| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 670,482 | 1,756,495 | +1,086,013 | 0.01 | 0.01 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 785,000 | 1,754,834 | +969,834 | 2.06 | 3.70 | +1.64 | buy |
| Logos Global Management LP | 0 | 925,000 | +925,000 | 0.00 | 4.80 | +4.80 | buy |
| Point72 Asset Management, L.P. | 0 | 761,429 | +761,429 | 0.00 | 0.11 | +0.11 | buy |
| TCG Crossover Management, LLC | 0 | 486,957 | +486,957 | 0.00 | 2.29 | +2.29 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,317,213 | 1,795,735 | +478,522 | 6.59 | 8.89 | +2.29 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 665,535 | 1,023,265 | +357,730 | 0.72 | 0.77 | +0.05 | buy |
| VANGUARD GROUP INC | 782,751 | 1,111,424 | +328,673 | 0.00 | 0.00 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,389,902 | 2,704,718 | +314,816 | 5.24 | 4.67 | -0.57 | buy |
| Woodline Partners LP | 0 | 267,863 | +267,863 | 0.00 | 0.12 | +0.12 | buy |
| Saturn V Capital Management LP | 254,803 | 503,089 | +248,286 | 6.36 | 8.57 | +2.21 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,287,233 | 2,509,456 | +222,223 | 13.14 | 11.91 | -1.23 | buy |
| MPM BioImpact LLC | 110,779 | 305,658 | +194,879 | 1.11 | 2.14 | +1.03 | buy |
| Sio Capital Management, LLC | 0 | 192,000 | +192,000 | 0.00 | 3.26 | +3.26 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 944,213 | 1,122,194 | +177,981 | 0.01 | 0.01 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 166,500 | +166,500 | 0.00 | 4.47 | +4.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 245,774 | 403,736 | +157,962 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.68 | +0.68 | buy |
| Walleye Capital LLC | 11,255 | 136,096 | +124,841 | 0.01 | 0.06 | +0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 101,187 | +101,187 | 0.00 | 1.13 | +1.13 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 213,061 | 312,049 | +98,988 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,702,237 | 1,785,571 | +83,334 | 1.95 | 1.60 | -0.35 | buy |
| Exome Asset Management LLC | 0 | 61,000 | +61,000 | 0.00 | 2.45 | +2.45 | buy |
| Blue Owl Capital Holdings LP | 155,260 | 215,260 | +60,000 | 1.93 | 2.70 | +0.77 | buy |
| Foresite Capital Management V, LLC | 243,513 | 299,069 | +55,556 | 14.23 | 8.61 | -5.63 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,093 | 141,153 | +49,060 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 574,464 | 618,501 | +44,037 | 0.07 | 0.05 | -0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 56,476 | 92,139 | +35,663 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 34,400 | +34,400 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 26,956 | 51,050 | +24,094 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 6,173 | 29,256 | +23,083 | 0.02 | 0.08 | +0.06 | buy |
| Trexquant Investment LP | 0 | 18,601 | +18,601 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 63,002 | 77,678 | +14,676 | 0.00 | 0.00 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 14,102 | +14,102 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 12,300 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 12,103 | +12,103 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 13,132 | 24,447 | +11,315 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,850 | 15,337 | +10,487 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 10,275 | +10,275 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 3,500 | 13,600 | +10,100 | 0.01 | 0.05 | +0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 3,319 | 13,319 | +10,000 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 403,532 | 413,097 | +9,565 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 9,475 | +9,475 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 48,886 | 58,044 | +9,158 | 0.49 | 0.43 | -0.07 | buy |
| Swiss National Bank | 23,800 | 32,000 | +8,200 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 6,642 | +6,642 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,901 | 14,978 | +6,077 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,334 | 28,294 | +5,960 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 5,298 | +5,298 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 8,768 | 13,982 | +5,214 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 4,792 | 9,642 | +4,850 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,800 | 15,948 | +4,148 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,193 | 11,746 | +3,553 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 14,423 | 17,943 | +3,520 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 273 | 3,331 | +3,058 | 0.02 | 0.07 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,867 | +2,867 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,074 | 3,927 | +2,853 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,400 | +2,400 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 17,030 | 19,302 | +2,272 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 4,646 | 6,813 | +2,167 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 1,824 | +1,824 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 12,273 | 13,998 | +1,725 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 8,163 | 9,718 | +1,555 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 39,264 | 40,732 | +1,468 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,492 | 13,908 | +1,416 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 2,824 | 4,071 | +1,247 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 97,388 | 98,375 | +987 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 832 | +832 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,488 | 2,312 | +824 | 0.05 | 0.05 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 738 | +738 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 885 | 1,610 | +725 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 321 | 568 | +247 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 200 | +200 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 10 | 32 | +22 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 10 | 21 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1 | 11 | +10 | 0.00 | 0.00 | 0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Amundi | 717 | 717 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artisan Partners Limited Partnership | 109,319 | 109,319 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polar Capital Holdings Plc | 244,928 | 244,928 | 0 | 0.08 | 0.07 | -0.01 | hold |
| US BANCORP \DE\ | 1,176 | 1,176 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Avior Wealth Management, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 23,702 | 23,700 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 10 | 2 | -8 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 19 | 3 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Private Wealth Management Group, LLC | 21 | 0 | -21 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 99 | 59 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 477 | 136 | -341 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 356 | 0 | -356 | 0.01 | 0.00 | -0.01 | sell |
| CIBC Private Wealth Group LLC | 388 | 0 | -388 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 529 | 0 | -529 | 0.00 | 0.00 | -0.00 | sell |
| Harvest Investment Services, LLC | 18,417 | 17,815 | -602 | 0.46 | 0.32 | -0.14 | sell |
| ADAR1 Capital Management, LLC | 896 | 0 | -896 | 0.02 | 0.00 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 4,641 | 2,904 | -1,737 | 0.04 | 0.02 | -0.02 | sell |