| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 7,334,323 | 12,161,496 | +4,827,173 | 1.15 | 1.39 | +0.23 | buy |
| MARSHALL WACE, LLP | 0 | 4,038,335 | +4,038,335 | 0.00 | 0.02 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 4,002,200 | +4,002,200 | 0.00 | 1.12 | +1.12 | buy |
| BIT Capital GmbH | 288,814 | 3,491,234 | +3,202,420 | 0.09 | 1.08 | +0.99 | buy |
| BAKER BROS. ADVISORS LP | 0 | 2,344,720 | +2,344,720 | 0.00 | 0.07 | +0.07 | buy |
| RTW INVESTMENTS, LP | 8,757,390 | 10,632,390 | +1,875,000 | 0.61 | 0.59 | -0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,387,658 | 3,138,522 | +1,750,864 | 0.01 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 1,610,130 | +1,610,130 | 0.00 | 0.42 | +0.42 | buy |
| DAFNA Capital Management LLC | 811,046 | 2,418,882 | +1,607,836 | 1.30 | 3.04 | +1.74 | buy |
| Sio Capital Management, LLC | 0 | 1,506,525 | +1,506,525 | 0.00 | 1.20 | +1.20 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 1,492,415 | +1,492,415 | 0.00 | 2.31 | +2.31 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,150,646 | +1,150,646 | 0.00 | 0.14 | +0.14 | buy |
| ARK Investment Management LLC | 2,156,012 | 3,301,050 | +1,145,038 | 0.10 | 0.14 | +0.04 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,045,000 | +1,045,000 | 0.00 | 5.74 | +5.74 | buy |
| Alyeska Investment Group, L.P. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 948,554 | +948,554 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,644,242 | 2,583,499 | +939,257 | 0.02 | 0.01 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,825 | 1,122,588 | +932,763 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 1,108,483 | +908,483 | 0.10 | 0.36 | +0.26 | buy |
| Blue Owl Capital Holdings LP | 0 | 904,504 | +904,504 | 0.00 | 1.34 | +1.34 | buy |
| Blue Owl Capital Holdings LP | 0 | 900,000 | +900,000 | 0.00 | 0.04 | +0.04 | buy |
| Eversept Partners, LP | 0 | 677,924 | +677,924 | 0.00 | 0.25 | +0.25 | buy |
| PFM Health Sciences, LP | 779,618 | 1,367,099 | +587,481 | 0.54 | 0.80 | +0.25 | buy |
| Eagle Health Investments LP | 1,519,388 | 2,060,427 | +541,039 | 2.30 | 2.39 | +0.09 | buy |
| Parkman Healthcare Partners LLC | 99,472 | 554,411 | +454,939 | 0.07 | 0.32 | +0.25 | buy |
| ROYCE & ASSOCIATES LP | 0 | 382,086 | +382,086 | 0.00 | 0.02 | +0.02 | buy |
| Birchview Capital, LP | 0 | 375,000 | +375,000 | 0.00 | 1.18 | +1.18 | buy |
| Walleye Capital LLC | 14,976 | 362,152 | +347,176 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 309,283 | +309,283 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 300,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.20 | +0.20 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.11 | +0.11 | buy |
| Jump Financial, LLC | 167,025 | 455,000 | +287,975 | 0.01 | 0.04 | +0.02 | buy |
| Ikarian Capital, LLC | 400,000 | 675,000 | +275,000 | 0.36 | 0.53 | +0.18 | buy |
| Burkehill Global Management, LP | 0 | 250,000 | +250,000 | 0.00 | 0.07 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 126,980 | 371,697 | +244,717 | 0.00 | 0.00 | +0.00 | buy |
| GMT CAPITAL CORP | 2,844,618 | 3,078,536 | +233,918 | 1.02 | 0.78 | -0.25 | buy |
| Aisling Capital Management LP | 1,198,418 | 1,432,336 | +233,918 | 1.73 | 1.66 | -0.06 | buy |
| Vivo Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.09 | +0.09 | buy |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 0 | 179,716 | +179,716 | 0.00 | 0.05 | +0.05 | buy |
| Woodline Partners LP | 0 | 175,439 | +175,439 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 23,529 | 189,753 | +166,224 | 0.00 | 0.03 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 105,230 | 267,465 | +162,235 | 0.02 | 0.05 | +0.03 | buy |
| Engineers Gate Manager LP | 79,800 | 217,992 | +138,192 | 0.01 | 0.02 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 247,337 | 368,828 | +121,491 | 0.00 | 0.00 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 247,337 | 368,828 | +121,491 | 0.02 | 0.03 | +0.01 | buy |
| BlackRock, Inc. | 594,269 | 683,241 | +88,972 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 83,000 | +83,000 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 111,088 | 191,305 | +80,217 | 0.02 | 0.02 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 33,533 | 102,828 | +69,295 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 68,485 | +68,485 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 1,137,520 | 1,205,887 | +68,367 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 181,168 | 244,526 | +63,358 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 424,800 | 487,674 | +62,874 | 0.10 | 0.09 | -0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 85,136 | 147,590 | +62,454 | 0.04 | 0.06 | +0.02 | buy |
| Atom Investors LP | 0 | 48,060 | +48,060 | 0.00 | 0.02 | +0.02 | buy |
| Fore Capital, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.58 | +0.58 | buy |
| Aquatic Capital Management LLC | 19,811 | 63,533 | +43,722 | 0.00 | 0.01 | +0.01 | buy |
| DCF Advisers, LLC | 0 | 42,500 | +42,500 | 0.00 | 0.09 | +0.09 | buy |
| Ensign Peak Advisors, Inc | 0 | 39,225 | +39,225 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 31,885 | +31,885 | 0.00 | 0.07 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 30,206 | +30,206 | 0.00 | 0.01 | +0.01 | buy |
| Shay Capital LLC | 0 | 27,600 | +27,600 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 5,653 | 29,652 | +23,999 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 58,000 | 80,000 | +22,000 | 2.07 | 2.64 | +0.57 | buy |
| HRT FINANCIAL LP | 24,408 | 45,886 | +21,478 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.05 | +0.05 | buy |
| Entropy Technologies, LP | 0 | 19,970 | +19,970 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 17,891 | +17,891 | 0.00 | 0.00 | +0.00 | buy |
| Gladstone Institutional Advisory LLC | 0 | 16,944 | +16,944 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 16,612 | +16,612 | 0.00 | 0.03 | +0.03 | buy |
| AXQ CAPITAL, LP | 0 | 15,916 | +15,916 | 0.00 | 0.01 | +0.01 | buy |
| AdvisorShares Investments LLC | 230,910 | 246,739 | +15,829 | 0.27 | 0.25 | -0.02 | buy |
| Tower Research Capital LLC (TRC) | 0 | 15,073 | +15,073 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 14,900 | +14,900 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 218,406 | 231,385 | +12,979 | 0.00 | 0.00 | -0.00 | buy |
| B. Riley Wealth Advisors, Inc. | 0 | 11,900 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 11,153 | +11,153 | 0.00 | 0.02 | +0.02 | buy |
| Vontobel Holding Ltd. | 0 | 10,100 | +10,100 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 21,600 | 29,000 | +7,400 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 85 | 7,268 | +7,183 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 7,124 | +7,124 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 517 | 7,517 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 336,728 | 341,821 | +5,093 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 852 | 3,863 | +3,011 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 14,531 | 17,429 | +2,898 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 5,483 | 8,060 | +2,577 | 0.02 | 0.02 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,192 | +2,192 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 2,834 | 4,754 | +1,920 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 78,794 | 80,442 | +1,648 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,353 | 16,735 | +1,382 | 0.01 | 0.01 | -0.00 | buy |
| GAMMA Investing LLC | 8,005 | 9,027 | +1,022 | 0.00 | 0.00 | -0.00 | buy |
| Arkos Global Advisors | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 39,471 | 40,457 | +986 | 0.07 | 0.06 | -0.01 | buy |
| Corient Private Wealth LLC | 38,438 | 39,173 | +735 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 1,100 | 1,820 | +720 | 0.00 | 0.00 | +0.00 | buy |
| Ancora Advisors LLC | 2,370 | 3,070 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 595 | 1,276 | +681 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 6,610 | 7,219 | +609 | 0.00 | 0.00 | -0.00 | buy |