| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 700,000 | 1,550,000 | +850,000 | 1.25 | 2.65 | +1.40 | buy |
| JPMORGAN CHASE & CO | 1,371,480 | 1,875,795 | +504,315 | 0.01 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 421,000 | 855,000 | +434,000 | 3.55 | 5.66 | +2.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,549,350 | 1,875,399 | +326,049 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 560,000 | 875,000 | +315,000 | 1.84 | 2.76 | +0.91 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 257,382 | +257,382 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,273,831 | 2,467,899 | +194,068 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 394,447 | 569,018 | +174,571 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 136,750 | +136,750 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 97,930 | 209,308 | +111,378 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 0 | 107,699 | +107,699 | 0.00 | 0.05 | +0.05 | buy |
| Bellevue Group AG | 459,314 | 560,000 | +100,686 | 0.70 | 0.86 | +0.16 | buy |
| HRT FINANCIAL LP | 0 | 90,822 | +90,822 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 449,926 | 524,730 | +74,804 | 5.21 | 5.50 | +0.29 | buy |
| Sofinnova Investments, Inc. | 78,320 | 146,239 | +67,919 | 0.25 | 0.57 | +0.32 | buy |
| LOOMIS SAYLES & CO L P | 317,222 | 381,864 | +64,642 | 0.03 | 0.04 | +0.01 | buy |
| Aberdeen Group plc | 375,614 | 438,174 | +62,560 | 0.04 | 0.04 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 127,737 | 184,695 | +56,958 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 51,623 | +51,623 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 744,222 | 789,724 | +45,502 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 31,709 | 75,872 | +44,163 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 42,419 | +42,419 | 0.00 | 0.03 | +0.03 | buy |
| Catalio Capital Management, LP | 122,978 | 159,384 | +36,406 | 1.64 | 2.19 | +0.55 | buy |
| MARSHALL WACE, LLP | 0 | 34,394 | +34,394 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 44,700 | 77,980 | +33,280 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,742 | 38,317 | +30,575 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 22,680 | 51,850 | +29,170 | 0.02 | 0.04 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,888 | +26,888 | 0.00 | 0.04 | +0.04 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 25,568 | +25,568 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 83,259 | 106,248 | +22,989 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 34,418 | 56,710 | +22,292 | 0.04 | 0.05 | +0.02 | buy |
| NORTHERN TRUST CORP | 247,195 | 264,990 | +17,795 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 32,406 | 49,996 | +17,590 | 0.02 | 0.05 | +0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 16,324 | +16,324 | 0.00 | 0.08 | +0.08 | buy |
| JANE STREET GROUP, LLC | 0 | 16,011 | +16,011 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 401,719 | 416,646 | +14,927 | 3.93 | 4.21 | +0.28 | buy |
| WELLS FARGO & COMPANY/MN | 14,690 | 28,924 | +14,234 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 14,219 | +14,219 | 0.00 | 0.24 | +0.24 | buy |
| Qube Research & Technologies Ltd | 0 | 12,758 | +12,758 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 98,621 | 110,971 | +12,350 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 12,009 | +12,009 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 30,638 | 42,057 | +11,419 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 9,270 | 19,552 | +10,282 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,540 | 34,670 | +10,130 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 53,538 | 63,538 | +10,000 | 0.59 | 0.66 | +0.08 | buy |
| Nuveen, LLC | 51,380 | 60,357 | +8,977 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 31,058 | 38,565 | +7,507 | 0.01 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 7,297 | +7,297 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,401 | 30,643 | +6,242 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251,195 | 257,382 | +6,187 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 6,035 | +6,035 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 0 | 6,027 | +6,027 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,735,376 | 1,741,351 | +5,975 | 0.02 | 0.02 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 5,808 | +5,808 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 2,634 | 7,964 | +5,330 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,382 | 39,360 | +4,978 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 10,006 | 14,925 | +4,919 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 8,704 | 12,971 | +4,267 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 4,788 | 8,408 | +3,620 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 28,773 | 32,308 | +3,535 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,890 | 114,109 | +3,219 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 3,130 | +3,130 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 3,000 | +3,000 | 0.00 | 0.02 | +0.02 | buy |
| JONES FINANCIAL COMPANIES LLLP | 1,627 | 4,616 | +2,989 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 33,058 | 35,844 | +2,786 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 3,769 | 6,254 | +2,485 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2,090 | +2,090 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 2,967 | 4,812 | +1,845 | 0.05 | 0.08 | +0.03 | buy |
| Swiss National Bank | 48,000 | 49,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 1,720 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 15,065 | 16,588 | +1,523 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,576 | 10,076 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,288 | 15,429 | +1,141 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 4,420 | 5,430 | +1,010 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 970 | +970 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 3,786 | 4,694 | +908 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,474 | 8,345 | +871 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 444 | +444 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 4,265 | 4,630 | +365 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 346 | +346 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 240 | 566 | +326 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,248 | 2,568 | +320 | 0.00 | 0.01 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 198 | +198 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 5,868 | 6,054 | +186 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 6,684 | 6,844 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,572 | 395,651 | +79 | 0.42 | 0.39 | -0.03 | buy |
| CoreCap Advisors, LLC | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,185 | 1,229 | +44 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 45,837 | 45,874 | +37 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 599 | 633 | +34 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 268 | 292 | +24 | 0.00 | 0.00 | -0.00 | buy |
| Kemnay Advisory Services Inc. | 246 | 269 | +23 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 19 | 30 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 2 | 7 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 44 | 47 | +3 | 0.00 | 0.00 | -0.00 | buy |