| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 1,341,862 | +1,341,862 | 0.00 | 2.45 | +2.45 | buy |
| BVF INC/IL | 650,000 | 1,272,312 | +622,312 | 1.74 | 2.59 | +0.85 | buy |
| STATE STREET CORP | 1,187,991 | 1,698,244 | +510,253 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,976,132 | 2,450,221 | +474,089 | 1.61 | 1.66 | +0.05 | buy |
| Bellevue Group AG | 0 | 459,314 | +459,314 | 0.00 | 0.70 | +0.70 | buy |
| Octagon Capital Advisors LP | 0 | 270,000 | +270,000 | 0.00 | 1.91 | +1.91 | buy |
| Opaleye Management Inc. | 200,000 | 421,000 | +221,000 | 2.10 | 3.55 | +1.45 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,518,274 | 1,735,376 | +217,102 | 0.02 | 0.02 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 196,028 | +196,028 | 0.00 | 1.48 | +1.48 | buy |
| Assenagon Asset Management S.A. | 357,836 | 546,247 | +188,411 | 0.04 | 0.06 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 223,575 | 394,447 | +170,872 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 170,000 | +170,000 | 0.00 | 0.58 | +0.58 | buy |
| Saturn V Capital Management LP | 298,429 | 449,926 | +151,497 | 4.35 | 5.21 | +0.86 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 511,163 | 657,000 | +145,837 | 0.52 | 0.50 | -0.02 | buy |
| Aberdeen Group plc | 234,358 | 375,614 | +141,256 | 0.03 | 0.04 | +0.01 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 141,234 | +141,234 | 0.00 | 0.81 | +0.81 | buy |
| Bank of New York Mellon Corp | 67,707 | 204,968 | +137,261 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,450,222 | 5,586,894 | +136,672 | 0.02 | 0.02 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,324 | 108,286 | +98,962 | 0.02 | 0.15 | +0.13 | buy |
| Frazier Life Sciences Management, L.P. | 1,260,000 | 1,354,852 | +94,852 | 2.69 | 2.23 | -0.46 | buy |
| Palo Alto Investors LP | 317,456 | 401,719 | +84,263 | 3.51 | 3.93 | +0.42 | buy |
| Jump Financial, LLC | 0 | 81,829 | +81,829 | 0.00 | 0.08 | +0.08 | buy |
| JENNISON ASSOCIATES LLC | 532,079 | 610,382 | +78,303 | 0.03 | 0.03 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 50,000 | 125,000 | +75,000 | 0.01 | 0.02 | +0.01 | buy |
| Foresite Capital Management V, LLC | 299,069 | 374,069 | +75,000 | 14.45 | 8.83 | -5.62 | buy |
| Freestone Grove Partners LP | 0 | 68,687 | +68,687 | 0.00 | 0.03 | +0.03 | buy |
| Casdin Capital, LLC | 0 | 65,000 | +65,000 | 0.00 | 0.31 | +0.31 | buy |
| Atle Fund Management AB | 47,967 | 107,255 | +59,288 | 1.22 | 1.03 | -0.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 684,958 | 744,222 | +59,264 | 0.00 | 0.00 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 57,796 | +57,796 | 0.00 | 0.13 | +0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 53,538 | +53,538 | 0.00 | 0.59 | +0.59 | buy |
| Logos Global Management LP | 510,000 | 560,000 | +50,000 | 2.70 | 1.84 | -0.85 | buy |
| ARMISTICE CAPITAL, LLC | 499,391 | 536,000 | +36,609 | 0.97 | 1.13 | +0.16 | buy |
| LOOMIS SAYLES & CO L P | 282,409 | 317,222 | +34,813 | 0.03 | 0.03 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 135,986 | 166,775 | +30,789 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 22,680 | +22,680 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 21,378 | +21,378 | 0.00 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 74,826 | 94,264 | +19,438 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 228,070 | 247,195 | +19,125 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 36,093 | 53,869 | +17,776 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 15,754 | 31,709 | +15,955 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 15,510 | +15,510 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 14,611 | +14,611 | 0.00 | 0.11 | +0.11 | buy |
| Ensign Peak Advisors, Inc | 177,050 | 191,487 | +14,437 | 0.02 | 0.02 | -0.00 | buy |
| SummitTX Capital, L.P. | 0 | 13,820 | +13,820 | 0.00 | 0.03 | +0.03 | buy |
| BAKER BROS. ADVISORS LP | 337,050 | 349,657 | +12,607 | 0.16 | 0.13 | -0.03 | buy |
| Catalio Capital Management, LP | 110,427 | 122,978 | +12,551 | 1.55 | 1.64 | +0.09 | buy |
| DnB Asset Management AS | 84,255 | 96,755 | +12,500 | 0.02 | 0.02 | -0.00 | buy |
| Atom Investors LP | 0 | 12,162 | +12,162 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 23,094 | 34,418 | +11,324 | 0.05 | 0.04 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,256 | 34,382 | +11,126 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 27,301 | 38,006 | +10,705 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 13,478 | 23,972 | +10,494 | 0.03 | 0.06 | +0.02 | buy |
| Man Group plc | 0 | 10,006 | +10,006 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 57,586 | 65,203 | +7,617 | 0.76 | 0.60 | -0.16 | buy |
| E Fund Management Co., Ltd. | 0 | 6,772 | +6,772 | 0.00 | 0.01 | +0.01 | buy |
| INCEPTIONR LLC | 0 | 6,489 | +6,489 | 0.00 | 0.10 | +0.10 | buy |
| EntryPoint Capital, LLC | 0 | 6,371 | +6,371 | 0.00 | 0.12 | +0.12 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 6,265 | +6,265 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,309 | 15,406 | +6,097 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 122,153 | 127,737 | +5,584 | 0.01 | 0.01 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 776 | 6,017 | +5,241 | 0.00 | 0.01 | +0.01 | buy |
| Eleva Capital SAS | 0 | 5,115 | +5,115 | 0.00 | 0.10 | +0.10 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 4,265 | +4,265 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,039 | 251,195 | +4,156 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF MONTREAL /CAN/ | 24,826 | 28,773 | +3,947 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 20,523 | 24,401 | +3,878 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 5,460 | 9,270 | +3,810 | 0.01 | 0.01 | +0.00 | buy |
| Virtu Financial LLC | 0 | 3,786 | +3,786 | 0.00 | 0.01 | +0.01 | buy |
| Bayforest Capital Ltd | 0 | 3,564 | +3,564 | 0.00 | 0.26 | +0.26 | buy |
| RHUMBLINE ADVISERS | 29,833 | 33,058 | +3,225 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,711 | 16,699 | +2,988 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 48,471 | 51,380 | +2,909 | 0.00 | 0.00 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 16,156 | 18,993 | +2,837 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,988 | 5,640 | +2,652 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 1,627 | +1,627 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,832 | 15,065 | +1,233 | 0.01 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50,103 | 50,959 | +856 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 232 | 1,001 | +769 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,716 | 7,474 | +758 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 693 | +693 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,751 | 8,372 | +621 | 0.05 | 0.04 | -0.01 | buy |
| Allworth Financial LP | 7 | 599 | +592 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 957,833 | 958,281 | +448 | 0.29 | 0.23 | -0.06 | buy |
| Entropy Technologies, LP | 4,357 | 4,788 | +431 | 0.02 | 0.01 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 287 | +287 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 2,059 | 2,248 | +189 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,392 | 395,572 | +180 | 0.49 | 0.42 | -0.07 | buy |
| Kemnay Advisory Services Inc. | 69 | 246 | +177 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,834 | 1,990 | +156 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 14,007 | 14,155 | +148 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 63 | 194 | +131 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 742 | 848 | +106 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 25,200 | 25,292 | +92 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 2,897 | 2,967 | +70 | 0.06 | 0.05 | -0.01 | buy |
| ANTIPODES PARTNERS Ltd | 419 | 476 | +57 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 31,002 | 31,058 | +56 | 0.01 | 0.01 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 73 | 92 | +19 | 0.00 | 0.00 | -0.00 | buy |