| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,272,279 | 2,385,857 | +1,113,578 | 4.08 | 6.46 | +2.38 | buy |
| Frazier Life Sciences Management, L.P. | 655,000 | 785,000 | +130,000 | 2.05 | 2.42 | +0.38 | buy |
| PERCEPTIVE ADVISORS LLC | 895,641 | 1,023,045 | +127,404 | 1.40 | 1.32 | -0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 527,739 | 590,831 | +63,092 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 500,380 | 443,178 | +57,202 | 0.02 | 0.02 | 0.00 | sell |
| Ikarian Capital, LLC | 142,766 | 194,982 | +52,216 | 2.49 | 3.08 | +0.59 | buy |
| Parkman Healthcare Partners LLC | 52,058 | 92,871 | +40,813 | 0.45 | 0.76 | +0.31 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 430,000 | 464,292 | +34,292 | 0.45 | 0.50 | +0.05 | buy |
| Hudson Bay Capital Management LP | 42,000 | 62,000 | +20,000 | 0.02 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 23,121 | 9,338 | +13,783 | 0.03 | 0.04 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 16,642 | 25,057 | +8,415 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,552 | 6,506 | +4,046 | 0.03 | 0.02 | 0.00 | sell |
| Informed Momentum Co LLC | 51,111 | 52,895 | +1,784 | 0.46 | 0.54 | +0.08 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 9,899 | 11,300 | +1,401 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,014 | 1,589 | -425 | 0.06 | 0.06 | +0.00 | sell |
| ALPS ADVISORS INC | 16,900 | 16,150 | -750 | 0.01 | 0.01 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 138,198 | 115,500 | -22,698 | 4.35 | 3.76 | -0.60 | sell |
| Rafferty Asset Management, LLC | 63,132 | 39,863 | -23,269 | 0.02 | 0.01 | -0.01 | sell |
| Cormorant Asset Management, LP | 225,000 | 125,000 | -100,000 | 0.62 | 0.34 | -0.27 | sell |
| 5AM Venture Management, LLC | 438,442 | 294,221 | -144,221 | 5.93 | 4.51 | -1.42 | sell |
| Atlas Venture Life Science Advisors, LLC | 2,745,335 | 2,555,172 | -190,163 | 19.98 | 17.58 | -2.40 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,308,405 | 750,000 | -558,405 | 0.14 | 0.09 | -0.05 | sell |
| ORBIMED ADVISORS LLC | 2,269,637 | 1,702,237 | -567,400 | 2.29 | 1.97 | -0.32 | sell |