| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 590,831 | 944,213 | +353,382 | 0.00 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 464,292 | 665,535 | +201,243 | 0.50 | 0.72 | +0.23 | buy |
| Saturn V Capital Management LP | 64,784 | 254,803 | +190,019 | 1.43 | 6.36 | +4.93 | buy |
| JENNISON ASSOCIATES LLC | 43,031 | 193,240 | +150,209 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 157,274 | 252,673 | +95,399 | 1.30 | 2.35 | +1.05 | buy |
| JANUS HENDERSON GROUP PLC | 443,178 | 521,773 | +78,595 | 0.02 | 0.02 | 0.00 | buy |
| Rafferty Asset Management, LLC | 39,863 | 102,865 | +63,002 | 0.01 | 0.02 | +0.01 | buy |
| MPM BioImpact LLC | 50,000 | 110,779 | +60,779 | 0.68 | 1.11 | +0.43 | buy |
| Nicholas Investment Partners, LP | 40,494 | 61,500 | +21,006 | 0.27 | 0.39 | +0.12 | buy |
| Blue Owl Capital Holdings LP | 140,260 | 155,260 | +15,000 | 1.94 | 1.93 | -0.01 | buy |
| Parkman Healthcare Partners LLC | 92,871 | 107,593 | +14,722 | 0.76 | 0.82 | +0.06 | buy |
| PROFUND ADVISORS LLC | 6,506 | 15,784 | +9,278 | 0.02 | 0.04 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 25,057 | 17,952 | +7,105 | 0.01 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 9,338 | 3,319 | +6,019 | 0.04 | 0.01 | 0.00 | sell |
| Paradigm Biocapital Advisors LP | 2,385,857 | 2,389,902 | +4,045 | 6.46 | 5.24 | -1.22 | buy |
| Legato Capital Management LLC | 5,273 | 7,872 | +2,599 | 0.04 | 0.06 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 2,793 | 4,641 | +1,848 | 0.03 | 0.04 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 58,260 | 56,476 | +1,784 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 16,150 | 17,030 | +880 | 0.01 | 0.01 | +0.00 | buy |
| Bleakley Financial Group, LLC | 3,716 | 4,572 | +856 | 0.01 | 0.01 | +0.00 | buy |
| Fortitude Family Office, LLC | 224 | 356 | +132 | 0.01 | 0.01 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 11,300 | 11,400 | +100 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,589 | 1,488 | -101 | 0.06 | 0.05 | -0.01 | sell |
| Informed Momentum Co LLC | 52,895 | 43,806 | -9,089 | 0.54 | 0.43 | -0.12 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,332,545 | 1,317,213 | -15,332 | 7.38 | 6.59 | -0.79 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 115,500 | 76,800 | -38,700 | 3.76 | 3.11 | -0.65 | sell |
| STEMPOINT CAPITAL LP | 125,429 | 60,129 | -65,300 | 1.95 | 1.00 | -0.95 | sell |
| PERCEPTIVE ADVISORS LLC | 1,023,045 | 939,866 | -83,179 | 1.32 | 1.02 | -0.30 | sell |
| Ikarian Capital, LLC | 194,982 | 25,372 | -169,610 | 3.08 | 0.43 | -2.65 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | 574,464 | -175,536 | 0.09 | 0.07 | -0.02 | sell |
| Atlas Venture Life Science Advisors, LLC | 2,555,172 | 2,287,233 | -267,939 | 17.58 | 13.14 | -4.43 | sell |
| Polar Capital Holdings Plc | 546,915 | 244,928 | -301,987 | 0.19 | 0.08 | -0.11 | sell |