| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 8,707,390 | 8,757,390 | +50,000 | 0.61 | 0.61 | -0.01 | buy |
| Deep Track Capital, LP | 7,859,648 | 7,334,323 | -525,325 | 1.26 | 1.15 | -0.10 | sell |
| GMT CAPITAL CORP | 2,844,618 | 2,844,618 | 0 | 0.74 | 1.02 | +0.28 | hold |
| TORONTO DOMINION BANK | 1,000,000 | 2,529,013 | +1,529,013 | 0.01 | 0.03 | +0.02 | buy |
| ARK Investment Management LLC | 2,121,118 | 2,156,012 | +34,894 | 0.07 | 0.10 | +0.03 | buy |
| UBS Group AG | 2,144,410 | 2,038,444 | -105,966 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,075,277 | 1,644,242 | +568,965 | 0.01 | 0.02 | +0.01 | buy |
| Jefferies Financial Group Inc. | 1,376,905 | 1,576,905 | +200,000 | 0.07 | 0.09 | +0.02 | buy |
| Eagle Health Investments LP | 935,450 | 1,519,388 | +583,938 | 1.41 | 2.30 | +0.90 | buy |
| D. E. Shaw & Co., Inc. | 678,792 | 1,453,876 | +775,084 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,715,872 | 1,387,658 | -1,328,214 | 0.01 | 0.01 | -0.01 | sell |
| Aisling Capital Management LP | 1,198,418 | 1,198,418 | 0 | 1.50 | 1.73 | +0.22 | hold |
| MORGAN STANLEY | 1,030,305 | 1,137,520 | +107,215 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.21 | +0.21 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 951,200 | 967,846 | +16,646 | 0.01 | 0.01 | +0.00 | buy |
| Propel Bio Management, LLC | 510,000 | 861,778 | +351,778 | 2.93 | 5.08 | +2.15 | buy |
| TWO SIGMA ADVISERS, LP | 548,500 | 856,500 | +308,000 | 0.01 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 844,816 | +844,816 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 811,046 | 811,046 | 0 | 1.15 | 1.30 | +0.15 | hold |
| PFM Health Sciences, LP | 1,662,836 | 779,618 | -883,218 | 0.81 | 0.54 | -0.27 | sell |
| AMERIPRISE FINANCIAL INC | 1,208,784 | 645,065 | -563,719 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 422,818 | 594,269 | +171,451 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 636,155 | 578,828 | -57,327 | 0.18 | 0.20 | +0.02 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 570,462 | 570,462 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 0 | 498,933 | +498,933 | 0.00 | 0.89 | +0.89 | buy |
| Blue Owl Capital Holdings LP | 604,914 | 469,914 | -135,000 | 1.08 | 1.00 | -0.08 | sell |
| Nantahala Capital Management, LLC | 1,729,930 | 443,293 | -1,286,637 | 0.61 | 0.18 | -0.43 | sell |
| Hennion & Walsh Asset Management, Inc. | 157,892 | 424,800 | +266,908 | 0.03 | 0.10 | +0.07 | buy |
| Ikarian Capital, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.36 | +0.36 | buy |
| JANE STREET GROUP, LLC | 304,321 | 336,728 | +32,407 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 311,488 | +311,488 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 290,000 | 290,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| BIT Capital GmbH | 9,428 | 288,814 | +279,386 | 0.00 | 0.09 | +0.08 | buy |
| Founders Fund VII Management, LLC | 278,880 | 278,880 | 0 | 93.02 | 94.84 | +1.82 | hold |
| Susquehanna Portfolio Strategies, LLC | 275,773 | 275,773 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 276,991 | 247,337 | -29,654 | 0.00 | 0.00 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 276,991 | 247,337 | -29,654 | 0.02 | 0.02 | +0.00 | sell |
| AdvisorShares Investments LLC | 232,345 | 230,910 | -1,435 | 0.22 | 0.27 | +0.05 | sell |
| Legal & General Group Plc | 0 | 218,406 | +218,406 | 0.00 | 0.00 | +0.00 | buy |
| Brown University | 214,200 | 214,200 | 0 | 0.73 | 1.04 | +0.31 | hold |
| Affinity Asset Advisors, LLC | 200,000 | 200,000 | 0 | 0.11 | 0.10 | -0.01 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 320,085 | 189,825 | -130,260 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 173,202 | 181,168 | +7,966 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 174,258 | +174,258 | 0.00 | 0.03 | +0.03 | buy |
| Jump Financial, LLC | 190,000 | 167,025 | -22,975 | 0.02 | 0.01 | -0.00 | sell |
| STABLEFORD CAPITAL II LLC | 164,662 | 160,625 | -4,037 | 0.34 | 0.40 | +0.06 | sell |
| Saba Capital Management, L.P. | 151,033 | 151,033 | 0 | 0.03 | 0.03 | +0.01 | hold |
| BRIDGER MANAGEMENT, LLC | 147,209 | 147,209 | 0 | 0.45 | 0.65 | +0.20 | hold |
| Bellevue Group AG | 0 | 142,243 | +142,243 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 142,645 | 139,937 | -2,708 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 200,739 | 126,980 | -73,759 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 0 | 115,616 | +115,616 | 0.00 | 0.11 | +0.11 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 200,000 | 111,088 | -88,912 | 0.03 | 0.02 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 120,888 | 105,230 | -15,658 | 0.02 | 0.02 | +0.01 | sell |
| Parkman Healthcare Partners LLC | 100,000 | 99,472 | -528 | 0.06 | 0.07 | +0.00 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 57,597 | 85,136 | +27,539 | 0.02 | 0.04 | +0.02 | buy |
| Engineers Gate Manager LP | 0 | 79,800 | +79,800 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 80,036 | 78,794 | -1,242 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 71,877 | 71,877 | 0 | 0.02 | 0.02 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 62,962 | 62,962 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Intellectus Partners, LLC | 50,000 | 61,000 | +11,000 | 0.06 | 0.08 | +0.03 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 60,823 | +60,823 | 0.00 | 0.06 | +0.06 | buy |
| Lion Point Capital, LP | 58,000 | 58,000 | 0 | 1.89 | 2.07 | +0.18 | hold |
| XTX Topco Ltd | 10,186 | 56,786 | +46,600 | 0.00 | 0.01 | +0.01 | buy |
| FreeGulliver LLC | 0 | 45,000 | +45,000 | 0.00 | 0.14 | +0.14 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 46,361 | 42,599 | -3,762 | 0.01 | 0.01 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 25,174 | 39,471 | +14,297 | 0.04 | 0.07 | +0.03 | buy |
| Corient Private Wealth LLC | 37,238 | 38,438 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 14,624 | 36,144 | +21,520 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 34,720 | +34,720 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 148,037 | 33,533 | -114,504 | 0.01 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 11,542 | 31,491 | +19,949 | 0.00 | 0.00 | +0.00 | buy |
| Conservest Capital Advisors, Inc. | 20,363 | 25,363 | +5,000 | 0.01 | 0.02 | +0.00 | buy |
| HRT FINANCIAL LP | 31,140 | 24,408 | -6,732 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 93,821 | 23,529 | -70,292 | 0.02 | 0.00 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 36,600 | 21,600 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 0 | 19,934 | +19,934 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 19,811 | +19,811 | 0.00 | 0.00 | +0.00 | buy |
| Zhang Financial LLC | 19,037 | 19,037 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 18,963 | +18,963 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 14,249 | 16,409 | +2,160 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 15,982 | +15,982 | 0.00 | 0.07 | +0.07 | buy |
| CWM, LLC | 15,650 | 15,530 | -120 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 16,076 | 15,353 | -723 | 0.01 | 0.01 | +0.00 | sell |
| OLD NATIONAL BANCORP /IN/ | 16,265 | 15,265 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| ACORN FINANCIAL ADVISORY SERVICES INC /ADV | 15,000 | 15,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| U.S. Capital Wealth Advisors, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 7,339 | 14,976 | +7,637 | 0.00 | 0.00 | +0.00 | buy |
| LGT Financial Advisors LLC | 14,700 | 14,700 | 0 | 0.18 | 0.62 | +0.44 | hold |
| RAYMOND JAMES FINANCIAL INC | 13,763 | 14,531 | +768 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 13,855 | +13,855 | 0.00 | 0.00 | +0.00 | buy |
| Ethos Financial Group, LLC | 12,308 | 13,532 | +1,224 | 0.01 | 0.01 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 13,194 | +13,194 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial, LLC | 12,284 | 12,144 | -140 | 0.00 | 0.00 | +0.00 | sell |
| Cerity Partners LLC | 10,814 | 10,214 | -600 | 0.00 | 0.00 | +0.00 | sell |
| MML INVESTORS SERVICES, LLC | 0 | 10,004 | +10,004 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 7,293 | 8,005 | +712 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 6,862 | +6,862 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 3,768 | 6,610 | +2,842 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,763 | 5,653 | +3,890 | 0.00 | 0.00 | +0.00 | buy |