| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,879,611 | 8,928,574 | +3,048,963 | 0.02 | 0.04 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 6,651,429 | 8,657,242 | +2,005,813 | 2.72 | 3.94 | +1.22 | buy |
| Avoro Capital Advisors LLC | 6,350,000 | 7,474,747 | +1,124,747 | 4.65 | 5.72 | +1.07 | buy |
| VANGUARD GROUP INC | 5,421,722 | 6,267,644 | +845,922 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,097,378 | 6,159,335 | +1,061,957 | 0.03 | 0.05 | +0.02 | buy |
| BVF INC/IL | 5,502,710 | 5,502,710 | 0 | 12.63 | 14.41 | +1.79 | hold |
| BlackRock, Inc. | 4,365,448 | 5,004,095 | +638,647 | 0.00 | 0.01 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 4,896,462 | 4,659,874 | -236,588 | 36.82 | 41.91 | +5.09 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,195,691 | 4,412,933 | -782,758 | 0.05 | 0.06 | +0.01 | sell |
| Siren, L.L.C. | 3,428,150 | 3,286,830 | -141,320 | 7.59 | 7.63 | +0.04 | sell |
| STATE STREET CORP | 2,019,454 | 2,209,837 | +190,383 | 0.00 | 0.01 | +0.00 | buy |
| Capital Research Global Investors | 1,262,182 | 1,560,791 | +298,609 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,276,766 | 1,417,389 | +140,623 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 939,094 | 1,069,238 | +130,144 | 0.38 | 0.57 | +0.18 | buy |
| ALLIANCEBERNSTEIN L.P. | 48,769 | 952,065 | +903,296 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 863,762 | 912,498 | +48,736 | 0.01 | 0.02 | +0.00 | buy |
| Merck & Co., Inc. | 772,165 | 772,165 | 0 | 19.17 | 21.75 | +2.58 | hold |
| FEDERATED HERMES, INC. | 558,700 | 763,920 | +205,220 | 0.06 | 0.10 | +0.04 | buy |
| Holocene Advisors, LP | 840,333 | 761,209 | -79,124 | 0.11 | 0.12 | +0.02 | sell |
| Commodore Capital LP | 750,000 | 750,000 | 0 | 2.07 | 3.88 | +1.81 | hold |
| GOLDMAN SACHS GROUP INC | 711,444 | 740,306 | +28,862 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 648,718 | 737,032 | +88,314 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 518,057 | 635,957 | +117,900 | 0.26 | 0.53 | +0.26 | buy |
| T. Rowe Price Investment Management, Inc. | 611,221 | 629,745 | +18,524 | 0.02 | 0.03 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 644,590 | 626,430 | -18,160 | 0.60 | 0.76 | +0.16 | sell |
| DIMENSIONAL FUND ADVISORS LP | 731,420 | 624,027 | -107,393 | 0.01 | 0.01 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 572,258 | 561,170 | -11,088 | 0.50 | 0.56 | +0.06 | sell |
| Octagon Capital Advisors LP | 360,000 | 535,000 | +175,000 | 3.18 | 5.21 | +2.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 439,825 | 497,026 | +57,201 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 450,374 | 496,871 | +46,497 | 1.49 | 1.98 | +0.49 | buy |
| JENNISON ASSOCIATES LLC | 1,027,739 | 496,665 | -531,074 | 0.03 | 0.02 | -0.01 | sell |
| Pictet Asset Management Holding SA | 346,817 | 483,199 | +136,382 | 0.02 | 0.04 | +0.02 | buy |
| NORTHERN TRUST CORP | 437,120 | 467,022 | +29,902 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 276,692 | 454,259 | +177,567 | 0.46 | 1.13 | +0.67 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 238,000 | 430,000 | +192,000 | 0.02 | 0.05 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 372,400 | 373,800 | +1,400 | 0.04 | 0.06 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 615,091 | 371,889 | -243,202 | 0.11 | 0.08 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 31,662 | 354,575 | +322,913 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 186,254 | 338,999 | +152,745 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 319,100 | 329,100 | +10,000 | 5.76 | 5.60 | -0.15 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 435,014 | 289,404 | -145,610 | 0.01 | 0.01 | -0.00 | sell |
| Nextech Invest, Ltd. | 340,909 | 278,896 | -62,013 | 2.94 | 2.10 | -0.84 | sell |
| MORGAN STANLEY | 377,799 | 274,018 | -103,781 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 429,975 | 265,532 | -164,443 | 0.04 | 0.03 | -0.01 | sell |
| RTW INVESTMENTS, LP | 0 | 240,000 | +240,000 | 0.00 | 0.19 | +0.19 | buy |
| GILDER GAGNON HOWE & CO LLC | 246,704 | 239,916 | -6,788 | 0.14 | 0.20 | +0.05 | sell |
| Deer Management Co. LLC | 325,895 | 230,811 | -95,084 | 1.65 | 1.75 | +0.10 | sell |
| TD ASSET MANAGEMENT INC | 209,248 | 221,178 | +11,930 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 277,726 | 206,445 | -71,281 | 2.36 | 1.84 | -0.52 | sell |
| Woodline Partners LP | 248,000 | 203,585 | -44,415 | 0.07 | 0.06 | -0.00 | sell |
| Candriam S.C.A. | 191,639 | 201,672 | +10,033 | 0.06 | 0.08 | +0.02 | buy |
| Polar Capital Holdings Plc | 397,041 | 200,946 | -196,095 | 0.11 | 0.07 | -0.04 | sell |
| Bank of New York Mellon Corp | 152,452 | 192,748 | +40,296 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 0 | 189,900 | +189,900 | 0.00 | 0.22 | +0.22 | buy |
| Point72 Asset Management, L.P. | 173,900 | 173,147 | -753 | 0.02 | 0.02 | -0.00 | sell |
| CITADEL ADVISORS LLC | 41,823 | 159,865 | +118,042 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 351,246 | 159,426 | -191,820 | 0.04 | 0.03 | -0.02 | sell |
| Foresite Capital Management VI LLC | 146,332 | 146,332 | 0 | 3.20 | 3.44 | +0.24 | hold |
| BARCLAYS PLC | 155,144 | 140,507 | -14,637 | 0.00 | 0.00 | +0.00 | sell |
| Patient Square Capital LP | 92,592 | 139,000 | +46,408 | 1.40 | 2.32 | +0.91 | buy |
| Eagle Health Investments LP | 0 | 136,300 | +136,300 | 0.00 | 2.33 | +2.33 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 126,490 | 135,894 | +9,404 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 192,699 | 131,353 | -61,346 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 250,000 | 130,000 | -120,000 | 1.40 | 0.67 | -0.72 | sell |
| Nuveen, LLC | 106,705 | 125,050 | +18,345 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 79,807 | 116,747 | +36,940 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 107,703 | 105,554 | -2,149 | 0.01 | 0.01 | +0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 105,194 | +105,194 | 0.00 | 0.02 | +0.02 | buy |
| Monashee Investment Management LLC | 0 | 100,000 | +100,000 | 0.00 | 4.38 | +4.38 | buy |
| Ensign Peak Advisors, Inc | 91,897 | 95,047 | +3,150 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 81,600 | 94,200 | +12,600 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 81,165 | +81,165 | 0.00 | 0.15 | +0.15 | buy |
| DEUTSCHE BANK AG\ | 72,737 | 79,843 | +7,106 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.24 | 0.38 | +0.14 | hold |
| Yiheng Capital Management, L.P. | 122,605 | 73,440 | -49,165 | 2.30 | 2.49 | +0.20 | sell |
| RHUMBLINE ADVISERS | 74,173 | 72,304 | -1,869 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 169,796 | 69,935 | -99,861 | 0.28 | 0.10 | -0.18 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 31,289 | 67,086 | +35,797 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 32,061 | 66,489 | +34,428 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 412 | 64,775 | +64,363 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 0 | 64,723 | +64,723 | 0.00 | 0.03 | +0.03 | buy |
| FIRST TRUST ADVISORS LP | 74,852 | 58,862 | -15,990 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 68,295 | 58,653 | -9,642 | 0.01 | 0.02 | +0.00 | sell |
| Neuberger Berman Group LLC | 0 | 58,482 | +58,482 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 57,585 | 56,455 | -1,130 | 0.37 | 0.49 | +0.12 | sell |
| Nicholas Investment Partners, LP | 52,625 | 55,788 | +3,163 | 0.23 | 0.32 | +0.09 | buy |
| Verition Fund Management LLC | 31,471 | 54,319 | +22,848 | 0.01 | 0.02 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 61,640 | 52,671 | -8,969 | 0.00 | 0.00 | +0.00 | sell |
| COMERICA BANK | 51,423 | 49,812 | -1,611 | 0.01 | 0.02 | +0.00 | sell |
| Russell Investments Group, Ltd. | 18,991 | 45,977 | +26,986 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,699 | 45,742 | +5,043 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 43,497 | 43,428 | -69 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,918 | 40,777 | +13,859 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,052 | 39,207 | +8,155 | 0.05 | 0.14 | +0.09 | buy |
| MOODY ALDRICH PARTNERS LLC | 28,910 | 38,535 | +9,625 | 0.31 | 0.56 | +0.25 | buy |
| MARSHALL WACE, LLP | 359,076 | 38,022 | -321,054 | 0.02 | 0.00 | -0.02 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 36,429 | +36,429 | 0.00 | 0.06 | +0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 34,589 | +34,589 | 0.00 | 0.39 | +0.39 | buy |
| State of New Jersey Common Pension Fund D | 0 | 33,538 | +33,538 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 32,235 | +32,235 | 0.00 | 0.42 | +0.42 | buy |