| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 445,873 | 749,827 | +303,954 | 0.01 | 0.02 | 0.00 | buy |
| Woodline Partners LP | 267,863 | 377,062 | +109,199 | 0.12 | 0.16 | +0.04 | buy |
| Rafferty Asset Management, LLC | 23,983 | 36,726 | +12,743 | 0.00 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 29,256 | 41,352 | +12,096 | 0.07 | 0.16 | +0.09 | buy |
| Logos Global Management LP | 925,000 | 935,000 | +10,000 | 4.80 | 5.15 | +0.34 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,122,194 | 1,131,947 | +9,753 | 0.01 | 0.01 | +0.00 | buy |
| Saturn V Capital Management LP | 503,089 | 511,041 | +7,952 | 8.57 | 8.98 | +0.41 | buy |
| MPM BioImpact LLC | 305,658 | 311,761 | +6,103 | 2.14 | 2.30 | +0.16 | buy |
| ALPS ADVISORS INC | 19,302 | 22,888 | +3,586 | 0.01 | 0.01 | +0.00 | buy |
| Exome Asset Management LLC | 61,000 | 64,516 | +3,516 | 2.45 | 2.14 | -0.30 | buy |
| China Universal Asset Management Co., Ltd. | 2,904 | 5,717 | +2,813 | 0.02 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 4,586 | 7,358 | +2,772 | 0.01 | 0.01 | 0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 101,187 | 103,862 | +2,675 | 1.13 | 1.15 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 13,319 | 14,683 | +1,364 | 0.04 | 0.06 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 92,139 | 92,579 | +440 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,600 | 14,000 | +400 | 0.05 | 0.05 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,312 | 2,353 | +41 | 0.05 | 0.05 | +0.00 | buy |
| Harvest Investment Services, LLC | 17,815 | 17,227 | -588 | 0.32 | 0.27 | -0.05 | sell |
| Sio Capital Management, LLC | 192,000 | 187,941 | -4,059 | 2.34 | 3.66 | +1.32 | sell |
| Artisan Partners Limited Partnership | 109,319 | 104,925 | -4,394 | 0.01 | 0.01 | +0.00 | sell |
| Blue Owl Capital Holdings LP | 215,260 | 175,260 | -40,000 | 2.70 | 1.67 | -1.03 | sell |
| Ally Bridge Group (NY) LLC | 166,500 | 100,000 | -66,500 | 4.47 | 2.63 | -1.84 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 618,501 | 550,000 | -68,501 | 0.05 | 0.05 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 553,437 | 387,017 | -166,420 | 0.60 | 0.40 | -0.20 | sell |
| Paradigm Biocapital Advisors LP | 2,704,718 | 1,497,720 | -1,206,998 | 4.67 | 2.58 | -2.09 | sell |