| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,245,710 | 4,935,159 | +1,689,449 | 0.01 | 0.02 | +0.01 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,384,456 | 2,142,617 | -241,839 | 19.07 | 18.81 | -0.25 | sell |
| BlackRock, Inc. | 2,044,827 | 2,019,283 | -25,544 | 0.00 | 0.00 | +0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,577,106 | 1,577,106 | 0 | 1.41 | 1.28 | -0.12 | hold |
| VANGUARD GROUP INC | 1,396,736 | 1,448,059 | +51,323 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,654,834 | 1,438,534 | -216,300 | 3.50 | 2.85 | -0.66 | sell |
| ORBIMED ADVISORS LLC | 1,415,020 | 1,415,020 | 0 | 1.88 | 2.24 | +0.36 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,432,090 | 1,410,077 | -22,013 | 0.01 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,515,625 | 1,326,429 | -189,196 | 0.01 | 0.01 | +0.00 | sell |
| STATE STREET CORP | 929,768 | 1,045,597 | +115,829 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 919,403 | 919,403 | 0 | 0.88 | 0.93 | +0.05 | hold |
| Siren, L.L.C. | 1,099,401 | 913,401 | -186,000 | 3.01 | 2.36 | -0.65 | sell |
| Woodline Partners LP | 866,955 | 866,955 | 0 | 0.24 | 0.27 | +0.03 | hold |
| JPMORGAN CHASE & CO | 843,616 | 752,879 | -90,737 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 598,589 | 628,151 | +29,562 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 225,856 | 529,081 | +303,225 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 140,000 | 500,000 | +360,000 | 0.39 | 1.50 | +1.11 | buy |
| TCG Crossover Management, LLC | 465,257 | 465,257 | 0 | 2.81 | 1.51 | -1.30 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 450,000 | 450,000 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Logos Global Management LP | 700,000 | 450,000 | -250,000 | 4.95 | 2.94 | -2.01 | sell |
| ARMISTICE CAPITAL, LLC | 436,000 | 436,000 | 0 | 0.88 | 0.90 | +0.03 | hold |
| Checkpoint Capital L.P. | 265,000 | 430,000 | +165,000 | 6.54 | 9.52 | +2.98 | buy |
| First Turn Management, LLC | 299,464 | 397,693 | +98,229 | 2.96 | 3.95 | +0.99 | buy |
| JANUS HENDERSON GROUP PLC | 1,553,961 | 361,704 | -1,192,257 | 0.04 | 0.01 | -0.03 | sell |
| Saturn V Capital Management LP | 396,115 | 340,897 | -55,218 | 8.50 | 4.94 | -3.56 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 338,101 | +338,101 | 0.00 | 0.05 | +0.05 | buy |
| BAKER BROS. ADVISORS LP | 337,050 | 337,050 | 0 | 0.17 | 0.16 | -0.01 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 308,030 | 308,043 | +13 | 0.29 | 0.33 | +0.05 | buy |
| Foresite Capital Management V, LLC | 299,069 | 299,069 | 0 | 19.62 | 18.17 | -1.45 | hold |
| Nantahala Capital Management, LLC | 287,800 | 287,800 | 0 | 1.08 | 1.17 | +0.10 | hold |
| Sio Capital Management, LLC | 284,787 | 284,787 | 0 | 6.05 | 4.76 | -1.29 | hold |
| Paradigm Biocapital Advisors LP | 1,210,971 | 247,716 | -963,255 | 2.74 | 0.48 | -2.25 | sell |
| First Light Asset Management, LLC | 0 | 231,186 | +231,186 | 0.00 | 1.44 | +1.44 | buy |
| DIMENSIONAL FUND ADVISORS LP | 192,856 | 230,423 | +37,567 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 204,241 | 226,655 | +22,414 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 145,691 | 224,300 | +78,609 | 1.64 | 2.74 | +1.10 | buy |
| NORTHERN TRUST CORP | 219,095 | 219,489 | +394 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 30,661 | 216,527 | +185,866 | 0.34 | 2.65 | +2.30 | buy |
| Opaleye Management Inc. | 186,418 | 193,773 | +7,355 | 2.00 | 1.81 | -0.19 | buy |
| TimesSquare Capital Management, LLC | 0 | 182,170 | +182,170 | 0.00 | 0.17 | +0.17 | buy |
| Ensign Peak Advisors, Inc | 141,545 | 177,050 | +35,505 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 145,549 | 171,623 | +26,074 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 168,822 | 161,184 | -7,638 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 21,593 | 161,000 | +139,407 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 197,824 | 149,864 | -47,960 | 0.01 | 0.01 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 86,487 | 141,479 | +54,992 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 86,558 | 107,203 | +20,645 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 122,260 | 102,260 | -20,000 | 2.09 | 2.10 | +0.01 | sell |
| Hudson Bay Capital Management LP | 0 | 102,185 | +102,185 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 121,584 | 91,380 | -30,204 | 0.00 | 0.00 | +0.00 | sell |
| Zimmer Partners, LP | 90,163 | 90,163 | 0 | 0.11 | 0.15 | +0.04 | hold |
| Nicholas Investment Partners, LP | 54,445 | 88,003 | +33,558 | 0.26 | 0.44 | +0.19 | buy |
| AMERIPRISE FINANCIAL INC | 121,520 | 74,350 | -47,170 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 74,000 | 74,000 | 0 | 1.41 | 1.31 | -0.10 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 82,451 | 67,196 | -15,255 | 0.00 | 0.00 | -0.00 | sell |
| iA Global Asset Management Inc. | 322 | 65,512 | +65,190 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 71,502 | 64,800 | -6,702 | 0.00 | 0.00 | +0.00 | sell |
| Exome Asset Management LLC | 61,356 | 61,356 | 0 | 2.68 | 2.68 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 53,048 | 59,248 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 110,679 | 56,075 | -54,604 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 50,394 | +50,394 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 50,270 | 47,694 | -2,576 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,836 | 47,577 | -4,259 | 0.00 | 0.00 | +0.00 | sell |
| Atle Fund Management AB | 24,652 | 45,690 | +21,038 | 0.56 | 1.19 | +0.63 | buy |
| Swiss National Bank | 42,900 | 43,600 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 9,382 | 43,287 | +33,905 | 0.01 | 0.07 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,703 | 37,610 | +32,907 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 31,489 | 37,302 | +5,813 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 35,755 | 34,490 | -1,265 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,997 | 32,617 | -43,380 | 0.01 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 30,799 | 32,539 | +1,740 | 0.14 | 0.18 | +0.04 | buy |
| Aberdeen Group plc | 32,061 | 32,061 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 0 | 27,938 | +27,938 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,461 | 27,055 | +4,594 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,097 | 25,147 | +1,050 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 25,140 | 25,146 | +6 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,140 | 24,540 | +400 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,250 | 22,093 | +1,843 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,852 | 21,490 | +4,638 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,817 | 21,443 | +4,626 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 21,274 | +21,274 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 16,717 | 18,886 | +2,169 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,156 | 18,156 | 0 | 0.09 | 0.09 | +0.00 | hold |
| BANK OF MONTREAL /CAN/ | 10,988 | 17,785 | +6,797 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 18,626 | 16,792 | -1,834 | 0.01 | 0.01 | +0.00 | sell |
| ROYAL BANK OF CANADA | 22,599 | 16,696 | -5,903 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 14,064 | 14,649 | +585 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 14,001 | +14,001 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 13,649 | 13,978 | +329 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 14,854 | 13,922 | -932 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 13,726 | +13,726 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 7,312 | 13,553 | +6,241 | 0.03 | 0.05 | +0.03 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 12,851 | 12,851 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,041 | 12,646 | -2,395 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,889 | 12,373 | -516 | 0.00 | 0.00 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 7,376 | 11,438 | +4,062 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 7,228 | 11,287 | +4,059 | 0.05 | 0.08 | +0.04 | buy |
| Lion Point Capital, LP | 10,600 | 10,600 | 0 | 3.81 | 3.98 | +0.17 | hold |
| Assenagon Asset Management S.A. | 0 | 10,433 | +10,433 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 9,226 | +9,226 | 0.00 | 0.00 | +0.00 | buy |