| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 5,673,078 | +5,673,078 | 0.00 | 2.76 | +2.76 | buy |
| MARSHALL WACE, LLP | 0 | 1,153,276 | +1,153,276 | 0.00 | 0.02 | +0.02 | buy |
| VR Adviser, LLC | 1,943,766 | 3,041,719 | +1,097,953 | 1.26 | 2.03 | +0.77 | buy |
| STATE STREET CORP | 91,053 | 1,118,458 | +1,027,405 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 925,067 | 1,925,066 | +999,999 | 0.91 | 2.43 | +1.52 | buy |
| Rosalind Advisors, Inc. | 0 | 700,000 | +700,000 | 0.00 | 5.12 | +5.12 | buy |
| Logos Global Management LP | 100,000 | 750,000 | +650,000 | 0.09 | 0.69 | +0.60 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 555,702 | +555,702 | 0.00 | 0.23 | +0.23 | buy |
| FCPM III SERVICES B.V. | 3,617,354 | 4,117,354 | +500,000 | 6.20 | 10.17 | +3.97 | buy |
| BRAIDWELL LP | 0 | 466,774 | +466,774 | 0.00 | 0.28 | +0.28 | buy |
| GREAT POINT PARTNERS LLC | 1,370,107 | 1,750,000 | +379,893 | 5.81 | 7.65 | +1.84 | buy |
| BlackRock, Inc. | 465,636 | 794,759 | +329,123 | 0.00 | 0.00 | +0.00 | buy |
| Clearline Capital LP | 0 | 326,168 | +326,168 | 0.00 | 0.45 | +0.45 | buy |
| Propel Bio Management, LLC | 0 | 314,543 | +314,543 | 0.00 | 3.52 | +3.52 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 232,608 | +232,608 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 292,118 | 488,368 | +196,250 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 173,028 | +173,028 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 185,808 | 342,573 | +156,765 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 128,839 | +128,839 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 116,721 | +116,721 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 145,640 | 261,891 | +116,251 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 112,892 | +112,892 | 0.00 | 0.00 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 95,745 | +95,745 | 0.00 | 0.02 | +0.02 | buy |
| Simplify Asset Management Inc. | 0 | 53,510 | +53,510 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 50,505 | +50,505 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 26,791 | 76,630 | +49,839 | 0.00 | 0.02 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 42,217 | +42,217 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 224,534 | 258,587 | +34,053 | 0.00 | 0.00 | +0.00 | buy |
| Irenic Capital Management LP | 0 | 32,663 | +32,663 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 38,946 | 64,549 | +25,603 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 22,216 | +22,216 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 22,015 | +22,015 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 15,047 | +15,047 | 0.00 | 0.22 | +0.22 | buy |
| AXQ CAPITAL, LP | 0 | 15,019 | +15,019 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 0 | 13,716 | +13,716 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 11,870 | +11,870 | 0.00 | 0.01 | +0.01 | buy |
| Cannon Global Investment Management, LLC | 0 | 11,700 | +11,700 | 0.00 | 0.51 | +0.51 | buy |
| Invesco Ltd. | 0 | 11,600 | +11,600 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 10,070 | +10,070 | 0.00 | 0.05 | +0.05 | buy |
| GROUP ONE TRADING LLC | 0 | 9,065 | +9,065 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 18,459 | 25,482 | +7,023 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,746 | 7,368 | +4,622 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 3,513 | +3,513 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 291 | 2,844 | +2,553 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,729 | 3,466 | +1,737 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 317,243 | 318,670 | +1,427 | 0.28 | 0.53 | +0.25 | buy |
| Mirae Asset Global Investments Co., Ltd. | 819 | 2,166 | +1,347 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 307 | +307 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 3 | 73 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 330 | 372 | +42 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 37 | +37 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| WPG Advisers, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 40 | 40 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 5,404,998 | 5,404,998 | 0 | 0.72 | 1.02 | +0.30 | hold |
| Bollard Group LLC | 23,987 | 23,987 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Sarissa Capital Management LP | 25,399 | 25,399 | 0 | 0.15 | 0.29 | +0.14 | hold |
| SBI Securities Co., Ltd. | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Paradigm Biocapital Advisors LP | 1,750,000 | 1,750,000 | 0 | 0.61 | 0.64 | +0.03 | hold |
| Frazier Life Sciences Management, L.P. | 2,543,939 | 2,543,939 | 0 | 0.89 | 1.17 | +0.27 | hold |
| JOHNSON & JOHNSON | 53,732 | 53,732 | 0 | 0.13 | 0.15 | +0.02 | hold |
| CITIGROUP INC | 6,340 | 5,373 | -967 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 1,399 | 136 | -1,263 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 28,204 | 26,880 | -1,324 | 0.00 | 0.01 | +0.00 | sell |
| Hudson Bay Capital Management LP | 5,110 | 0 | -5,110 | 0.00 | 0.00 | -0.00 | sell |
| Chung Wu Investment Group, LLC | 8,300 | 0 | -8,300 | 0.09 | 0.00 | -0.09 | sell |
| Susquehanna Portfolio Strategies, LLC | 10,207 | 0 | -10,207 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 10,745 | 0 | -10,745 | 0.02 | 0.00 | -0.02 | sell |
| Persistent Asset Partners Ltd | 10,798 | 0 | -10,798 | 0.07 | 0.00 | -0.07 | sell |
| TUDOR INVESTMENT CORP ET AL | 167,673 | 152,571 | -15,102 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 91,810 | 75,890 | -15,920 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 17,542 | 0 | -17,542 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 20,700 | 0 | -20,700 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 410,417 | 321,917 | -88,500 | 1.12 | 0.99 | -0.13 | sell |
| AMERIPRISE FINANCIAL INC | 163,061 | 0 | -163,061 | 0.00 | 0.00 | -0.00 | sell |
| FINDELL CAPITAL MANAGEMENT LLC | 231,000 | 0 | -231,000 | 1.00 | 0.00 | -1.00 | sell |
| CITADEL ADVISORS LLC | 433,894 | 148,768 | -285,126 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,526,170 | 1,539,670 | -986,500 | 0.00 | 0.00 | -0.00 | sell |