| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 3,668,216 | 5,414,576 | +1,746,360 | 0.02 | 0.04 | +0.01 | buy |
| TCG Crossover Management, LLC | 3,858,000 | 3,858,000 | 0 | 2.43 | 2.06 | -0.37 | hold |
| MILLENNIUM MANAGEMENT LLC | 3,382,066 | 3,756,672 | +374,606 | 0.02 | 0.02 | +0.00 | buy |
| ARK Investment Management LLC | 2,100,511 | 2,005,125 | -95,386 | 0.11 | 0.12 | +0.00 | sell |
| Vivo Capital, LLC | 1,608,000 | 1,608,000 | 0 | 0.90 | 0.84 | -0.06 | hold |
| GMT CAPITAL CORP | 0 | 1,547,800 | +1,547,800 | 0.00 | 0.39 | +0.39 | buy |
| Paradigm Biocapital Advisors LP | 2,335,926 | 1,160,000 | -1,175,926 | 0.54 | 0.26 | -0.28 | sell |
| Logos Global Management LP | 1,159,030 | 1,159,030 | 0 | 0.81 | 0.82 | +0.01 | hold |
| MORGAN STANLEY | 0 | 1,000,489 | +1,000,489 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 964,500 | 964,500 | 0 | 2.52 | 2.33 | -0.19 | hold |
| Sio Capital Management, LLC | 293,417 | 914,639 | +621,222 | 0.67 | 2.58 | +1.91 | buy |
| Rosalind Advisors, Inc. | 734,000 | 781,423 | +47,423 | 3.51 | 3.27 | -0.24 | buy |
| Polar Asset Management Partners Inc. | 309,600 | 567,600 | +258,000 | 0.05 | 0.09 | +0.04 | buy |
| Woodline Partners LP | 0 | 514,418 | +514,418 | 0.00 | 0.03 | +0.03 | buy |
| PFM Health Sciences, LP | 1,089,592 | 451,267 | -638,325 | 0.36 | 0.16 | -0.20 | sell |
| Laurion Capital Management LP | 510,907 | 439,311 | -71,596 | 0.10 | 0.18 | +0.08 | sell |
| BARCLAYS PLC | 417,976 | 410,476 | -7,500 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 386,500 | +386,500 | 0.00 | 1.97 | +1.97 | buy |
| Walleye Capital LLC | 0 | 337,456 | +337,456 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 302,937 | 301,815 | -1,122 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 500,512 | 300,512 | -200,000 | 0.48 | 0.29 | -0.18 | sell |
| FRANKLIN RESOURCES INC | 283,186 | 295,785 | +12,599 | 0.00 | 0.00 | -0.00 | buy |
| Founders Fund VII Management, LLC | 278,880 | 278,880 | 0 | 13.10 | 100.00 | +86.90 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 288,459 | 269,369 | -19,090 | 0.00 | 0.00 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 288,459 | 269,369 | -19,090 | 0.02 | 0.02 | -0.00 | sell |
| Shay Capital LLC | 315,076 | 248,076 | -67,000 | 0.53 | 0.46 | -0.07 | sell |
| DAFNA Capital Management LLC | 243,210 | 243,210 | 0 | 0.35 | 0.36 | +0.01 | hold |
| GROUP ONE TRADING LLC | 45,616 | 239,882 | +194,266 | 0.01 | 0.06 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 348,544 | 229,184 | -119,360 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 302,908 | 202,908 | -100,000 | 0.57 | 0.40 | -0.17 | sell |
| Nantahala Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.11 | +0.11 | buy |
| Saba Capital Management, L.P. | 151,033 | 151,033 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Hennion & Walsh Asset Management, Inc. | 109,989 | 148,134 | +38,145 | 0.03 | 0.04 | +0.01 | buy |
| ROYAL BANK OF CANADA | 53,477 | 119,343 | +65,866 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 110,932 | 116,256 | +5,324 | 0.00 | 0.00 | +0.00 | buy |
| Oasis Management Co Ltd. | 107,911 | 107,911 | 0 | 0.21 | 0.23 | +0.02 | hold |
| SIMPLEX TRADING, LLC | 21,492 | 101,258 | +79,766 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 263,800 | 81,400 | -182,400 | 0.00 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.29 | +0.29 | buy |
| GILDER GAGNON HOWE & CO LLC | 76,556 | 75,559 | -997 | 0.01 | 0.01 | -0.00 | sell |
| Brown University | 72,700 | 72,700 | 0 | 0.17 | 0.19 | +0.02 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 93,023 | 62,314 | -30,709 | 0.02 | 0.01 | -0.01 | sell |
| Point72 Asset Management, L.P. | 0 | 58,900 | +58,900 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,562 | 53,993 | +34,431 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 53,344 | 52,405 | -939 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 42,656 | 47,283 | +4,627 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 60,882 | 43,882 | -17,000 | 0.06 | 0.05 | -0.01 | sell |
| EntryPoint Capital, LLC | 92,130 | 42,208 | -49,922 | 0.26 | 0.15 | -0.11 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 16,199 | 42,169 | +25,970 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 41,423 | +41,423 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 57,800 | 39,500 | -18,300 | 0.00 | 0.00 | -0.00 | sell |
| Fore Capital, LLC | 30,000 | 35,000 | +5,000 | 0.27 | 0.42 | +0.15 | buy |
| STIFEL FINANCIAL CORP | 37,400 | 34,700 | -2,700 | 0.00 | 0.00 | -0.00 | sell |
| HAP Trading, LLC | 0 | 34,436 | +34,436 | 0.00 | 0.11 | +0.11 | buy |
| Legal & General Group Plc | 33,952 | 33,952 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 23,565 | 27,679 | +4,114 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 25,005 | 25,517 | +512 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 21,005 | 21,005 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 20,727 | +20,727 | 0.00 | 0.01 | +0.01 | buy |
| Spire Wealth Management | 0 | 18,790 | +18,790 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 0 | 15,966 | +15,966 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 0 | 15,781 | +15,781 | 0.00 | 0.08 | +0.08 | buy |
| OLD NATIONAL BANCORP /IN/ | 14,600 | 14,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 13,966 | +13,966 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 13,044 | 13,281 | +237 | 0.04 | 0.04 | +0.00 | buy |
| Jump Financial, LLC | 24,916 | 11,600 | -13,316 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 11,286 | 11,286 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighTower Advisors, LLC | 12,132 | 11,032 | -1,100 | 0.00 | 0.00 | -0.00 | sell |
| MCDONALD PARTNERS LLC | 10,990 | 10,990 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 0 | 10,448 | +10,448 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 10,381 | +10,381 | 0.00 | 0.00 | +0.00 | buy |
| Conservest Capital Advisors, Inc. | 10,363 | 10,363 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LPL Financial LLC | 13,330 | 10,237 | -3,093 | 0.00 | 0.00 | -0.00 | sell |
| Intellectus Partners, LLC | 10,100 | 10,100 | 0 | 0.02 | 0.02 | -0.00 | hold |
| CANTOR FITZGERALD, L. P. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| SHELL ASSET MANAGEMENT CO | 15,914 | 9,445 | -6,469 | 0.00 | 0.00 | -0.00 | sell |
| Close Asset Management Ltd | 6,400 | 6,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| North Star Investment Management Corp. | 200 | 4,797 | +4,597 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 100 | 4,000 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 3,800 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,533 | 3,288 | +1,755 | 0.00 | 0.00 | +0.00 | buy |
| Crewe Advisors LLC | 1,945 | 1,945 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 1,770 | 1,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Colonial Trust Advisors | 1,510 | 1,500 | -10 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 1,376 | 1,376 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ancora Advisors LLC | 1,330 | 1,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 855 | 855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 1,200 | 800 | -400 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Anchor Investment Management, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADIRONDACK TRUST CO | 505 | 505 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 501 | 501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Westside Investment Management, Inc. | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 175 | 475 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Pacifica Partners Inc. | 420 | 420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Westside Investment Management, Inc. | 500 | 400 | -100 | 0.00 | 0.00 | -0.00 | sell |
| New England Capital Financial Advisors LLC | 358 | 358 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 0 | 288 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 13,368 | 261 | -13,107 | 0.00 | 0.00 | -0.00 | sell |