| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 448,631 | +448,631 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 956,307 | 1,118,817 | +162,510 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 139,357 | +139,357 | 0.00 | 0.42 | +0.42 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 107,300 | +107,300 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,470 | 123,371 | +81,901 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 64,941 | +64,941 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 81,469 | 129,639 | +48,170 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 243,554 | 289,154 | +45,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 31,309 | +31,309 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 28,310 | +28,310 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 27,504 | +27,504 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 24,621 | +24,621 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 23,875 | +23,875 | 0.00 | 0.00 | +0.00 | buy |
| KELLEHER FINANCIAL ADVISORS | 0 | 20,773 | +20,773 | 0.00 | 0.19 | +0.19 | buy |
| BBR PARTNERS, LLC | 20,000 | 40,000 | +20,000 | 0.03 | 0.07 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 13,223 | 33,054 | +19,831 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 747,616 | 766,940 | +19,324 | 1.32 | 1.30 | -0.02 | buy |
| Rinkey Investments | 0 | 15,186 | +15,186 | 0.00 | 0.12 | +0.12 | buy |
| BARCLAYS PLC | 4,412 | 16,463 | +12,051 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 12,027 | +12,027 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,357 | +10,357 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 9,346 | +9,346 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 7,672 | +7,672 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 6,145 | +6,145 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 5,699 | +5,699 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 1,627 | 6,909 | +5,282 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 4,523 | +4,523 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 16,708 | 19,851 | +3,143 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 10,477 | 12,654 | +2,177 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 1,146 | +1,146 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 16,812 | 17,654 | +842 | 0.00 | 0.00 | +0.00 | buy |
| Raleigh Capital Management Inc. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,649 | 5,896 | +247 | 0.00 | 0.00 | +0.00 | buy |
| Planned Solutions, Inc. | 0 | 217 | +217 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 5,293 | 5,353 | +60 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 31 | 82 | +51 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 97 | 134 | +37 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 8 | 26 | +18 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 83,103 | 83,104 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,231 | 1,231 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 910 | 910 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | 4,178,823 | 0 | 0.96 | 1.14 | +0.19 | hold |
| RTW INVESTMENTS, LP | 863,389 | 863,389 | 0 | 0.23 | 0.30 | +0.07 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 54,379 | 54,379 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Alpha Wave Global, LP | 3,612,211 | 3,612,211 | 0 | 20.89 | 26.65 | +5.76 | hold |
| Arax Advisory Partners | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asset Management, L.P. | 864,942 | 864,942 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Vivaldi Capital Management LP | 58,752 | 58,752 | 0 | 0.29 | 0.41 | +0.12 | hold |
| Russell Investments Group, Ltd. | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,208,473 | 1,208,473 | 0 | 4.37 | 5.51 | +1.14 | hold |
| Ikarian Capital, LLC | 204,513 | 204,513 | 0 | 1.10 | 1.51 | +0.40 | hold |
| 72 Investment Holdings, LLC | 1,017,751 | 1,017,751 | 0 | 44.23 | 51.95 | +7.72 | hold |
| Smartleaf Asset Management LLC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 28 | 28 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,088 | 1,088 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 135 | 135 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,494 | 3,493 | -1 | 0.00 | 0.00 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 12 | 0 | -12 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 6,758 | 6,716 | -42 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 866 | 709 | -157 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 37,190 | 34,173 | -3,017 | 0.00 | 0.00 | +0.00 | sell |
| BML Capital Management, LLC | 63,916 | 60,000 | -3,916 | 0.81 | 0.84 | +0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 34,276 | 25,507 | -8,769 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 18,465 | 9,147 | -9,318 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 39,737 | 29,642 | -10,095 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 60,166 | 49,266 | -10,900 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 12,435 | 0 | -12,435 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 16,470 | 2,648 | -13,822 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 14,654 | 0 | -14,654 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 66,175 | 50,478 | -15,697 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,353 | 0 | -17,353 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 21,920 | 0 | -21,920 | 0.01 | 0.00 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 360,120 | 338,024 | -22,096 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 22,554 | 0 | -22,554 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 22,611 | 0 | -22,611 | 0.01 | 0.00 | -0.01 | sell |
| Prosight Management, LP | 59,542 | 0 | -59,542 | 0.31 | 0.00 | -0.31 | sell |
| Board of Trustees of The Leland Stanford Junior University | 100,438 | 0 | -100,438 | 0.12 | 0.00 | -0.12 | sell |
| SECTORAL ASSET MANAGEMENT INC | 1,084,404 | 977,245 | -107,159 | 7.62 | 13.70 | +6.08 | sell |
| Alyeska Investment Group, L.P. | 321,715 | 122,113 | -199,602 | 0.03 | 0.01 | -0.02 | sell |
| EcoR1 Capital, LLC | 1,219,774 | 346,772 | -873,002 | 0.65 | 0.28 | -0.36 | sell |