| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 502,230 | 866,955 | +364,725 | 0.16 | 0.24 | +0.08 | buy |
| Logos Global Management LP | 394,342 | 700,000 | +305,658 | 3.48 | 4.95 | +1.47 | buy |
| First Turn Management, LLC | 0 | 299,464 | +299,464 | 0.00 | 2.96 | +2.96 | buy |
| BAKER BROS. ADVISORS LP | 77,050 | 337,050 | +260,000 | 0.04 | 0.17 | +0.13 | buy |
| Sio Capital Management, LLC | 73,511 | 284,787 | +211,276 | 1.11 | 6.05 | +4.95 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,358,254 | 1,515,625 | +157,371 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 450,000 | +150,000 | 0.03 | 0.04 | +0.01 | buy |
| Palo Alto Investors LP | 0 | 145,691 | +145,691 | 0.00 | 1.64 | +1.64 | buy |
| Vestal Point Capital, LP | 0 | 140,000 | +140,000 | 0.00 | 0.39 | +0.39 | buy |
| Nantahala Capital Management, LLC | 148,391 | 287,800 | +139,409 | 0.61 | 1.08 | +0.47 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 782,333 | 919,403 | +137,070 | 0.77 | 0.88 | +0.11 | buy |
| JANUS HENDERSON GROUP PLC | 1,423,259 | 1,553,961 | +130,702 | 0.04 | 0.04 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 181,818 | 308,030 | +126,212 | 0.18 | 0.29 | +0.11 | buy |
| BANK OF AMERICA CORP /DE/ | 53,808 | 168,822 | +115,014 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 85,000 | 186,418 | +101,418 | 0.94 | 2.00 | +1.06 | buy |
| GOLDMAN SACHS GROUP INC | 130,751 | 225,856 | +95,105 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,305,046 | 1,396,736 | +91,690 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 759,338 | 843,616 | +84,278 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 72,628 | 145,549 | +72,921 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 72,513 | 141,545 | +69,032 | 0.01 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 0 | 54,445 | +54,445 | 0.00 | 0.26 | +0.26 | buy |
| AMERIPRISE FINANCIAL INC | 67,905 | 121,520 | +53,615 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 139,393 | 192,856 | +53,463 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 42,900 | 90,163 | +47,263 | 0.04 | 0.11 | +0.07 | buy |
| ExodusPoint Capital Management, LP | 13,565 | 57,945 | +44,380 | 0.01 | 0.04 | +0.03 | buy |
| BARCLAYS PLC | 45,708 | 86,558 | +40,850 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 32,061 | +32,061 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 30,799 | +30,799 | 0.00 | 0.14 | +0.14 | buy |
| Catalio Capital Management, LP | 0 | 30,661 | +30,661 | 0.00 | 0.34 | +0.34 | buy |
| Bollard Group LLC | 0 | 30,635 | +30,635 | 0.00 | 0.04 | +0.04 | buy |
| Siren, L.L.C. | 1,071,865 | 1,099,401 | +27,536 | 3.00 | 3.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 571,984 | 598,589 | +26,605 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 96,557 | 121,584 | +25,027 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 0 | 24,652 | +24,652 | 0.00 | 0.56 | +0.56 | buy |
| ROYAL BANK OF CANADA | 0 | 22,599 | +22,599 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 243,311 | 265,000 | +21,689 | 6.63 | 6.54 | -0.09 | buy |
| FMR LLC | 3,224,381 | 3,245,710 | +21,329 | 0.01 | 0.01 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 19,726 | +19,726 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 13,649 | +13,649 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,585 | 51,836 | +11,251 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 918,567 | 929,768 | +11,201 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 42,448 | 53,048 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,276 | 16,852 | +10,576 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 208,813 | 219,095 | +10,282 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 10,246 | +10,246 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 194,725 | 204,241 | +9,516 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 9,382 | +9,382 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 63,503 | 71,502 | +7,999 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 7,228 | +7,228 | 0.00 | 0.05 | +0.05 | buy |
| Swiss National Bank | 35,900 | 42,900 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 5,851 | 10,988 | +5,137 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 4,050 | 9,129 | +5,079 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,941 | 75,997 | +5,056 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 0 | 4,583 | +4,583 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 193,664 | 197,824 | +4,160 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 20,415 | 24,097 | +3,682 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 32,144 | 35,755 | +3,611 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 83,276 | 86,487 | +3,211 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 823 | 3,975 | +3,152 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,060 | 24,140 | +3,080 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 13,834 | 16,817 | +2,983 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 2,244 | +2,244 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 14,705 | 16,717 | +2,012 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 23,700 | 25,140 | +1,440 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,454 | 14,854 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,948 | 12,222 | +1,274 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 5,315 | 6,534 | +1,219 | 0.00 | 0.00 | +0.00 | buy |
| Avanza Fonder AB | 0 | 1,083 | +1,083 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4,965 | 6,017 | +1,052 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 6,391 | 7,376 | +985 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 11,983 | 12,889 | +906 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 3,700 | 4,600 | +900 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 5,951 | 6,695 | +744 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 333 | 1,044 | +711 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,890 | 5,490 | +600 | 0.00 | 0.00 | +0.00 | buy |
| iA Global Asset Management Inc. | 0 | 322 | +322 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 6,458 | 6,733 | +275 | 0.12 | 0.13 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 2,309 | 2,515 | +206 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 81 | 284 | +203 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 202 | +202 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,157 | 1,338 | +181 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 46 | 148 | +102 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,152 | 20,250 | +98 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 10 | 72 | +62 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,934 | 6,956 | +22 | 0.03 | 0.03 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 525 | 533 | +8 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 17 | 25 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 10 | 16 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 1,415,020 | 1,415,020 | 0 | 1.69 | 1.88 | +0.20 | hold |
| ASSETMARK, INC | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,577,106 | 1,577,106 | 0 | 1.31 | 1.41 | +0.10 | hold |
| Daiwa Securities Group Inc. | 113 | 113 | 0 | 0.00 | 0.00 | -0.00 | hold |
| J.Safra Asset Management Corp | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ARMISTICE CAPITAL, LLC | 436,000 | 436,000 | 0 | 0.58 | 0.88 | +0.30 | hold |