| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | 4,178,823 | 0 | 2.40 | 0.68 | -1.71 | hold |
| FMR LLC | 87,313 | 3,702,718 | +3,615,405 | 0.00 | 0.00 | +0.00 | buy |
| Alpha Wave Global, LP | 3,612,211 | 3,612,211 | 0 | 17.04 | 7.08 | -9.96 | hold |
| Versant Venture Management, LLC | 2,656,888 | 2,656,888 | 0 | 58.25 | 28.14 | -30.11 | hold |
| BlackRock, Inc. | 1,473,104 | 1,692,006 | +218,902 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 1,201,616 | 1,571,738 | +370,122 | 0.01 | 0.00 | -0.01 | buy |
| VANGUARD GROUP INC | 1,330,286 | 1,321,202 | -9,084 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 587,084 | 1,096,334 | +509,250 | 0.01 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 251,131 | 1,023,542 | +772,411 | 0.00 | 0.00 | +0.00 | buy |
| 72 Investment Holdings, LLC | 1,017,751 | 1,017,751 | 0 | 69.77 | 32.20 | -37.57 | hold |
| TANG CAPITAL MANAGEMENT LLC | 897,616 | 865,169 | -32,447 | 1.61 | 0.68 | -0.93 | sell |
| Intrinsic Edge Capital Management LLC | 0 | 569,705 | +569,705 | 0.00 | 1.77 | +1.77 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 539,348 | +539,348 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 417,984 | 510,749 | +92,765 | 0.00 | 0.00 | -0.00 | buy |
| C WorldWide Group Holding A/S | 0 | 500,000 | +500,000 | 0.00 | 0.14 | +0.14 | buy |
| Squarepoint Ops LLC | 89,788 | 491,898 | +402,110 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 130,726 | 489,432 | +358,706 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 242,113 | 463,495 | +221,382 | 0.03 | 0.02 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 454,896 | 461,075 | +6,179 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 191,397 | 431,100 | +239,703 | 0.37 | 0.30 | -0.07 | buy |
| Candriam S.C.A. | 228,942 | 374,932 | +145,990 | 0.06 | 0.03 | -0.03 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 0 | 372,200 | +372,200 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 60,182 | 293,446 | +233,264 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 275,000 | +275,000 | 0.00 | 0.16 | +0.16 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 270,919 | +270,919 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 41,276 | 257,942 | +216,666 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 236,227 | 257,460 | +21,233 | 0.64 | 0.21 | -0.43 | buy |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 0 | 241,300 | +241,300 | 0.00 | 0.21 | +0.21 | buy |
| MORGAN STANLEY | 296,219 | 233,382 | -62,837 | 0.00 | 0.00 | -0.00 | sell |
| PLUSTICK MANAGEMENT LLC | 200,000 | 200,000 | 0 | 3.91 | 1.42 | -2.49 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 185,642 | 185,642 | 0 | 0.03 | 0.01 | -0.02 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 174,692 | +174,692 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 173,183 | +173,183 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 29,309 | 171,283 | +141,974 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 170,224 | +170,224 | 0.00 | 0.20 | +0.20 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160,526 | 169,122 | +8,596 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 165,279 | 161,911 | -3,368 | 0.00 | 0.00 | -0.00 | sell |
| Sovran Advisors, LLC | 106,920 | 160,134 | +53,214 | 0.29 | 0.25 | -0.04 | buy |
| AWM Investment Company, Inc. | 0 | 150,000 | +150,000 | 0.00 | 0.23 | +0.23 | buy |
| Blue Owl Capital Holdings LP | 0 | 150,000 | +150,000 | 0.00 | 0.74 | +0.74 | buy |
| AMERIPRISE FINANCIAL INC | 55,673 | 136,896 | +81,223 | 0.00 | 0.00 | -0.00 | buy |
| SCOGGIN MANAGEMENT LP | 225,000 | 125,000 | -100,000 | 4.02 | 0.74 | -3.27 | sell |
| BANK OF AMERICA CORP /DE/ | 349,128 | 114,688 | -234,440 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 40,886 | 113,094 | +72,208 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 43,774 | 96,780 | +53,006 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 85,782 | +85,782 | 0.00 | 0.04 | +0.04 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 83,365 | 83,243 | -122 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 399,430 | 80,574 | -318,856 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 7,697 | 77,426 | +69,729 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 77,275 | 77,275 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 0 | 76,025 | +76,025 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 47,826 | 72,432 | +24,606 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,551 | 67,722 | +17,171 | 0.00 | 0.00 | -0.00 | buy |
| Vivaldi Capital Management LP | 51,752 | 64,052 | +12,300 | 0.34 | 0.14 | -0.20 | buy |
| FEDERATED HERMES, INC. | 0 | 62,636 | +62,636 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 59,085 | +59,085 | 0.00 | 0.81 | +0.81 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 61,321 | 54,402 | -6,919 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 82,000 | 53,732 | -28,268 | 1.60 | 0.40 | -1.20 | sell |
| PERCEPTIVE ADVISORS LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 18,000 | 48,071 | +30,071 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 9,787 | 46,847 | +37,060 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 46,268 | +46,268 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 44,290 | +44,290 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 44,822 | 44,055 | -767 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 48,283 | 43,172 | -5,111 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 42,729 | +42,729 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 42,500 | +42,500 | 0.00 | 0.55 | +0.55 | buy |
| Jump Financial, LLC | 0 | 40,851 | +40,851 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 40,615 | +40,615 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 285,543 | 39,905 | -245,638 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 3,847 | 37,674 | +33,827 | 0.05 | 0.16 | +0.11 | buy |
| MARSHALL WACE, LLP | 0 | 35,252 | +35,252 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,113 | 32,235 | +8,122 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 31,058 | +31,058 | 0.00 | 0.01 | +0.01 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 27,304 | 27,304 | 0 | 0.02 | 0.01 | -0.01 | hold |
| TD ASSET MANAGEMENT INC | 31,400 | 26,978 | -4,422 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 14,605 | 23,921 | +9,316 | 0.05 | 0.03 | -0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 23,147 | +23,147 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 22,971 | +22,971 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,448 | 22,916 | +12,468 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 21,800 | 21,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,988 | 20,816 | -172 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 25,019 | 20,250 | -4,769 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 5,098 | 19,839 | +14,741 | 0.09 | 0.07 | -0.02 | buy |
| AlphaQuest LLC | 14,390 | 19,613 | +5,223 | 0.04 | 0.02 | -0.03 | buy |
| DnB Asset Management AS | 0 | 19,163 | +19,163 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 0 | 19,159 | +19,159 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,697 | 18,851 | +7,154 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 0 | 17,481 | +17,481 | 0.00 | 0.00 | +0.00 | buy |
| KELLEHER FINANCIAL ADVISORS | 17,023 | 17,023 | 0 | 0.20 | 0.06 | -0.14 | hold |
| Quantbot Technologies LP | 0 | 16,879 | +16,879 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 11,842 | 16,455 | +4,613 | 0.05 | 0.02 | -0.02 | buy |
| Marex Group plc | 0 | 16,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 15,739 | +15,739 | 0.00 | 0.04 | +0.04 | buy |
| Russell Investments Group, Ltd. | 144,513 | 15,461 | -129,052 | 0.01 | 0.00 | -0.01 | sell |
| Brevan Howard Capital Management LP | 0 | 15,408 | +15,408 | 0.00 | 0.00 | +0.00 | buy |
| Rinkey Investments | 15,186 | 15,186 | 0 | 0.19 | 0.06 | -0.13 | hold |
| CITIGROUP INC | 7,281 | 14,952 | +7,671 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 11,210 | 14,203 | +2,993 | 0.00 | 0.00 | -0.00 | buy |