| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,577,106 | 1,976,132 | +399,026 | 1.28 | 1.61 | +0.32 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,326,429 | 1,698,005 | +371,576 | 0.01 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 231,186 | 523,167 | +291,981 | 1.44 | 3.18 | +1.74 | buy |
| Vestal Point Capital, LP | 500,000 | 735,000 | +235,000 | 1.50 | 2.14 | +0.64 | buy |
| Aberdeen Group plc | 32,061 | 234,358 | +202,297 | 0.00 | 0.03 | +0.03 | buy |
| Sofinnova Investments, Inc. | 13,553 | 111,010 | +97,457 | 0.05 | 0.38 | +0.33 | buy |
| Palo Alto Investors LP | 224,300 | 317,456 | +93,156 | 2.74 | 3.51 | +0.77 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 308,043 | 395,392 | +87,349 | 0.33 | 0.49 | +0.16 | buy |
| DnB Asset Management AS | 5,522 | 84,255 | +78,733 | 0.00 | 0.02 | +0.02 | buy |
| Siren, L.L.C. | 913,401 | 988,401 | +75,000 | 2.36 | 2.34 | -0.02 | buy |
| ARMISTICE CAPITAL, LLC | 436,000 | 499,391 | +63,391 | 0.43 | 0.47 | +0.04 | buy |
| Logos Global Management LP | 450,000 | 510,000 | +60,000 | 2.94 | 2.70 | -0.24 | buy |
| Checkpoint Capital L.P. | 430,000 | 452,992 | +22,992 | 9.52 | 11.40 | +1.88 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 67,196 | 50,103 | +17,093 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 16,792 | 31,002 | +14,210 | 0.01 | 0.01 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 59,248 | 69,634 | +10,386 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 193,773 | 200,000 | +6,227 | 1.81 | 2.10 | +0.29 | buy |
| TimesSquare Capital Management, LLC | 182,170 | 187,777 | +5,607 | 100.00 | 0.22 | -99.78 | buy |
| PROFUND ADVISORS LLC | 8,118 | 13,478 | +5,360 | 0.02 | 0.03 | 0.00 | buy |
| Atle Fund Management AB | 45,690 | 47,967 | +2,277 | 1.19 | 1.22 | +0.03 | buy |
| iA Global Asset Management Inc. | 65,512 | 66,430 | +918 | 0.06 | 0.07 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 2,158 | 2,897 | +739 | 0.04 | 0.06 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 7,094 | 7,751 | +657 | 0.04 | 0.05 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,028 | 9,324 | +296 | 0.01 | 0.02 | +0.00 | buy |
| Avanza Fonder AB | 1,668 | 1,903 | +235 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 6 | 63 | +57 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 748 | 742 | -6 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 37,302 | 36,093 | -1,209 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 13,726 | 12,267 | -1,459 | 0.00 | 0.00 | +0.00 | sell |
| Lion Point Capital, LP | 10,600 | 8,100 | -2,500 | 3.98 | 3.33 | -0.65 | sell |
| Legato Capital Management LLC | 11,287 | 8,248 | -3,039 | 0.08 | 0.06 | -0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,156 | 13,985 | -4,171 | 0.09 | 0.08 | -0.01 | sell |
| Exome Asset Management LLC | 61,356 | 46,743 | -14,613 | 2.68 | 1.83 | -0.84 | sell |
| PFM Health Sciences, LP | 32,539 | 11,002 | -21,537 | 0.17 | 0.09 | -0.08 | sell |
| Nicholas Investment Partners, LP | 88,003 | 48,082 | -39,921 | 0.44 | 0.28 | -0.17 | sell |
| Saturn V Capital Management LP | 340,897 | 298,429 | -42,468 | 4.94 | 4.35 | -0.59 | sell |
| Zimmer Partners, LP | 90,163 | 27,500 | -62,663 | 0.13 | 0.06 | -0.07 | sell |
| Catalio Capital Management, LP | 216,527 | 110,427 | -106,100 | 2.65 | 1.55 | -1.10 | sell |
| Nantahala Capital Management, LLC | 287,800 | 132,800 | -155,000 | 0.66 | 0.35 | -0.31 | sell |
| Frazier Life Sciences Management, L.P. | 1,438,534 | 1,260,000 | -178,534 | 2.85 | 2.69 | -0.16 | sell |
| Sio Capital Management, LLC | 284,787 | 57,586 | -227,201 | 4.76 | 0.72 | -4.04 | sell |
| First Turn Management, LLC | 397,693 | 153,206 | -244,487 | 3.95 | 1.39 | -2.56 | sell |
| ORBIMED ADVISORS LLC | 1,415,020 | 1,067,550 | -347,470 | 2.24 | 1.73 | -0.51 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 919,403 | 511,163 | -408,240 | 0.93 | 0.52 | -0.41 | sell |
| Atlas Venture Life Science Advisors, LLC | 2,142,617 | 1,513,875 | -628,742 | 18.81 | 13.90 | -4.92 | sell |