| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 3,858,000 | 3,858,000 | 0 | 2.06 | 1.43 | -0.63 | hold |
| MILLENNIUM MANAGEMENT LLC | 3,756,672 | 3,413,448 | -343,224 | 0.02 | 0.01 | -0.01 | sell |
| RTW INVESTMENTS, LP | 0 | 3,098,987 | +3,098,987 | 0.00 | 0.18 | +0.18 | buy |
| ARK Investment Management LLC | 2,005,125 | 1,736,202 | -268,923 | 0.12 | 0.05 | -0.06 | sell |
| Vivo Capital, LLC | 1,608,000 | 1,608,000 | 0 | 0.84 | 0.68 | -0.16 | hold |
| GMT CAPITAL CORP | 1,547,800 | 1,547,800 | 0 | 0.39 | 0.29 | -0.10 | hold |
| Altium Capital Management LLC | 0 | 1,424,400 | +1,424,400 | 0.00 | 1.68 | +1.68 | buy |
| CITADEL ADVISORS LLC | 5,414,576 | 1,105,676 | -4,308,900 | 0.04 | 0.00 | -0.03 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.25 | +0.25 | buy |
| Nantahala Capital Management, LLC | 200,000 | 1,000,000 | +800,000 | 0.11 | 0.26 | +0.16 | buy |
| Aisling Capital Management LP | 964,500 | 964,500 | 0 | 2.33 | 1.29 | -1.03 | hold |
| Affinity Asset Advisors, LLC | 300,512 | 850,512 | +550,000 | 0.29 | 0.50 | +0.21 | buy |
| Rosalind Advisors, Inc. | 781,423 | 707,625 | -73,798 | 3.27 | 1.44 | -1.83 | sell |
| MORGAN STANLEY | 1,000,489 | 695,669 | -304,820 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 650,279 | +650,279 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 514,418 | 461,929 | -52,489 | 0.03 | 0.01 | -0.02 | sell |
| PFM Health Sciences, LP | 451,267 | 451,267 | 0 | 0.16 | 0.13 | -0.03 | hold |
| Laurion Capital Management LP | 439,311 | 439,311 | 0 | 0.18 | 0.10 | -0.07 | hold |
| BARCLAYS PLC | 410,476 | 419,194 | +8,718 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 369,070 | +369,070 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 385,409 | 343,507 | -41,902 | 0.00 | 0.00 | -0.00 | sell |
| Founders Fund VII Management, LLC | 278,880 | 278,880 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 269,369 | 253,345 | -16,024 | 0.00 | 0.00 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 269,369 | 253,345 | -16,024 | 0.02 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 243,210 | 243,210 | 0 | 0.36 | 0.23 | -0.13 | hold |
| Brown University | 72,700 | 214,200 | +141,500 | 0.19 | 0.35 | +0.16 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 81,400 | 212,700 | +131,300 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 202,908 | 202,894 | -14 | 0.40 | 0.22 | -0.18 | sell |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 229,184 | 179,383 | -49,801 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 148,134 | 174,921 | +26,787 | 0.04 | 0.03 | -0.01 | buy |
| Shay Capital LLC | 248,076 | 171,172 | -76,904 | 0.46 | 0.16 | -0.30 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 169,479 | +169,479 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 161,238 | +161,238 | 0.00 | 0.14 | +0.14 | buy |
| WELLS FARGO & COMPANY/MN | 301,815 | 156,748 | -145,067 | 0.00 | 0.00 | -0.00 | sell |
| Saba Capital Management, L.P. | 151,033 | 151,033 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Cubist Systematic Strategies, LLC | 41,423 | 126,636 | +85,213 | 0.00 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 0 | 115,697 | +115,697 | 0.00 | 0.04 | +0.04 | buy |
| Oasis Management Co Ltd. | 107,911 | 107,911 | 0 | 0.23 | 0.13 | -0.10 | hold |
| Walleye Trading LLC | 144 | 106,013 | +105,869 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 105,286 | +105,286 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,256 | 81,475 | -34,781 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 58,900 | 67,999 | +9,099 | 0.00 | 0.00 | -0.00 | buy |
| AdvisorShares Investments LLC | 43,882 | 66,602 | +22,720 | 0.05 | 0.05 | -0.00 | buy |
| EntryPoint Capital, LLC | 42,208 | 65,519 | +23,311 | 0.15 | 0.10 | -0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 62,314 | 62,300 | -14 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 119,343 | 59,713 | -59,630 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 52,405 | 55,332 | +2,927 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 13,966 | 48,415 | +34,449 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 42,169 | 42,169 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 39,500 | 41,500 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| Green Alpha Advisors, LLC | 15,781 | 37,614 | +21,833 | 0.08 | 0.11 | +0.04 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 35,604 | +35,604 | 0.00 | 0.02 | +0.02 | buy |
| Fore Capital, LLC | 35,000 | 35,000 | 0 | 0.42 | 0.16 | -0.26 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 27,679 | 33,976 | +6,297 | 0.00 | 0.00 | -0.00 | buy |
| SVB WEALTH LLC | 0 | 26,607 | +26,607 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 25,517 | 25,261 | -256 | 0.00 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 80,000 | 25,209 | -54,791 | 0.29 | 0.09 | -0.20 | sell |
| STIFEL FINANCIAL CORP | 34,700 | 22,100 | -12,600 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 0 | 21,945 | +21,945 | 0.00 | 0.01 | +0.01 | buy |
| Essential Planning, LLC. | 0 | 18,395 | +18,395 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 17,515 | +17,515 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 17,489 | +17,489 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 13,281 | 16,121 | +2,840 | 0.04 | 0.02 | -0.01 | buy |
| Simplify Asset Management Inc. | 0 | 14,248 | +14,248 | 0.00 | 0.00 | +0.00 | buy |
| Prime Capital Investment Advisors, LLC | 0 | 13,960 | +13,960 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 15,966 | 13,789 | -2,177 | 0.00 | 0.00 | -0.00 | sell |
| Conservest Capital Advisors, Inc. | 10,363 | 13,363 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 11,312 | +11,312 | 0.00 | 0.00 | +0.00 | buy |
| Wealthfront Advisers LLC | 0 | 11,250 | +11,250 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 11,032 | 10,882 | -150 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 855 | 10,855 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,782 | +10,782 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 10,100 | 10,100 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Close Asset Management Ltd | 6,400 | 6,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 3,288 | 5,346 | +2,058 | 0.00 | 0.00 | -0.00 | buy |
| North Star Investment Management Corp. | 4,797 | 3,372 | -1,425 | 0.00 | 0.00 | -0.00 | sell |
| Blue Trust, Inc. | 261 | 2,799 | +2,538 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,448 | 2,403 | -8,045 | 0.00 | 0.00 | -0.00 | sell |
| Colonial Trust Advisors | 1,500 | 2,000 | +500 | 0.00 | 0.00 | -0.00 | buy |
| Crewe Advisors LLC | 1,945 | 1,945 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 1,770 | 1,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,694 | +1,694 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,376 | 1,376 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ancora Advisors LLC | 1,330 | 1,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 0 | 800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 682 | +682 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Anchor Investment Management, LLC | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADIRONDACK TRUST CO | 505 | 505 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 501 | 501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 54 | 500 | +446 | 0.00 | 0.00 | +0.00 | buy |
| Westside Investment Management, Inc. | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 475 | 475 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pacifica Partners Inc. | 420 | 420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Westside Investment Management, Inc. | 500 | 400 | -100 | 0.00 | 0.00 | -0.00 | sell |
| New England Capital Financial Advisors LLC | 358 | 358 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 800 | 300 | -500 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 288 | 288 | 0 | 0.00 | 0.00 | -0.00 | hold |