| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 406,814 | 1,866,248 | +1,459,434 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 749,827 | 1,217,815 | +467,988 | 0.02 | 0.04 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,131,947 | 1,394,637 | +262,690 | 0.01 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 160,000 | 356,000 | +196,000 | 0.21 | 0.52 | +0.32 | buy |
| CITADEL ADVISORS LLC | 411,024 | 591,271 | +180,247 | 0.02 | 0.03 | +0.01 | buy |
| Checkpoint Capital L.P. | 25,543 | 185,000 | +159,457 | 0.62 | 5.97 | +5.35 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 86,420 | +86,420 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 53,566 | 139,720 | +86,154 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 81,190 | +81,190 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 69,937 | 150,024 | +80,087 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 77,050 | +77,050 | 0.00 | 0.05 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 18,649 | 93,103 | +74,454 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 0 | 56,400 | +56,400 | 0.00 | 1.34 | +1.34 | buy |
| JPMORGAN CHASE & CO | 16,255 | 61,017 | +44,762 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 311,761 | 346,401 | +34,640 | 2.30 | 3.12 | +0.82 | buy |
| CITIGROUP INC | 14,883 | 42,635 | +27,752 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 25,778 | +25,778 | 0.00 | 0.14 | +0.14 | buy |
| Cubist Systematic Strategies, LLC | 0 | 20,187 | +20,187 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,156 | 28,807 | +19,651 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 377,062 | 396,600 | +19,538 | 0.16 | 0.17 | +0.01 | buy |
| VANGUARD GROUP INC | 1,049,530 | 1,068,246 | +18,716 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 170,718 | 187,017 | +16,299 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 220,014 | 236,244 | +16,230 | 0.01 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 13,353 | +13,353 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 12,851 | +12,851 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 11,775 | +11,775 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 11,507 | +11,507 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 10,358 | +10,358 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 6,940 | 16,337 | +9,397 | 0.01 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,065 | 38,459 | +9,394 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,851,153 | 1,859,732 | +8,579 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 7,879 | +7,879 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 12,970 | 20,778 | +7,808 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 7,667 | +7,667 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 9,160 | 16,093 | +6,933 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 103,862 | 110,381 | +6,519 | 1.15 | 1.56 | +0.41 | buy |
| Brevan Howard Capital Management LP | 0 | 6,213 | +6,213 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 5,278 | +5,278 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 5,628 | 10,881 | +5,253 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 5,114 | +5,114 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 4,875 | +4,875 | 0.00 | 0.02 | +0.02 | buy |
| Exome Asset Management LLC | 64,516 | 69,072 | +4,556 | 2.14 | 3.29 | +1.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160,554 | 165,072 | +4,518 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 4,497 | +4,497 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 52,905 | 57,261 | +4,356 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 40,732 | 44,932 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 14,000 | 18,156 | +4,156 | 0.05 | 0.10 | +0.04 | buy |
| FIDUCIARY TRUST CO | 0 | 4,051 | +4,051 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 4,050 | +4,050 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 4,647 | 7,890 | +3,243 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 4,864 | 8,076 | +3,212 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 14,637 | 17,688 | +3,051 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 7,700 | 10,600 | +2,900 | 1.52 | 3.52 | +2.00 | buy |
| RHUMBLINE ADVISERS | 27,483 | 29,036 | +1,553 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 5,508 | 6,966 | +1,458 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 22,888 | 24,067 | +1,179 | 0.01 | 0.01 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 1,176 | +1,176 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 11,377 | 12,132 | +755 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,717 | 6,310 | +593 | 0.03 | 0.04 | +0.01 | buy |
| Sterling Capital Management LLC | 63 | 566 | +503 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4,461 | 4,857 | +396 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 2,163 | 2,446 | +283 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 559 | 825 | +266 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 171,566 | 171,810 | +244 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 100 | 239 | +139 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 400 | 525 | +125 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,262 | 12,331 | +69 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 22 | 80 | +58 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 6 | 54 | +48 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 39 | 83 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 30 | +10 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 1,785,571 | 1,785,571 | 0 | 1.61 | 2.35 | +0.75 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,999 | 1,999 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 21,060 | 21,060 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,867 | 2,867 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 150,000 | 150,000 | 0 | 0.62 | 0.67 | +0.04 | hold |
| Daiwa Securities Group Inc. | 113 | 113 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Foresite Capital Management V, LLC | 299,069 | 299,069 | 0 | 10.21 | 15.78 | +5.56 | hold |
| WOLFF WIESE MAGANA LLC | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 486,957 | 486,957 | 0 | 2.03 | 3.02 | +0.99 | hold |
| Paradigm Biocapital Advisors LP | 1,497,720 | 1,497,720 | 0 | 2.58 | 3.30 | +0.73 | hold |
| Frazier Life Sciences Management, L.P. | 1,754,834 | 1,754,834 | 0 | 3.46 | 4.62 | +1.16 | hold |
| Covestor Ltd | 2 | 2 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,509,456 | 2,509,456 | 0 | 11.43 | 19.41 | +7.98 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 730 | 730 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 1,176 | 1,176 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 23,700 | 23,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 900 | 900 | 0 | 0.00 | 0.00 | +0.00 | hold |