| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 502,230 | 866,955 | +364,725 | 0.16 | 0.24 | +0.08 | buy |
| Logos Global Management LP | 394,342 | 700,000 | +305,658 | 3.48 | 4.95 | +1.47 | buy |
| BAKER BROS. ADVISORS LP | 77,050 | 337,050 | +260,000 | 0.04 | 0.17 | +0.13 | buy |
| Sio Capital Management, LLC | 73,511 | 284,787 | +211,276 | 1.09 | 5.76 | +4.67 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,358,254 | 1,515,625 | +157,371 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 450,000 | +150,000 | 0.03 | 0.04 | +0.01 | buy |
| Nantahala Capital Management, LLC | 148,391 | 287,800 | +139,409 | 0.29 | 0.60 | +0.30 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 782,333 | 919,403 | +137,070 | 0.77 | 0.88 | +0.12 | buy |
| JANUS HENDERSON GROUP PLC | 1,423,259 | 1,553,961 | +130,702 | 0.04 | 0.04 | 0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 181,818 | 308,030 | +126,212 | 0.18 | 0.29 | +0.11 | buy |
| Opaleye Management Inc. | 85,000 | 186,418 | +101,418 | 0.94 | 2.00 | +1.06 | buy |
| Zimmer Partners, LP | 42,900 | 90,163 | +47,263 | 0.04 | 0.10 | +0.06 | buy |
| Siren, L.L.C. | 1,071,865 | 1,099,401 | +27,536 | 3.00 | 3.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 243,311 | 265,000 | +21,689 | 6.63 | 6.54 | -0.09 | buy |
| TD ASSET MANAGEMENT INC | 42,448 | 53,048 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 25,479 | 18,626 | +6,853 | 0.01 | 0.01 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 87,290 | 82,451 | +4,839 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 13,621 | 12,317 | +1,304 | 0.06 | 0.03 | 0.00 | sell |
| HighVista Strategies LLC | 6,458 | 6,733 | +275 | 0.12 | 0.13 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 6,934 | 6,956 | +22 | 0.03 | 0.03 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,200 | 18,156 | -44 | 0.07 | 0.09 | +0.02 | sell |
| Sofinnova Investments, Inc. | 7,485 | 7,312 | -173 | 0.02 | 0.02 | -0.00 | sell |
| Exome Asset Management LLC | 61,656 | 61,356 | -300 | 2.74 | 2.68 | -0.06 | sell |
| PROFUND ADVISORS LLC | 7,160 | 6,714 | -446 | 0.02 | 0.01 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 2,556 | 1,784 | -772 | 0.03 | 0.03 | -0.00 | sell |
| Harvest Investment Services, LLC | 15,382 | 14,316 | -1,066 | 0.21 | 0.17 | -0.04 | sell |
| Rafferty Asset Management, LLC | 34,041 | 31,489 | -2,552 | 0.01 | 0.01 | -0.00 | sell |
| Patient Square Capital LP | 83,000 | 74,000 | -9,000 | 1.70 | 1.41 | -0.29 | sell |
| Blue Owl Capital Holdings LP | 140,260 | 122,260 | -18,000 | 2.25 | 2.09 | -0.16 | sell |
| Frazier Life Sciences Management, L.P. | 1,754,834 | 1,654,834 | -100,000 | 3.98 | 3.50 | -0.48 | sell |
| Saturn V Capital Management LP | 518,177 | 396,115 | -122,062 | 12.98 | 8.50 | -4.48 | sell |
| Bain Capital Life Sciences Investors, LLC | 983,500 | 583,500 | -400,000 | 7.22 | 3.87 | -3.36 | sell |