| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 22,748,880 | 22,748,880 | 0 | 0.80 | 0.69 | -0.11 | hold |
| FMR LLC | 7,618,948 | 7,608,439 | -10,509 | 0.00 | 0.00 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 6,457,293 | 6,457,293 | 0 | 0.68 | 0.54 | -0.14 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 3.80 | 3.38 | -0.42 | hold |
| Laurion Capital Management LP | 3,182,889 | 3,182,889 | 0 | 0.26 | 0.21 | -0.05 | hold |
| VANGUARD GROUP INC | 1,743,463 | 1,812,899 | +69,436 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,111,123 | 1,111,123 | 0 | 0.03 | 0.02 | -0.00 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Artal Group S.A. | 2,347,424 | 1,000,000 | -1,347,424 | 0.18 | 0.06 | -0.12 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 794,063 | 841,208 | +47,145 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 608,007 | 657,707 | +49,700 | 0.00 | 0.00 | +0.00 | buy |
| Sarissa Capital Management LP | 618,000 | 618,000 | 0 | 0.21 | 0.26 | +0.04 | hold |
| NORTHERN TRUST CORP | 397,221 | 398,362 | +1,141 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 357,151 | 365,859 | +8,708 | 0.01 | 0.01 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 346,087 | 346,087 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 51,600 | 334,658 | +283,058 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 158,392 | +158,392 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 60,170 | 154,436 | +94,266 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 162,700 | 132,700 | -30,000 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 108,209 | 104,551 | -3,658 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,918 | 103,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 38,336 | 93,171 | +54,835 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 76,314 | +76,314 | 0.00 | 0.00 | +0.00 | buy |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 53,708 | +53,708 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 42,990 | 43,670 | +680 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 51,111 | 40,897 | -10,214 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 52,080 | 38,475 | -13,605 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 31,835 | 31,835 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOURGEON CAPITAL MANAGEMENT LLC | 29,450 | 29,450 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 20,486 | 24,919 | +4,433 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 22,488 | +22,488 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,495 | 21,867 | +372 | 0.00 | 0.00 | +0.00 | buy |
| MONEY CONCEPTS CAPITAL CORP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 18,727 | 18,809 | +82 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 18,645 | +18,645 | 0.00 | 0.01 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 17,320 | 18,054 | +734 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 17,705 | +17,705 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 18,038 | 17,382 | -656 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 16,550 | +16,550 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,894 | 14,667 | -1,227 | 0.00 | 0.00 | -0.00 | sell |
| GRIMES & COMPANY, INC. | 13,656 | 14,114 | +458 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 21,296 | 13,182 | -8,114 | 0.00 | 0.00 | -0.00 | sell |
| UNITED BANK | 10,900 | 10,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 5,737 | 7,517 | +1,780 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,201 | 3,837 | -2,364 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,627 | 3,627 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 10,000 | 3,429 | -6,571 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,111 | 3,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 0 | 2,661 | +2,661 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,315 | 1,611 | -3,704 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 2,077 | 1,506 | -571 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,286 | 1,270 | -2,016 | 0.00 | 0.00 | -0.00 | sell |
| HARBOUR INVESTMENTS, INC. | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Bay Advisors LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 0 | 31 | +31 | 0.00 | 0.00 | 0.00 | buy |
| Avior Wealth Management, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 10,050 | 0 | -10,050 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 30,646 | 0 | -30,646 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 797 | 0 | -797 | 0.00 | 0.00 | -0.00 | sell |