| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 6,651,429 | 8,657,242 | +2,005,813 | 2.72 | 3.94 | +1.22 | buy |
| Avoro Capital Advisors LLC | 6,350,000 | 7,474,747 | +1,124,747 | 4.65 | 5.72 | +1.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,097,378 | 6,159,335 | +1,061,957 | 0.03 | 0.05 | +0.02 | buy |
| Capital Research Global Investors | 1,262,182 | 1,560,791 | +298,609 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 238,000 | 430,000 | +192,000 | 0.02 | 0.05 | +0.03 | buy |
| BRAIDWELL LP | 276,692 | 454,259 | +177,567 | 0.46 | 1.13 | +0.67 | buy |
| Octagon Capital Advisors LP | 360,000 | 535,000 | +175,000 | 3.18 | 5.21 | +2.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 939,094 | 1,069,238 | +130,144 | 0.38 | 0.57 | +0.18 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 518,057 | 635,957 | +117,900 | 0.26 | 0.53 | +0.26 | buy |
| Rock Springs Capital Management LP | 450,374 | 496,871 | +46,497 | 1.49 | 1.98 | +0.49 | buy |
| Patient Square Capital LP | 92,592 | 139,000 | +46,408 | 1.40 | 2.32 | +0.91 | buy |
| T. Rowe Price Investment Management, Inc. | 611,221 | 629,745 | +18,524 | 0.02 | 0.03 | +0.01 | buy |
| BAMCO INC /NY/ | 7,000 | 20,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 209,248 | 221,178 | +11,930 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 191,639 | 201,672 | +10,033 | 0.06 | 0.08 | +0.02 | buy |
| Boxer Capital Management, LLC | 319,100 | 329,100 | +10,000 | 5.76 | 5.60 | -0.15 | buy |
| MOODY ALDRICH PARTNERS LLC | 28,910 | 38,535 | +9,625 | 0.31 | 0.56 | +0.25 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 61,640 | 52,671 | +8,969 | 0.00 | 0.00 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,052 | 39,207 | +8,155 | 0.07 | 0.14 | +0.07 | buy |
| PROFUND ADVISORS LLC | 15,013 | 22,240 | +7,227 | 0.03 | 0.05 | 0.00 | buy |
| Proficio Capital Partners LLC | 7,000 | 10,845 | +3,845 | 0.03 | 0.06 | +0.03 | buy |
| Nicholas Investment Partners, LP | 52,625 | 55,788 | +3,163 | 0.23 | 0.32 | +0.09 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,482 | 12,523 | +3,041 | 0.01 | 0.02 | +0.01 | buy |
| Legato Capital Management LLC | 6,783 | 9,534 | +2,751 | 0.04 | 0.06 | +0.02 | buy |
| ProShare Advisors LLC | 11,169 | 13,489 | +2,320 | 0.00 | 0.00 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 22,532 | 24,524 | +1,992 | 0.11 | 0.15 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 29,928 | 30,573 | +645 | 0.13 | 0.18 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 2,406 | 2,966 | +560 | 0.04 | 0.06 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,538 | 1,413 | -125 | 0.00 | 0.00 | +0.00 | sell |
| Keudell/Morrison Wealth Management | 7,660 | 6,600 | -1,060 | 0.07 | 0.11 | +0.03 | sell |
| Informed Momentum Co LLC | 57,585 | 56,455 | -1,130 | 0.37 | 0.49 | +0.12 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 11,877 | 9,098 | -2,779 | 0.10 | 0.16 | +0.06 | sell |
| Perbak Capital Partners LLP | 7,504 | 2,638 | -4,866 | 0.07 | 0.06 | -0.01 | sell |
| Knights of Columbus Asset Advisors LLC | 18,891 | 12,890 | -6,001 | 0.06 | 0.06 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 246,704 | 239,916 | -6,788 | 0.14 | 0.20 | +0.05 | sell |
| HighVista Strategies LLC | 15,728 | 6,835 | -8,893 | 0.22 | 0.14 | -0.08 | sell |
| Rafferty Asset Management, LLC | 68,295 | 58,653 | -9,642 | 0.01 | 0.02 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 572,258 | 561,170 | -11,088 | 0.49 | 0.56 | +0.06 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 644,590 | 626,430 | -18,160 | 0.60 | 0.76 | +0.16 | sell |
| Yiheng Capital Management, L.P. | 122,605 | 73,440 | -49,165 | 1.02 | 1.16 | +0.13 | sell |
| Nextech Invest, Ltd. | 340,909 | 278,896 | -62,013 | 2.94 | 2.10 | -0.84 | sell |
| First Turn Management, LLC | 277,726 | 206,445 | -71,281 | 2.36 | 1.84 | -0.52 | sell |
| Holocene Advisors, LP | 840,333 | 761,209 | -79,124 | 0.11 | 0.12 | +0.02 | sell |
| Deer Management Co. LLC | 325,895 | 230,811 | -95,084 | 1.65 | 1.75 | +0.10 | sell |
| PERCEPTIVE ADVISORS LLC | 169,796 | 69,935 | -99,861 | 0.28 | 0.10 | -0.18 | sell |
| Logos Global Management LP | 250,000 | 130,000 | -120,000 | 1.40 | 0.67 | -0.72 | sell |
| Siren, L.L.C. | 3,428,150 | 3,286,830 | -141,320 | 7.59 | 7.63 | +0.04 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 435,014 | 289,404 | -145,610 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 397,041 | 200,946 | -196,095 | 0.11 | 0.07 | -0.04 | sell |
| Atlas Venture Life Science Advisors, LLC | 4,896,462 | 4,659,874 | -236,588 | 36.82 | 41.91 | +5.09 | sell |
| Alyeska Investment Group, L.P. | 615,091 | 371,889 | -243,202 | 0.11 | 0.08 | -0.02 | sell |
| AJU IB Investment Co., Ltd. | 457,059 | 19,648 | -437,411 | 22.47 | 6.71 | -15.76 | sell |
| JENNISON ASSOCIATES LLC | 1,027,739 | 496,665 | -531,074 | 0.03 | 0.02 | -0.01 | sell |