| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 7,334,323 | 12,161,496 | +4,827,173 | 1.15 | 1.39 | +0.23 | buy |
| RTW INVESTMENTS, LP | 8,757,390 | 10,632,390 | +1,875,000 | 0.61 | 0.59 | -0.02 | buy |
| MARSHALL WACE, LLP | 0 | 4,038,335 | +4,038,335 | 0.00 | 0.02 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 4,002,200 | +4,002,200 | 0.00 | 1.12 | +1.12 | buy |
| BIT Capital GmbH | 288,814 | 3,491,234 | +3,202,420 | 0.09 | 1.08 | +0.99 | buy |
| ARK Investment Management LLC | 2,156,012 | 3,301,050 | +1,145,038 | 0.10 | 0.14 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,387,658 | 3,138,522 | +1,750,864 | 0.01 | 0.01 | +0.01 | buy |
| GMT CAPITAL CORP | 2,844,618 | 3,078,536 | +233,918 | 1.02 | 0.78 | -0.25 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,644,242 | 2,583,499 | +939,257 | 0.02 | 0.01 | -0.01 | buy |
| DAFNA Capital Management LLC | 811,046 | 2,418,882 | +1,607,836 | 1.30 | 3.04 | +1.74 | buy |
| BAKER BROS. ADVISORS LP | 0 | 2,344,720 | +2,344,720 | 0.00 | 0.07 | +0.07 | buy |
| Eagle Health Investments LP | 1,519,388 | 2,060,427 | +541,039 | 2.30 | 2.39 | +0.09 | buy |
| UBS Group AG | 2,038,444 | 1,855,070 | -183,374 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 1,610,130 | +1,610,130 | 0.00 | 0.42 | +0.42 | buy |
| Sio Capital Management, LLC | 0 | 1,506,525 | +1,506,525 | 0.00 | 1.20 | +1.20 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 1,492,415 | +1,492,415 | 0.00 | 2.31 | +2.31 | buy |
| Jefferies Financial Group Inc. | 1,576,905 | 1,467,362 | -109,543 | 0.09 | 0.10 | +0.01 | sell |
| Aisling Capital Management LP | 1,198,418 | 1,432,336 | +233,918 | 1.73 | 1.66 | -0.06 | buy |
| PFM Health Sciences, LP | 779,618 | 1,367,099 | +587,481 | 0.54 | 0.80 | +0.25 | buy |
| MORGAN STANLEY | 1,137,520 | 1,205,887 | +68,367 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,150,646 | +1,150,646 | 0.00 | 0.14 | +0.14 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,825 | 1,122,588 | +932,763 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 1,108,483 | +908,483 | 0.10 | 0.36 | +0.26 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,045,000 | +1,045,000 | 0.00 | 5.74 | +5.74 | buy |
| Alyeska Investment Group, L.P. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 948,554 | +948,554 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 904,504 | +904,504 | 0.00 | 1.34 | +1.34 | buy |
| Blue Owl Capital Holdings LP | 0 | 900,000 | +900,000 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 967,846 | 865,354 | -102,492 | 0.01 | 0.01 | -0.00 | sell |
| Propel Bio Management, LLC | 861,778 | 742,049 | -119,729 | 5.08 | 2.60 | -2.48 | sell |
| BlackRock, Inc. | 594,269 | 683,241 | +88,972 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 0 | 677,924 | +677,924 | 0.00 | 0.25 | +0.25 | buy |
| Ikarian Capital, LLC | 400,000 | 675,000 | +275,000 | 0.36 | 0.53 | +0.18 | buy |
| AMERIPRISE FINANCIAL INC | 645,065 | 570,496 | -74,569 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 99,472 | 554,411 | +454,939 | 0.07 | 0.32 | +0.25 | buy |
| Hennion & Walsh Asset Management, Inc. | 424,800 | 487,674 | +62,874 | 0.10 | 0.09 | -0.01 | buy |
| Jump Financial, LLC | 167,025 | 455,000 | +287,975 | 0.01 | 0.04 | +0.02 | buy |
| CenterBook Partners LP | 578,828 | 409,237 | -169,591 | 0.20 | 0.12 | -0.07 | sell |
| ROYCE & ASSOCIATES LP | 0 | 382,086 | +382,086 | 0.00 | 0.02 | +0.02 | buy |
| Birchview Capital, LP | 0 | 375,000 | +375,000 | 0.00 | 1.18 | +1.18 | buy |
| GOLDMAN SACHS GROUP INC | 126,980 | 371,697 | +244,717 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 247,337 | 368,828 | +121,491 | 0.00 | 0.00 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 247,337 | 368,828 | +121,491 | 0.02 | 0.03 | +0.01 | buy |
| HighVista Strategies LLC | 498,933 | 364,360 | -134,573 | 0.89 | 0.56 | -0.33 | sell |
| Walleye Capital LLC | 14,976 | 362,152 | +347,176 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 336,728 | 341,821 | +5,093 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 309,283 | +309,283 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 570,462 | 300,000 | -270,462 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 300,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.20 | +0.20 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.11 | +0.11 | buy |
| TORONTO DOMINION BANK | 2,529,013 | 277,755 | -2,251,258 | 0.03 | 0.00 | -0.03 | sell |
| Susquehanna Portfolio Strategies, LLC | 275,773 | 275,773 | 0 | 0.03 | 0.02 | -0.01 | hold |
| CITADEL ADVISORS LLC | 311,488 | 269,489 | -41,999 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 105,230 | 267,465 | +162,235 | 0.02 | 0.05 | +0.03 | buy |
| Burkehill Global Management, LP | 0 | 250,000 | +250,000 | 0.00 | 0.07 | +0.07 | buy |
| AdvisorShares Investments LLC | 230,910 | 246,739 | +15,829 | 0.27 | 0.25 | -0.02 | buy |
| ROYAL BANK OF CANADA | 181,168 | 244,526 | +63,358 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,453,876 | 236,380 | -1,217,496 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 218,406 | 231,385 | +12,979 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 79,800 | 217,992 | +138,192 | 0.01 | 0.02 | +0.01 | buy |
| Brown University | 214,200 | 214,200 | 0 | 1.04 | 1.16 | +0.13 | hold |
| Vivo Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.09 | +0.09 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 111,088 | 191,305 | +80,217 | 0.02 | 0.02 | +0.00 | buy |
| GROUP ONE TRADING LLC | 23,529 | 189,753 | +166,224 | 0.00 | 0.03 | +0.03 | buy |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 0 | 179,716 | +179,716 | 0.00 | 0.05 | +0.05 | buy |
| Woodline Partners LP | 0 | 175,439 | +175,439 | 0.00 | 0.00 | +0.00 | buy |
| STABLEFORD CAPITAL II LLC | 160,625 | 161,139 | +514 | 0.40 | 0.33 | -0.07 | buy |
| Simplify Asset Management Inc. | 290,000 | 159,052 | -130,948 | 0.03 | 0.01 | -0.02 | sell |
| Saba Capital Management, L.P. | 151,033 | 151,033 | 0 | 0.03 | 0.03 | -0.01 | hold |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 85,136 | 147,590 | +62,454 | 0.04 | 0.06 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 139,937 | 140,387 | +450 | 0.00 | 0.00 | -0.00 | buy |
| Palo Alto Investors LP | 115,616 | 115,616 | 0 | 0.11 | 0.10 | -0.01 | hold |
| Schonfeld Strategic Advisors LLC | 33,533 | 102,828 | +69,295 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 83,000 | +83,000 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 78,794 | 80,442 | +1,648 | 0.00 | 0.00 | -0.00 | buy |
| Lion Point Capital, LP | 58,000 | 80,000 | +22,000 | 2.07 | 2.64 | +0.57 | buy |
| Polar Asset Management Partners Inc. | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 68,485 | +68,485 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 19,811 | 63,533 | +43,722 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 62,962 | 62,962 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Intellectus Partners, LLC | 61,000 | 61,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Atom Investors LP | 0 | 48,060 | +48,060 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 24,408 | 45,886 | +21,478 | 0.00 | 0.00 | +0.00 | buy |
| Fore Capital, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.58 | +0.58 | buy |
| Y-Intercept (Hong Kong) Ltd | 174,258 | 44,978 | -129,280 | 0.03 | 0.00 | -0.02 | sell |
| FLAGSHIP HARBOR ADVISORS, LLC | 42,599 | 42,599 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DCF Advisers, LLC | 0 | 42,500 | +42,500 | 0.00 | 0.09 | +0.09 | buy |
| Virtus Investment Advisers, LLC | 39,471 | 40,457 | +986 | 0.07 | 0.06 | -0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 39,225 | +39,225 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 38,438 | 39,173 | +735 | 0.00 | 0.00 | -0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 31,885 | +31,885 | 0.00 | 0.07 | +0.07 | buy |
| HighTower Advisors, LLC | 31,491 | 30,641 | -850 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 30,206 | +30,206 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 5,653 | 29,652 | +23,999 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 21,600 | 29,000 | +7,400 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 27,600 | +27,600 | 0.00 | 0.02 | +0.02 | buy |
| Conservest Capital Advisors, Inc. | 25,363 | 25,363 | 0 | 0.02 | 0.01 | -0.00 | hold |
| FNY Investment Advisers, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.05 | +0.05 | buy |
| Entropy Technologies, LP | 0 | 19,970 | +19,970 | 0.00 | 0.01 | +0.01 | buy |