| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 770,455 | 1,511,932 | +741,477 | 0.77 | 1.79 | +1.02 | buy |
| UBS Group AG | 85,928 | 667,164 | +581,236 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 537,738 | +537,738 | 0.00 | 0.03 | +0.03 | buy |
| Granahan Investment Management, LLC | 51,842 | 176,166 | +124,324 | 0.06 | 0.23 | +0.16 | buy |
| SCOGGIN MANAGEMENT LP | 0 | 100,000 | +100,000 | 0.00 | 1.27 | +1.27 | buy |
| MORGAN STANLEY | 92,284 | 188,744 | +96,460 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 212 | 81,139 | +80,927 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 77,275 | +77,275 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 783,921 | 852,244 | +68,323 | 0.06 | 0.06 | -0.00 | buy |
| Rock Springs Capital Management LP | 29,305 | 83,082 | +53,777 | 0.03 | 0.12 | +0.09 | buy |
| LORD, ABBETT & CO. LLC | 0 | 49,622 | +49,622 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 27,935 | +27,935 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 27,829 | +27,829 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 27,569 | +27,569 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 334,026 | 360,392 | +26,366 | 0.00 | 0.00 | -0.00 | buy |
| Lisanti Capital Growth, LLC | 0 | 25,665 | +25,665 | 0.00 | 0.20 | +0.20 | buy |
| VANGUARD GROUP INC | 1,178,447 | 1,199,462 | +21,015 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 18,000 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 48,088 | 66,030 | +17,942 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 16,316 | +16,316 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,155,625 | 1,166,517 | +10,892 | 0.00 | 0.00 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 10,159 | +10,159 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 9,594 | +9,594 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 8,571 | +8,571 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 34,019 | 41,781 | +7,762 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 6,544 | +6,544 | 0.00 | 0.02 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 0 | 5,334 | +5,334 | 0.00 | 0.04 | +0.04 | buy |
| Banque Transatlantique SA | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Delta Investment Management, LLC | 19,241 | 24,001 | +4,760 | 0.11 | 0.12 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 43,989 | 48,616 | +4,627 | 0.06 | 0.06 | +0.00 | buy |
| Vivaldi Capital Management LP | 56,252 | 59,252 | +3,000 | 0.21 | 0.25 | +0.03 | buy |
| Swiss National Bank | 18,900 | 21,300 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 28,216 | 30,488 | +2,272 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 7,586 | 9,306 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 139,288 | 140,954 | +1,666 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 7,446 | 8,871 | +1,425 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 8,485 | 9,561 | +1,076 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 460 | +460 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 135 | 434 | +299 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,504 | 7,669 | +165 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 577 | 704 | +127 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 109 | 227 | +118 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 34 | 84 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 83,139 | 83,172 | +33 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 916 | 948 | +32 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,231 | 1,231 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,200 | 9,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 766,940 | 766,940 | 0 | 1.47 | 1.09 | -0.37 | hold |
| SECTORAL ASSET MANAGEMENT INC | 977,245 | 977,245 | 0 | 18.83 | 19.56 | +0.72 | hold |
| CIBC Private Wealth Group LLC | 1,146 | 1,146 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | 4,178,823 | 0 | 1.61 | 1.79 | +0.19 | hold |
| BBR PARTNERS, LLC | 40,000 | 40,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Alyeska Investment Group, L.P. | 142,113 | 142,113 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Daiwa Securities Group Inc. | 91 | 91 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 863,389 | 863,389 | 0 | 0.38 | 0.34 | -0.04 | hold |
| KELLEHER FINANCIAL ADVISORS | 17,023 | 17,023 | 0 | 0.19 | 0.17 | -0.01 | hold |
| Alpha Wave Global, LP | 3,612,211 | 3,612,211 | 0 | 48.29 | 41.37 | -6.92 | hold |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 27,304 | 27,304 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Russell Investments Group, Ltd. | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 1,600 | 1,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rinkey Investments | 15,186 | 15,186 | 0 | 0.14 | 0.12 | -0.02 | hold |
| 72 Investment Holdings, LLC | 1,017,751 | 1,017,751 | 0 | 59.83 | 73.53 | +13.71 | hold |
| Fortitude Family Office, LLC | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Smartleaf Asset Management LLC | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 28 | 28 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,525 | 2,525 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 8,742 | 8,742 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,493 | 3,493 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 34 | 33 | -1 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 7,672 | 7,659 | -13 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 116 | 75 | -41 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 101 | 38 | -63 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 6,245 | 6,154 | -91 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 402 | 217 | -185 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 9,723 | 9,466 | -257 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 278 | 0 | -278 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 8,342 | 8,051 | -291 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,831 | 5,516 | -315 | 0.02 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,914 | 7,525 | -389 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 29,214 | 28,694 | -520 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,789 | 1,007 | -782 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 18,754 | 17,967 | -787 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,860 | 928 | -932 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 32,506 | 30,405 | -2,101 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,309 | 0 | -2,309 | 0.03 | 0.00 | -0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,196 | 124,046 | -3,150 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 5,458 | 0 | -5,458 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 30,057 | 24,401 | -5,656 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 7,447 | 0 | -7,447 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 17,453 | 9,711 | -7,742 | 0.00 | 0.00 | -0.00 | sell |