| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,450,222 | 5,586,894 | +136,672 | 0.02 | 0.02 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,976,132 | 2,450,221 | +474,089 | 1.61 | 1.66 | +0.05 | buy |
| BlackRock, Inc. | 2,274,980 | 2,273,831 | -1,149 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,518,274 | 1,735,376 | +217,102 | 0.02 | 0.02 | -0.00 | buy |
| STATE STREET CORP | 1,187,991 | 1,698,244 | +510,253 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,698,005 | 1,549,350 | -148,655 | 0.01 | 0.01 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 1,513,875 | 1,513,875 | 0 | 13.90 | 12.25 | -1.64 | hold |
| JPMORGAN CHASE & CO | 1,581,127 | 1,371,480 | -209,647 | 0.01 | 0.01 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,260,000 | 1,354,852 | +94,852 | 2.69 | 2.23 | -0.46 | buy |
| TCG Crossover Management, LLC | 0 | 1,341,862 | +1,341,862 | 0.00 | 2.45 | +2.45 | buy |
| BVF INC/IL | 650,000 | 1,272,312 | +622,312 | 1.74 | 2.59 | +0.85 | buy |
| ORBIMED ADVISORS LLC | 1,067,550 | 1,067,550 | 0 | 1.73 | 1.49 | -0.25 | hold |
| Siren, L.L.C. | 988,401 | 988,401 | 0 | 2.34 | 1.75 | -0.59 | hold |
| Woodline Partners LP | 957,833 | 958,281 | +448 | 0.29 | 0.23 | -0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 684,958 | 744,222 | +59,264 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 735,000 | 700,000 | -35,000 | 2.14 | 1.25 | -0.89 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 511,163 | 657,000 | +145,837 | 0.52 | 0.50 | -0.02 | buy |
| GOLDMAN SACHS GROUP INC | 754,195 | 639,842 | -114,353 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 532,079 | 610,382 | +78,303 | 0.03 | 0.03 | +0.00 | buy |
| Logos Global Management LP | 510,000 | 560,000 | +50,000 | 2.70 | 1.84 | -0.85 | buy |
| Assenagon Asset Management S.A. | 357,836 | 546,247 | +188,411 | 0.04 | 0.06 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 499,391 | 536,000 | +36,609 | 0.97 | 1.13 | +0.16 | buy |
| Bellevue Group AG | 0 | 459,314 | +459,314 | 0.00 | 0.70 | +0.70 | buy |
| Saturn V Capital Management LP | 298,429 | 449,926 | +151,497 | 4.35 | 5.21 | +0.86 | buy |
| Opaleye Management Inc. | 200,000 | 421,000 | +221,000 | 2.10 | 3.55 | +1.45 | buy |
| Palo Alto Investors LP | 317,456 | 401,719 | +84,263 | 3.51 | 3.93 | +0.42 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,392 | 395,572 | +180 | 0.49 | 0.42 | -0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 223,575 | 394,447 | +170,872 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 394,374 | 387,005 | -7,369 | 0.03 | 0.03 | -0.00 | sell |
| Aberdeen Group plc | 234,358 | 375,614 | +141,256 | 0.03 | 0.04 | +0.01 | buy |
| Foresite Capital Management V, LLC | 299,069 | 374,069 | +75,000 | 14.45 | 8.83 | -5.62 | buy |
| BAKER BROS. ADVISORS LP | 337,050 | 349,657 | +12,607 | 0.16 | 0.13 | -0.03 | buy |
| LOOMIS SAYLES & CO L P | 282,409 | 317,222 | +34,813 | 0.03 | 0.03 | +0.00 | buy |
| Checkpoint Capital L.P. | 452,992 | 286,661 | -166,331 | 11.40 | 6.58 | -4.82 | sell |
| Octagon Capital Advisors LP | 0 | 270,000 | +270,000 | 0.00 | 1.91 | +1.91 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,039 | 251,195 | +4,156 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 228,070 | 247,195 | +19,125 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 67,707 | 204,968 | +137,261 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 196,028 | +196,028 | 0.00 | 1.48 | +1.48 | buy |
| Ensign Peak Advisors, Inc | 177,050 | 191,487 | +14,437 | 0.02 | 0.02 | -0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 170,000 | +170,000 | 0.00 | 0.58 | +0.58 | buy |
| BANK OF AMERICA CORP /DE/ | 135,986 | 166,775 | +30,789 | 0.00 | 0.00 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 141,234 | +141,234 | 0.00 | 0.81 | +0.81 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 122,153 | 127,737 | +5,584 | 0.01 | 0.01 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 50,000 | 125,000 | +75,000 | 0.01 | 0.02 | +0.01 | buy |
| Catalio Capital Management, LP | 110,427 | 122,978 | +12,551 | 1.55 | 1.64 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114,351 | 110,890 | -3,461 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,324 | 108,286 | +98,962 | 0.02 | 0.15 | +0.13 | buy |
| Atle Fund Management AB | 47,967 | 107,255 | +59,288 | 1.22 | 1.03 | -0.19 | buy |
| UBS Group AG | 116,112 | 98,621 | -17,491 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 100,395 | 97,930 | -2,465 | 0.01 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 84,255 | 96,755 | +12,500 | 0.02 | 0.02 | -0.00 | buy |
| MORGAN STANLEY | 74,826 | 94,264 | +19,438 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 184,779 | 83,259 | -101,520 | 0.01 | 0.00 | -0.01 | sell |
| Jump Financial, LLC | 0 | 81,829 | +81,829 | 0.00 | 0.08 | +0.08 | buy |
| Sofinnova Investments, Inc. | 111,010 | 78,320 | -32,690 | 0.38 | 0.25 | -0.13 | sell |
| Freestone Grove Partners LP | 0 | 68,687 | +68,687 | 0.00 | 0.03 | +0.03 | buy |
| iA Global Asset Management Inc. | 66,430 | 66,243 | -187 | 0.07 | 0.06 | -0.01 | sell |
| Sio Capital Management, LLC | 57,586 | 65,203 | +7,617 | 0.76 | 0.60 | -0.16 | buy |
| Casdin Capital, LLC | 0 | 65,000 | +65,000 | 0.00 | 0.31 | +0.31 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 57,796 | +57,796 | 0.00 | 0.13 | +0.13 | buy |
| Rafferty Asset Management, LLC | 36,093 | 53,869 | +17,776 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 53,538 | +53,538 | 0.00 | 0.59 | +0.59 | buy |
| Nuveen, LLC | 48,471 | 51,380 | +2,909 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50,103 | 50,959 | +856 | 0.00 | 0.00 | -0.00 | buy |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.26 | 0.16 | -0.10 | hold |
| Swiss National Bank | 48,000 | 48,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 82,984 | 45,837 | -37,147 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 80,274 | 44,700 | -35,574 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 40,203 | 39,910 | -293 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 58,053 | 39,400 | -18,653 | 0.01 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 27,301 | 38,006 | +10,705 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 35,000 | 35,000 | 0 | 0.21 | 0.15 | -0.06 | hold |
| XTX Topco Ltd | 23,094 | 34,418 | +11,324 | 0.05 | 0.04 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,256 | 34,382 | +11,126 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 99,612 | 33,267 | -66,345 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 29,833 | 33,058 | +3,225 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,510 | 32,493 | -20,017 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 49,713 | 32,406 | -17,307 | 0.07 | 0.02 | -0.05 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 62,820 | 31,820 | -31,000 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 15,754 | 31,709 | +15,955 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 31,002 | 31,058 | +56 | 0.01 | 0.01 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 66,125 | 31,002 | -35,123 | 0.03 | 0.01 | -0.02 | sell |
| Invesco Ltd. | 61,070 | 30,638 | -30,432 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 69,634 | 30,476 | -39,158 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 30,000 | 30,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 76,338 | 29,218 | -47,120 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 24,826 | 28,773 | +3,947 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 132,800 | 25,653 | -107,147 | 0.63 | 0.10 | -0.53 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 25,200 | 25,292 | +92 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,540 | 24,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 20,523 | 24,401 | +3,878 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 13,478 | 23,972 | +10,494 | 0.03 | 0.06 | +0.02 | buy |
| ALGERT GLOBAL LLC | 0 | 22,680 | +22,680 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 21,378 | +21,378 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 23,653 | 19,377 | -4,276 | 0.00 | 0.00 | -0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 16,156 | 18,993 | +2,837 | 0.01 | 0.01 | -0.00 | buy |
| Zimmer Partners, LP | 27,500 | 16,700 | -10,800 | 0.06 | 0.03 | -0.03 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,711 | 16,699 | +2,988 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 15,510 | +15,510 | 0.00 | 0.00 | +0.00 | buy |