| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,577,106 | +1,577,106 | 0.00 | 1.31 | +1.31 | buy |
| FMR LLC | 1,866,248 | 3,224,381 | +1,358,133 | 0.01 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 0 | 1,071,865 | +1,071,865 | 0.00 | 3.00 | +3.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,395,405 | 2,343,499 | +948,094 | 0.02 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 61,017 | 759,338 | +698,321 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,068,246 | 1,305,046 | +236,800 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 1,859,732 | 2,094,560 | +234,828 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,217,815 | 1,423,259 | +205,444 | 0.04 | 0.04 | +0.00 | buy |
| Logos Global Management LP | 200,000 | 394,342 | +194,342 | 1.48 | 3.48 | +2.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 600,515 | 782,333 | +181,818 | 0.72 | 0.77 | +0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 181,818 | +181,818 | 0.00 | 0.18 | +0.18 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 150,000 | +150,000 | 0.00 | 0.26 | +0.26 | buy |
| STATE STREET CORP | 768,735 | 918,567 | +149,832 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 81,190 | 219,603 | +138,413 | 0.01 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 110,381 | 236,471 | +126,090 | 1.56 | 2.45 | +0.89 | buy |
| Woodline Partners LP | 396,600 | 502,230 | +105,630 | 0.17 | 0.16 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 86,420 | 191,220 | +104,800 | 0.01 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 7,879 | 108,499 | +100,620 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 472,706 | 571,984 | +99,278 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 0 | 85,000 | +85,000 | 0.00 | 0.94 | +0.94 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.16 | +0.16 | buy |
| ARMISTICE CAPITAL, LLC | 356,000 | 436,000 | +80,000 | 0.52 | 0.58 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 5,278 | 67,905 | +62,627 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 185,000 | 243,311 | +58,311 | 5.97 | 6.63 | +0.66 | buy |
| UBS Group AG | 24,342 | 72,628 | +48,286 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 45,448 | +45,448 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,807 | 70,941 | +42,134 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 40,000 | 72,513 | +32,513 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 165,072 | 194,725 | +29,653 | 0.00 | 0.00 | -0.00 | buy |
| Patient Square Capital LP | 56,400 | 83,000 | +26,600 | 1.34 | 1.70 | +0.37 | buy |
| Ghisallo Capital Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.11 | +0.11 | buy |
| Atom Investors LP | 0 | 22,561 | +22,561 | 0.00 | 0.14 | +0.14 | buy |
| NORTHERN TRUST CORP | 187,017 | 208,813 | +21,796 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 150,024 | 170,210 | +20,186 | 0.00 | 0.00 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 120,260 | 140,260 | +20,000 | 1.76 | 2.25 | +0.49 | buy |
| BANK OF AMERICA CORP /DE/ | 35,345 | 53,808 | +18,463 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 13,565 | +13,565 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 12,188 | +12,188 | 0.00 | 0.02 | +0.02 | buy |
| Zimmer Partners, LP | 33,100 | 42,900 | +9,800 | 0.04 | 0.04 | +0.01 | buy |
| Saturn V Capital Management LP | 509,406 | 518,177 | +8,771 | 12.65 | 12.98 | +0.33 | buy |
| Quantbot Technologies LP | 4 | 7,565 | +7,561 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 6,391 | +6,391 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 27,749 | 34,041 | +6,292 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 8,076 | 14,329 | +6,253 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 57,261 | 63,503 | +6,242 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 900 | 7,000 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 5,851 | +5,851 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 5,800 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 40,064 | 45,708 | +5,644 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,114 | 10,286 | +5,172 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 5,064 | +5,064 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,531 | 20,152 | +4,621 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 4,279 | +4,279 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 4,217 | +4,217 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 12,851 | 16,810 | +3,959 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 32,200 | 35,900 | +3,700 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 93,103 | 96,557 | +3,454 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 29,036 | 32,144 | +3,108 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 7,890 | 10,948 | +3,058 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 10,881 | 13,834 | +2,953 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,331 | 15,138 | +2,807 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 17,688 | 20,415 | +2,727 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 4,900 | 7,552 | +2,652 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 2,556 | +2,556 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,459 | 40,585 | +2,126 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,778 | 22,836 | +2,058 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,840 | +1,840 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 5,537 | 7,160 | +1,623 | 0.01 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 24,067 | 25,479 | +1,412 | 0.01 | 0.01 | -0.00 | buy |
| Corebridge Financial, Inc. | 9,809 | 11,180 | +1,371 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 12,132 | 13,454 | +1,322 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 7 | 947 | +940 | 0.00 | 0.03 | +0.03 | buy |
| Pictet Asset Management Holding SA | 129,482 | 130,386 | +904 | 0.01 | 0.01 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,107 | 4,890 | +783 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,310 | 6,934 | +624 | 0.04 | 0.03 | -0.01 | buy |
| Arizona State Retirement System | 4,725 | 5,315 | +590 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 54 | 577 | +523 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 42,635 | 42,975 | +340 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,999 | 2,309 | +310 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 80 | 333 | +253 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 568 | 787 | +219 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,867 | 3,076 | +209 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 992 | 1,157 | +165 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 625 | 762 | +137 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4,857 | 4,965 | +108 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 5,862 | 5,951 | +89 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,156 | 18,200 | +44 | 0.10 | 0.09 | -0.01 | buy |
| US BANCORP \DE\ | 1,176 | 1,203 | +27 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 30 | 45 | +15 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 239 | 250 | +11 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 1 | 7 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 1 | 4 | +3 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 15 | 17 | +2 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |