| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1,539,670 | 4,932,149 | +3,392,479 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 794,759 | 3,468,107 | +2,673,348 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,118,458 | 2,616,336 | +1,497,878 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 845,000 | +845,000 | 0.00 | 0.94 | +0.94 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 342,573 | 1,062,469 | +719,896 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 680,626 | +680,626 | 0.00 | 0.59 | +0.59 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 646,550 | +646,550 | 0.00 | 1.18 | +1.18 | buy |
| Woodline Partners LP | 0 | 379,723 | +379,723 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 64,549 | 328,742 | +264,193 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 258,587 | 428,067 | +169,480 | 0.00 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 0 | 149,681 | +149,681 | 0.00 | 0.15 | +0.15 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 121,398 | +121,398 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 466,774 | 573,104 | +106,330 | 0.28 | 0.39 | +0.11 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,216 | 121,398 | +99,182 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 97,722 | +97,722 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 94,815 | +94,815 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 321,917 | 416,417 | +94,500 | 0.99 | 1.10 | +0.11 | buy |
| XTX Topco Ltd | 0 | 82,645 | +82,645 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 261,891 | 328,892 | +67,001 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 112,892 | 177,739 | +64,847 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,373 | 63,130 | +57,757 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 57,528 | +57,528 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,600 | 68,301 | +56,701 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 54,998 | +54,998 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 54,671 | +54,671 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 46,612 | +46,612 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 41,815 | +41,815 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 40,351 | +40,351 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 37,210 | +37,210 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 37,012 | +37,012 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 36,273 | +36,273 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 32,663 | +32,663 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 27,100 | +27,100 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 24,442 | +24,442 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 22,785 | +22,785 | 0.00 | 0.10 | +0.10 | buy |
| JPMORGAN CHASE & CO | 0 | 21,621 | +21,621 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,513 | 24,381 | +20,868 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 17,238 | +17,238 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 15,301 | +15,301 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 136 | 14,565 | +14,429 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 13,695 | +13,695 | 0.00 | 0.03 | +0.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 12,035 | +12,035 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 148,768 | 160,414 | +11,646 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,793 | +10,793 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 10,785 | +10,785 | 0.00 | 0.05 | +0.05 | buy |
| Engineers Gate Manager LP | 26,880 | 36,951 | +10,071 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 13,716 | 23,019 | +9,303 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 8,011 | +8,011 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,844 | 10,708 | +7,864 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 488,368 | 493,278 | +4,910 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 15,047 | 18,828 | +3,781 | 0.22 | 0.28 | +0.06 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,703 | +3,703 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 555,702 | 558,702 | +3,000 | 0.23 | 0.19 | -0.04 | buy |
| PROFUND ADVISORS LLC | 22,015 | 24,591 | +2,576 | 0.01 | 0.01 | -0.00 | buy |
| Global Retirement Partners, LLC | 0 | 2,089 | +2,089 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 1,975 | +1,975 | 0.00 | 0.00 | +0.00 | buy |
| Winthrop Capital Management, LLC | 0 | 1,481 | +1,481 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 7,368 | 8,624 | +1,256 | 0.01 | 0.01 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 815 | +815 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 372 | 1,072 | +700 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 562 | +562 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 355 | +355 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,166 | 2,423 | +257 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 39 | 147 | +108 | 0.00 | 0.00 | +0.00 | buy |
| WPG Advisers, LLC | 21 | 22 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Sarissa Capital Management LP | 25,399 | 25,399 | 0 | 0.29 | 0.26 | -0.02 | hold |
| VR Adviser, LLC | 3,041,719 | 3,041,719 | 0 | 2.03 | 1.70 | -0.33 | hold |
| Caligan Partners LP | 1,925,066 | 1,925,066 | 0 | 2.43 | 1.71 | -0.72 | hold |
| TCG Crossover Management, LLC | 5,673,078 | 5,673,078 | 0 | 2.76 | 2.51 | -0.25 | hold |
| SBI Securities Co., Ltd. | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Paradigm Biocapital Advisors LP | 1,750,000 | 1,750,000 | 0 | 0.64 | 0.60 | -0.03 | hold |
| Frazier Life Sciences Management, L.P. | 2,543,939 | 2,543,939 | 0 | 1.17 | 1.02 | -0.15 | hold |
| JOHNSON & JOHNSON | 53,732 | 53,732 | 0 | 0.15 | 0.12 | -0.02 | hold |
| FCPM III SERVICES B.V. | 4,117,354 | 4,117,354 | 0 | 10.17 | 10.10 | -0.07 | hold |
| Fortitude Family Office, LLC | 31 | 0 | -31 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Advisory Services, LLC | 37 | 0 | -37 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 48 | 5 | -43 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 73 | 10 | -63 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 307 | 0 | -307 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 50,505 | 48,818 | -1,687 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,466 | 1,741 | -1,725 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 25,482 | 23,231 | -2,251 | 0.00 | 0.00 | -0.00 | sell |
| AXIOM INVESTORS LLC /DE | 95,745 | 92,105 | -3,640 | 0.02 | 0.01 | -0.00 | sell |
| GROUP ONE TRADING LLC | 9,065 | 2,963 | -6,102 | 0.01 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 10,070 | 0 | -10,070 | 0.05 | 0.00 | -0.05 | sell |
| Cannon Global Investment Management, LLC | 11,700 | 0 | -11,700 | 0.51 | 0.00 | -0.51 | sell |
| WINTON GROUP Ltd | 11,870 | 0 | -11,870 | 0.01 | 0.00 | -0.01 | sell |
| AXQ CAPITAL, LP | 15,019 | 0 | -15,019 | 0.03 | 0.00 | -0.03 | sell |
| Bollard Group LLC | 23,987 | 0 | -23,987 | 0.01 | 0.00 | -0.01 | sell |
| Irenic Capital Management LP | 32,663 | 0 | -32,663 | 0.05 | 0.00 | -0.05 | sell |
| Clearline Capital LP | 326,168 | 285,276 | -40,892 | 0.45 | 0.34 | -0.11 | sell |
| Brevan Howard Capital Management LP | 42,217 | 0 | -42,217 | 0.01 | 0.00 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 1,750,000 | 1,700,000 | -50,000 | 7.65 | 7.37 | -0.27 | sell |
| Rosalind Advisors, Inc. | 700,000 | 648,600 | -51,400 | 5.12 | 4.49 | -0.63 | sell |
| Simplify Asset Management Inc. | 53,510 | 0 | -53,510 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 75,890 | 0 | -75,890 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 76,630 | 0 | -76,630 | 0.02 | 0.00 | -0.02 | sell |