| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 752,879 | 1,581,127 | +828,248 | 0.00 | 0.01 | +0.01 | buy |
| BVF INC/IL | 0 | 650,000 | +650,000 | 0.00 | 1.74 | +1.74 | buy |
| JENNISON ASSOCIATES LLC | 0 | 532,079 | +532,079 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 4,935,159 | 5,450,222 | +515,063 | 0.02 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 450,743 | +450,743 | 0.00 | 0.66 | +0.66 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,577,106 | 1,976,132 | +399,026 | 1.28 | 1.61 | +0.32 | buy |
| Pictet Asset Management Holding SA | 3,563 | 394,374 | +390,811 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,326,429 | 1,698,005 | +371,576 | 0.01 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 10,433 | 357,836 | +347,403 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 1,448,059 | 1,767,680 | +319,621 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 231,186 | 523,167 | +291,981 | 1.44 | 3.18 | +1.74 | buy |
| LOOMIS SAYLES & CO L P | 0 | 282,409 | +282,409 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 2,019,283 | 2,274,980 | +255,697 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 250,000 | +250,000 | 0.00 | 6.44 | +6.44 | buy |
| Vestal Point Capital, LP | 500,000 | 735,000 | +235,000 | 1.50 | 2.14 | +0.64 | buy |
| GOLDMAN SACHS GROUP INC | 529,081 | 754,195 | +225,114 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 32,061 | 234,358 | +202,297 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 1,045,597 | 1,187,991 | +142,394 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,410,077 | 1,518,274 | +108,197 | 0.02 | 0.02 | +0.00 | buy |
| Sofinnova Investments, Inc. | 13,553 | 111,010 | +97,457 | 0.05 | 0.38 | +0.33 | buy |
| Palo Alto Investors LP | 224,300 | 317,456 | +93,156 | 2.74 | 3.51 | +0.77 | buy |
| Woodline Partners LP | 866,955 | 957,833 | +90,878 | 0.27 | 0.29 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 308,043 | 395,392 | +87,349 | 0.33 | 0.49 | +0.16 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 37,610 | 122,153 | +84,543 | 0.00 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 5,522 | 84,255 | +78,733 | 0.00 | 0.02 | +0.02 | buy |
| Siren, L.L.C. | 913,401 | 988,401 | +75,000 | 2.36 | 2.34 | -0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 66,125 | +66,125 | 0.00 | 0.03 | +0.03 | buy |
| ARMISTICE CAPITAL, LLC | 436,000 | 499,391 | +63,391 | 0.90 | 0.97 | +0.07 | buy |
| Logos Global Management LP | 450,000 | 510,000 | +60,000 | 2.94 | 2.70 | -0.24 | buy |
| ExodusPoint Capital Management, LP | 0 | 58,211 | +58,211 | 0.00 | 0.05 | +0.05 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 58,053 | +58,053 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 6,133 | 63,535 | +57,402 | 0.00 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 628,151 | 684,958 | +56,807 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 6,800 | 62,820 | +56,020 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 50,394 | 100,395 | +50,001 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.26 | +0.26 | buy |
| Brevan Howard Capital Management LP | 0 | 49,713 | +49,713 | 0.00 | 0.07 | +0.07 | buy |
| BNP Paribas Asset Management Holding S.A. | 213 | 40,203 | +39,990 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 21,443 | 61,070 | +39,627 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.21 | +0.21 | buy |
| CITIGROUP INC | 4,045 | 36,176 | +32,131 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 30,000 | +30,000 | 0.00 | 0.02 | +0.02 | buy |
| Eagle Health Investments LP | 0 | 27,100 | +27,100 | 0.00 | 0.47 | +0.47 | buy |
| MILLENNIUM MANAGEMENT LLC | 161,000 | 184,779 | +23,779 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 23,094 | +23,094 | 0.00 | 0.05 | +0.05 | buy |
| Checkpoint Capital L.P. | 430,000 | 452,992 | +22,992 | 9.52 | 11.40 | +1.88 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 91,380 | 114,351 | +22,971 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,438 | 23,683 | +21,245 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 226,655 | 247,039 | +20,384 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 56,075 | 74,826 | +18,751 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 11,438 | 27,301 | +15,863 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 16,792 | 31,002 | +14,210 | 0.01 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 8,064 | 21,122 | +13,058 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 5,290 | 17,399 | +12,109 | 0.03 | 0.07 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 59,248 | 69,634 | +10,386 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 5,377 | 15,754 | +10,377 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 4,266 | 13,186 | +8,920 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 74,350 | 82,984 | +8,634 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 219,489 | 228,070 | +8,581 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 8,306 | +8,306 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 7,767 | +7,767 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 7,319 | +7,319 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 17,785 | 24,826 | +7,041 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 6,735 | +6,735 | 0.00 | 0.07 | +0.07 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,494 | +6,494 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 193,773 | 200,000 | +6,227 | 1.81 | 2.10 | +0.29 | buy |
| WELLS FARGO & COMPANY/MN | 27,055 | 33,265 | +6,210 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 182,170 | 187,777 | +5,607 | 0.17 | 0.22 | +0.05 | buy |
| Engineers Gate Manager LP | 0 | 5,460 | +5,460 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 8,118 | 13,478 | +5,360 | 0.02 | 0.03 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,577 | 52,510 | +4,933 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,373 | 17,106 | +4,733 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 4,443 | +4,443 | 0.00 | 0.08 | +0.08 | buy |
| Swiss National Bank | 43,600 | 48,000 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 4,357 | +4,357 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 0 | 3,864 | +3,864 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 2,200 | 6,000 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 12,851 | 16,156 | +3,305 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 3,287 | +3,287 | 0.00 | 0.02 | +0.02 | buy |
| Allianz Asset Management GmbH | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 64,800 | 67,707 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| SAXON INTERESTS, INC. | 0 | 2,576 | +2,576 | 0.00 | 0.07 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 27,938 | 30,328 | +2,390 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 45,690 | 47,967 | +2,277 | 1.19 | 1.22 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 8,006 | 9,910 | +1,904 | 0.00 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 1,780 | +1,780 | 0.00 | 0.07 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 18,886 | 20,523 | +1,637 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,093 | 23,256 | +1,163 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,646 | 13,711 | +1,065 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 5,188 | 6,227 | +1,039 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,011 | +1,011 | 0.00 | 0.00 | +0.00 | buy |
| iA Global Asset Management Inc. | 65,512 | 66,430 | +918 | 0.06 | 0.07 | +0.01 | buy |
| Nuveen, LLC | 47,694 | 48,471 | +777 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 2,158 | 2,897 | +739 | 0.04 | 0.06 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 7,094 | 7,751 | +657 | 0.04 | 0.05 | +0.01 | buy |
| KLP KAPITALFORVALTNING AS | 4,600 | 5,200 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,344 | 1,834 | +490 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 0 | 419 | +419 | 0.00 | 0.00 | +0.00 | buy |