| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 5,538,168 | 8,221,929 | +2,683,761 | 0.24 | 0.33 | +0.09 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,485,000 | +1,485,000 | 0.00 | 3.46 | +3.46 | buy |
| Nantahala Capital Management, LLC | 2,829,232 | 4,179,930 | +1,350,698 | 0.67 | 0.83 | +0.16 | buy |
| PFM Health Sciences, LP | 451,267 | 1,779,259 | +1,327,992 | 0.10 | 0.43 | +0.33 | buy |
| HSBC HOLDINGS PLC | 0 | 1,075,485 | +1,075,485 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 62,300 | 700,000 | +637,700 | 0.01 | 0.06 | +0.05 | buy |
| UBS Group AG | 1,049,161 | 1,678,608 | +629,447 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 544,721 | +544,721 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 500,000 | +500,000 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 399,963 | +399,963 | 0.00 | 0.02 | +0.02 | buy |
| 22NW, LP | 646,559 | 882,844 | +236,285 | 1.24 | 1.56 | +0.32 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 619,495 | 854,840 | +235,345 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 23,746 | 244,893 | +221,147 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 213,544 | +213,544 | 0.00 | 0.49 | +0.49 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 186,881 | +186,881 | 0.00 | 0.00 | +0.00 | buy |
| STABLEFORD CAPITAL II LLC | 0 | 163,941 | +163,941 | 0.00 | 0.27 | +0.27 | buy |
| JANE STREET GROUP, LLC | 0 | 157,677 | +157,677 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGER MANAGEMENT, LLC | 0 | 147,209 | +147,209 | 0.00 | 0.24 | +0.24 | buy |
| SIMPLEX TRADING, LLC | 48,651 | 183,031 | +134,380 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 711,046 | 811,046 | +100,000 | 0.58 | 0.63 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 118,192 | 212,800 | +94,608 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 89,446 | 178,200 | +88,754 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 78,560 | +78,560 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 48,289 | 117,683 | +69,394 | 0.01 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 66,975 | +66,975 | 0.00 | 0.02 | +0.02 | buy |
| Gladstone Institutional Advisory LLC | 0 | 37,270 | +37,270 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 140,541 | 173,541 | +33,000 | 0.08 | 0.09 | +0.01 | buy |
| Northeast Financial Consultants Inc | 0 | 21,000 | +21,000 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 19,213 | +19,213 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,096 | +18,096 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 14,446 | 28,171 | +13,725 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 14,273 | 23,842 | +9,569 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 906 | 10,180 | +9,274 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,455 | 18,272 | +5,817 | 0.00 | 0.00 | +0.00 | buy |
| Conservest Capital Advisors, Inc. | 15,363 | 20,363 | +5,000 | 0.00 | 0.01 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 11,675 | 16,511 | +4,836 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 990 | 3,728 | +2,738 | 0.00 | 0.00 | +0.00 | buy |
| Key FInancial Inc | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10,855 | 13,125 | +2,270 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,013 | 3,514 | +1,501 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,754,856 | 1,755,938 | +1,082 | 0.03 | 0.03 | -0.01 | buy |
| Farther Finance Advisors, LLC | 30 | 1,000 | +970 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 851 | +851 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 104 | 658 | +554 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 933 | 1,445 | +512 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 10,757 | 11,242 | +485 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 327 | +327 | 0.00 | 0.00 | +0.00 | buy |
| Kilter Group LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 288 | 441 | +153 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 120 | 240 | +120 | 0.00 | 0.00 | +0.00 | buy |
| New England Capital Financial Advisors LLC | 300 | 404 | +104 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 98 | +98 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Wealth Investment Group, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Global Wealth Strategies & Associates | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 300 | 304 | +4 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 800 | 800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADIRONDACK TRUST CO | 505 | 505 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GMT CAPITAL CORP | 1,781,718 | 1,781,718 | 0 | 0.27 | 0.21 | -0.06 | hold |
| CIBC Private Wealth Group LLC | 23 | 23 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Oasis Management Co Ltd. | 107,911 | 107,911 | 0 | 0.10 | 0.07 | -0.03 | hold |
| GHP Investment Advisors, Inc. | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ancora Advisors LLC | 1,330 | 1,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Saba Capital Management, L.P. | 151,033 | 151,033 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Westside Investment Management, Inc. | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Colonial Trust Advisors | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Anfield Capital Management, LLC | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tradewinds Capital Management, LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Anchor Investment Management, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TruNorth Capital Management, LLC | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Brown University | 214,200 | 214,200 | 0 | 0.28 | 0.42 | +0.14 | hold |
| Vivo Capital, LLC | 3,362,385 | 3,362,385 | 0 | 1.27 | 0.96 | -0.31 | hold |
| Intellectus Partners, LLC | 10,100 | 10,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NVWM, LLC | 202 | 202 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Close Asset Management Ltd | 3,900 | 3,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,100 | 1,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Crewe Advisors LLC | 1,945 | 1,945 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 112 | 112 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aisling Capital Management LP | 1,198,418 | 1,198,418 | 0 | 1.19 | 0.93 | -0.26 | hold |
| Pacifica Partners Inc. | 420 | 420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TFC Financial Management, Inc. | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Founders Fund VII Management, LLC | 278,880 | 278,880 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Missouri Trust & Investment Co | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ethos Financial Group, LLC | 12,308 | 12,308 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LGT Financial Advisors LLC | 14,700 | 14,700 | 0 | 0.13 | 0.10 | -0.02 | hold |
| TD Waterhouse Canada Inc. | 1,770 | 1,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CROWLEY WEALTH MANAGEMENT, INC. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,261 | 1,261 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIFTH THIRD BANCORP | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CENTRAL TRUST Co | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 501 | 501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OLD NATIONAL BANCORP /IN/ | 15,600 | 15,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 22,100 | 22,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Parallel Advisors, LLC | 134 | 85 | -49 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 10,287 | 10,214 | -73 | 0.00 | 0.00 | -0.00 | sell |
| Westside Investment Management, Inc. | 500 | 400 | -100 | 0.00 | 0.00 | -0.00 | sell |