| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,586,894 | 4,894,473 | -692,421 | 0.02 | 0.02 | -0.00 | sell |
| BlackRock, Inc. | 2,273,831 | 2,467,899 | +194,068 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,450,221 | 2,450,221 | 0 | 1.66 | 1.56 | -0.10 | hold |
| JPMORGAN CHASE & CO | 1,371,480 | 1,875,795 | +504,315 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,549,350 | 1,875,399 | +326,049 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,735,376 | 1,741,351 | +5,975 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 1,698,244 | 1,648,836 | -49,408 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 700,000 | 1,550,000 | +850,000 | 1.25 | 2.65 | +1.40 | buy |
| Atlas Venture Life Science Advisors, LLC | 1,513,875 | 1,513,875 | 0 | 12.25 | 12.56 | +0.31 | hold |
| Frazier Life Sciences Management, L.P. | 1,354,852 | 1,354,852 | 0 | 2.23 | 2.16 | -0.07 | hold |
| TCG Crossover Management, LLC | 1,341,862 | 1,341,862 | 0 | 2.45 | 2.36 | -0.10 | hold |
| BVF INC/IL | 1,272,312 | 1,153,612 | -118,700 | 2.59 | 2.16 | -0.43 | sell |
| Woodline Partners LP | 958,281 | 958,281 | 0 | 0.23 | 0.22 | -0.02 | hold |
| Siren, L.L.C. | 988,401 | 888,401 | -100,000 | 1.75 | 1.32 | -0.43 | sell |
| Logos Global Management LP | 560,000 | 875,000 | +315,000 | 1.84 | 2.76 | +0.91 | buy |
| Opaleye Management Inc. | 421,000 | 855,000 | +434,000 | 3.55 | 5.66 | +2.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 744,222 | 789,724 | +45,502 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 657,000 | 657,000 | 0 | 0.50 | 0.50 | +0.01 | hold |
| DIMENSIONAL FUND ADVISORS LP | 394,447 | 569,018 | +174,571 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 459,314 | 560,000 | +100,686 | 0.70 | 0.86 | +0.16 | buy |
| Saturn V Capital Management LP | 449,926 | 524,730 | +74,804 | 5.21 | 5.50 | +0.29 | buy |
| ARMISTICE CAPITAL, LLC | 536,000 | 460,000 | -76,000 | 1.13 | 0.93 | -0.20 | sell |
| JENNISON ASSOCIATES LLC | 610,382 | 439,520 | -170,862 | 0.03 | 0.02 | -0.01 | sell |
| Aberdeen Group plc | 375,614 | 438,174 | +62,560 | 0.04 | 0.04 | +0.01 | buy |
| Palo Alto Investors LP | 401,719 | 416,646 | +14,927 | 3.93 | 4.21 | +0.28 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,572 | 395,651 | +79 | 0.42 | 0.39 | -0.03 | buy |
| Pictet Asset Management Holding SA | 387,005 | 385,375 | -1,630 | 0.03 | 0.03 | +0.00 | sell |
| Assenagon Asset Management S.A. | 546,247 | 384,158 | -162,089 | 0.06 | 0.04 | -0.02 | sell |
| LOOMIS SAYLES & CO L P | 317,222 | 381,864 | +64,642 | 0.03 | 0.04 | +0.01 | buy |
| Foresite Capital Management V, LLC | 374,069 | 374,069 | 0 | 8.83 | 7.55 | -1.27 | hold |
| ORBIMED ADVISORS LLC | 1,067,550 | 357,535 | -710,015 | 1.49 | 0.50 | -0.99 | sell |
| BAKER BROS. ADVISORS LP | 349,657 | 349,657 | 0 | 0.13 | 0.13 | -0.00 | hold |
| Octagon Capital Advisors LP | 270,000 | 270,000 | 0 | 1.91 | 1.81 | -0.10 | hold |
| NORTHERN TRUST CORP | 247,195 | 264,990 | +17,795 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 257,382 | +257,382 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251,195 | 257,382 | +6,187 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 286,661 | 240,125 | -46,536 | 6.58 | 4.51 | -2.07 | sell |
| CITADEL ADVISORS LLC | 97,930 | 209,308 | +111,378 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 204,968 | 204,727 | -241 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 127,737 | 184,695 | +56,958 | 0.01 | 0.01 | +0.00 | buy |
| Catalio Capital Management, LP | 122,978 | 159,384 | +36,406 | 1.64 | 2.19 | +0.55 | buy |
| Sofinnova Investments, Inc. | 78,320 | 146,239 | +67,919 | 0.25 | 0.57 | +0.32 | buy |
| Bain Capital Life Sciences Investors, LLC | 141,234 | 141,234 | 0 | 0.81 | 0.61 | -0.20 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 136,750 | +136,750 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 166,775 | 135,111 | -31,664 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 125,000 | 125,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 191,487 | 122,111 | -69,376 | 0.02 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,890 | 114,109 | +3,219 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 98,621 | 110,971 | +12,350 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 107,699 | +107,699 | 0.00 | 0.05 | +0.05 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 108,286 | 106,769 | -1,517 | 0.15 | 0.14 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 83,259 | 106,248 | +22,989 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 639,842 | 97,383 | -542,459 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 94,264 | 91,595 | -2,669 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 90,822 | +90,822 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 196,028 | 82,800 | -113,228 | 1.48 | 0.67 | -0.80 | sell |
| RAYMOND JAMES FINANCIAL INC | 44,700 | 77,980 | +33,280 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 31,709 | 75,872 | +44,163 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 96,755 | 73,127 | -23,628 | 0.02 | 0.01 | -0.01 | sell |
| iA Global Asset Management Inc. | 66,243 | 66,023 | -220 | 0.06 | 0.06 | -0.00 | sell |
| Casdin Capital, LLC | 65,000 | 65,000 | 0 | 0.31 | 0.24 | -0.08 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 53,538 | 63,538 | +10,000 | 0.59 | 0.66 | +0.08 | buy |
| Nuveen, LLC | 51,380 | 60,357 | +8,977 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 57,796 | 57,796 | 0 | 0.13 | 0.10 | -0.04 | hold |
| XTX Topco Ltd | 34,418 | 56,710 | +22,292 | 0.04 | 0.05 | +0.02 | buy |
| ALGERT GLOBAL LLC | 22,680 | 51,850 | +29,170 | 0.02 | 0.04 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 51,623 | +51,623 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50,959 | 50,000 | -959 | 0.00 | 0.00 | +0.00 | sell |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.16 | 0.13 | -0.03 | hold |
| Brevan Howard Capital Management LP | 32,406 | 49,996 | +17,590 | 0.02 | 0.05 | +0.03 | buy |
| Swiss National Bank | 48,000 | 49,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 45,837 | 45,874 | +37 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 107,255 | 43,682 | -63,573 | 1.03 | 0.86 | -0.17 | sell |
| Quadrature Capital Ltd | 0 | 42,419 | +42,419 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 30,638 | 42,057 | +11,419 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,382 | 39,360 | +4,978 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 31,058 | 38,565 | +7,507 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 7,742 | 38,317 | +30,575 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 39,910 | 38,262 | -1,648 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 38,006 | 36,634 | -1,372 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 33,058 | 35,844 | +2,786 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 39,400 | 35,034 | -4,366 | 0.00 | 0.00 | -0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 35,000 | 35,000 | 0 | 0.15 | 0.10 | -0.05 | hold |
| ALLIANCEBERNSTEIN L.P. | 24,540 | 34,670 | +10,130 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 34,394 | +34,394 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 81,829 | 32,549 | -49,280 | 0.08 | 0.02 | -0.06 | sell |
| BANK OF MONTREAL /CAN/ | 28,773 | 32,308 | +3,535 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,401 | 30,643 | +6,242 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 30,000 | 30,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 29,218 | 29,117 | -101 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 14,690 | 28,924 | +14,234 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 31,002 | 28,663 | -2,339 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,493 | 27,771 | -4,722 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,888 | +26,888 | 0.00 | 0.04 | +0.04 | buy |
| Rafferty Asset Management, LLC | 53,869 | 26,566 | -27,303 | 0.01 | 0.00 | -0.01 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 25,568 | +25,568 | 0.00 | 0.10 | +0.10 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 25,292 | 22,333 | -2,959 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 30,476 | 21,600 | -8,876 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 9,270 | 19,552 | +10,282 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 33,267 | 18,710 | -14,557 | 0.00 | 0.00 | -0.00 | sell |