| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 770,455 | +770,455 | 0.00 | 0.77 | +0.77 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 448,631 | 822,957 | +374,326 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 930,021 | 1,155,625 | +225,604 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 289,154 | 494,316 | +205,162 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 6,145 | 85,928 | +79,783 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 28,310 | 103,000 | +74,690 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,118,817 | 1,178,447 | +59,630 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 51,842 | +51,842 | 0.00 | 0.06 | +0.06 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 43,989 | +43,989 | 0.00 | 0.06 | +0.06 | buy |
| MORGAN STANLEY | 50,478 | 92,284 | +41,806 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,309 | 67,891 | +36,582 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 29,305 | +29,305 | 0.00 | 0.03 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 122,113 | 142,113 | +20,000 | 0.01 | 0.02 | +0.00 | buy |
| Delta Investment Management, LLC | 0 | 19,241 | +19,241 | 0.00 | 0.11 | +0.11 | buy |
| Swiss National Bank | 0 | 18,900 | +18,900 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 19,851 | 38,246 | +18,395 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 17,716 | +17,716 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 33,054 | 49,786 | +16,732 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 16,463 | 30,057 | +13,594 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 129,639 | 139,288 | +9,649 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 23,875 | 32,506 | +8,631 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 9,147 | 17,453 | +8,306 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 910 | 9,200 | +8,290 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,088 | 8,742 | +7,654 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 7,447 | +7,447 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 7,446 | +7,446 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,831 | +5,831 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 5,353 | 9,723 | +4,370 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,371 | 127,196 | +3,825 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 24,621 | 28,216 | +3,595 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 5,699 | 8,342 | +2,643 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 2,309 | +2,309 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 5,896 | 7,504 | +1,608 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 709 | 1,860 | +1,151 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 17,654 | 18,754 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,909 | 7,914 | +1,005 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 4,523 | 5,458 | +935 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 916 | +916 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 40 | 402 | +362 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 278 | +278 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 101 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 91 | +91 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 134 | 212 | +78 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 83,104 | 83,139 | +35 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 82 | 109 | +27 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 22 | 34 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 26 | 34 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,231 | 1,231 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 766,940 | 766,940 | 0 | 1.30 | 1.47 | +0.16 | hold |
| SECTORAL ASSET MANAGEMENT INC | 977,245 | 977,245 | 0 | 13.70 | 18.83 | +5.13 | hold |
| CIBC Private Wealth Group LLC | 1,146 | 1,146 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | 4,178,823 | 0 | 1.14 | 1.61 | +0.46 | hold |
| BBR PARTNERS, LLC | 40,000 | 40,000 | 0 | 0.07 | 0.08 | +0.01 | hold |
| RTW INVESTMENTS, LP | 863,389 | 863,389 | 0 | 0.30 | 0.38 | +0.08 | hold |
| MetLife Investment Management, LLC | 7,672 | 7,672 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alpha Wave Global, LP | 3,612,211 | 3,612,211 | 0 | 26.65 | 48.29 | +21.64 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rinkey Investments | 15,186 | 15,186 | 0 | 0.12 | 0.14 | +0.02 | hold |
| 72 Investment Holdings, LLC | 1,017,751 | 1,017,751 | 0 | 51.95 | 59.83 | +7.88 | hold |
| Smartleaf Asset Management LLC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 28 | 28 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,493 | 3,493 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 135 | 135 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 13 | 4 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 34,173 | 34,019 | -154 | 0.00 | 0.00 | +0.00 | sell |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 27,504 | 27,304 | -200 | 0.01 | 0.01 | +0.00 | sell |
| Planned Solutions, Inc. | 217 | 0 | -217 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 29,642 | 29,214 | -428 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 6,716 | 6,245 | -471 | 0.00 | 0.00 | +0.00 | sell |
| Raleigh Capital Management Inc. | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,648 | 1,789 | -859 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 9,346 | 7,586 | -1,760 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 10,357 | 8,385 | -1,972 | 0.02 | 0.02 | -0.00 | sell |
| Vivaldi Capital Management LP | 58,752 | 56,252 | -2,500 | 0.41 | 0.21 | -0.19 | sell |
| KELLEHER FINANCIAL ADVISORS | 20,773 | 17,023 | -3,750 | 0.19 | 0.19 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 338,024 | 334,026 | -3,998 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 12,027 | 7,938 | -4,089 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 25,507 | 17,079 | -8,428 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 12,654 | 0 | -12,654 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 54,379 | 39,746 | -14,633 | 0.04 | 0.03 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 64,941 | 48,088 | -16,853 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 49,266 | 25,366 | -23,900 | 0.00 | 0.00 | -0.00 | sell |
| BML Capital Management, LLC | 60,000 | 9,271 | -50,729 | 0.84 | 0.17 | -0.67 | sell |
| Ikarian Capital, LLC | 204,513 | 149,502 | -55,011 | 1.51 | 1.23 | -0.28 | sell |
| Point72 Asset Management, L.P. | 864,942 | 783,921 | -81,021 | 0.07 | 0.06 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 107,300 | 0 | -107,300 | 0.02 | 0.00 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 139,357 | 0 | -139,357 | 0.42 | 0.00 | -0.42 | sell |
| Samsara BioCapital, LLC | 1,208,473 | 986,981 | -221,492 | 5.51 | 3.91 | -1.60 | sell |
| EcoR1 Capital, LLC | 346,772 | 0 | -346,772 | 0.28 | 0.00 | -0.28 | sell |