| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,217,815 | 1,423,259 | +205,444 | 0.04 | 0.04 | 0.00 | buy |
| Logos Global Management LP | 200,000 | 394,342 | +194,342 | 1.48 | 3.48 | +2.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 600,515 | 782,333 | +181,818 | 0.72 | 0.77 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 110,381 | 236,471 | +126,090 | 1.56 | 2.45 | +0.89 | buy |
| Woodline Partners LP | 396,600 | 502,230 | +105,630 | 0.17 | 0.16 | -0.01 | buy |
| ARMISTICE CAPITAL, LLC | 356,000 | 436,000 | +80,000 | 0.31 | 0.32 | +0.02 | buy |
| Checkpoint Capital L.P. | 185,000 | 243,311 | +58,311 | 5.97 | 6.63 | +0.66 | buy |
| Patient Square Capital LP | 56,400 | 83,000 | +26,600 | 1.34 | 1.70 | +0.37 | buy |
| Blue Owl Capital Holdings LP | 120,260 | 140,260 | +20,000 | 1.76 | 2.25 | +0.49 | buy |
| Zimmer Partners, LP | 33,100 | 42,900 | +9,800 | 0.04 | 0.04 | +0.00 | buy |
| Saturn V Capital Management LP | 509,406 | 518,177 | +8,771 | 12.65 | 12.98 | +0.33 | buy |
| Rafferty Asset Management, LLC | 27,749 | 34,041 | +6,292 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 91,490 | 87,290 | +4,200 | 0.01 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 5,537 | 7,160 | +1,623 | 0.01 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 24,067 | 25,479 | +1,412 | 0.01 | 0.01 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 14,257 | 13,621 | +636 | 0.07 | 0.06 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,310 | 6,934 | +624 | 0.04 | 0.03 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 625 | 762 | +137 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,156 | 18,200 | +44 | 0.10 | 0.09 | -0.01 | buy |
| Harvest Investment Services, LLC | 15,614 | 15,382 | -232 | 0.24 | 0.21 | -0.03 | sell |
| Nantahala Capital Management, LLC | 150,000 | 148,391 | -1,609 | 0.41 | 0.29 | -0.12 | sell |
| TD ASSET MANAGEMENT INC | 44,932 | 42,448 | -2,484 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 69,072 | 61,656 | -7,416 | 3.29 | 2.74 | -0.55 | sell |
| Sofinnova Investments, Inc. | 22,752 | 7,485 | -15,267 | 0.11 | 0.02 | -0.08 | sell |
| TCG Crossover Management, LLC | 486,957 | 465,257 | -21,700 | 3.02 | 3.15 | +0.13 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,394,637 | 1,358,254 | -36,383 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 300,000 | -50,000 | 0.04 | 0.03 | -0.01 | sell |
| Atlas Venture Life Science Advisors, LLC | 2,509,456 | 2,384,456 | -125,000 | 19.41 | 22.69 | +3.27 | sell |
| Paradigm Biocapital Advisors LP | 1,497,720 | 1,210,971 | -286,749 | 3.30 | 2.77 | -0.54 | sell |
| ORBIMED ADVISORS LLC | 1,785,571 | 1,415,020 | -370,551 | 2.35 | 1.69 | -0.66 | sell |