000 | 20,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 81,600 | 94,200 | +12,600 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 209,248 | 221,178 | +11,930 | 0.01 | 0.01 | +0.00 | buy |
| CLOUGH CAPITAL PARTNERS L P | 0 | 10,925 | +10,925 | 0.00 | 0.08 | +0.08 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 10,307 | +10,307 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 191,639 | 201,672 | +10,033 | 0.06 | 0.08 | +0.02 | buy |
| Boxer Capital Management, LLC | 319,100 | 329,100 | +10,000 | 5.76 | 5.60 | -0.15 | buy |
| MOODY ALDRICH PARTNERS LLC | 28,910 | 38,535 | +9,625 | 0.31 | 0.56 | +0.25 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 126,490 | 135,894 | +9,404 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 5,027 | 13,769 | +8,742 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,052 | 39,207 | +8,155 | 0.05 | 0.14 | +0.09 | buy |
| Scientech Research LLC | 0 | 7,379 | +7,379 | 0.00 | 0.36 | +0.36 | buy |
| PROFUND ADVISORS LLC | 15,013 | 22,240 | +7,227 | 0.03 | 0.05 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 72,737 | 79,843 | +7,106 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 4,571 | 11,534 | +6,963 | 0.02 | 0.04 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,711 | 21,514 | +6,803 | 0.01 | 0.01 | +0.01 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 6,204 | +6,204 | 0.00 | 0.01 | +0.01 | buy |
| Abel Hall, LLC | 0 | 5,836 | +5,836 | 0.00 | 0.11 | +0.11 | buy |
| LBP AM SA | 0 | 5,667 | +5,667 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 5,500 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 5,113 | +5,113 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,699 | 45,742 | +5,043 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 4,963 | +4,963 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 0 | 3,900 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| Proficio Capital Partners LLC | 7,000 | 10,845 | +3,845 | 0.03 | 0.06 | +0.03 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 3,646 | +3,646 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,906 | 10,507 | +3,601 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 3,464 | +3,464 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 3,350 | +3,350 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 3,282 | +3,282 | 0.00 | 0.05 | +0.05 | buy |
| Private Advisor Group, LLC | 0 | 3,239 | +3,239 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 52,625 | 55,788 | +3,163 | 0.23 | 0.32 | +0.09 | buy |
| Ensign Peak Advisors, Inc | 91,897 | 95,047 | +3,150 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,482 | 12,523 | +3,041 | 0.01 | 0.02 | +0.01 | buy |
| CIBC Asset Management Inc | 0 | 2,939 | +2,939 | 0.00 | 0.00 | +0.00 | buy |
| MOSAIC FINANCIAL GROUP, LLC | 0 | 2,890 | +2,890 | 0.00 | 0.15 | +0.15 | buy |
| Orion Porfolio Solutions, LLC | 0 | 2,868 | +2,868 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 2,819 | +2,819 | 0.00 | 0.00 | +0.00 | buy |
| DRIVE WEALTH MANAGEMENT, LLC | 0 | 2,797 | +2,797 | 0.00 | 0.04 | +0.04 | buy |