| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,272,279 | 2,385,857 | +1,113,578 | 4.08 | 6.46 | +2.38 | buy |
| ALLIANCEBERNSTEIN L.P. | 9,130 | 363,085 | +353,955 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 195,091 | +195,091 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 140,260 | +140,260 | 0.00 | 1.94 | +1.94 | buy |
| Frazier Life Sciences Management, L.P. | 655,000 | 785,000 | +130,000 | 2.05 | 2.42 | +0.38 | buy |
| PERCEPTIVE ADVISORS LLC | 895,641 | 1,023,045 | +127,404 | 1.41 | 1.32 | -0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 54,745 | 177,726 | +122,981 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 665,452 | 764,544 | +99,092 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 80,000 | +80,000 | 0.00 | 0.03 | +0.03 | buy |
| Saturn V Capital Management LP | 0 | 64,784 | +64,784 | 0.00 | 1.43 | +1.43 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 527,739 | 590,831 | +63,092 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 49,557 | 112,387 | +62,830 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 161,021 | 221,424 | +60,403 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 58,260 | +58,260 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 142,766 | 194,982 | +52,216 | 2.49 | 3.08 | +0.59 | buy |
| Qube Research & Technologies Ltd | 0 | 50,711 | +50,711 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 137,523 | 187,580 | +50,057 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 50,000 | +50,000 | 0.00 | 0.68 | +0.68 | buy |
| JENNISON ASSOCIATES LLC | 0 | 43,031 | +43,031 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 43,000 | +43,000 | 0.00 | 0.27 | +0.27 | buy |
| Parkman Healthcare Partners LLC | 52,058 | 92,871 | +40,813 | 0.45 | 0.76 | +0.31 | buy |
| Nicholas Investment Partners, LP | 0 | 40,494 | +40,494 | 0.00 | 0.27 | +0.27 | buy |
| GOLDMAN SACHS GROUP INC | 27,354 | 62,175 | +34,821 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 430,000 | 464,292 | +34,292 | 0.45 | 0.50 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 20,697 | +20,697 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 42,000 | 62,000 | +20,000 | 0.02 | 0.03 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 29,690 | 48,280 | +18,590 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,870 | +16,870 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 214,398 | 229,419 | +15,021 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 13,802 | +13,802 | 0.00 | 0.06 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 9,300 | 23,094 | +13,794 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 31,286 | 43,150 | +11,864 | 0.05 | 0.08 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 11,427 | +11,427 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 10,649 | 20,845 | +10,196 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 6,032 | 16,029 | +9,997 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 9,844 | +9,844 | 0.00 | 0.05 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 12,700 | 22,346 | +9,646 | 0.01 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 9,135 | +9,135 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 16,642 | 25,057 | +8,415 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 6,882 | +6,882 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,293 | 9,686 | +6,393 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,525 | 18,889 | +6,364 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 89,038 | 95,259 | +6,221 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 6,120 | +6,120 | 0.00 | 0.06 | +0.06 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,010 | 10,000 | +5,990 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 84,200 | 89,725 | +5,525 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 5,273 | +5,273 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 0 | 4,306 | +4,306 | 0.00 | 0.01 | +0.01 | buy |
| FIDUCIARY TRUST CO | 0 | 4,051 | +4,051 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 3,716 | +3,716 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 3,578 | +3,578 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 5,200 | 8,107 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 2,793 | +2,793 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 2,651 | +2,651 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 305 | 2,339 | +2,034 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 51,111 | 52,895 | +1,784 | 0.46 | 0.54 | +0.08 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 9,899 | 11,300 | +1,401 | 0.01 | 0.01 | +0.00 | buy |
| STRS OHIO | 600 | 1,000 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 252 | +252 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 400 | 600 | +200 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,145 | 1,285 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 99 | +99 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 4,405 | 4,444 | +39 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 8,775 | 8,782 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 885 | 885 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 20,214 | 20,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 4,792 | 4,792 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rock Springs Capital Management LP | 363,468 | 363,468 | 0 | 0.46 | 0.52 | +0.06 | hold |
| Bain Capital Life Sciences Investors, LLC | 1,332,545 | 1,332,545 | 0 | 7.00 | 7.38 | +0.38 | hold |
| Foresite Capital Management V, LLC | 243,513 | 243,513 | 0 | 18.25 | 19.16 | +0.91 | hold |
| Polar Capital Holdings Plc | 546,915 | 546,915 | 0 | 0.19 | 0.19 | +0.00 | hold |
| Covestor Ltd | 2 | 2 | 0 | 0.00 | 0.00 | 0.00 | hold |
| US BANCORP \DE\ | 1,176 | 1,176 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 529 | 529 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 9 | 0 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Ulland Investment Advisors, LLC | 34 | 0 | -34 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 30,550 | 30,504 | -46 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 4,609 | 4,522 | -87 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 232 | 0 | -232 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,960 | 8,600 | -360 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,014 | 1,589 | -425 | 0.06 | 0.06 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 8,760 | 8,160 | -600 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 16,900 | 16,150 | -750 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 13,936 | 12,646 | -1,290 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,171 | 6,762 | -1,409 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 17,400 | 15,800 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 31,561 | 28,464 | -3,097 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 10,552 | 6,506 | -4,046 | 0.03 | 0.02 | -0.01 | sell |
| UBS Group AG | 19,016 | 13,622 | -5,394 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 26,547 | 16,681 | -9,866 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 13,290 | 2,571 | -10,719 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 12,534 | 0 | -12,534 | 0.01 | 0.00 | -0.01 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 23,121 | 9,338 | -13,783 | 0.02 | 0.02 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 53,823 | 31,960 | -21,863 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 138,198 | 115,500 | -22,698 | 4.72 | 3.76 | -0.97 | sell |
| Rafferty Asset Management, LLC | 63,132 | 39,863 | -23,269 | 0.02 | 0.01 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 25,330 | 0 | -25,330 | 0.02 | 0.00 | -0.02 | sell |
| Invesco Ltd. | 161,213 | 114,068 | -47,145 | 0.00 | 0.00 | -0.00 | sell |