| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,224,381 | 3,245,710 | +21,329 | 0.01 | 0.01 | -0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,384,456 | 2,384,456 | 0 | 22.69 | 19.07 | -3.62 | hold |
| BlackRock, Inc. | 2,094,560 | 2,044,827 | -49,733 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,754,834 | 1,654,834 | -100,000 | 3.98 | 3.50 | -0.48 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,577,106 | 1,577,106 | 0 | 1.31 | 1.41 | +0.10 | hold |
| JANUS HENDERSON GROUP PLC | 1,423,259 | 1,553,961 | +130,702 | 0.04 | 0.04 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,358,254 | 1,515,625 | +157,371 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,343,499 | 1,432,090 | -911,409 | 0.02 | 0.01 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 1,415,020 | 1,415,020 | 0 | 1.69 | 1.88 | +0.20 | hold |
| VANGUARD GROUP INC | 1,305,046 | 1,396,736 | +91,690 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,210,971 | 1,210,971 | 0 | 2.77 | 2.74 | -0.03 | hold |
| Siren, L.L.C. | 1,071,865 | 1,099,401 | +27,536 | 3.00 | 3.01 | +0.01 | buy |
| STATE STREET CORP | 918,567 | 929,768 | +11,201 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 782,333 | 919,403 | +137,070 | 0.77 | 0.88 | +0.11 | buy |
| Woodline Partners LP | 502,230 | 866,955 | +364,725 | 0.16 | 0.24 | +0.08 | buy |
| JPMORGAN CHASE & CO | 759,338 | 843,616 | +84,278 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 394,342 | 700,000 | +305,658 | 3.48 | 4.95 | +1.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 571,984 | 598,589 | +26,605 | 0.00 | 0.00 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 983,500 | 583,500 | -400,000 | 7.22 | 3.87 | -3.36 | sell |
| TCG Crossover Management, LLC | 465,257 | 465,257 | 0 | 3.15 | 2.81 | -0.34 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 450,000 | +150,000 | 0.03 | 0.04 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 436,000 | 436,000 | 0 | 0.58 | 0.88 | +0.30 | hold |
| Saturn V Capital Management LP | 518,177 | 396,115 | -122,062 | 12.98 | 8.50 | -4.48 | sell |
| BAKER BROS. ADVISORS LP | 77,050 | 337,050 | +260,000 | 0.04 | 0.17 | +0.13 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 181,818 | 308,030 | +126,212 | 0.18 | 0.29 | +0.11 | buy |
| First Turn Management, LLC | 0 | 299,464 | +299,464 | 0.00 | 2.96 | +2.96 | buy |
| Foresite Capital Management V, LLC | 299,069 | 299,069 | 0 | 16.94 | 19.62 | +2.68 | hold |
| Nantahala Capital Management, LLC | 148,391 | 287,800 | +139,409 | 0.61 | 1.08 | +0.47 | buy |
| Sio Capital Management, LLC | 73,511 | 284,787 | +211,276 | 1.11 | 6.05 | +4.95 | buy |
| Checkpoint Capital L.P. | 243,311 | 265,000 | +21,689 | 6.63 | 6.54 | -0.09 | buy |
| GOLDMAN SACHS GROUP INC | 130,751 | 225,856 | +95,105 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 208,813 | 219,095 | +10,282 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 194,725 | 204,241 | +9,516 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 193,664 | 197,824 | +4,160 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 139,393 | 192,856 | +53,463 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 85,000 | 186,418 | +101,418 | 0.94 | 2.00 | +1.06 | buy |
| BANK OF AMERICA CORP /DE/ | 53,808 | 168,822 | +115,014 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 145,691 | +145,691 | 0.00 | 1.64 | +1.64 | buy |
| UBS Group AG | 72,628 | 145,549 | +72,921 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 72,513 | 141,545 | +69,032 | 0.01 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 140,000 | +140,000 | 0.00 | 0.39 | +0.39 | buy |
| Blue Owl Capital Holdings LP | 140,260 | 122,260 | -18,000 | 2.25 | 2.09 | -0.16 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 96,557 | 121,584 | +25,027 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 67,905 | 121,520 | +53,615 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 170,210 | 110,679 | -59,531 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 191,220 | 96,420 | -94,800 | 0.01 | 0.01 | -0.01 | sell |
| Zimmer Partners, LP | 42,900 | 90,163 | +47,263 | 0.04 | 0.11 | +0.07 | buy |
| BARCLAYS PLC | 45,708 | 86,558 | +40,850 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 83,276 | 86,487 | +3,211 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 87,290 | 82,451 | -4,839 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,941 | 75,997 | +5,056 | 0.01 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 83,000 | 74,000 | -9,000 | 1.70 | 1.41 | -0.29 | sell |
| Bank of New York Mellon Corp | 63,503 | 71,502 | +7,999 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 61,656 | 61,356 | -300 | 2.74 | 2.68 | -0.06 | sell |
| ExodusPoint Capital Management, LP | 13,565 | 57,945 | +44,380 | 0.01 | 0.04 | +0.03 | buy |
| Nicholas Investment Partners, LP | 0 | 54,445 | +54,445 | 0.00 | 0.26 | +0.26 | buy |
| TD ASSET MANAGEMENT INC | 42,448 | 53,048 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,585 | 51,836 | +11,251 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 112,717 | 50,270 | -62,447 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 35,900 | 42,900 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 32,144 | 35,755 | +3,611 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 32,061 | +32,061 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 34,041 | 31,489 | -2,552 | 0.01 | 0.01 | -0.00 | sell |
| PFM Health Sciences, LP | 0 | 30,799 | +30,799 | 0.00 | 0.14 | +0.14 | buy |
| Catalio Capital Management, LP | 0 | 30,661 | +30,661 | 0.00 | 0.34 | +0.34 | buy |
| Bollard Group LLC | 0 | 30,635 | +30,635 | 0.00 | 0.04 | +0.04 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 23,700 | 25,140 | +1,440 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 0 | 24,652 | +24,652 | 0.00 | 0.56 | +0.56 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,060 | 24,140 | +3,080 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 20,415 | 24,097 | +3,682 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 22,599 | +22,599 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,836 | 22,461 | -375 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 108,499 | 21,593 | -86,906 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,152 | 20,250 | +98 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 19,726 | +19,726 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 25,479 | 18,626 | -6,853 | 0.01 | 0.01 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,200 | 18,156 | -44 | 0.09 | 0.09 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,276 | 16,852 | +10,576 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 13,834 | 16,817 | +2,983 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,705 | 16,717 | +2,012 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 42,975 | 16,109 | -26,866 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,138 | 15,041 | -97 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 13,454 | 14,854 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 15,382 | 14,316 | -1,066 | 0.21 | 0.17 | -0.04 | sell |
| Walleye Capital LLC | 22,075 | 14,064 | -8,011 | 0.01 | 0.01 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 13,649 | +13,649 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 11,983 | 12,889 | +906 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 14,628 | 12,851 | -1,777 | 0.01 | 0.01 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 13,621 | 12,317 | -1,304 | 0.02 | 0.02 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 10,948 | 12,222 | +1,274 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 5,851 | 10,988 | +5,137 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 10,600 | 10,600 | 0 | 3.36 | 3.81 | +0.45 | hold |
| FIRST TRUST ADVISORS LP | 0 | 10,246 | +10,246 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 9,382 | +9,382 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 4,050 | 9,129 | +5,079 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 6,391 | 7,376 | +985 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 7,485 | 7,312 | -173 | 0.03 | 0.03 | -0.00 | sell |
| Legato Capital Management LLC | 0 | 7,228 | +7,228 | 0.00 | 0.05 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 6,934 | 6,956 | +22 | 0.03 | 0.03 | +0.00 | buy |
| HighVista Strategies LLC | 6,458 | 6,733 | +275 | 0.12 | 0.13 | +0.01 | buy |