| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 206,952 | 956,307 | +749,355 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 88,218 | 360,120 | +271,902 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 547,616 | 747,616 | +200,000 | 1.27 | 1.32 | +0.04 | buy |
| STATE STREET CORP | 65,144 | 243,554 | +178,410 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 199,602 | 321,715 | +122,113 | 0.03 | 0.03 | +0.00 | buy |
| Ikarian Capital, LLC | 85,000 | 204,513 | +119,513 | 0.52 | 1.10 | +0.59 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 83,103 | +83,103 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 66,175 | +66,175 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 40,639 | 81,469 | +40,830 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 34,276 | +34,276 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 22,601 | 54,379 | +31,778 | 0.01 | 0.03 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,683 | 41,470 | +29,787 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 11,181 | 39,737 | +28,556 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 22,611 | +22,611 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 22,554 | +22,554 | 0.00 | 0.00 | +0.00 | buy |
| BBR PARTNERS, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 750 | 18,465 | +17,715 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 17,353 | +17,353 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 16,708 | +16,708 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,068,675 | 1,084,404 | +15,729 | 9.38 | 7.62 | -1.76 | buy |
| Engineers Gate Manager LP | 0 | 14,654 | +14,654 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 23,537 | 37,190 | +13,653 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 46,866 | 60,166 | +13,300 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 13,223 | +13,223 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 12,435 | +12,435 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 4,598 | 16,812 | +12,214 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 10,477 | +10,477 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 5,649 | +5,649 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 5,293 | +5,293 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 331 | 1,231 | +900 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 382 | 1,088 | +706 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 454 | 910 | +456 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 451 | 866 | +415 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,221 | 16,470 | +249 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 8 | +8 | 0.00 | 0.00 | 0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,490 | 3,494 | +4 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 21,920 | 21,920 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 100,438 | 100,438 | 0 | 0.20 | 0.12 | -0.08 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | 4,178,823 | 0 | 1.19 | 0.96 | -0.23 | hold |
| RTW INVESTMENTS, LP | 863,389 | 863,389 | 0 | 0.28 | 0.23 | -0.05 | hold |
| Alpha Wave Global, LP | 3,612,211 | 3,612,211 | 0 | 24.51 | 20.89 | -3.62 | hold |
| EcoR1 Capital, LLC | 1,219,774 | 1,219,774 | 0 | 0.69 | 0.65 | -0.05 | hold |
| Point72 Asset Management, L.P. | 864,942 | 864,942 | 0 | 0.06 | 0.05 | -0.01 | hold |
| BML Capital Management, LLC | 63,916 | 63,916 | 0 | 0.96 | 0.81 | -0.15 | hold |
| Vivaldi Capital Management LP | 58,752 | 58,752 | 0 | 0.27 | 0.29 | +0.02 | hold |
| Samsara BioCapital, LLC | 1,208,473 | 1,208,473 | 0 | 4.17 | 4.37 | +0.20 | hold |
| 72 Investment Holdings, LLC | 1,017,751 | 1,017,751 | 0 | 33.88 | 44.23 | +10.35 | hold |
| Federation des caisses Desjardins du Quebec | 28 | 28 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 135 | 135 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 288 | 12 | -276 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 571 | 0 | -571 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 644 | 0 | -644 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 982 | 0 | -982 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,373 | 97 | -1,276 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 1,973 | 0 | -1,973 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 6,563 | 4,412 | -2,151 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 65,000 | 59,542 | -5,458 | 0.40 | 0.31 | -0.10 | sell |
| Marquette Asset Management, LLC | 5,865 | 0 | -5,865 | 0.02 | 0.00 | -0.02 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 9,350 | 0 | -9,350 | 0.03 | 0.00 | -0.03 | sell |
| Acuitas Investments, LLC | 31,488 | 0 | -31,488 | 0.35 | 0.00 | -0.35 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 37,176 | 0 | -37,176 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 134,740 | 0 | -134,740 | 0.00 | 0.00 | -0.00 | sell |