| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | 4,178,823 | 0 | 2.06 | 2.40 | +0.34 | hold |
| Alpha Wave Global, LP | 3,612,211 | 3,612,211 | 0 | 11.41 | 17.04 | +5.63 | hold |
| Versant Venture Management, LLC | 0 | 2,656,888 | +2,656,888 | 0.00 | 58.25 | +58.25 | buy |
| BlackRock, Inc. | 1,432,461 | 1,473,104 | +40,643 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,290,994 | 1,330,286 | +39,292 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 881,481 | 1,201,616 | +320,135 | 0.01 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 1,717,066 | 1,073,461 | -643,605 | 2.15 | 1.48 | -0.67 | sell |
| 72 Investment Holdings, LLC | 1,017,751 | 1,017,751 | 0 | 77.84 | 69.77 | -8.07 | hold |
| TANG CAPITAL MANAGEMENT LLC | 897,616 | 897,616 | 0 | 1.33 | 1.61 | +0.28 | hold |
| RTW INVESTMENTS, LP | 863,389 | 863,389 | 0 | 0.36 | 0.50 | +0.14 | hold |
| First Light Asset Management, LLC | 0 | 693,044 | +693,044 | 0.00 | 3.04 | +3.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,122,738 | 627,618 | -495,120 | 0.06 | 0.05 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 8,563 | 587,084 | +578,521 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 416,122 | 454,896 | +38,774 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 375,728 | 417,984 | +42,256 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 9,037 | 399,430 | +390,393 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 342,312 | 368,176 | +25,864 | 4.07 | 3.76 | -0.30 | buy |
| Invesco Ltd. | 266,680 | 364,265 | +97,585 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 67,978 | 349,128 | +281,150 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 343,012 | 343,012 | 0 | 2.06 | 2.09 | +0.03 | hold |
| Point72 Asset Management, L.P. | 618,142 | 340,000 | -278,142 | 0.04 | 0.03 | -0.01 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 240,000 | 323,857 | +83,857 | 0.27 | 0.49 | +0.22 | buy |
| MORGAN STANLEY | 585,355 | 296,219 | -289,136 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 178,214 | 285,543 | +107,329 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,933 | 251,131 | +236,198 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 217,113 | 242,113 | +25,000 | 0.02 | 0.03 | +0.01 | buy |
| Rock Springs Capital Management LP | 83,982 | 236,227 | +152,245 | 0.15 | 0.64 | +0.49 | buy |
| Candriam S.C.A. | 171,274 | 228,942 | +57,668 | 0.03 | 0.06 | +0.03 | buy |
| SCOGGIN MANAGEMENT LP | 200,000 | 225,000 | +25,000 | 2.71 | 4.02 | +1.31 | buy |
| PLUSTICK MANAGEMENT LLC | 0 | 200,000 | +200,000 | 0.00 | 3.91 | +3.91 | buy |
| Granahan Investment Management, LLC | 183,252 | 191,397 | +8,145 | 0.22 | 0.37 | +0.15 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 93,280 | 185,642 | +92,362 | 0.01 | 0.03 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 343,322 | 175,363 | -167,959 | 8.37 | 6.84 | -1.53 | sell |
| NORTHERN TRUST CORP | 170,736 | 165,279 | -5,457 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 142,112 | 160,526 | +18,414 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 44,231 | 144,513 | +100,282 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 74,286 | 130,726 | +56,440 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 131,730 | 114,612 | -17,118 | 0.01 | 0.02 | +0.00 | sell |
| Sovran Advisors, LLC | 40,423 | 106,920 | +66,497 | 0.13 | 0.29 | +0.15 | buy |
| Tyro Capital Management LLC | 0 | 100,672 | +100,672 | 0.00 | 1.74 | +1.74 | buy |
| Squarepoint Ops LLC | 9,973 | 89,788 | +79,815 | 0.00 | 0.01 | +0.01 | buy |
| Lisanti Capital Growth, LLC | 36,185 | 87,753 | +51,568 | 0.29 | 1.00 | +0.71 | buy |
| FMR LLC | 81,639 | 87,313 | +5,674 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 84,011 | +84,011 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 83,297 | 83,365 | +68 | 0.00 | 0.01 | +0.00 | buy |
| Knott David M Jr | 82,000 | 82,000 | 0 | 1.09 | 1.60 | +0.51 | hold |
| Informed Momentum Co LLC | 0 | 80,187 | +80,187 | 0.00 | 0.42 | +0.42 | buy |
| Ensign Peak Advisors, Inc | 77,275 | 77,275 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Calamos Advisors LLC | 17,565 | 77,266 | +59,701 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 22,313 | 67,225 | +44,912 | 0.00 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 34,827 | 61,321 | +26,494 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 60,182 | +60,182 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 53,943 | 55,673 | +1,730 | 0.00 | 0.00 | +0.00 | buy |
| Vivaldi Capital Management LP | 59,252 | 51,752 | -7,500 | 0.26 | 0.34 | +0.08 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,185 | 50,551 | +28,366 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 27,126 | 48,283 | +21,157 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 45,810 | 47,826 | +2,016 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 43,954 | 44,822 | +868 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 43,774 | +43,774 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,285 | 42,456 | +29,171 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 41,276 | +41,276 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 40,886 | 40,886 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 0 | 31,400 | +31,400 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 29,309 | +29,309 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 0 | 28,259 | +28,259 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 27,304 | 27,304 | 0 | 0.01 | 0.02 | +0.01 | hold |
| RHUMBLINE ADVISERS | 24,363 | 25,019 | +656 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 24,113 | +24,113 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 21,300 | 21,800 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 21,062 | +21,062 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 20,988 | +20,988 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 18,000 | 18,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 17,897 | +17,897 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 14,068 | 17,141 | +3,073 | 0.00 | 0.00 | +0.00 | buy |
| KELLEHER FINANCIAL ADVISORS | 17,023 | 17,023 | 0 | 0.17 | 0.20 | +0.02 | hold |
| Rinkey Investments | 15,186 | 15,186 | 0 | 0.13 | 0.19 | +0.05 | hold |
| ALLIANCEBERNSTEIN L.P. | 15,106 | 15,106 | 0 | 0.00 | 0.00 | +0.00 | hold |
| READYSTATE ASSET MANAGEMENT LP | 0 | 14,701 | +14,701 | 0.00 | 0.03 | +0.03 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 50,041 | 14,605 | -35,436 | 0.06 | 0.05 | -0.01 | sell |
| AlphaQuest LLC | 10,219 | 14,390 | +4,171 | 0.03 | 0.04 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 11,864 | 13,459 | +1,595 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,400 | 12,079 | +2,679 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 11,842 | +11,842 | 0.00 | 0.05 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 25,155 | 11,697 | -13,458 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 11,619 | +11,619 | 0.00 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 10,361 | 11,222 | +861 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 9,561 | 11,210 | +1,649 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 7,021 | 10,946 | +3,925 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 10,989 | 10,763 | -226 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 9,326 | 10,448 | +1,122 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 10,163 | +10,163 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 10,940 | 9,787 | -1,153 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 9,787 | +9,787 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,656 | +9,656 | 0.00 | 0.00 | +0.00 | buy |
| Delta Investment Management, LLC | 19,874 | 9,017 | -10,857 | 0.11 | 0.08 | -0.04 | sell |
| Voleon Capital Management LP | 0 | 8,591 | +8,591 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 8,500 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,653 | 7,999 | +2,346 | 0.02 | 0.03 | +0.02 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 7,992 | +7,992 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 7,697 | +7,697 | 0.00 | 0.00 | +0.00 | buy |