| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BIT Capital GmbH | 3,491,234 | 6,348,797 | +2,857,563 | 0.93 | 2.66 | +1.73 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,002,200 | 5,000,000 | +997,800 | 1.12 | 3.21 | +2.09 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 68,485 | 384,351 | +315,866 | 0.02 | 0.35 | +0.33 | buy |
| AdvisorShares Investments LLC | 246,739 | 421,347 | +174,608 | 0.25 | 0.72 | +0.47 | buy |
| ARK Investment Management LLC | 3,301,050 | 3,451,965 | +150,915 | 0.14 | 0.32 | +0.18 | buy |
| RTW INVESTMENTS, LP | 10,632,390 | 10,700,974 | +68,584 | 0.59 | 1.29 | +0.71 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 147,590 | 175,373 | +27,783 | 0.06 | 0.16 | +0.10 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 13,058 | 30,208 | +17,150 | 0.01 | 0.07 | +0.06 | buy |
| HighVista Strategies LLC | 364,360 | 371,120 | +6,760 | 0.56 | 1.20 | +0.64 | buy |
| China Universal Asset Management Co., Ltd. | 16,735 | 21,183 | +4,448 | 0.01 | 0.02 | +0.01 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 42,599 | 44,599 | +2,000 | 0.01 | 0.02 | +0.01 | buy |
| TSFG, LLC | 100 | 350 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Conservest Capital Advisors, Inc. | 25,363 | 25,005 | -358 | 0.01 | 0.03 | +0.02 | sell |
| Colonial Trust Advisors | 2,000 | 1,000 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| Intellectus Partners, LLC | 61,000 | 59,500 | -1,500 | 0.07 | 0.15 | +0.08 | sell |
| Eversept Partners, LP | 677,924 | 672,825 | -5,099 | 0.20 | 0.49 | +0.30 | sell |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 179,716 | 150,000 | -29,716 | 0.05 | 0.09 | +0.04 | sell |
| Simplify Asset Management Inc. | 159,052 | 114,281 | -44,771 | 0.01 | 0.02 | +0.01 | sell |
| Nikko Asset Management Americas, Inc. | 368,828 | 319,472 | -49,356 | 0.03 | 0.06 | +0.03 | sell |
| STABLEFORD CAPITAL II LLC | 161,139 | 91,873 | -69,266 | 0.33 | 0.45 | +0.12 | sell |
| Hennion & Walsh Asset Management, Inc. | 487,674 | 417,833 | -69,841 | 0.09 | 0.17 | +0.08 | sell |
| Birchview Capital, LP | 375,000 | 30,000 | -345,000 | 1.18 | 0.20 | -0.98 | sell |
| DAFNA Capital Management LLC | 2,418,882 | 2,011,952 | -406,930 | 3.04 | 5.43 | +2.39 | sell |
| PFM Health Sciences, LP | 1,367,099 | 247,589 | -1,119,510 | 0.69 | 0.30 | -0.39 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 1,492,415 | 205,932 | -1,286,483 | 2.30 | 0.67 | -1.63 | sell |