| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hudson Bay Capital Management LP | 0 | 2,466,236 | +2,466,236 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 495,300 | 756,011 | +260,711 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 137,134 | +137,134 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 76,685 | +76,685 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 50,300 | +50,300 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 117,788 | 165,805 | +48,017 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 41,495 | +41,495 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 81,114 | 116,635 | +35,521 | 0.00 | 0.00 | -0.00 | buy |
| CHIRON CAPITAL MANAGEMENT, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| MAI Capital Management | 470,068 | 475,891 | +5,823 | 0.00 | 0.00 | -0.00 | buy |
| Ground Swell Capital, LLC | 20,674 | 26,103 | +5,429 | 0.02 | 0.03 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 5,053 | +5,053 | 0.00 | 0.00 | +0.00 | buy |
| MONEY CONCEPTS CAPITAL CORP | 20,000 | 25,000 | +5,000 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 3,600 | 3,759 | +159 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,954,285 | 1,954,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UNITED BANK | 15,300 | 15,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GRIMES & COMPANY, INC. | 15,142 | 15,142 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 22,748,880 | 22,748,880 | 0 | 0.30 | 0.18 | -0.12 | hold |
| Bollard Group LLC | 55,555 | 55,555 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sarissa Capital Management LP | 618,000 | 618,000 | 0 | 0.10 | 0.11 | +0.00 | hold |
| LMR Partners LLP | 51,111 | 51,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 528 | 528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 6,361,723 | 6,361,723 | 0 | 1.42 | 0.92 | -0.50 | hold |
| Eagle Bay Advisors LLC | 150 | 150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalyst Funds Management Pty Ltd | 9,800 | 9,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 1,074,658 | 1,074,658 | 0 | 0.27 | 0.18 | -0.09 | hold |
| DIMENSIONAL FUND ADVISORS LP | 24,219 | 24,219 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,792 | 17,792 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 81,305 | 81,305 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 115,934 | 115,934 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 34 | 0 | -34 | 0.00 | 0.00 | 0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 65 | 0 | -65 | 0.00 | 0.00 | 0.00 | sell |
| Smartleaf Asset Management LLC | 102 | 0 | -102 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 229 | 0 | -229 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 322 | 0 | -322 | 0.00 | 0.00 | -0.00 | sell |
| NBC SECURITIES, INC. | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 1,231 | 0 | -1,231 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 1,945 | 0 | -1,945 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 424,832 | 422,143 | -2,689 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 16,473 | 13,593 | -2,880 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 49,038 | 44,728 | -4,310 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 7,075,802 | 7,071,110 | -4,692 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 5,111 | 0 | -5,111 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 5,505 | 0 | -5,505 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 6,456 | 0 | -6,456 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,204 | 0 | -11,204 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 15,610 | 4,298 | -11,312 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 11,328 | 0 | -11,328 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 12,370 | 0 | -12,370 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 14,402 | 26 | -14,376 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 25,751 | 11,024 | -14,727 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 346,087 | 329,378 | -16,709 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 17,596 | 0 | -17,596 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,524 | 0 | -19,524 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 22,488 | 0 | -22,488 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 165,900 | 135,900 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 31,855 | 0 | -31,855 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 63,262 | 29,530 | -33,732 | 0.01 | 0.00 | -0.01 | sell |
| Paloma Partners Management Co | 35,100 | 0 | -35,100 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 52,287 | 0 | -52,287 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 52,914 | 0 | -52,914 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 95,367 | 30,825 | -64,542 | 0.00 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 77,800 | 0 | -77,800 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 389,638 | 303,825 | -85,813 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 132,298 | 0 | -132,298 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,167 | 0 | -247,167 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 380,743 | 113,365 | -267,378 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 375,342 | 28,227 | -347,115 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 2,525,449 | 28,981 | -2,496,468 | 0.08 | 0.00 | -0.08 | sell |
| Paradigm Biocapital Advisors LP | 6,457,293 | 0 | -6,457,293 | 0.25 | 0.00 | -0.25 | sell |