| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 529,500 | 701,431 | +171,931 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 139,600 | +139,600 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,024 | 99,739 | +88,715 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 26,698 | 84,945 | +58,247 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 48,196 | +48,196 | 0.00 | 0.00 | +0.00 | buy |
| MONEY CONCEPTS CAPITAL CORP | 25,000 | 51,535 | +26,535 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 24,054 | +24,054 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 422,143 | 438,010 | +15,867 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 13,425 | +13,425 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 0 | 12,731 | +12,731 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 11,859 | +11,859 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 10,764 | +10,764 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 283,199 | 288,363 | +5,164 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 6,419,633 | 6,422,496 | +2,863 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 4,569 | 6,959 | +2,390 | 0.00 | 0.00 | +0.00 | buy |
| UNITED BANK | 15,300 | 15,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 39,646,039 | 39,646,039 | 0 | 0.59 | 0.48 | -0.11 | hold |
| Trustees of Columbia University in the City of New York | 91,910 | 91,910 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 1.69 | 1.73 | +0.04 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.31 | 0.23 | -0.08 | hold |
| HSBC HOLDINGS PLC | 44,728 | 44,728 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 115,934 | 115,934 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NBC SECURITIES, INC. | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 26 | 0 | -26 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,149 | 1,017 | -132 | 0.00 | 0.00 | -0.00 | sell |
| Eagle Bay Advisors LLC | 150 | 0 | -150 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,601 | 3,448 | -153 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 481 | 133 | -348 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 3,045 | 1,985 | -1,060 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 2,422 | 678 | -1,744 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,942,821 | 1,940,223 | -2,598 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 488,363 | 484,506 | -3,857 | 0.00 | 0.00 | -0.00 | sell |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 30,000 | 20,773 | -9,227 | 0.01 | 0.00 | -0.00 | sell |
| WEDBUSH SECURITIES INC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,069 | 0 | -10,069 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 157,617 | 147,022 | -10,595 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 132,600 | 120,900 | -11,700 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 16,102 | 0 | -16,102 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 165,805 | 148,073 | -17,732 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 37,190 | 18,668 | -18,522 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 27,500 | 0 | -27,500 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 28,090 | 0 | -28,090 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 163,064 | 122,991 | -40,073 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 51,111 | 0 | -51,111 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 54,470 | 0 | -54,470 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 71,788 | 0 | -71,788 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 261,837 | 186,849 | -74,988 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 86,685 | 0 | -86,685 | 0.00 | 0.00 | -0.00 | sell |
| Sarissa Capital Management LP | 618,000 | 508,016 | -109,984 | 0.21 | 0.24 | +0.02 | sell |
| CITADEL ADVISORS LLC | 200,405 | 0 | -200,405 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 329,378 | 0 | -329,378 | 0.00 | 0.00 | -0.00 | sell |
| Lynx1 Capital Management LP | 637,218 | 0 | -637,218 | 0.27 | 0.00 | -0.27 | sell |