| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,935,159 | 5,450,222 | +515,063 | 0.02 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 2,019,283 | 2,274,980 | +255,697 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,577,106 | 1,976,132 | +399,026 | 1.28 | 1.61 | +0.32 | buy |
| VANGUARD GROUP INC | 1,448,059 | 1,767,680 | +319,621 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,326,429 | 1,698,005 | +371,576 | 0.01 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 752,879 | 1,581,127 | +828,248 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,410,077 | 1,518,274 | +108,197 | 0.02 | 0.02 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,142,617 | 1,513,875 | -628,742 | 18.81 | 13.90 | -4.92 | sell |
| Frazier Life Sciences Management, L.P. | 1,438,534 | 1,260,000 | -178,534 | 2.85 | 2.69 | -0.16 | sell |
| STATE STREET CORP | 1,045,597 | 1,187,991 | +142,394 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,415,020 | 1,067,550 | -347,470 | 2.24 | 1.73 | -0.51 | sell |
| Siren, L.L.C. | 913,401 | 988,401 | +75,000 | 2.36 | 2.34 | -0.02 | buy |
| Woodline Partners LP | 866,955 | 957,833 | +90,878 | 0.27 | 0.29 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 529,081 | 754,195 | +225,114 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 500,000 | 735,000 | +235,000 | 1.50 | 2.14 | +0.64 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 628,151 | 684,958 | +56,807 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 0 | 650,000 | +650,000 | 0.00 | 1.74 | +1.74 | buy |
| JENNISON ASSOCIATES LLC | 0 | 532,079 | +532,079 | 0.00 | 0.03 | +0.03 | buy |
| First Light Asset Management, LLC | 231,186 | 523,167 | +291,981 | 1.44 | 3.18 | +1.74 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 919,403 | 511,163 | -408,240 | 0.93 | 0.52 | -0.41 | sell |
| Logos Global Management LP | 450,000 | 510,000 | +60,000 | 2.94 | 2.70 | -0.24 | buy |
| ARMISTICE CAPITAL, LLC | 436,000 | 499,391 | +63,391 | 0.90 | 0.97 | +0.07 | buy |
| Checkpoint Capital L.P. | 430,000 | 452,992 | +22,992 | 9.52 | 11.40 | +1.88 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 450,743 | +450,743 | 0.00 | 0.66 | +0.66 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 308,043 | 395,392 | +87,349 | 0.33 | 0.49 | +0.16 | buy |
| Pictet Asset Management Holding SA | 3,563 | 394,374 | +390,811 | 0.00 | 0.03 | +0.03 | buy |
| Assenagon Asset Management S.A. | 10,433 | 357,836 | +347,403 | 0.00 | 0.04 | +0.04 | buy |
| BAKER BROS. ADVISORS LP | 337,050 | 337,050 | 0 | 0.16 | 0.16 | -0.00 | hold |
| Palo Alto Investors LP | 224,300 | 317,456 | +93,156 | 2.74 | 3.51 | +0.77 | buy |
| Foresite Capital Management V, LLC | 299,069 | 299,069 | 0 | 18.17 | 14.45 | -3.73 | hold |
| Saturn V Capital Management LP | 340,897 | 298,429 | -42,468 | 4.94 | 4.35 | -0.59 | sell |
| LOOMIS SAYLES & CO L P | 0 | 282,409 | +282,409 | 0.00 | 0.03 | +0.03 | buy |
| GREAT POINT PARTNERS LLC | 0 | 250,000 | +250,000 | 0.00 | 6.44 | +6.44 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 226,655 | 247,039 | +20,384 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 32,061 | 234,358 | +202,297 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 219,489 | 228,070 | +8,581 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 230,423 | 223,575 | -6,848 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 338,101 | 221,761 | -116,340 | 0.05 | 0.03 | -0.01 | sell |
| Opaleye Management Inc. | 193,773 | 200,000 | +6,227 | 1.81 | 2.10 | +0.29 | buy |
| TimesSquare Capital Management, LLC | 182,170 | 187,777 | +5,607 | 0.17 | 0.22 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 161,000 | 184,779 | +23,779 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 177,050 | 177,050 | 0 | 0.02 | 0.02 | +0.01 | hold |
| First Turn Management, LLC | 397,693 | 153,206 | -244,487 | 3.95 | 1.39 | -2.56 | sell |
| BANK OF AMERICA CORP /DE/ | 161,184 | 135,986 | -25,198 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 287,800 | 132,800 | -155,000 | 1.17 | 0.63 | -0.55 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 37,610 | 122,153 | +84,543 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 171,623 | 116,112 | -55,511 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 91,380 | 114,351 | +22,971 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 13,553 | 111,010 | +97,457 | 0.05 | 0.38 | +0.33 | buy |
| Catalio Capital Management, LP | 216,527 | 110,427 | -106,100 | 2.65 | 1.55 | -1.10 | sell |
| CITADEL ADVISORS LLC | 50,394 | 100,395 | +50,001 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 107,203 | 99,612 | -7,591 | 0.00 | 0.00 | +0.00 | sell |
| DnB Asset Management AS | 5,522 | 84,255 | +78,733 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 74,350 | 82,984 | +8,634 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 141,479 | 80,274 | -61,205 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 149,864 | 76,338 | -73,526 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 56,075 | 74,826 | +18,751 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 74,000 | 74,000 | 0 | 1.31 | 1.26 | -0.05 | hold |
| TD ASSET MANAGEMENT INC | 59,248 | 69,634 | +10,386 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 64,800 | 67,707 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| iA Global Asset Management Inc. | 65,512 | 66,430 | +918 | 0.06 | 0.07 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 66,125 | +66,125 | 0.00 | 0.03 | +0.03 | buy |
| Verition Fund Management LLC | 6,133 | 63,535 | +57,402 | 0.00 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 6,800 | 62,820 | +56,020 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 21,443 | 61,070 | +39,627 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 58,211 | +58,211 | 0.00 | 0.05 | +0.05 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 58,053 | +58,053 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 284,787 | 57,586 | -227,201 | 4.76 | 0.76 | -4.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,577 | 52,510 | +4,933 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 67,196 | 50,103 | -17,093 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.26 | +0.26 | buy |
| Brevan Howard Capital Management LP | 0 | 49,713 | +49,713 | 0.00 | 0.07 | +0.07 | buy |
| Nuveen, LLC | 47,694 | 48,471 | +777 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 88,003 | 48,082 | -39,921 | 0.44 | 0.28 | -0.17 | sell |
| Swiss National Bank | 43,600 | 48,000 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 45,690 | 47,967 | +2,277 | 1.19 | 1.22 | +0.03 | buy |
| Exome Asset Management LLC | 61,356 | 46,743 | -14,613 | 2.68 | 1.83 | -0.84 | sell |
| BNP Paribas Asset Management Holding S.A. | 213 | 40,203 | +39,990 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,045 | 36,176 | +32,131 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 37,302 | 36,093 | -1,209 | 0.01 | 0.01 | +0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.21 | +0.21 | buy |
| WELLS FARGO & COMPANY/MN | 27,055 | 33,265 | +6,210 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 16,792 | 31,002 | +14,210 | 0.01 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 27,938 | 30,328 | +2,390 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 30,000 | +30,000 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 34,490 | 29,833 | -4,657 | 0.00 | 0.00 | +0.00 | sell |
| Zimmer Partners, LP | 90,163 | 27,500 | -62,663 | 0.15 | 0.06 | -0.09 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 11,438 | 27,301 | +15,863 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 27,100 | +27,100 | 0.00 | 0.47 | +0.47 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 25,146 | 25,200 | +54 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 17,785 | 24,826 | +7,041 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,540 | 24,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 2,438 | 23,683 | +21,245 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 25,147 | 23,653 | -1,494 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,093 | 23,256 | +1,163 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 23,094 | +23,094 | 0.00 | 0.05 | +0.05 | buy |
| SG Americas Securities, LLC | 8,064 | 21,122 | +13,058 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 18,886 | 20,523 | +1,637 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 5,290 | 17,399 | +12,109 | 0.03 | 0.07 | +0.04 | buy |