| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| UBS Group AG | 0 | 1,531,636 | +1,531,636 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 525,613 | +525,613 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 474,575 | +474,575 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 403,859 | +403,859 | 0.00 | 0.16 | +0.16 | buy |
| Virtu Financial LLC | 0 | 275,912 | +275,912 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 84,945 | 180,788 | +95,843 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 94,394 | +94,394 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 0 | 87,485 | +87,485 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 122,991 | 169,636 | +46,645 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 40,943 | +40,943 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 133 | 400 | +267 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,017 | 1,017 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 39,646,039 | 39,646,039 | 0 | 0.48 | 1.08 | +0.61 | hold |
| Trustees of Columbia University in the City of New York | 91,910 | 91,910 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sarissa Capital Management LP | 508,016 | 508,016 | 0 | 0.24 | 0.53 | +0.30 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 1.73 | 3.96 | +2.24 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.23 | 0.34 | +0.12 | hold |
| STATE STREET CORP | 115,934 | 115,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 678 | 0 | -678 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,448 | 2,295 | -1,153 | 0.00 | 0.00 | +0.00 | sell |
| Chicago Partners Investment Group LLC | 12,731 | 10,887 | -1,844 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 1,985 | 0 | -1,985 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 438,010 | 435,560 | -2,450 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 6,959 | 0 | -6,959 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 10,764 | 0 | -10,764 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 11,859 | 0 | -11,859 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 13,425 | 0 | -13,425 | 0.00 | 0.00 | -0.00 | sell |
| UNITED BANK | 15,300 | 0 | -15,300 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 18,668 | 0 | -18,668 | 0.00 | 0.00 | -0.00 | sell |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 20,773 | 0 | -20,773 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 24,054 | 0 | -24,054 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,940,223 | 1,915,606 | -24,617 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 44,728 | 0 | -44,728 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 48,196 | 0 | -48,196 | 0.00 | 0.00 | -0.00 | sell |
| MONEY CONCEPTS CAPITAL CORP | 51,535 | 0 | -51,535 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 147,022 | 72,417 | -74,605 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 99,739 | 0 | -99,739 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 484,506 | 374,763 | -109,743 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 120,900 | 0 | -120,900 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 139,600 | 0 | -139,600 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 148,073 | 0 | -148,073 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 186,849 | 0 | -186,849 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 701,431 | 468,112 | -233,319 | 0.00 | 0.00 | +0.00 | sell |
| MAI Capital Management | 288,363 | 3,652 | -284,711 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 6,422,496 | 2,092,686 | -4,329,810 | 0.00 | 0.00 | -0.00 | sell |