| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 93,171 | 375,342 | +282,171 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 247,167 | +247,167 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 158,392 | 389,638 | +231,246 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 334,658 | 495,300 | +160,642 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,812,899 | 1,954,285 | +141,386 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 132,298 | +132,298 | 0.00 | 0.01 | +0.01 | buy |
| MAI Capital Management | 365,859 | 470,068 | +104,209 | 0.01 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 95,367 | +95,367 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 77,800 | +77,800 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 63,262 | +63,262 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 52,914 | +52,914 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 52,287 | +52,287 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 35,100 | +35,100 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 132,700 | 165,900 | +33,200 | 0.01 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 31,855 | +31,855 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 17,705 | 49,038 | +31,333 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 53,708 | 81,305 | +27,597 | 0.00 | 0.00 | -0.00 | buy |
| Ground Swell Capital, LLC | 0 | 20,674 | +20,674 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 17,596 | +17,596 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 14,402 | +14,402 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,611 | 15,610 | +13,999 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,370 | +12,370 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 11,328 | +11,328 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,204 | +11,204 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 40,897 | 51,111 | +10,214 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 9,800 | +9,800 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 5,111 | +5,111 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 76,314 | 81,114 | +4,800 | 0.00 | 0.00 | -0.00 | buy |
| UNITED BANK | 10,900 | 15,300 | +4,400 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 1,945 | +1,945 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,231 | +1,231 | 0.00 | 0.00 | +0.00 | buy |
| GRIMES & COMPANY, INC. | 14,114 | 15,142 | +1,028 | 0.00 | 0.00 | -0.00 | buy |
| NBC SECURITIES, INC. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 528 | +528 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 31 | 34 | +3 | 0.00 | 0.00 | 0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 22,748,880 | 22,748,880 | 0 | 0.69 | 0.30 | -0.39 | hold |
| Ensign Peak Advisors, Inc | 346,087 | 346,087 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sarissa Capital Management LP | 618,000 | 618,000 | 0 | 0.26 | 0.10 | -0.15 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 3.38 | 1.42 | -1.95 | hold |
| Paradigm Biocapital Advisors LP | 6,457,293 | 6,457,293 | 0 | 0.54 | 0.25 | -0.29 | hold |
| Eagle Bay Advisors LLC | 150 | 150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.06 | 0.27 | +0.21 | hold |
| MONEY CONCEPTS CAPITAL CORP | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF MONTREAL /CAN/ | 22,488 | 22,488 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 24,919 | 24,219 | -700 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 7,517 | 6,456 | -1,061 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,270 | 0 | -1,270 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 1,506 | 65 | -1,441 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 18,054 | 16,473 | -1,581 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 2,661 | 0 | -2,661 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,111 | 0 | -3,111 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 3,429 | 229 | -3,200 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,627 | 0 | -3,627 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,837 | 0 | -3,837 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 38,475 | 25,751 | -12,724 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 13,182 | 0 | -13,182 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 14,667 | 0 | -14,667 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 16,550 | 0 | -16,550 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 17,382 | 0 | -17,382 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 398,362 | 380,743 | -17,619 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 18,645 | 0 | -18,645 | 0.01 | 0.00 | -0.01 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 18,809 | 0 | -18,809 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,867 | 322 | -21,545 | 0.00 | 0.00 | -0.00 | sell |
| BOURGEON CAPITAL MANAGEMENT LLC | 29,450 | 0 | -29,450 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 31,835 | 0 | -31,835 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 154,436 | 117,788 | -36,648 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 43,670 | 5,505 | -38,165 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,918 | 17,792 | -86,126 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 104,551 | 0 | -104,551 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 841,208 | 424,832 | -416,376 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 7,608,439 | 7,075,802 | -532,637 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 657,707 | 115,934 | -541,773 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 3,182,889 | 2,525,449 | -657,440 | 0.21 | 0.08 | -0.13 | sell |
| Artal Group S.A. | 1,000,000 | 0 | -1,000,000 | 0.06 | 0.00 | -0.06 | sell |
| Woodline Partners LP | 1,111,123 | 0 | -1,111,123 | 0.02 | 0.00 | -0.02 | sell |