| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,358,709 | 2,265,988 | +907,279 | 0.69 | 0.93 | +0.24 | buy |
| Affinity Asset Advisors, LLC | 0 | 550,000 | +550,000 | 0.00 | 0.96 | +0.96 | buy |
| PFM Health Sciences, LP | 52,871 | 338,761 | +285,890 | 0.02 | 0.18 | +0.16 | buy |
| ExodusPoint Capital Management, LP | 0 | 277,209 | +277,209 | 0.00 | 0.03 | +0.03 | buy |
| Sio Capital Management, LLC | 0 | 251,532 | +251,532 | 0.00 | 0.57 | +0.57 | buy |
| ARK Investment Management LLC | 2,432,831 | 2,618,871 | +186,040 | 0.14 | 0.14 | -0.00 | buy |
| BARCLAYS PLC | 413,066 | 501,310 | +88,244 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 74,331 | +74,331 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 43,007 | +43,007 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 42,400 | +42,400 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 224,804 | 265,613 | +40,809 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 40,774 | +40,774 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 38,900 | +38,900 | 0.00 | 0.00 | +0.00 | buy |
| Empire Financial Management Company, LLC | 0 | 31,000 | +31,000 | 0.00 | 0.11 | +0.11 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 30,259 | +30,259 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 29,988 | +29,988 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 24,037 | 53,587 | +29,550 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 18,958 | 48,419 | +29,461 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 19,493 | +19,493 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 14,160 | +14,160 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 13,287 | +13,287 | 0.00 | 0.00 | +0.00 | buy |
| EWA, LLC | 0 | 12,272 | +12,272 | 0.00 | 0.07 | +0.07 | buy |
| HighTower Advisors, LLC | 0 | 11,564 | +11,564 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 18,260 | 29,651 | +11,391 | 0.00 | 0.00 | +0.00 | buy |
| MCDONALD PARTNERS LLC | 0 | 11,390 | +11,390 | 0.00 | 0.03 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 516 | 11,122 | +10,606 | 0.00 | 0.00 | +0.00 | buy |
| Conservest Capital Advisors, Inc. | 0 | 10,363 | +10,363 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 105,958 | 110,939 | +4,981 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 2,296 | +2,296 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,678 | 15,328 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 1,480 | +1,480 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 370 | 1,370 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 480 | 855 | +375 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 300 | 550 | +250 | 0.00 | 0.00 | +0.00 | buy |
| NVWM, LLC | 0 | 202 | +202 | 0.00 | 0.00 | +0.00 | buy |
| CENTRAL TRUST Co | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| ARROW FINANCIAL CORP | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 85 | 134 | +49 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 49 | +49 | 0.00 | 0.00 | 0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 479 | 487 | +8 | 0.00 | 0.00 | +0.00 | buy |
| ADIRONDACK TRUST CO | 505 | 505 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 660 | 660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Oasis Management Co Ltd. | 207,911 | 207,911 | 0 | 0.41 | 0.61 | +0.20 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,286,000 | 1,286,000 | 0 | 0.19 | 0.18 | -0.01 | hold |
| DAFNA Capital Management LLC | 193,000 | 193,000 | 0 | 0.44 | 0.40 | -0.04 | hold |
| Laurion Capital Management LP | 510,907 | 510,907 | 0 | 0.10 | 0.16 | +0.06 | hold |
| Lee Financial Co | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GHP Investment Advisors, Inc. | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AdvisorNet Financial, Inc | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Saba Capital Management, L.P. | 201,033 | 201,033 | 0 | 0.05 | 0.04 | -0.00 | hold |
| Westside Investment Management, Inc. | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Gradient Investments LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Colonial Trust Advisors | 1,510 | 1,510 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 135 | 135 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tradewinds Capital Management, LLC | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Anchor Investment Management, LLC | 550 | 550 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brown University | 72,700 | 72,700 | 0 | 0.22 | 0.23 | +0.01 | hold |
| Vivo Capital, LLC | 1,608,000 | 1,608,000 | 0 | 1.30 | 1.15 | -0.15 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Crewe Advisors LLC | 1,945 | 1,945 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Larson Financial Group LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aisling Capital Management LP | 964,500 | 964,500 | 0 | 2.94 | 2.52 | -0.42 | hold |
| Princeton Global Asset Management LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Banque Cantonale Vaudoise | 6,000 | 6,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pacifica Partners Inc. | 420 | 420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 964,550 | 964,550 | 0 | 0.72 | 0.94 | +0.22 | hold |
| TFC Financial Management, Inc. | 52 | 52 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 3,858,000 | 3,858,000 | 0 | 4.20 | 3.74 | -0.46 | hold |
| Founders Fund VII Management, LLC | 278,880 | 278,880 | 0 | 10.63 | 10.17 | -0.45 | hold |
| SJS Investment Consulting Inc. | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Missouri Trust & Investment Co | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| New England Capital Financial Advisors LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JAMISON PRIVATE WEALTH MANAGEMENT, INC. | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Glen Eagle Advisors, LLC | 52 | 52 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 501 | 501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OLD NATIONAL BANCORP /IN/ | 14,600 | 14,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 16,121 | 16,121 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 135 | 100 | -35 | 0.00 | 0.00 | -0.00 | sell |
| Impact Partnership Wealth, LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 64 | 0 | -64 | 0.00 | 0.00 | 0.00 | sell |
| Authentikos Wealth Advisory, LLC | 70 | 0 | -70 | 0.00 | 0.00 | -0.00 | sell |
| Westside Investment Management, Inc. | 500 | 400 | -100 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 135 | 10 | -125 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 12,680 | 12,482 | -198 | 0.00 | 0.00 | +0.00 | sell |
| Legacy Financial Group LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 230 | 0 | -230 | 0.00 | 0.00 | -0.00 | sell |
| AE Wealth Management LLC | 14,332 | 14,024 | -308 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 324 | 0 | -324 | 0.00 | 0.00 | -0.00 | sell |
| Close Asset Management Ltd | 6,800 | 6,400 | -400 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 556 | 1 | -555 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 12,549 | 11,992 | -557 | 0.06 | 0.07 | +0.01 | sell |
| China Universal Asset Management Co., Ltd. | 690 | 0 | -690 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,565,856 | 1,565,000 | -856 | 0.01 | 0.01 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,205 | 14,653 | -1,552 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 1,895 | 215 | -1,680 | 0.00 | 0.00 | -0.00 | sell |