| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 785,000 | 1,754,834 | +969,834 | 2.06 | 3.70 | +1.64 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,317,213 | 1,795,735 | +478,522 | 6.59 | 8.89 | +2.29 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 665,535 | 1,023,265 | +357,730 | 0.72 | 0.77 | +0.05 | buy |
| Paradigm Biocapital Advisors LP | 2,389,902 | 2,704,718 | +314,816 | 5.24 | 4.67 | -0.57 | buy |
| Saturn V Capital Management LP | 254,803 | 503,089 | +248,286 | 6.36 | 8.57 | +2.21 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,287,233 | 2,509,456 | +222,223 | 13.14 | 11.91 | -1.23 | buy |
| MPM BioImpact LLC | 110,779 | 305,658 | +194,879 | 1.11 | 2.14 | +1.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 944,213 | 1,122,194 | +177,981 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 213,061 | 312,049 | +98,988 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,702,237 | 1,785,571 | +83,334 | 1.95 | 1.60 | -0.35 | buy |
| JANUS HENDERSON GROUP PLC | 521,773 | 445,873 | +75,900 | 0.02 | 0.01 | 0.00 | sell |
| Blue Owl Capital Holdings LP | 155,260 | 215,260 | +60,000 | 1.93 | 2.70 | +0.77 | buy |
| Foresite Capital Management V, LLC | 243,513 | 299,069 | +55,556 | 14.23 | 8.61 | -5.63 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 574,464 | 618,501 | +44,037 | 0.07 | 0.05 | -0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 56,476 | 92,139 | +35,663 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 6,173 | 29,256 | +23,083 | 0.02 | 0.07 | +0.05 | buy |
| PROFUND ADVISORS LLC | 15,784 | 4,586 | +11,198 | 0.04 | 0.01 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 3,319 | 13,319 | +10,000 | 0.01 | 0.04 | 0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 48,886 | 58,044 | +9,158 | 0.43 | 0.36 | -0.07 | buy |
| EntryPoint Capital, LLC | 273 | 3,331 | +3,058 | 0.02 | 0.22 | +0.20 | buy |
| ALPS ADVISORS INC | 17,030 | 19,302 | +2,272 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,488 | 2,312 | +824 | 0.05 | 0.05 | +0.00 | buy |
| Harvest Investment Services, LLC | 18,417 | 17,815 | -602 | 0.46 | 0.32 | -0.14 | sell |
| China Universal Asset Management Co., Ltd. | 4,641 | 2,904 | -1,737 | 0.04 | 0.02 | -0.02 | sell |
| Artia Global Partners LP | 87,040 | 13,440 | -73,600 | 1.33 | 0.16 | -1.17 | sell |
| Rafferty Asset Management, LLC | 102,865 | 23,983 | -78,882 | 0.02 | 0.00 | -0.02 | sell |
| First Turn Management, LLC | 252,673 | 138,907 | -113,766 | 2.35 | 1.02 | -1.33 | sell |
| PERCEPTIVE ADVISORS LLC | 939,866 | 553,437 | -386,429 | 1.02 | 0.60 | -0.42 | sell |