| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 3,858,000 | 3,858,000 | 0 | 3.74 | 2.54 | -1.21 | hold |
| CITADEL ADVISORS LLC | 1,565,000 | 3,856,324 | +2,291,324 | 0.01 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 104,889 | 3,225,545 | +3,120,656 | 0.00 | 0.02 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 2,265,988 | 2,390,988 | +125,000 | 0.93 | 0.70 | -0.23 | buy |
| ARK Investment Management LLC | 2,618,871 | 2,161,234 | -457,637 | 0.14 | 0.12 | -0.01 | sell |
| Vivo Capital, LLC | 1,608,000 | 1,608,000 | 0 | 1.15 | 1.05 | -0.10 | hold |
| PFM Health Sciences, LP | 338,761 | 1,089,592 | +750,831 | 0.18 | 0.45 | +0.27 | buy |
| Affinity Asset Advisors, LLC | 550,000 | 1,027,868 | +477,868 | 0.96 | 1.39 | +0.43 | buy |
| Aisling Capital Management LP | 964,500 | 964,500 | 0 | 2.52 | 2.72 | +0.20 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,286,000 | 791,359 | -494,641 | 0.18 | 0.08 | -0.09 | sell |
| Rosalind Advisors, Inc. | 798,500 | 734,000 | -64,500 | 5.85 | 5.71 | -0.14 | sell |
| Soleus Capital Management, L.P. | 964,550 | 565,550 | -399,000 | 0.94 | 0.41 | -0.52 | sell |
| Laurion Capital Management LP | 510,907 | 510,907 | 0 | 0.16 | 0.12 | -0.04 | hold |
| BARCLAYS PLC | 501,310 | 410,476 | -90,834 | 0.00 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 364,962 | 327,204 | -37,758 | 0.00 | 0.00 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 364,962 | 327,204 | -37,758 | 0.03 | 0.03 | -0.00 | sell |
| Founders Fund VII Management, LLC | 278,880 | 278,880 | 0 | 10.17 | 11.95 | +1.78 | hold |
| FRANKLIN RESOURCES INC | 0 | 268,114 | +268,114 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 91,000 | 260,100 | +169,100 | 0.00 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 500,000 | 257,980 | -242,020 | 0.49 | 0.19 | -0.30 | sell |
| DAFNA Capital Management LLC | 193,000 | 243,210 | +50,210 | 0.40 | 0.46 | +0.06 | buy |
| Oasis Management Co Ltd. | 207,911 | 207,911 | 0 | 0.61 | 0.59 | -0.03 | hold |
| WELLS FARGO & COMPANY/MN | 190,232 | 191,776 | +1,544 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 74,331 | 162,123 | +87,792 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 156,700 | +156,700 | 0.00 | 0.03 | +0.03 | buy |
| Saba Capital Management, L.P. | 201,033 | 151,033 | -50,000 | 0.04 | 0.03 | -0.02 | sell |
| GILDER GAGNON HOWE & CO LLC | 30,259 | 75,795 | +45,536 | 0.00 | 0.01 | +0.00 | buy |
| Brown University | 72,700 | 72,700 | 0 | 0.23 | 0.24 | +0.01 | hold |
| AdvisorShares Investments LLC | 75,821 | 53,639 | -22,182 | 0.16 | 0.08 | -0.08 | sell |
| SVB WEALTH LLC | 0 | 53,214 | +53,214 | 0.00 | 0.01 | +0.01 | buy |
| Shay Capital LLC | 0 | 46,000 | +46,000 | 0.00 | 0.11 | +0.11 | buy |
| ALPS ADVISORS INC | 43,007 | 45,297 | +2,290 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 29,651 | 45,207 | +15,556 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,961 | 44,794 | -18,167 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 38,900 | 37,200 | -1,700 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 55,417 | 36,849 | -18,568 | 0.01 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 0 | 35,608 | +35,608 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 40,774 | 28,218 | -12,556 | 0.00 | 0.00 | -0.00 | sell |
| Empire Financial Management Company, LLC | 31,000 | 27,500 | -3,500 | 0.11 | 0.08 | -0.03 | sell |
| Virtu Financial LLC | 0 | 24,189 | +24,189 | 0.00 | 0.02 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 22,684 | +22,684 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 21,900 | +21,900 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 14,160 | 20,340 | +6,180 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 13,287 | 19,082 | +5,795 | 0.00 | 0.00 | -0.00 | buy |
| Vident Advisory, LLC | 0 | 16,967 | +16,967 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 16,740 | +16,740 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 16,300 | +16,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 15,328 | 16,199 | +871 | 0.00 | 0.00 | -0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 0 | 15,914 | +15,914 | 0.00 | 0.00 | +0.00 | buy |
| OLD NATIONAL BANCORP /IN/ | 14,600 | 14,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 29,988 | 14,403 | -15,585 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 16,121 | 14,105 | -2,016 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 12,482 | 13,988 | +1,506 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 87 | 12,928 | +12,841 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 12,634 | +12,634 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 12,167 | 12,500 | +333 | 0.00 | 0.00 | -0.00 | buy |
| MCDONALD PARTNERS LLC | 11,390 | 11,290 | -100 | 0.03 | 0.03 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 11,992 | 11,221 | -771 | 0.07 | 0.05 | -0.02 | sell |
| Conservest Capital Advisors, Inc. | 10,363 | 10,363 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HighTower Advisors, LLC | 11,564 | 10,351 | -1,213 | 0.00 | 0.00 | -0.00 | sell |
| Intellectus Partners, LLC | 0 | 10,100 | +10,100 | 0.00 | 0.02 | +0.02 | buy |
| Close Asset Management Ltd | 6,400 | 6,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 11,122 | 4,334 | -6,788 | 0.00 | 0.00 | -0.00 | sell |
| Crewe Advisors LLC | 1,945 | 1,945 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Colonial Trust Advisors | 1,510 | 1,510 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 1,370 | 1,470 | +100 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 1,350 | 1,350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ancora Advisors LLC | 1,330 | 1,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 0 | 970 | +970 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 229 | 865 | +636 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 855 | 855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 660 | 718 | +58 | 0.00 | 0.00 | -0.00 | buy |
| NewEdge Advisors, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Anchor Investment Management, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADIRONDACK TRUST CO | 505 | 505 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 501 | 501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Westside Investment Management, Inc. | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 487 | 487 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pacifica Partners Inc. | 420 | 420 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Westside Investment Management, Inc. | 500 | 400 | -100 | 0.00 | 0.00 | -0.00 | sell |
| New England Capital Financial Advisors LLC | 300 | 308 | +8 | 0.00 | 0.00 | -0.00 | buy |
| GHP Investment Advisors, Inc. | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NVWM, LLC | 202 | 202 | 0 | 0.00 | 0.00 | -0.00 | hold |
| North Star Investment Management Corp. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 215 | 175 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 135 | 135 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 134 | 134 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CENTRAL TRUST Co | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ARROW FINANCIAL CORP | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ELEVATION WEALTH PARTNERS, LLC | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Glen Eagle Advisors, LLC | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AdvisorNet Financial, Inc | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Missouri Trust & Investment Co | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| JAMISON PRIVATE WEALTH MANAGEMENT, INC. | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |