| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Atlas Venture Life Science Advisors, LLC | 2,509,456 | 2,509,456 | 0 | 11.91 | 11.43 | -0.48 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,756,495 | 1,840,226 | +83,731 | 0.01 | 0.02 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,795,735 | 1,795,735 | 0 | 8.89 | 9.18 | +0.30 | hold |
| ORBIMED ADVISORS LLC | 1,785,571 | 1,785,571 | 0 | 1.60 | 1.61 | +0.01 | hold |
| Frazier Life Sciences Management, L.P. | 1,754,834 | 1,754,834 | 0 | 3.70 | 3.46 | -0.24 | hold |
| Paradigm Biocapital Advisors LP | 2,704,718 | 1,497,720 | -1,206,998 | 4.67 | 2.58 | -2.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,122,194 | 1,131,947 | +9,753 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 1,111,424 | 1,049,530 | -61,894 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,023,265 | 1,023,265 | 0 | 0.77 | 0.75 | -0.02 | hold |
| Logos Global Management LP | 925,000 | 935,000 | +10,000 | 4.80 | 5.15 | +0.34 | buy |
| STATE STREET CORP | 592,795 | 827,910 | +235,115 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 761,429 | 755,867 | -5,562 | 0.11 | 0.13 | +0.02 | sell |
| JANUS HENDERSON GROUP PLC | 445,873 | 749,827 | +303,954 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 618,501 | 550,000 | -68,501 | 0.05 | 0.05 | -0.00 | sell |
| Saturn V Capital Management LP | 503,089 | 511,041 | +7,952 | 8.57 | 8.98 | +0.41 | buy |
| TCG Crossover Management, LLC | 486,957 | 486,957 | 0 | 2.29 | 2.03 | -0.26 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 403,736 | 474,719 | +70,983 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 321,521 | 411,024 | +89,503 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 413,097 | 406,814 | -6,283 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 553,437 | 387,017 | -166,420 | 0.60 | 0.41 | -0.19 | sell |
| Woodline Partners LP | 267,863 | 377,062 | +109,199 | 0.12 | 0.16 | +0.04 | buy |
| MPM BioImpact LLC | 305,658 | 311,761 | +6,103 | 2.14 | 2.30 | +0.16 | buy |
| Foresite Capital Management V, LLC | 299,069 | 299,069 | 0 | 8.61 | 10.21 | +1.61 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 312,049 | 220,014 | -92,035 | 0.01 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 136,096 | 209,236 | +73,140 | 0.06 | 0.11 | +0.04 | buy |
| Sio Capital Management, LLC | 192,000 | 187,941 | -4,059 | 3.26 | 4.14 | +0.87 | sell |
| Blue Owl Capital Holdings LP | 215,260 | 175,260 | -40,000 | 2.70 | 1.67 | -1.03 | sell |
| GOLDMAN SACHS GROUP INC | 54,247 | 171,566 | +117,319 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 98,375 | 170,718 | +72,343 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 141,153 | 160,554 | +19,401 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 160,000 | +160,000 | 0.00 | 0.21 | +0.21 | buy |
| Pictet Asset Management Holding SA | 216,701 | 157,548 | -59,153 | 0.01 | 0.01 | -0.00 | sell |
| Nantahala Capital Management, LLC | 150,000 | 150,000 | 0 | 0.68 | 0.62 | -0.06 | hold |
| Artisan Partners Limited Partnership | 109,319 | 104,925 | -4,394 | 0.01 | 0.01 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 101,187 | 103,862 | +2,675 | 1.13 | 1.15 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 166,500 | 100,000 | -66,500 | 4.47 | 2.63 | -1.84 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 92,139 | 92,579 | +440 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 5,018 | 81,586 | +76,568 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 60,589 | 70,092 | +9,503 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 98,934 | 69,937 | -28,997 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 61,000 | 64,516 | +3,516 | 2.45 | 2.14 | -0.30 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 53,566 | +53,566 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 51,050 | 52,905 | +1,855 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 29,256 | 41,352 | +12,096 | 0.08 | 0.17 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 40,732 | 40,732 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 17,943 | 40,145 | +22,202 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 23,983 | 36,726 | +12,743 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 32,000 | 34,800 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 34,400 | 34,400 | 0 | 0.03 | 0.03 | +0.00 | hold |
| UBS Group AG | 77,678 | 33,092 | -44,586 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,294 | 29,065 | +771 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 24,447 | 27,483 | +3,036 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 25,543 | +25,543 | 0.00 | 0.62 | +0.62 | buy |
| JANE STREET GROUP, LLC | 32,411 | 24,731 | -7,680 | 0.00 | 0.00 | +0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 23,700 | 23,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 19,302 | 22,888 | +3,586 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 22,564 | +22,564 | 0.00 | 0.19 | +0.19 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,060 | 21,060 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 14,102 | 19,560 | +5,458 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,337 | 18,649 | +3,312 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 17,815 | 17,227 | -588 | 0.32 | 0.27 | -0.05 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,948 | 16,967 | +1,019 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 13,998 | 16,255 | +2,257 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 18,601 | 16,075 | -2,526 | 0.01 | 0.01 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 10,275 | 15,419 | +5,144 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 14,132 | 14,883 | +751 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 13,319 | 14,683 | +1,364 | 0.02 | 0.02 | +0.00 | buy |
| Legal & General Group Plc | 13,982 | 14,637 | +655 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,600 | 14,000 | +400 | 0.05 | 0.05 | +0.00 | buy |
| Artia Global Partners LP | 13,440 | 13,440 | 0 | 0.16 | 0.19 | +0.03 | hold |
| WELLS FARGO & COMPANY/MN | 11,746 | 12,970 | +1,224 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,978 | 12,369 | -2,609 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,784 | 12,262 | +6,478 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 11,980 | +11,980 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 9,642 | 11,377 | +1,735 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 8,839 | 10,551 | +1,712 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,555 | 10,255 | -2,300 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 9,565 | +9,565 | 0.00 | 0.16 | +0.16 | buy |
| DEUTSCHE BANK AG\ | 6,813 | 9,160 | +2,347 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,908 | 9,156 | -4,752 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 9,057 | +9,057 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 8,805 | +8,805 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 7,900 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 0 | 7,700 | +7,700 | 0.00 | 1.52 | +1.52 | buy |
| PROFUND ADVISORS LLC | 4,586 | 7,358 | +2,772 | 0.01 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 5,298 | 6,940 | +1,642 | 0.01 | 0.01 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 6,609 | +6,609 | 0.00 | 0.05 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 5,515 | 6,020 | +505 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,904 | 5,717 | +2,813 | 0.02 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 5,638 | 5,628 | -10 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 0 | 5,508 | +5,508 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 6,924 | 5,281 | -1,643 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 0 | 5,121 | +5,121 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 4,071 | 4,864 | +793 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 9,718 | 4,703 | -5,015 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 4,647 | +4,647 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 4,461 | +4,461 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2,964 | +2,964 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,867 | 2,867 | 0 | 0.00 | 0.00 | -0.00 | hold |