| Fund | Previous Shares | Current Shares | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 919,403 | 511,163 | +408,240 | 0.93 | 0.52 | 0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,326,429 | 1,698,005 | +371,576 | 0.01 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 67,196 | 50,103 | +17,093 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 16,792 | 31,002 | +14,210 | 0.01 | 0.01 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 59,248 | 69,634 | +10,386 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 193,773 | 200,000 | +6,227 | 1.81 | 2.10 | +0.28 | buy |
| PROFUND ADVISORS LLC | 8,118 | 13,478 | +5,360 | 0.02 | 0.03 | 0.00 | buy |
| Atle Fund Management AB | 45,690 | 47,967 | +2,277 | 1.19 | 1.22 | 0.00 | buy |
| J.Safra Asset Management Corp | 6 | 63 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 37,302 | 36,093 | -1,209 | 0.01 | 0.01 | +0.00 | sell |