| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 12,161,496 | 12,161,496 | 0 | 1.39 | 2.54 | +1.15 | hold |
| RTW INVESTMENTS, LP | 10,632,390 | 10,700,974 | +68,584 | 0.59 | 1.29 | +0.71 | buy |
| BIT Capital GmbH | 3,491,234 | 6,348,797 | +2,857,563 | 1.08 | 3.08 | +2.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,002,200 | 5,000,000 | +997,800 | 1.12 | 3.21 | +2.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,583,499 | 4,470,485 | +1,886,986 | 0.01 | 0.05 | +0.04 | buy |
| MARSHALL WACE, LLP | 4,038,335 | 4,328,682 | +290,347 | 0.02 | 0.05 | +0.03 | buy |
| ARK Investment Management LLC | 3,301,050 | 3,451,965 | +150,915 | 0.14 | 0.32 | +0.18 | buy |
| Point72 Asset Management, L.P. | 0 | 2,620,878 | +2,620,878 | 0.00 | 0.06 | +0.06 | buy |
| Logos Global Management LP | 0 | 2,250,000 | +2,250,000 | 0.00 | 1.37 | +1.37 | buy |
| Eagle Health Investments LP | 2,060,427 | 2,060,427 | 0 | 2.39 | 4.83 | +2.44 | hold |
| BANK OF AMERICA CORP /DE/ | 0 | 2,019,348 | +2,019,348 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 2,418,882 | 2,011,952 | -406,930 | 3.04 | 5.43 | +2.39 | sell |
| UBS Group AG | 1,855,070 | 1,482,470 | -372,600 | 0.00 | 0.00 | +0.00 | sell |
| Aisling Capital Management LP | 1,432,336 | 1,432,336 | 0 | 1.66 | 4.30 | +2.63 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 865,354 | 1,431,889 | +566,535 | 0.01 | 0.03 | +0.02 | buy |
| Candriam S.C.A. | 0 | 1,274,278 | +1,274,278 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 175,439 | 1,086,004 | +910,565 | 0.00 | 0.05 | +0.04 | buy |
| CITADEL ADVISORS LLC | 269,489 | 1,004,880 | +735,391 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 1,467,362 | 994,393 | -472,969 | 0.10 | 0.13 | +0.03 | sell |
| BlackRock, Inc. | 683,241 | 925,391 | +242,150 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 309,283 | 860,158 | +550,875 | 0.01 | 0.08 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,138,522 | 770,987 | -2,367,535 | 0.01 | 0.01 | -0.01 | sell |
| Caption Management, LLC | 1,610,130 | 756,116 | -854,014 | 0.42 | 0.38 | -0.05 | sell |
| Eversept Partners, LP | 677,924 | 672,825 | -5,099 | 0.25 | 0.52 | +0.27 | sell |
| MORGAN STANLEY | 1,205,887 | 594,906 | -610,981 | 0.00 | 0.00 | +0.00 | sell |
| Propel Bio Management, LLC | 742,049 | 573,086 | -168,963 | 2.60 | 4.24 | +1.65 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 300,000 | 503,382 | +203,382 | 0.20 | 0.79 | +0.60 | buy |
| JANE STREET GROUP, LLC | 341,821 | 501,930 | +160,109 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 948,554 | 499,676 | -448,878 | 0.01 | 0.01 | +0.00 | sell |
| Walleye Capital LLC | 362,152 | 487,165 | +125,013 | 0.01 | 0.03 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 39,225 | 474,653 | +435,428 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 450,000 | +450,000 | 0.00 | 0.97 | +0.97 | buy |
| AdvisorShares Investments LLC | 246,739 | 421,347 | +174,608 | 0.25 | 0.72 | +0.47 | buy |
| Hennion & Walsh Asset Management, Inc. | 487,674 | 417,833 | -69,841 | 0.09 | 0.17 | +0.08 | sell |
| GOLDMAN SACHS GROUP INC | 371,697 | 391,587 | +19,890 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 68,485 | 384,351 | +315,866 | 0.02 | 0.35 | +0.33 | buy |
| HighVista Strategies LLC | 364,360 | 371,120 | +6,760 | 0.56 | 1.20 | +0.64 | buy |
| Legal & General Group Plc | 231,385 | 332,206 | +100,821 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 368,828 | 323,209 | -45,619 | 0.00 | 0.00 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 368,828 | 319,472 | -49,356 | 0.03 | 0.06 | +0.03 | sell |
| Affinity Asset Advisors, LLC | 1,108,483 | 301,183 | -807,300 | 0.36 | 0.21 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 300,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| SEVEN GRAND MANAGERS, LLC | 300,000 | 300,000 | 0 | 0.11 | 0.17 | +0.06 | hold |
| ROYAL BANK OF CANADA | 244,526 | 299,808 | +55,282 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 570,496 | 291,950 | -278,546 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 284,769 | +284,769 | 0.00 | 0.70 | +0.70 | buy |
| TORONTO DOMINION BANK | 277,755 | 277,755 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ROYCE & ASSOCIATES LP | 382,086 | 267,059 | -115,027 | 0.02 | 0.03 | +0.01 | sell |
| Jump Financial, LLC | 455,000 | 261,616 | -193,384 | 0.04 | 0.03 | -0.00 | sell |
| PFM Health Sciences, LP | 1,367,099 | 247,589 | -1,119,510 | 0.80 | 0.30 | -0.49 | sell |
| D. E. Shaw & Co., Inc. | 236,380 | 240,874 | +4,494 | 0.00 | 0.00 | +0.00 | buy |
| Brown University | 214,200 | 214,200 | 0 | 1.16 | 3.18 | +2.02 | hold |
| HEIGHTS CAPITAL MANAGEMENT, INC | 1,492,415 | 205,932 | -1,286,483 | 2.31 | 0.67 | -1.64 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 147,590 | 175,373 | +27,783 | 0.06 | 0.16 | +0.10 | buy |
| Engineers Gate Manager LP | 217,992 | 171,897 | -46,095 | 0.02 | 0.03 | +0.02 | sell |
| Y-Intercept (Hong Kong) Ltd | 44,978 | 168,090 | +123,112 | 0.00 | 0.05 | +0.04 | buy |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 179,716 | 150,000 | -29,716 | 0.05 | 0.09 | +0.04 | sell |
| HRT FINANCIAL LP | 45,886 | 146,127 | +100,241 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 16,293 | 138,671 | +122,378 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 138,480 | +138,480 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 136,462 | +136,462 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 140,387 | 135,631 | -4,756 | 0.00 | 0.00 | +0.00 | sell |
| K2 PRINCIPAL FUND, L.P. | 0 | 135,100 | +135,100 | 0.00 | 0.18 | +0.18 | buy |
| CenterBook Partners LP | 409,237 | 125,594 | -283,643 | 0.12 | 0.09 | -0.03 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 119,222 | +119,222 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 115,839 | +115,839 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 115,616 | 115,616 | 0 | 0.10 | 0.23 | +0.13 | hold |
| Simplify Asset Management Inc. | 159,052 | 114,281 | -44,771 | 0.01 | 0.02 | +0.01 | sell |
| LPL Financial LLC | 0 | 109,568 | +109,568 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 189,753 | 98,298 | -91,455 | 0.03 | 0.04 | +0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 275,773 | 94,802 | -180,971 | 0.02 | 0.02 | -0.00 | sell |
| CreativeOne Wealth, LLC | 0 | 94,439 | +94,439 | 0.00 | 0.03 | +0.03 | buy |
| STABLEFORD CAPITAL II LLC | 161,139 | 91,873 | -69,266 | 0.33 | 0.45 | +0.12 | sell |
| STATE STREET CORP | 80,442 | 81,279 | +837 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 80,000 | 80,000 | 0 | 2.64 | 5.41 | +2.77 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 62,962 | 75,187 | +12,225 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,122,588 | 66,562 | -1,056,026 | 0.01 | 0.00 | -0.01 | sell |
| Aquatic Capital Management LLC | 63,533 | 65,180 | +1,647 | 0.01 | 0.03 | +0.02 | buy |
| Dorsey Wright & Associates | 0 | 62,449 | +62,449 | 0.00 | 0.15 | +0.15 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 61,816 | +61,816 | 0.00 | 0.05 | +0.05 | buy |
| STIFEL FINANCIAL CORP | 29,000 | 60,469 | +31,469 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 61,000 | 59,500 | -1,500 | 0.07 | 0.15 | +0.08 | sell |
| DCF Advisers, LLC | 42,500 | 54,250 | +11,750 | 0.09 | 0.20 | +0.11 | buy |
| CIBC WORLD MARKET INC. | 0 | 52,110 | +52,110 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 549 | 51,727 | +51,178 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 50,102 | +50,102 | 0.00 | 0.00 | +0.00 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 0 | 48,657 | +48,657 | 0.00 | 0.01 | +0.01 | buy |
| Fore Capital, LLC | 45,000 | 45,000 | 0 | 0.58 | 0.84 | +0.26 | hold |
| FLAGSHIP HARBOR ADVISORS, LLC | 42,599 | 44,599 | +2,000 | 0.01 | 0.02 | +0.01 | buy |
| HighTower Advisors, LLC | 30,641 | 40,727 | +10,086 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 39,173 | 38,130 | -1,043 | 0.00 | 0.00 | +0.00 | sell |
| MOUNT VERNON ASSOCIATES INC /MD/ | 0 | 38,000 | +38,000 | 0.00 | 0.35 | +0.35 | buy |
| Merit Financial Group, LLC | 0 | 37,847 | +37,847 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 37,585 | +37,585 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 19,970 | 36,480 | +16,510 | 0.01 | 0.02 | +0.02 | buy |
| Gladstone Institutional Advisory LLC | 16,944 | 35,589 | +18,645 | 0.00 | 0.02 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 30,206 | 34,317 | +4,111 | 0.01 | 0.03 | +0.02 | buy |
| Atom Investors LP | 48,060 | 32,885 | -15,175 | 0.02 | 0.04 | +0.02 | sell |
| Burns Matteson Capital Management, LLC | 0 | 32,861 | +32,861 | 0.00 | 0.15 | +0.15 | buy |
| RAYMOND JAMES FINANCIAL INC | 17,429 | 32,642 | +15,213 | 0.00 | 0.00 | +0.00 | buy |