| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 421,000 | 855,000 | +434,000 | 3.55 | 5.66 | +2.12 | buy |
| Bellevue Group AG | 459,314 | 560,000 | +100,686 | 0.70 | 0.86 | +0.16 | buy |
| Sofinnova Investments, Inc. | 78,320 | 146,239 | +67,919 | 0.19 | 0.55 | +0.36 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 53,538 | 63,538 | +10,000 | 0.54 | 0.61 | +0.06 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,572 | 395,651 | +79 | 0.42 | 0.39 | -0.03 | buy |
| J.Safra Asset Management Corp | 194 | 161 | -33 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,372 | 8,239 | -133 | 0.04 | 0.04 | -0.00 | sell |
| SummitTX Capital, L.P. | 13,820 | 6,309 | -7,511 | 0.03 | 0.01 | -0.02 | sell |
| Atle Fund Management AB | 107,255 | 43,682 | -63,573 | 1.03 | 0.86 | -0.17 | sell |
| ARMISTICE CAPITAL, LLC | 536,000 | 460,000 | -76,000 | 0.61 | 0.41 | -0.20 | sell |
| BVF INC/IL | 1,272,312 | 1,153,612 | -118,700 | 2.59 | 2.16 | -0.43 | sell |