| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 2,385,857 | 2,389,902 | +4,045 | 6.46 | 5.24 | -1.22 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,555,172 | 2,287,233 | -267,939 | 17.58 | 13.14 | -4.43 | sell |
| ORBIMED ADVISORS LLC | 1,702,237 | 1,702,237 | 0 | 1.97 | 1.95 | -0.02 | hold |
| Bain Capital Life Sciences Investors, LLC | 1,332,545 | 1,317,213 | -15,332 | 7.38 | 6.59 | -0.79 | sell |
| STATE STREET CORP | 559,195 | 1,091,211 | +532,016 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 590,831 | 944,213 | +353,382 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,023,045 | 939,866 | -83,179 | 1.32 | 1.03 | -0.29 | sell |
| Frazier Life Sciences Management, L.P. | 785,000 | 785,000 | 0 | 2.42 | 2.06 | -0.36 | hold |
| VANGUARD GROUP INC | 764,544 | 782,751 | +18,207 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 177,726 | 670,482 | +492,756 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 464,292 | 665,535 | +201,243 | 0.50 | 0.72 | +0.23 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | 574,464 | -175,536 | 0.09 | 0.07 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 443,178 | 521,773 | +78,595 | 0.02 | 0.02 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 363,085 | 496,881 | +133,796 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 217,412 | 403,532 | +186,120 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 363,468 | 363,468 | 0 | 0.52 | 0.58 | +0.06 | hold |
| CITADEL ADVISORS LLC | 187,924 | 325,724 | +137,800 | 0.01 | 0.02 | +0.01 | buy |
| Saturn V Capital Management LP | 64,784 | 254,803 | +190,019 | 1.43 | 6.36 | +4.93 | buy |
| First Turn Management, LLC | 157,274 | 252,673 | +95,399 | 1.30 | 2.35 | +1.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 229,419 | 245,774 | +16,355 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 546,915 | 244,928 | -301,987 | 0.19 | 0.08 | -0.11 | sell |
| Foresite Capital Management V, LLC | 243,513 | 243,513 | 0 | 19.16 | 14.23 | -4.93 | hold |
| Pictet Asset Management Holding SA | 195,091 | 231,797 | +36,706 | 0.01 | 0.02 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 31,960 | 213,691 | +181,731 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 187,580 | 213,061 | +25,481 | 0.01 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 43,031 | 193,240 | +150,209 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 140,260 | 155,260 | +15,000 | 1.94 | 1.93 | -0.01 | buy |
| MORGAN STANLEY | 112,387 | 136,634 | +24,247 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 125,000 | 125,000 | 0 | 0.35 | 0.34 | -0.00 | hold |
| LORD, ABBETT & CO. LLC | 0 | 119,312 | +119,312 | 0.00 | 0.02 | +0.02 | buy |
| MPM BioImpact LLC | 50,000 | 110,779 | +60,779 | 0.68 | 1.11 | +0.43 | buy |
| Artisan Partners Limited Partnership | 0 | 109,319 | +109,319 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 92,871 | 107,593 | +14,722 | 0.76 | 0.82 | +0.06 | buy |
| Rafferty Asset Management, LLC | 39,863 | 102,865 | +63,002 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 221,424 | 102,016 | -119,408 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 95,259 | 97,388 | +2,129 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 89,725 | 92,093 | +2,368 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 16,681 | 89,253 | +72,572 | 0.00 | 0.01 | +0.00 | buy |
| Artia Global Partners LP | 0 | 87,040 | +87,040 | 0.00 | 1.33 | +1.33 | buy |
| Candriam S.C.A. | 80,000 | 80,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 115,500 | 76,800 | -38,700 | 3.76 | 3.11 | -0.65 | sell |
| Qube Research & Technologies Ltd | 50,711 | 74,777 | +24,066 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 114,068 | 71,435 | -42,633 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 62,175 | 68,403 | +6,228 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 13,622 | 63,002 | +49,380 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 40,494 | 61,500 | +21,006 | 0.27 | 0.39 | +0.12 | buy |
| STEMPOINT CAPITAL LP | 125,429 | 60,129 | -65,300 | 1.95 | 1.00 | -0.95 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 58,260 | 56,476 | -1,784 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 48,886 | +48,886 | 0.00 | 0.49 | +0.49 | buy |
| Schonfeld Strategic Advisors LLC | 22,346 | 48,579 | +26,233 | 0.01 | 0.02 | +0.01 | buy |
| Informed Momentum Co LLC | 52,895 | 43,806 | -9,089 | 0.54 | 0.43 | -0.12 | sell |
| JANE STREET GROUP, LLC | 20,845 | 40,816 | +19,971 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 20,214 | 39,264 | +19,050 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 32,117 | +32,117 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 30,504 | 26,956 | -3,548 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 194,982 | 25,372 | -169,610 | 3.08 | 0.43 | -2.65 | sell |
| Swiss National Bank | 15,800 | 23,800 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 10,000 | 23,702 | +13,702 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,889 | 22,334 | +3,445 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 19,698 | +19,698 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,686 | 19,259 | +9,573 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 18,417 | +18,417 | 0.00 | 0.46 | +0.46 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 25,057 | 17,952 | -7,105 | 0.01 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 16,150 | 17,030 | +880 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 6,506 | 15,784 | +9,278 | 0.02 | 0.04 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 23,094 | 14,711 | -8,383 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 28,464 | 14,423 | -14,041 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 13,488 | +13,488 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 12,646 | 13,132 | +486 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,882 | 12,492 | +5,610 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 3,578 | 12,473 | +8,895 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 16,029 | 12,273 | -3,756 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,600 | 11,800 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 11,300 | 11,400 | +100 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 0 | 11,255 | +11,255 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 6,762 | 8,901 | +2,139 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,782 | 8,768 | -14 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 48,280 | 8,520 | -39,760 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 2,571 | 8,193 | +5,622 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 8,160 | 8,163 | +3 | 0.00 | 0.00 | -0.00 | buy |
| Legato Capital Management LLC | 5,273 | 7,872 | +2,599 | 0.04 | 0.06 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 43,150 | 6,759 | -36,391 | 0.08 | 0.01 | -0.07 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 6,453 | +6,453 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 6,173 | +6,173 | 0.00 | 0.02 | +0.02 | buy |
| E Fund Management Co., Ltd. | 0 | 4,861 | +4,861 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 4,850 | +4,850 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 4,792 | 4,792 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 4,444 | 4,649 | +205 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 4,522 | 4,646 | +124 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,793 | 4,641 | +1,848 | 0.03 | 0.04 | +0.01 | buy |
| Bleakley Financial Group, LLC | 3,716 | 4,572 | +856 | 0.01 | 0.01 | +0.00 | buy |
| Simplicity Wealth,LLC | 0 | 4,566 | +4,566 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 11,427 | 4,560 | -6,867 | 0.02 | 0.01 | -0.01 | sell |
| FIDUCIARY TRUST CO | 4,051 | 4,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 3,500 | +3,500 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 3,385 | +3,385 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 9,338 | 3,319 | -6,019 | 0.02 | 0.01 | -0.01 | sell |
| Arizona State Retirement System | 0 | 3,317 | +3,317 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,000 | 3,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |