| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Atlas Venture Life Science Advisors, LLC | 2,509,456 | 2,509,456 | 0 | 11.43 | 19.41 | +7.98 | hold |
| FMR LLC | 406,814 | 1,866,248 | +1,459,434 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 1,851,153 | 1,859,732 | +8,579 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,785,571 | 1,785,571 | 0 | 1.61 | 2.35 | +0.75 | hold |
| Frazier Life Sciences Management, L.P. | 1,754,834 | 1,754,834 | 0 | 3.46 | 4.62 | +1.16 | hold |
| Paradigm Biocapital Advisors LP | 1,497,720 | 1,497,720 | 0 | 2.58 | 3.30 | +0.73 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,840,226 | 1,395,405 | -444,821 | 0.02 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,131,947 | 1,394,637 | +262,690 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 749,827 | 1,217,815 | +467,988 | 0.02 | 0.04 | +0.02 | buy |
| VANGUARD GROUP INC | 1,049,530 | 1,068,246 | +18,716 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,795,735 | 983,500 | -812,235 | 9.18 | 7.33 | -1.85 | sell |
| STATE STREET CORP | 827,910 | 768,735 | -59,175 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,023,265 | 600,515 | -422,750 | 0.75 | 0.72 | -0.03 | sell |
| CITADEL ADVISORS LLC | 411,024 | 591,271 | +180,247 | 0.02 | 0.03 | +0.01 | buy |
| Saturn V Capital Management LP | 511,041 | 509,406 | -1,635 | 8.98 | 12.65 | +3.67 | sell |
| TCG Crossover Management, LLC | 486,957 | 486,957 | 0 | 2.03 | 3.02 | +0.99 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 474,719 | 472,706 | -2,013 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 377,062 | 396,600 | +19,538 | 0.16 | 0.17 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 160,000 | 356,000 | +196,000 | 0.21 | 0.52 | +0.32 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | 350,000 | -200,000 | 0.05 | 0.04 | -0.01 | sell |
| MPM BioImpact LLC | 311,761 | 346,401 | +34,640 | 2.30 | 3.12 | +0.82 | buy |
| Foresite Capital Management V, LLC | 299,069 | 299,069 | 0 | 10.21 | 15.78 | +5.56 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 220,014 | 236,244 | +16,230 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 935,000 | 200,000 | -735,000 | 5.15 | 1.48 | -3.66 | sell |
| NORTHERN TRUST CORP | 170,718 | 187,017 | +16,299 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 25,543 | 185,000 | +159,457 | 0.62 | 5.97 | +5.35 | buy |
| GOLDMAN SACHS GROUP INC | 171,566 | 171,810 | +244 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160,554 | 165,072 | +4,518 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 69,937 | 150,024 | +80,087 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 150,000 | 150,000 | 0 | 0.62 | 0.67 | +0.04 | hold |
| DIMENSIONAL FUND ADVISORS LP | 53,566 | 139,720 | +86,154 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 157,548 | 129,482 | -28,066 | 0.01 | 0.01 | +0.00 | sell |
| Blue Owl Capital Holdings LP | 175,260 | 120,260 | -55,000 | 1.67 | 1.76 | +0.09 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 103,862 | 110,381 | +6,519 | 1.15 | 1.56 | +0.41 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 18,649 | 93,103 | +74,454 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 92,579 | 91,490 | -1,089 | 0.00 | 0.01 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 86,420 | +86,420 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 81,190 | +81,190 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 77,050 | +77,050 | 0.00 | 0.05 | +0.05 | buy |
| Sio Capital Management, LLC | 187,941 | 73,511 | -114,430 | 4.14 | 1.31 | -2.83 | sell |
| Exome Asset Management LLC | 64,516 | 69,072 | +4,556 | 2.14 | 3.29 | +1.15 | buy |
| JPMORGAN CHASE & CO | 16,255 | 61,017 | +44,762 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 52,905 | 57,261 | +4,356 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 0 | 56,400 | +56,400 | 0.00 | 1.34 | +1.34 | buy |
| TD ASSET MANAGEMENT INC | 40,732 | 44,932 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 14,883 | 42,635 | +27,752 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 40,145 | 40,064 | -81 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,065 | 38,459 | +9,394 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 70,092 | 35,345 | -34,747 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 34,400 | 33,100 | -1,300 | 0.03 | 0.04 | +0.00 | sell |
| Swiss National Bank | 34,800 | 32,200 | -2,600 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 27,483 | 29,036 | +1,553 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,156 | 28,807 | +19,651 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 36,726 | 27,749 | -8,977 | 0.01 | 0.01 | +0.00 | sell |
| Walleye Capital LLC | 209,236 | 27,004 | -182,232 | 0.11 | 0.02 | -0.09 | sell |
| PDT Partners, LLC | 0 | 25,778 | +25,778 | 0.00 | 0.14 | +0.14 | buy |
| UBS Group AG | 33,092 | 24,342 | -8,750 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 22,888 | 24,067 | +1,179 | 0.01 | 0.01 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 23,700 | 23,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sofinnova Investments, Inc. | 41,352 | 22,752 | -18,600 | 0.17 | 0.11 | -0.06 | sell |
| JANE STREET GROUP, LLC | 24,731 | 21,203 | -3,528 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 21,060 | 21,060 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 12,970 | 20,778 | +7,808 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 20,187 | +20,187 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 14,000 | 18,156 | +4,156 | 0.05 | 0.10 | +0.04 | buy |
| Legal & General Group Plc | 14,637 | 17,688 | +3,051 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 19,560 | 17,005 | -2,555 | 0.01 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 6,940 | 16,337 | +9,397 | 0.01 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 9,160 | 16,093 | +6,933 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 17,227 | 15,614 | -1,613 | 0.27 | 0.24 | -0.03 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,967 | 15,531 | -1,436 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 14,683 | 14,257 | -426 | 0.02 | 0.02 | +0.00 | sell |
| Point72 Asset Management, L.P. | 755,867 | 13,444 | -742,423 | 0.13 | 0.00 | -0.13 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 13,353 | +13,353 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 16,075 | 12,874 | -3,201 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 12,851 | +12,851 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,262 | 12,331 | +69 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,369 | 12,213 | -156 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 11,377 | 12,132 | +755 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 11,775 | +11,775 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 11,507 | +11,507 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 5,628 | 10,881 | +5,253 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 7,700 | 10,600 | +2,900 | 1.52 | 3.52 | +2.00 | buy |
| HRT FINANCIAL LP | 0 | 10,358 | +10,358 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 10,551 | 9,809 | -742 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 4,864 | 8,076 | +3,212 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 4,647 | 7,890 | +3,243 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 7,879 | +7,879 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 7,667 | +7,667 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 5,508 | 6,966 | +1,458 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 9,565 | 6,458 | -3,107 | 0.16 | 0.15 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 5,717 | 6,310 | +593 | 0.03 | 0.04 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,255 | 6,276 | -3,979 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 6,213 | +6,213 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 6,020 | 5,862 | -158 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 7,358 | 5,537 | -1,821 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 5,278 | +5,278 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 5,114 | +5,114 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 5,281 | 4,900 | -381 | 0.00 | 0.00 | -0.00 | sell |